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颗粒越小，风味越妙

实验与分析 2016年第4期 30-32页

作者： sascha Hupach Shinadzu德国有限责任公司

咖啡的口味到底苦还是酸？牛奶为何能够分布如此均匀？食品中颗粒的大小既影响了食品的口味又影响到人们享受食品时的乐趣．静态激光衍射是当下最流行的食品粒度检测方法。

关键词：颗粒风味粒度检测激光衍射食品口味咖啡牛奶

Linking Numerical Water Quality Models in an Environmental Information System for Integrated Environmental Assessments

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Journal of Environmental Protection 2013年第7期4卷 126-137页

作者： Franklin Torres-Bejarano Hermilo Ramirez Ralf Denzer Steven Frysinger Thorsten Hell sascha Schlobinski Cismet GmbH Saarbrücken Germany. Department of Postgraduates Studies Mexican Petroleum Institute Mexico City Mexico Environmental Informatics Group (EIG) Saarbrücken Germany Environmental Informatics Group (EIG) Saarbrücken Germany 3Cismet GmbH Saarbrücken Germany.

Decision makers involved in prevention of water contamination often lack the technical knowledge of water quality evaluation or the comprehension of complex software for environmental information management required to make effective decisions. Providing information about the environment is not an easy task due to its complex structure, relationships, and dynamic processes. Because environmental models play an important role in environmental decision support systems, the integration of models into user-friendly integrated information systems is a key factor in the support of such users. This paper presents an environmental information system which supports water protection of Coatzacoalcos River in Mexico, having as a main building block water quality assessments supported by mathematical modeling through the two-dimensional Saint Venant and Advection-Diffusion-Reaction equations to calculate the river hydrodynamics and the contaminant transport, respectively. The mathematical modeling solution yields appropriate results representing the river contaminant distribution when compared with field measurements. But the direct use of these models by decision makers is difficult at best, meaning they are not likely to be used in making practical decisions. The system described in this paper integrates these models, and several other tools, into a seamless, user-centered application, improving model usability, initial configuration, and results visualization.

关键词： Environmental Information Systems Environmental Decision Support Systems Water Quality Modeling Integrated Modeling

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全自动分析检测系统

流程工业 2017年第22期 36-37页

作者： sascha Hupach Shimadzu公司

如今，所有的大型流程工艺设备在生产过程中部会向控制系统提供过程分析数据，尤其在生产过程调节中，对这些控制系统有很高的可用性以及提高数据密度的要求。

关键词：全自动分析检测系统控制系统生产过程分析数据工艺设备数据密度可用性

Effects of Resistant Starch on Symptoms,Fecal Markers,and Gut Microbiota in Parkinson’s Disease—The RESISTA-PD Trial

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Genomics, Proteomics & Bioinformatics 2022年第2期20卷 274-287页

作者： Anouck Becker Georges Pierre Schmartz Laura Groger Nadja Grammes Valentina Galata Hannah Philippeit Jacqueline Weiland Nicole Ludwig Eckart Meese sascha Tierling Jorn Walter Andreas Schwiertz Jorg Spiegel Gudrun Wagenpfeil Klaus Faßbender Andreas Keller Marcus M.Unger Department of Neurology Saarland UniversityD-66421 HomburgGermany Chair for Clinical Bioinformatics Saarland UniversityD-66123 SaarbruckenGermany Department of Human Genetics Saarland UniversityD-66421 HomburgGermany Department of Genetics/Epigenetics Saarland UniversityD-66123 SaarbruckenGermany Institute of Microecology D-35745 HerbornGermany Institute of Medical Biometry Epidemiology and Medical InformaticsSaarland UniversityD-66421 HomburgGermany Department of Neurology Stanford UniversityPalo AltoCA 94305USA

