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Role of p53 suppression in the pathogenesis of hepatocellular carcinoma

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World Journal of Gastrointestinal Pathophysiology 2023年第3期14卷 46-70页

作者： Heena b Choudhary satish k Mandlik Deepa S Mandlik Department of Pharmacology BVDUPoona College of PharmacyPune 411038MaharashtraIndia Department of Pharmaceutics BVDUPoona College of PharmacyPune 411038MaharashtraIndia

In the world,hepatocellular carcinoma(HCC)is among the top 10 most prevalent *** formation has indeed been linked to numerous etiological factors,including alcohol usage,hepatitis viruses and liver *** the most prevalent defects in a wide range of tumours,notably HCC,is the silencing of the p53 tumour suppressor *** control of the cell cycle and the preservation of gene function are both critically important functions of *** order to pinpoint the core mechanisms of HCC and find more efficient treatments,molecular research employing HCC tissues has been the main *** p53 triggers necessary reactions that achieve cell cycle arrest,genetic stability,DNA repair and the elimination of DNA-damaged cells’responses to biological stressors(like oncogenes or DNA damage).To the contrary hand,the oncogene protein of the murine double minute 2(MDM2)is a significant biological inhibitor of ***2 causes p53 protein degradation,which in turn adversely controls p53 *** carrying wt-p53,the majority of HCCs show abnormalities in the p53-expressed apoptotic *** p53 in-vivo expression might have two clinical impacts on HCC:(1)Increased levels of exogenous p53 protein cause tumour cells to undergo apoptosis by preventing cell growth through a number of biological pathways;and(2)Exogenous p53 makes HCC susceptible to various anticancer *** review describes the functions and primary mechanisms of p53 in pathological mechanism,chemoresistance and therapeutic mechanisms of HCC.

关键词： Hepatocellular carcinoma p53 Tumour suppressor gene Murine double minute 2 Chemoresistance

Use of Isoproturon Imprinted Polymer Membranes as a Selective Recognition Platform in a Resistance based Electrochemical Sensor

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Open Journal of Applied biosensor 2013年第1期2卷 20-28页

作者： krishna Pal Singh Ramesh kumar Prajapati Saurabh Ahlawat Sweeti Ahlawat Manjul Mungali satish kumar Clay Product Environment Study Technology Division CSIR-Central Building Research Institute Roorkee India Membrane biophysics & Nanobiosensor Research Laboratory CBSH G.B. Pant University of Agriculture & Technology Pantnagar India Membrane biophysics & Nanobiosensor Research Laboratory CBSH G.B. Pant University of Agriculture & TechnologyPantnagar India

Methacrylic acid with isoproturon has been utilized to prepare molecularly imprinted polymeric (MIP) membrane on Whatman filter paper no. 5 for selective electrochemical estimation of isoproturon pesticide. MIP membrane was prepared by radical polymerization and characterized using Ultra Violet spectrophotometer, Fourier Transform Infra Red (FTIR) spectroscopy and Scanning Electron Microscopy (SEM). Contact angle study was used to determine the surface energy of the MIP membrane and electrical conductivity measurements were performed by applying a small-amplitude alternating voltage (20 mV) with frequencies varying from 20 Hz to 80 kHz generated by a low-frequency wave form generator. Different isoproturon concentrations in samples were tested and analyzed. Results indicate linear increase in membrane resistance with increasing isoproturon in 10-3 to 10-6 M range. The selectivity of the electrochemical sensor was confirmed by testing isoproturon in presence of the structurally related compounds monouran and diuran. Results reveal highly selective and sensitive sensor, which can be employed for regular estimation of isoproturon in fields.

