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A novel herbal combination ameliorates ovarian dysfunction and regulates altered biochemical parameters in rats with letrozole-induced polycystic ovary syndrome

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Asian pacific Journal of Reproduction 2023年第1期12卷 23-34页

作者： Sunita Shailajan sasikumar menon Swati Singh Yugandhara Patil Herbal Research Lab(Department of Botany) Ramnarain Ruia Autonomous CollegeMatungaMumbai-400019India Therapeutic Drug Monitoring Laboratory Sion(East)Mumbai-400022India

Objective:To investigate the potential activity of novel herbal combination and novel herbal formulation(syrup)in female Sprague Dawley rats with letrozole-induced polycystic ovary syndrome(PCOS).Methods:Forty-two rats were randomly divided into seven groups with six rats in each *** 1 received 0.5%carboxy methylcellulose orally for 37 days and served as the normal control *** 2 was orally administered with letrozole of 1 mg/kg for 21 days and served as the PCOS induction group without *** 3 to 7 were administered with letrozole of 1 mg/kg for 21 days orally to induce PCOS,and then respectively received clomiphene citrate at 1 mg/kg,100 and 200 mg/kg of novel herbal combination,200 mg/kg of novel herbal formulation(syrup),and 400 mg/kg of marketed formulation of Pushyanuga churna,once daily for 15 *** of the novel herbal combination and its syrup formulation were evaluated on the hormonal profile,the levels of antioxidants,the lipid profile and on the ovarian morphology,using letrozole-induced PCOS model in ***:Letrozole caused alterations in hormonal levels and lipid levels similar to PCOS and ovarian histology showed presence of ovarian cysts confirming the induction of PCOS in *** treatment with the novel herbal combination and its syrup formulation in PCOS-induced rats,the altered hormonal and lipid profiles showed significant recovery to normal *** histology confirmed the restoration of folliculogenesis in the PCOS-induced *** treatment with the syrup formulation of novel herbal combination was found to be more effective than novel herbal combination and showed better recovery in various parameters *** results of the study,however,suggested that treatment with novel herbal combination and its syrup formulation provided minimal protection against oxidative stress caused due to the induction of ***:The integrated approach for management of PCOS is to counterbalance the limita

关键词： Polycystic ovarian syndrome Polyherbal combination Letrozole Pushyanuga churna Clomiphene citrate Histopathology Biochemical Herbal

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Anti-androgenic effect of Symplocos racemosa *** letrozole induced polycystic ovary using rat model

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Journal of Coastal Life Medicine 2013年第4期 309-314页

作者： Mamata Jadhav sasikumar menon Sunita Shailajan Ramnarain Ruia College MatungaMumbai 400019India Institute for Advanced Training and Research in Interdisciplinary Science 194Scheme No.6Road No.15Sion KoliwadaSion(E)Mumbai 400022India Herbal Research Lab Ramnarain Ruia CollegeMatungaMumbai 400019India

Objective:To investigate the anti-androgenic properties of Symplocos racemosa Roxb.(***)in the treatment of hyperandrogenemia associated polycystic ovary syndrome(PCOS)in a letrozole induced PCOS rat ***:The testosterone levels were used to evaluate the anti-androgenic effect of *** in letrozole induced PCOS rats for 21 *** low(250 mg/kg),mid(500 mg/kg)and high dose(1000 mg/kg)of *** was given to the PCOS induced rats for 15 d post letrozole induction to determine the effective dose of *** in the treatment of hyperandrogenemia associated *** hormones such as estrogen and progesterone were also assayed along with testosterone to determine the fluctuations in sex steroid levels in PCOS rats induced by ***:*** treatment significantly decreased testosterone levels which were found to be elevated in PCOS rats induced by *** significantly restored other blood biochemical parameters such as estrogen,progesterone and cholesterol *** also restored the histology of ovarian *** ovarian weights and uterine weights were also significantly recovered after the *** ***:The mid dose(500 mg/kg)and high dose(1000 mg/kg)of *** were found to be effective in the treatment of hyperandrogenemia in *** effect of *** was found to be comparable with clomiphene *** citrate which was being used as the major medicine in the treatment of PCOS could now be replaced with *** in the management of PCOS.

关键词： Symplocos racemosa Roxb. Letrozole Polycystic ovary syndrome Clomiphene citrate

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A sensitive, rapid and validated liquid chromatography ? tandem mass spectrometry (LC-MS-MS) method for determination of Mimosine in Mimosa pudica Linn

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Natural Science 2010年第7期2卷 713-717页

作者： Parikshit A. Champanerkar Vikas V. Vaidya Sunita Shailajan sasikumar N. menon 不详

A rapid, sensitive and accurate liquid chroma-tographic tandem mass spectrometric method is described for the determination of Mimosine in Mimosa pudica Linn. whole plant powder. Mi-mosine was extracted from the plant using 1.0% HCl in water. The chromatographic separation was achieved using a Thermo Hypurity C18 (50 x 4.6 mm) 5.0 μ column interfaced with a triple quadrapole mass spectrometer. The mobile phase consisted of a mixture of Methanol: 10 mM ammonium formate buffer whose pH was ad-justed to 3.00 ± 0.05 with formic acid (80:20, v/v) and was delivered at a flow rate of 1.0 mL min-1. Electrospray ionization (ESI) source operated in the negative ion mode was used for the quantitation. Detection was performed using an Applied Biosystems Sciex API 3200 Mass spec-trometer. The method was found to be simple, precise, accurate, fast, specific and sensitive and can be used for routine quality control analysis of Mimosine in Mimosa pudica Linn.

关键词： LC-MS-MS Mimosine Mimosa pudica Linn

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A sensitive, rapid and validated liquid chromatography - tandem mass spectrometry (LC-MS-MS)method for determination of Mimosine in Mimosa pudica Linn

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Natural Science（自然科学期刊） 2010年第7期

作者： Parikshit A. Champanerkar Vikas V. Vaidya Sunita Shailajan sasikumar N. menon

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