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Evolution of heart transplant donor characteristics in the 21st century: A United States single center’s experience

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World Journal of Transplantation 2024年第3期14卷 22-29页

作者： Alexander M Spring christiana Gjelaj Shivank Madan Snehal R Patel Omar Saeed Sandhya Murthy Yogita Rochlani Daniel B Sims sasha Vukelic Stephen J Forest Jamil F Borgi Daniel J Goldstein Ulrich P Jorde Montefiore-Einstein center for Heart and Vascular care Montefiore Medical CenterAlbert Einstein College of MedicineBronxNY 10467United States Division of cardiothoracic Surgery Tulane UniversityNew OrleansLA 70112United States

Despite a record setting number of heart transplants performed annually,the national donor shortage continues to plague transplant teams across the United *** we describe the barriers to adaptation of numerous“non-traditional”orthotopic heart transplant donor characteristics including donors with hepatitis c virus,those meeting criteria for donation after cardiac death,donors with coronavirus disease 19 infection,donors with the human immunodeficiency virus,and grafts with left ventricular systolic *** center’s objective was to increase our transplant volume by expanding our donor pool from“traditional”donors to these“non-traditional”*** detail how medical advances such as certain laboratory studies,pharmacologic interventions,and organ care systems have allowed our center to expand the donor pool thereby increasing transplantation volume without adverse effects on outcomes.

关键词： Orthotopic heart transplantation Hepatitis c virus cOVID-19 Left ventricular systolic dysfunction Human immunodeficiency virus Donation after cardiac death

Effects of calcium on the evolution of nitrogen during pyrolysis of a typical low rank coal

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International Journal of coal Science & Technology 2020年第2期7卷 397-404页

作者： Xiongchao Lin sasha Yang Xujun chen Panpan Zheng Yonggang Wang Shu Zhang School of chemical and Environmental Engineering China University of Mining and Technology(Beijing)Beijing100083China Department of New Energy Science and Technology Nanjing Forestry UniversityNanjing210037JiangsuChina

This study aims to investigate the effects of calcium on the migration of nitrogen in coal(coal-N)to N-containing gas species,particularly,NH3 and HcN(volatile-N)in volatiles,as well as the chemical transformation of the N in char during coal pyrolysis under different *** pyrolysis experiments of Shengli brown coal and its derived coal samples loaded with different contents of calcium were conducted under 600–800°c in a novel fluidized bed *** experimental results showed that during coal pyrolysis,the generation of NH3 is mainly derived from secondary reactions among volatiles,tar and char with the catalytic effect of mineral matter,especially calcium in *** pyrolysis temperature from 600 to 800°c could enhance the release of N in coal to ***,the increased pyrolysis temperature could also inhibit the generation of NH3 while facilitating the formation of *** release of HcN is more sensitive to pyrolysis ***,under higher pyrolysis temperatures,more N-containing structures in coal would become thermally unstable and crack into HcN;On the other hand,higher pyrolysis temperature could also enhance the decomposition of N in coal to N-containing species in tar or N2,thus reducing the release of HcN and *** in tar could either undergo secondary decomposition reactions,generating NH3,HcN,N2 and other N-containing species in gas phase,or experience condensation polymerization by forming macromolecular structure and be retained in char at high pyrolysis *** could significantly restrain the release of N from coal,thus reducing the yields of NH3 and *** coal pyrolysis,calcium catalytically enhances the fracture and combination of chemical bonds,generating abundant free *** free radicals could continuously attack N-containing structures and consequently release the N-containing gaseous products,such as NH3,HcN,N2 etc.,resulting in the decrease of N in ***

关键词： Brown coal Pyrolysis Nitrogen calcium Transformation

Engineering Fe‑N_(4)Electronic Structure with Adjacent co‑N_(2)c_(2)and co Nanoclusters on carbon Nanotubes for Efficient Oxygen Electrocatalysis

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纳微快报:英文版 2023年第12期15卷 283-297页