关键词： Sensor Isoproturon Molecular Imprinting Monouran Diuran

Socio-cultural features and help-seeking preferences for leprosy and tuberculosis: a cultural epidemiological study in a tribal district of Maharashtra, India

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Infectious Diseases of Poverty 2015年第1期4卷 257-270页

作者： Amar Prakash Maske Pravin Arun Sawant Saju Joseph Uma satish Mahajan Abhay Machindra kudale The Maharashtra Association of Anthropological Sciences Centre for Health Research and Development(MAAS-CHRD)201Akanksha ResidencyB-WingSecond FloorNear Shivaji StatueAundh GaonPune 411007MaharashtraIndia Savitribai Phule Pune University GaneshkhindPuneMaharashtra 411007India

background:India is a major contributor to the global burden of leprosy and tuberculosis(Tb),which adversely affects the poorest tribal *** prioritisation by disease control programmes,programme performance for leprosy and Tb in tribal communities continues to be a *** addition to access to services and infrastructural limitations,socio-cultural concepts of illness causation and related help seeking(HS)rooted in distinct features of tribal culture need to be addressed to improve programme ***:A cultural epidemiological survey of leprosy and Tb patients was carried out using a locally adapted,semi-structured explanatory model interviews.A total of 100 leprosy and 50 Tb patients registered for treatment at government health facilities were selected randomly from tribal dominant blocks of the Thane district,Maharashtra *** perceived causes(PCs)of leprosy and Tb in patients were compared based on prominence *** relationship between PCs as predictors,and disease conditions and HS preferences as outcome variables were assessed using multivariate logistic ***:In the multivariate logistic regression model with disease conditions as outcome variables,Tb patients were significantly more likely to report PCs in the categories of ingestion;health,illness and injury;and traditional,cultural and *** patients more frequently first sought help from private facilities as compared to leprosy patients who preferred government health *** a combined analysis of leprosy and Tb patients employing multivariate logistic regression,it was found that patients who reported PCs in the environmental and contact-related categories were more likely to visit traditional rather than non-traditional *** another multivariate combined model,it was found that patients who reported PCs in the traditional,cultural and supernatural category were significantly more likely to visit private rathe

关键词： Socio-cultural features Help seeking Leprosy Tuberculosis Tribal Cultural epidemiology ACSM IEC India

Identification of HCV Inhibitors from a Cell-based Sub-Genomic Replicon Screen

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Open Journal of Medicinal Chemistry 2013年第1期3卷 16-25页

作者： David C. Pryde Thien-Duc Tran Mark Gardner Chris Pickford Stephen M. Shaw Mike Westby Tanya Parkinson Caroline Smith-burchnell Rob Webster satish Dayal Anti-Infectives Research Unit Pfizer Global Research and Develoapment Sandwich UK Anti-Infectives Research Unit Pfizer Global Research and Development Sandwich UK Pharmacokinetics Dynamics and Metabolism Pfizer Global Research and Development Sandwich UK Worldwide Medicinal Chemistry Pfizer Global Research and Development Sandwich UK

A high throughput screen of the Pfizer compound collection was carried out using a hepatitis C virus (HCV) genotype 1b subgenomic replicon cell line. Those confirmed hits that demonstrated broad spectrum activity without overt cytotoxicity were further evaluated, leading to the identification of a series of pyrrolopyridines with excellent antiviral activity in a fully infectious HCV cell-based assay and pharmacokinetic properties.

关键词： HCV Replicon Antiviral Cell-based Screen

An Efficient and Rapid Synthesis of 2-amino-4-arylthiazoles Employing Microwave Irradiation in Water

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奈必洛尔,而非美托洛尔,降低一氧化氮敏感性高血压患者的血压

Green and Sustainable Chemistry（绿色与可持续化学） 2011年第2期

作者： kishor S. Jain Jitender b. bariwal Muthu k. kathiravan Vikas k. Raskar Gajanan S. Wankhede Nitin A. Londhe satish N. Dighe P. G. Research Centre Department of Pharmaceutical Chemistry Sinhgad College of Pharmacy

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中华高血压杂志 2014年第12期22卷 1107-1107页

作者：赵狄练桂丽 Luis EO Alfredo G Cyndya AS Amy CA Leena C bonnie kb satish RR David R Italo b

