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Prognostic model of survival outcomes in non-small cell lung cancer patients initiated on afatinib: pooled analysis of clinical trial data

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Cancer Biology & Medicine 2019年第2期16卷 341-349页

作者： Ashley M. Hopkins Adel Shahnam Sasha Zhang Chris S. Karapetis Andrew Rowland Michael J. Sorich Flinders Centre for Innovation in Cancer Department of Clinical Pharmacology College of Medicine and Public Health Flinders University Adelaide 5042 Australia The Canberra Hospital Garran 2605 Australia

Objective: Several predictors of survival have been identified in EGFR-positive non-small cell lung cancer(NSCLC) patients treated with first generation EGFR inhibitors. Prognostic models of survival outcomes with afatinib have not been evaluated.Methods: A prognostic tool for overall survival(OS)/progression free survival(PFS) based on pre-treatment clinicopathological factors was developed for EGFR-positive advanced NSCLC patients treated with first-line afatinib using penalised regression of individual-participant data from LUX-Lung 3 and 6(n = 468). Favourable, intermediate and poor risk groups were identified and externally validated using LUX-Lung 1(n = 390) and LUX-Lung 2(n = 129) trials that initiated afatinib following previous chemotherapy or EGFR inhibitor treatment.Results: Discriminative performance was good in the development and validation cohorts. For patients treated with first-line afatinib, the median OS for the favourable, intermediate and poor risk groups were > 47.7, 29.3 and 16.4 months, respectively, and the median PFS were 17.3, 13.2 and 8.3 months, respectively. The improvement in median OS with afatinib use compared to chemotherapy was > 12.4 months for the favourable risk group, whereas no OS benefit was apparent for the poor risk group. The improvement in median PFS with afatinib use compared to chemotherapy was 10.2 months for the favourable risk group and 3.2 months for the poor risk group.Conclusions: A prognostic tool was developed and validated to identify favourable, intermediate and poor risk groups for OS/PFS in EGFR-positive advanced NSCLC patients treated with afatinib. The prognostic groups can inform the likely absolute OS/PFS benefit expected from afatinib compared to chemotherapy in first-line treatment.

关键词： Afatinib non-small cell lung cancer prognostic model

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Effects of calcium on the evolution of nitrogen during pyrolysis of a typical low rank coal

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International Journal of Coal Science & Technology 2020年第2期7卷 397-404页

作者： Xiongchao Lin sasha Yang Xujun Chen Panpan Zheng Yonggang Wang Shu zhang School of Chemical and Environmental Engineering China University of Mining and Technology(Beijing)Beijing100083China Department of New Energy Science and Technology Nanjing Forestry UniversityNanjing210037JiangsuChina

This study aims to investigate the effects of calcium on the migration of nitrogen in coal(coal-N)to N-containing gas species,particularly,NH3 and HCN(volatile-N)in volatiles,as well as the chemical transformation of the N in char during coal pyrolysis under different temperatures.The pyrolysis experiments of Shengli brown coal and its derived coal samples loaded with different contents of calcium were conducted under 600–800°C in a novel fluidized bed reactor.The experimental results showed that during coal pyrolysis,the generation of NH3 is mainly derived from secondary reactions among volatiles,tar and char with the catalytic effect of mineral matter,especially calcium in coal.Increasing pyrolysis temperature from 600 to 800°C could enhance the release of N in coal to volatiles.Meanwhile,the increased pyrolysis temperature could also inhibit the generation of NH3 while facilitating the formation of HCN.The release of HCN is more sensitive to pyrolysis temperatures.Specifically,under higher pyrolysis temperatures,more N-containing structures in coal would become thermally unstable and crack into HCN;On the other hand,higher pyrolysis temperature could also enhance the decomposition of N in coal to N-containing species in tar or N2,thus reducing the release of HCN and NH3.Nitrogen in tar could either undergo secondary decomposition reactions,generating NH3,HCN,N2 and other N-containing species in gas phase,or experience condensation polymerization by forming macromolecular structure and be retained in char at high pyrolysis temperatures.Calcium could significantly restrain the release of N from coal,thus reducing the yields of NH3 and HCN.During coal pyrolysis,calcium catalytically enhances the fracture and combination of chemical bonds,generating abundant free radicals.These free radicals could continuously attack N-containing structures and consequently release the N-containing gaseous products,such as NH3,HCN,N2 etc.,resulting in the decrease of N in char.Calcium also plays important roles in nitrogen transfo

关键词： Brown coal Pyrolysis Nitrogen Calcium Transformation

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Engineering Fe‑N_(4)Electronic Structure with Adjacent Co‑N_(2)C_(2)and Co Nanoclusters on Carbon Nanotubes for Efficient Oxygen Electrocatalysis

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纳微快报:英文版 2023年第12期15卷 283-297页