作者： Mingjie Wu Xiaohua Yang Xun cui Ning chen Lei Du Mohamed cherif Fu‑Kuo chiang Yuren Wen Amir Hassanpour Francois Vidal sasha Omanovic Yingkui Yang Shuhui Sun Gaixia Zhang State Key Laboratory of New Textile Materials and Advanced Processing Technologies Wuhan Textile UniversityWuhan 430200People’s Republic of China Institut National de la Recherche Scientifique(INRS) Center Energie Materiaux TelecommunicationsVarennesQC J3X 1P7Canada Department of chemical Engineering McGill University3610 University StreetMontrealQC H3A 0C5Canada Department of Electrical Engineering Ecole de Technologie Superieure(ETS)MontrealQC H3C 1K3Canada canadian Light Source(cLS) 44 Innovation BoulevardSaskatoonSK S7N 2V3Canada National Institute of Low-carbon-and-clean-Energy Beijing 102211People’s Republic of China School of Materials Science and Engineering University of Science and Technology BeijingBeijing 100083People’s Republic of China

Regulating the local configuration of atomically dispersed transition-metal atom catalysts is the key to oxygen electrocatalysis performance *** the previously reported singleatom or dual-atom configurations,we designed a new type of binary-atom catalyst,through engineering Fe-N_(4)electronic structure with adjacent co-N_(2)c_(2)and nitrogen-coordinated co nanoclusters,as oxygen *** resultant optimized electronic structure of the Fe-N_(4)active center favors the binding capability of intermediates and enhances oxygen reduction reaction(ORR)activity in both alkaline and acid *** addition,anchoring M-N-c atomic sites on highly graphitized carbon supports guarantees of efficient charge-and mass-transports,and escorts the high bifunctional catalytic activity of the entire ***,through the combination of electrochemical studies and in-situ X-ray absorption spectroscopy analyses,the ORR degradation mechanisms under highly oxidative conditions during oxygen evolution reaction processes were *** work developed a new binary-atom catalyst and systematically investigates the effect of highly oxidative environments on ORR electrochemical *** demonstrates the strategy for facilitating oxygen electrocatalytic activity and stability of the atomically dispersed M-N-c catalysts.

关键词： Atomically dispersed Fe-N-c catalysts ORR/OER Rechargeable zinc-air battery Fuel cells

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意式邮轮复刻明艳水上城

旅行者 2018年第8期 10-11页

作者：沈洁

世界杯的硝烟还未完全散尽，葡萄牙球星c罗便以过亿欧元的身价从西班牙皇家马德里转投意大利尤文图斯。上海母港出发的歌诗达·威尼斯号亦将与意大利尤文图斯俱乐部合作，为登船的乘客们奉上一场独一无二的足球盛宴。

关键词：邮轮皇家马德里意大利世界杯西班牙葡萄牙俱乐部威尼斯

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于吉:念念不忘

艺术界 2014年第3期 194-195页

作者：赵梦莎 Dominik Salter Dvorak

“念念不忘”是于吉时隔三年第二次在c空间个展。经过连续两个月在北京的驻地工作,作品的制作也是在展厅中完成。完整呈现的7件“石肉”系列雕塑作为此次展览的主体,为整个展览奠定了统一的基调。于吉在过去多年的创作中一直努力剔除传... 详细信息

“念念不忘”是于吉时隔三年第二次在c空间个展。经过连续两个月在北京的驻地工作,作品的制作也是在展厅中完成。完整呈现的7件“石肉”系列雕塑作为此次展览的主体,为整个展览奠定了统一的基调。于吉在过去多年的创作中一直努力剔除传统造像中的宗教脉络,

关键词： c-空间审美情趣艺术家雕塑

Microalgae cultivation Using Offshore Membrane Enclosures for Growing Algae (OMEGA)

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Journal of Sustainable Bioenergy Systems 2013年第1期3卷 18-32页

