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Phytochemical Loaded Nanovehicles of Biopolymer for Breast Cancer:A Systemic Review

Clinical Complementary Medicine and Pharmacology 2023年第4期3卷 60-78页

作者： Vivek P.Chavda Suneetha Vuppu Rajashri Bezbaruah Lakshmi Vineela Nalla Siva Nageswara Rao Gajula Pankti C.Balar Toshika Mishra Nikita Sharma sathvika kamaraj Thushar Suresh Anand Sairam Bedanta Bhattacharjee Department of Pharmaceutics and Pharmaceutical Technology LM College of PharmacyAhmedabadGujarat 380009India Department of Biotechnology ScienceInnovationand Society Research lab 115Hexagon(SMV)Vellore Institute of TechnologyVelloreTamil Nadu 632014India Institute of Pharmacy Assam Medical College and HospitalDibrugarhAssam 786002India Department of Pharmaceutical Science Faculty of Science and EngineeringDibrugarh UniversityDibrugarhAssam 786004India Department of Pharmacy Koneru Lakshmaiah Education FoundationVaddeswaramAndhra PradeshIndia Department of Pharmaceutical Analysis GITAM School of PharmacyGITAM(Deemed to be University)RushikondaVisakhapatnamAndhra Pradesh 530045India Pharmacy Section LM College of PharmacyAhmedabadGujarat 380009India Departemnt of Pharmacology and Toxicology Girijananda Chowdhury Institute of Pharmaceutical Science-TezpurSonitpurAssam 784501India

Background:Breast cancer is one of the most common malignancies affecting women worldwide,emphasizing the need for effective therapeutic *** derived from plants have gained significant attention due to their potential anticancer ***:This review aims to comprehensively assess the existing literature on using phytochemical-loaded for-mulations as a therapeutic approach for breast *** analyzing the available evidence,we aim to determine the potential benefits and limitations of these formulations in terms of their anticancer activity,bioavailability,and ***:A systematic search of relevant databases was conducted to identify studies investigating phytochemical-loaded formulations in the context of breast cancer *** inclusion criteria encompassed clinical trials,preclinical studies,and in-vitro experiments that reported using phytochemicals in various formulations for breast cancer *** extraction was performed to ensure the reliability and validity of the included ***:The review highlights the diverse range of phytochemicals used in different formulations for breast cancer *** suggest that these formulations exhibit promising anticancer effects by targeting mul-tiple signaling pathways in breast cancer progression,including cell proliferation,apoptosis,angiogenesis,and ***,various delivery systems,such as nanoparticles,liposomes,and micelles,have enhanced phytochemicals’bioavailability and targeted ***:Phytochemical-loaded formulations hold immense potential as a therapeutic approach for breast cancer *** reviewed evidence indicates their ability to inhibit tumor growth,enhance chemotherapy effectiveness,and reduce adverse ***,further research is warranted to optimize the formulation strategies,investigate the long-term safety profiles,and conduct large-scale clinical trials to establish their efficacy and applicabi

关键词： Breast cancer Cancer Phytochemicals Nanocerriers Nanoparticles

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