奈必洛尔不像其他选择性β1受体阻滞剂,其引起血管扩张是通过增加一氧化氮的生物利用度。此机制对于奈必洛尔降压作用的相关影响仍不清楚,因为正常情况下为压力感受性反射的缓冲作用所掩盖。自主神经调节障碍提供了一个对一氧化氮降压... 详细信息

奈必洛尔不像其他选择性β1受体阻滞剂,其引起血管扩张是通过增加一氧化氮的生物利用度。此机制对于奈必洛尔降压作用的相关影响仍不清楚,因为正常情况下为压力感受性反射的缓冲作用所掩盖。自主神经调节障碍提供了一个对一氧化氮降压作用敏感的独特高血压模型。该研究在此类患者中验证奈必洛尔通过不依赖于β受体阻滞机制降低血压的假设。

关键词：一氧化氮敏感性高血压患者奈必洛尔美托洛尔选择性β1受体阻滞剂压力感受性反射降压作用生物利用度

Assessment of geodetic strain and stress variations in Nepal due to 25 April 2015 Gorkha earthquake: Insights from the GNSS data analysis and b-value

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Potential Application of Silica Aerogel Granules for Cleanup of Accidental Spillage of Various Organic Liquids

Geodesy and Geodynamics 2022年第3期

作者： Sravanthi Gunti Priyom Roy J.Narendran Ramesh Pudi S.Muralikrishnan k.Vinod kumar M.Subrahmanyam Y.Israel b.satish kumar

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Induced Polyploidy via Colchicine Treatment Increases Flower Size and Fruit Weight in Cape Gooseberry(Physalis peruviana L.)

Soft Nanoscience Letters（软纳米科学报） 2011年第4期

作者： Vinayak G. Parale Dinesh b. Mahadik Mahendra S. kavale A. Venkateswara Rao Pratap b. Wagh satish C. Gupta Air Glass Laboratory Department of Physics Shivaji University Applied Physics Division bhabha Atomic Research Centre

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Journal of Agricultural Science and Technology(b) 2020年第3期10卷 144-155页

作者： Ravindra kumar Shubhranshu Sengupta Sanyat Misra satish Chandra Narayan kamleshwari Prasad Singh Department of Horticulture Birsa Agricultural UniversityKankeRanchi-834006JharkhandIndia Department of Plant breeding and Genetics Birsa Agricultural UniversityKankeRanchi-834006JharkhandIndia krishi Vigyan kendra Katihar-854103Bihar Agricultural UniversitySabourBhagalpur-813210BiharIndia

An induced polyploid plant through colchicine treatment offers probably the best scope for improvement in flower size and fruit ***,in the present study,an attempt was made to induce polyploidy in Cape gooseberry using colchicine with the objective of creating more genetic *** colchicine concentrations were used as 0.10%(C1),0.20%(C2)and 0.40%(C3)for the duration 12(H1),24(H2)and 36(H3)hours for each concentration with seedling apex dip method(M1),cotton plug method(M2)and lanolin paste method(M3).The plants treated with 0.10%of colchicine by cotton plug method for 12 h showed the better performance during the years 2017-2018 and 2018-2019 in respect of more delay in the flower bud emergence(54 d and 53 d from the date of transplanting),anthesis(19 d and 20 d from the first appearance of bud to full anthesis of flower)and fruit setting(8.00 d and 9.00 d from the date of anthesis),bigger flower size(2.93 cm2 and 3.00 cm2)than the untreated *** lower percentage of pollen viability(40.33%and 40.67%)was noticed in the same treatment in comparison to control(70.33%and 72.33%).The fruit maturity was also extended(59 d and 60 d from the date of fruit set)with bigger sized fruits(length:2.53 cm and 2.57 cm,breadth:2.27 cm and 2.33 cm)as well as more fruit weight(8.70 g and 8.33 g)by the application of colchicine at 0.10%with cotton plug method for 12 *** the basis of results obtained,the application of colchicine at 0.10%for 12 h duration with cotton plug method was found to be the best and effective treatment for induction of polyploidy as well as more flower size and fruit weight in Cape gooseberry.

关键词： Cape gooseberry colchicine polyploid flower size fruit weight.