作者： Mingjie Wu Xiaohua Yang Xun Cui Ning Chen Lei Du Mohamed Cherif Fu‑Kuo Chiang Yuren Wen Amir Hassanpour Francois Vidal sasha Omanovic Yingkui Yang Shuhui Sun Gaixia zhang State Key Laboratory of New Textile Materials and Advanced Processing Technologies Wuhan Textile UniversityWuhan 430200People’s Republic of China Institut National de la Recherche Scientifique(INRS) Center Energie Materiaux TelecommunicationsVarennesQC J3X 1P7Canada Department of Chemical Engineering McGill University3610 University StreetMontrealQC H3A 0C5Canada Department of Electrical Engineering Ecole de Technologie Superieure(ETS)MontrealQC H3C 1K3Canada Canadian Light Source(CLS) 44 Innovation BoulevardSaskatoonSK S7N 2V3Canada National Institute of Low-Carbon-and-Clean-Energy Beijing 102211People’s Republic of China School of Materials Science and Engineering University of Science and Technology BeijingBeijing 100083People’s Republic of China

Regulating the local configuration of atomically dispersed transition-metal atom catalysts is the key to oxygen electrocatalysis performance enhancement.Unlike the previously reported singleatom or dual-atom configurations,we designed a new type of binary-atom catalyst,through engineering Fe-N_(4)electronic structure with adjacent Co-N_(2)C_(2)and nitrogen-coordinated Co nanoclusters,as oxygen electrocatalysts.The resultant optimized electronic structure of the Fe-N_(4)active center favors the binding capability of intermediates and enhances oxygen reduction reaction(ORR)activity in both alkaline and acid conditions.In addition,anchoring M-N-C atomic sites on highly graphitized carbon supports guarantees of efficient charge-and mass-transports,and escorts the high bifunctional catalytic activity of the entire catalyst.Further,through the combination of electrochemical studies and in-situ X-ray absorption spectroscopy analyses,the ORR degradation mechanisms under highly oxidative conditions during oxygen evolution reaction processes were revealed.This work developed a new binary-atom catalyst and systematically investigates the effect of highly oxidative environments on ORR electrochemical behavior.It demonstrates the strategy for facilitating oxygen electrocatalytic activity and stability of the atomically dispersed M-N-C catalysts.

关键词： Atomically dispersed Fe-N-C catalysts ORR/OER Rechargeable zinc-air battery Fuel cells

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灰色层染

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现代装饰 2018年第4期 164-170页

作者： Ruth Calimlim Gunter Fleitz Fabian Friedhoff Julia Heuer Dina Hool Peter Ippolito Veronica Piazza Robert Pruim Markus Schmidt Fabiane Unger Trinhviet Sasha Zhang Sui Sicong 德国Ippolito Fleitz Group GmbH

＂灰色层染＂样板间运用深灰、浅灰、明灰、暗灰等不同层次与不同饱和度的灰色调,营造了一个平静温和的居住氛围。同时,不同质感和不同纹理的织物交织在一起丰富了节奏感,使得整个房间不会单调或冷清。这种层次感为整个空间增添了更多... 详细信息

＂灰色层染＂样板间运用深灰、浅灰、明灰、暗灰等不同层次与不同饱和度的灰色调,营造了一个平静温和的居住氛围。同时,不同质感和不同纹理的织物交织在一起丰富了节奏感,使得整个房间不会单调或冷清。这种层次感为整个空间增添了更多的探索性,并与窗外优美的天际线一起构成了城市中的＂灵魂避难所＂。

关键词：色层样板间饱和度节奏感层次感避难所天际线色调

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援藏高原某医院护士心理健康状况及影响因素的研究

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中华现代护理杂志 2017年第7期23卷 909-911页

作者：王秀锋彭艳丽张久聪孔德华朱艳丽盖萨莎张潇艺张方信兰州军区兰州总医院消化内科 730050 甘肃省甘南藏族自治州人民医院护理部 747000

目的探讨部队援建藏区高原某医院护士心理健康状况及影响因素.方法采用90项症状清单、应付方式问卷、个人评价问卷对73名部队援建藏区高原某医院护士进行调查评估.结果高原藏区医院护士SCL-90各因子得分均高于中国常模与高原军人.相... 详细信息

目的探讨部队援建藏区高原某医院护士心理健康状况及影响因素.方法采用90项症状清单、应付方式问卷、个人评价问卷对73名部队援建藏区高原某医院护士进行调查评估.结果高原藏区医院护士SCL-90各因子得分均高于中国常模与高原军人.相关分析显示,应付方式中的解决问题应付因子与SCL-90中恐惧因子呈负相关（r=-0.231,P〈0.01）,自责因子与SCL-90所有因子呈正相关（r值0.301~0.432;P〈0.01）;个人评价总分与SCL-90所有因子呈负相关（r值-0.308^-0.423;P〈0.01）.结论部队援建藏区高原某医院护士心理健康状况不佳,应付方式与个人评价是重影响因素.

关键词：护士心理健康应付方式部队援建高原

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