作者： Patrick Wiley Linden Harris Sigrid Reinsch sasha Tozzi Tsegereda Embaye Kit clark Brandi McKuin Zbigniew Kolber Russel Adams Hiromi Kagawa Tra-My Justine Richardson John Malinowski colin Beal Matthew A. claxton Emil Geiger Jon Rask J. Elliot campbell Jonathan D. Trent Advanced Organic Methods Penryn USA Department of chemistry University of California Santa Cruz USA Department of Mechanical Engineering University of Nevada Reno USA Department of Ocean Sciences University of California Santa Cruz USA Dynamac corporation NASA Ames Research Center Moffett Field USA NASA Ames Research center Moffett Field USA School of Engineering University of California Merced USA SETI Institute Mountain View USA Universities Space Research Association Columbia USA

OMEGA is a system for cultivating microalgae using wastewater contained in floating photobioreactors (PBRs) deployed in marine environments and thereby eliminating competition with agriculture for water, fertilizer, and land. The offshore placement in protected bays near coastal cities co-locates OMEGA with wastewater outfalls and sources of cO2-rich flue gas on shore. To evaluate the feasibility of OMEGA, microalgae were grown on secondary-treated wastewater supplemented with simulated flue gas (8.5% cO2 V/V) in a 110-liter prototype system tested using a seawater tank. The flow-through system consisted of tubular PBRs made of transparent linear low-density polyethylene, a gas exchange and harvesting column (GEHc), two pumps, and an instrumentation and control (I&c) system. The PBRs contained regularly spaced swirl vanes to create helical flow and mixing for the circulating culture. About 5% of the culture volume was continuously diverted through the GEHc to manage dissolved oxygen concentrations, provide supplemental cO2, harvest microalgae from a settling chamber, and add fresh wastewater to replenish nutrients. The I&c system controlled cO2 injection and recorded dissolved oxygen levels, totalized cO2 flow, temperature, circulation rates, photosynthetic active radiation (PAR), and the photosynthetic efficiency as determined by fast repetition rate fluorometry. In two experimental trials, totaling 23 days in April and May 2012, microalgae productivity averaged 14.1 ± 1.3 grams of dry biomass per square meter of PBR surface area per day (n = 16), supplemental cO2 was converted to biomass with >50% efficiency, and >90% of the ammonia-nitrogen was recovered from secondary effluent. If OMEGA can be optimized for energy efficiency and scaled up economically, it has the potential to contribute significantly to biofuels production and wastewater treatment.

关键词： Biofuels Wastewater Treatment Microalgae Photobioreactor cO2 Mass Transfer Fast Repetition Rate Fluorometry Instrumentation and control

computers, Teachers, Peers : Science Learning Partners

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Intravenous immune globulin suppresses angiogenesis in mice and humans

2000年

作者： Linn, Marcia c. Hsi, Sherry

ISBN: (纸本)9780805833430;9780585362984;9781135666705;9781135666699

Linn and Hsi show how computers, teachers, and peers can serve as learning partners--helping students build on their ideas and become lifelong science learners. They invite everyone interested in improving science education to build on their experiences, share insights on the Internet, and create instruction. computers, Teachers, Peers: • offers case studies to bring the ideas of students learning science to life. •Join sasha, chris, Pat, and Lee as they try to make sense of experiments using computers to display data in real time;• • provides principles to help teachers improve their instruction, use technology better, and inspire more students to love science. •Find out how to use visualization tools, online discussion, and more to make science relevant;• • gives researchers and instructional designers a model for effective research and curriculum design. •Linn and Hsi report that the partnership approach to research resulted in a 400% increase in student understanding of science;• • helps schools develop technology plans that continuously improve science instruction. •Find out how schools can design better ways to use technology for learning;• • describes a partnership inquiry process where science teachers, science education researchers, discipline specialists, and technologists consider each others''perspectives and jointly design instruction. •Boys and girls are equally successful in the resulting science courses;• and • features practical tools for learning and instruction, including''Points to Ponder''--to encourage reflection on the ideas in each chapter (partnership groups or classes might use the points as discussion starters or assignments), and''Ask Mr. K.''--an interview, in each chapter, with the classroom teacher who was a founding member of the cLP partnership (in these interviews Mr. K. adds insights from his own classroom experiences). This book is supplemented by a cD-ROM (included in each copy) and a Web site (***) with the comp

