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Third time re-irradiation of liver metastasis with robotic radiosurgery: a case series

Hepatoma Research 2019年第7期5卷 1-8页

作者： Debnarayan Dutta sathiya krishnamoorthy Rupa Das Ram Madhavan Haridas Nair RaghavendraHolla Amrita Institute of Medical Sciences and Research Centre KochiKerala 682041India Department of Radiation Oncology Global HospitalChennai 600035India

Re-irradiation(Re-RT)in liver tumours is rarely reported owing to poor tolerance of liver and high incidence of radiation induced liver disease *** based robotic radiosurgery allows to deliver high dose radiation to the liver tumour and restricts the dose to healthy uninvolved liver,thereby increasing the potential for *** to radiation is low for entire liver and hence re-radiation is a *** the other hand,as regenerative potential of hepatocytes is rapid,replacement of necrotic liver tissue occurs with regenerated *** regenerated hepatocytes are radiation na?ve,do not have"memory"of radation therapy treatment and hence have potential of *** are reporting a series of two breast cancer patients presented with liver oligometastasis treated with fiducial based CyberKnife system(CK).Both the patients were treated multiple times with CK and had long-term survival(>2 years)without any clinical features of radiation induced liver *** selected patients are suitable for multiple sessions of CK for liver lesions with long-term outcome.

关键词： Liver lesions re-radiation robotic radiosurgery

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Arteriovenous Malformation (AVM) Treated with Robotic Radiosurgery: Impact of Beam Reduction in 12 Gy Normal Brain Volume and It’s Clinical Implication

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International Journal of Medical Physics, Clinical Engineering and Radiation Oncology 2019年第3期8卷 131-140页

作者： Debnarayan Dutta sathiya krishnamoorthy Ganapathy Krishnan Harikrishnaperumal Sudahar Department of Radiation Oncology Amrita Institute of Medical Science Kochi India Department of Radiation Oncology Global Hospital Chennai India Department of Medical Physics Apollo Speciality Cancer Hospital Chennai India

Purpose: Dosimetric study to evaluate impact of “beam” reduction in AVM radiosurgery on normal brain dose parameters and it’s clinical implications. Materials and Methods: Five small volume AVMs (nidus volume 0.31 - 1.94 cc) planned for single fraction SRS with robotic radiosurgery system. Planning scans done with CT scan brain, CT & MR angiography, then nidus volume and organ at risk (OARs) were contoured. Planning was done with multiplan planning system. Plan evaluated as per Flickenger model parameters of 12 Gy nomal brain vol & marginal dose. 7.5 mm and 10 mm cons used, optimization done with seqential algorithm. 20 Gy was prescribed to isodose with appropriate nidus coverage (>98%). Total beams of five plans were 85 - 250, monitor unit 17,259 - 24,602 MU. 12 Gy normal brain volume is 0.9 - 7.6 cc. Then beam reduction is done by reducing beams with minimum MU in steps of 50, 100, 150, 200, 250 MU and after beam reduction, re-optimization done. Prescription isodose was changed to keep the nidus coverage > 98%. Impacts of beam reduction on 12 Gy normal brain vol and conformity/homogeniety index were analyzed. Results: Optimal plans of five patients with 20 Gy prescribed to 88% - 90% isodose, nidus coverage more than 98%. In dosimetric parameters, mean CI was 1.36 - 1.51, nCI 1.41 - 1.51, HI 1.1 - 1.4 and mean 12 Gy normal brain volume 0.17, 1.44, 5.3, 5.5 and 7.6cc respectively. After beam reduction of less than 50 MU contribution (in case#1), prescibing at suitable isodose (85%) beam reduces to 79 and 12 Gy volume marginally increases to 26.4 cc. Beam reduction of less than 100 MU reduces to 53 - 92 beamlets. Reduction of beams with less than 150 MU contribution did not significantly change the 12Gy normal brain volume. However, reduction of beamlets with more than 200 MU, 250 MU, 300 MU, 450 MU and 550 MU significantly affects the 12 Gy normal brain volume. Prescription-isodose modified from 83% to 50% to have >98% coverage. CI and HI increased from 1.36 - 1.51

关键词： AVM Robotic Radiosurgery CK-Cyberknife 12 Gy Volume Beam Reduction

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