关键词： Science--Study and teaching (Middle school)--United States--case studies Science--Study and teaching (Secondary)--United States--case studies computer-assisted instruction--United States--case studies Group work in education--United States--case studies

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Signal Transduction and Targeted Therapy 2016年第1期1卷 141-148页

作者： Reo Yasuma Valeria cicatiello Takeshi Mizutani Laura Tudisco Younghee Kim Valeria Tarallo sasha Bogdanovich Yoshio Hirano Nagaraj Kerur Shengjian Li Tetsuhiro Yasuma Benjamin J Fowler charles B Wright Ivana Apicella Adelaide Greco Arturo Brunetti Balamurali K Ambati Sevim Barbasso Helmers Ingrid E Lundberg Ondrej Viklicky Jeanette HW Leusen J Sjef Verbeek Bradley D Gelfand Ana Bastos-carvalho Sandro De Falco Jayakrishna Ambati Department of Ophthalmology and Visual Sciences University of KentuckyLexingtonKYUSA Department of Ophthalmology Nagoya University Graduate School of MedicineNagoyaJapan Angiogenesis Lab Institute of Genetics and Biophysics—CNRNaplesItaly Bio-Ker MultiMedica GroupNaplesItaly Department of Physiology University of KentuckyLexingtonKYUSA Department of Advanced Biomedical Sciences University of Naples‘Federico II’NaplesItaly cEINGE—Biotecnologie Avanzate s.c.ar.l.NaplesItaly Department of Ophthalmology and Visual Sciences Moran Eye CenterUniversity of Utah School of MedicineSalt Lake CityUTUSA Department of Ophthalmology Veterans Affairs Salt Lake City Healthcare SystemSalt Lake CityUTUSA Rheumatology Unit Department of MedicineKarolinska InstitutetKarolinska University HospitalStockholmSweden Department of Nephrology Institute for Clinical and Experimental MedicinePrague 4Czech Republic Immunotherapy Laboratory Laboratory for Translational ImmunologyUniversity Medical Center UtrechtUtrechtThe Netherlands Department of Human Genetics Leiden University Medical CenterLeidenThe Netherlands Department of Biomedical Engineering University of KentuckyLexingtonKYUSA Department of Microbiology Immunologyand Molecular GeneticsUniversity of KentuckyLexingtonKYUSA IRccS MultiMedica MilanoItaly

Human intravenous immune globulin(IVIg),a purified IgG fraction composed of~60%IgG1 and obtained from the pooled plasma of thousands of donors,is clinically used for a wide range of *** biological actions of IVIg are incompletely understood and have been attributed both to the polyclonal antibodies therein and also to their IgG(IgG)Fc ***,we demonstrated that multiple therapeutic human IgG1 antibodies suppress angiogenesis in a target-independent manner via FcγRI,a high-affinity receptor for *** we show that IVIg possesses similar anti-angiogenic activity and inhibited blood vessel growth in five different mouse models of prevalent human diseases,namely,neovascular age-related macular degeneration,corneal neovascularization,colorectal cancer,fibrosarcoma and peripheral arterial ischemic *** was mediated by the Fc region of IVIg,required FcγRI and had similar potency in transgenic mice expressing human Fcγ***,IVIg therapy administered to humans for the treatment of inflammatory or autoimmune diseases reduced kidney and muscle blood vessel *** data place IVIg,an agent approved by the US Food and Drug Administration,as a novel angioinhibitory drug in doses that are currently administered in the clinical *** addition,they raise the possibility of an unintended effect of IVIg on blood vessels.

关键词： doses inhibited degeneration

Human IgG1 antibodies suppress angiogenesis in a target-independent manner

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Signal Transduction and Targeted Therapy 2016年第1期1卷 158-171页

作者： sasha Bogdanovich Younghee Kim Takeshi Mizutani Reo Yasuma Laura Tudisco Valeria cicatiello Ana Bastos-carvalho Nagaraj Kerur Yoshio Hirano Judit Z Baffi Valeria Tarallo Shengjian Li Tetsuhiro Yasuma Parthasarathy Arpitha Benjamin J Fowler charles B Wright Ivana Apicella Adelaide Greco Arturo Brunetti Menotti Ruvo Annamaria Sandomenico Miho Nozaki Ryo Ijima Hiroki Kaneko Yuichiro Ogura Hiroko Terasaki Balamurali K Ambati Jeanette HW Leusen Wallace Y Langdon Michael R clark Kathryn L Armour Pierre Bruhns J Sjef Verbeek Bradley D Gelfand Sandro De Falco Jayakrishna Ambati Department of Ophthalmology and Visual Sciences University of KentuckyLexingtonKYUSA Department of Ophthalmology and Visual Science Nagoya City University Graduate School of Medical SciencesNagoyaJapan Department of Ophthalmology Nagoya University Graduate School of MedicineNagoyaJapan Angiogenesis Lab Institute of Genetics and Biophysics—CNRNaplesItaly Bio-Ker MultiMedica GroupNaplesItaly Department of Advanced Biomedical Sciences University of Naples‘Federico II’NaplesItaly cEINGE—Biotecnologie Avanzate s.c.a.r.l.NaplesItaly Istituto di Biostrutture e Bioimmagini CNRNaplesItaly Department of Ophthalmology and Visual Sciences Moran Eye CenterUniversity of Utah School of MedicineSalt Lake CityUTUSA Department of Ophthalmology Veterans Affairs Salt Lake City Healthcare SystemSalt Lake CityUTUSA Immunotherapy Laboratory Laboratory for Translational ImmunologyUniversity Medical Center UtrechtUtrechtThe Netherlands School of Pathology and Laboratory Medicine University of Western AustraliaCrawleyWAAustralia Division of Immunology Department of PathologyUniversity of CambridgeCambridgeUK Department of Immunology Unit of Antibodies in Therapy and PathologyInstitut PasteurParisFrance Institut National de la Santéet de la Recherche Médicale(INSERM)U1222 ParisFrance Department of Human Genetics Leiden University Medical CenterLeidenThe Netherlands Department of Biomedical Engineering University of KentuckyLexingtonKYUSA Department of Microbiology Immunologyand Molecular GeneticsUniversity of KentuckyLexingtonKYUSA IRccS MultiMedica MilanoItaly Department of Physiology University of KentuckyLexingtonKYUSA.

Aberrant angiogenesis is implicated in diseases affecting nearly 10%of the world’s *** most widely used antiangiogenic drug is bevacizumab,a humanized IgG1 monoclonal antibody that targets human *** bevacizumab does not recognize mouse Vegfa,it inhibits angiogenesis in *** we show bevacizumab suppressed angiogenesis in three mouse models not via Vegfa blockade but rather Fc-mediated signaling through FcγRI(cD64)and c-cbl,impairing macrophage *** approved humanized or human IgG1 antibodies without mouse targets(adalimumab,alemtuzumab,ofatumumab,omalizumab,palivizumab and tocilizumab),mouse IgG2a,and overexpression of human IgG1-Fc or mouse IgG2a-Fc,also inhibited angiogenesis in wild-type and FcγR humanized *** anti-angiogenic effect was abolished by Fcgr1 ablation or knockdown,Fc cleavage,IgG-Fc inhibition,disruption of Fc-FcγR interaction,or elimination of FcRγ-initated ***,bevacizumab’s Fc region potentiated its anti-angiogenic activity in humanized VEGFA ***,mice deficient in FcγRI exhibited increased developmental and pathological *** findings reveal an unexpected anti-angiogenic function for FcγRI and a potentially concerning off-target effect of hIgG1 therapies.

关键词： cD64 angiogenesis antibodies