The composition of the gut microbiota is linked to multiple diseases,including Parkinson’s disease(PD).Abundance of bacteria producing short-chain fatty acids(SCFAs)and fecal SCFA concentrations are reduced in *** exert various beneficial functions in *** the interventional,monocentric,open-label clinical trial “Effects of Resistant Starch on Bowel Habits,Short Chain Fatty Acids and Gut Microbiota in Parkinson’s Disease”(RESISTA-PD;ID:NCT02784145),we aimed at altering fecal SCFAs by an 8-week prebiotic intervention with resistant starch(RS).We enrolled 87 subjects in three study-arms:32 PD patients received RS(PD+RS),30 control subjects received RS,and 25 PD patients received solely dietary *** performed paired-end 100 bp length metagenomic sequencing of fecal samples using the BGISEQ platform at an average of 9.9 *** was *** the PD+RS group,fecal butyrate concentrations increased significantly,and fecal calprotectin concentrations dropped significantly after 8 weeks of RS ***,we observed a reduction in non-motor symptom load in the PD+RS *** reference-based analysis of metagenomes highlighted stable alpha-diversity and beta-diversity across the three groups,including bacteria producing ***-free analysis suggested punctual,yet pronounced differences in the metagenomic signature in the PD+RS ***-PD highlights that a prebiotic treatment with RS is safe and well-tolerated in *** stable alpha-diversity and beta-diversity alongside altered fecal butyrate and calprotectin concentrations call for long-term studies,also investigating whether RS is able to modify the clinical course of PD.

关键词： Parkinson’s disease Short-chain fatty acid Microbiota Metagenomics Intestinal inflammation

3D printed micro-optics for quantum technology:Optimised coupling of single quantum dot emission into a single-mode fibre

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Light(Advanced Manufacturing) 2021年第2期2卷 1-17页

作者： Marc Sartison Ksenia Weber Simon Thiele Lucas Bremer Sarah Fischbach Thomas Herzog sascha Kolatschek Michael Jetter Stephan Reitzenstein Alois Herkommer Peter Michler Simone Luca Portalupi Harald Giessen Institut für Halbleiteroptik und Funktionelle Grenzflächen Research Center SCoPEand Integrated Quantum Science and Technology Center IQSTUniversity of Stuttgart70569 StuttgartGermany 4^(th)Physics Institute Research Center SCoPEand Integrated Quantum Science and Technology Center IQSTUniversity of Stuttgart70569 StuttgartGermany Institute of Applied Optics(ITO)and Research Center SCoPE University of Stuttgart70569 StuttgartGermany Institute of Solid State Physics Technical University of Berlin10623 BerlinGermany

Future quantum technology relies crucially on building quantum networks with high *** achieve this challenging goal,it is of utmost importance to connect individual quantum systems such that their emitted single photons overlap with the highest possible degree of *** requires perfect mode overlap of the emitted light from different emitters,which necessitates the use of single-mode ***,we present an advanced manufacturing approach to accomplish this *** combined 3D printed complex micro-optics,such as hemispherical and Weierstrass solid immersion lenses,as well as total internal reflection solid immersion lenses,on top of individual indium arsenide quantum dots with 3D printed optics on single-mode fibres and compared their key *** observed a systematic increase in the collection efficiency under variations of the lens geometry from roughly 2 for hemispheric solid immersion lenses up to a maximum of greater than 9 for the total internal reflection ***,the temperature-induced stress was estimated for these particular lens dimensions and results to be approximately 5 ***,the use of solid immersion lenses further increased the localisation accuracy of the emitters to less than 1 nm when acquiring micro-photoluminescence ***,we show that the single-photon character of the source is preserved after device fabrication,reaching a g^((2))(0)value of approximately 0.19 under pulsed optical *** printed lens device can be further joined with an optical fibre and permanently *** integrated system can be cooled by dipping into liquid helium using a Stirling cryocooler or by a closed-cycle helium cryostat without the necessity for optical windows,as all access is through the integrated single-mode *** identify the ideal optical designs and present experiments that demonstrate excellent high-rate single-photon emission.

关键词： mode fibre optics

Promotion of Adhesive Polymer Bonding by Plasma Modification Using Defined Ambient Conditions and Process Gases

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Journal of Energy and Power Engineering 2017年第2期11卷 135-139页

作者： Vitali Fischer Elisabeth Stammen Klaus Dilger Marko Eichler sascha Paulmann Claus-Peter Klages Institute of Joining and Welding Technische Universitgit Braunschweig Braunschweig 38106 Germany Fraunhofer Institute for Surface Engineering and Thin Films Braunschweig 38108 Germany

Adhesive bonding technology is often the preferred solution for the joining of polymers. In many cases a wet chemical pretreatment has to he used to achieve sufficient adhesion strength and durability of the adhesive joint. Since several years, plasma treatment has been a proven method to attain these goals. However, conventional treatments in oxidizing gases such as air are often not satisfying. In this work, the PP （polymers polypropylene）, PVDF （polyvinylidene fluoride）, PA6 （polyamide 6）, POM （polyoxymethylene） and PC （polycarbonate） were pretreated by means of a plasma jet running at atmospheric pressure in a virtually oxygen-free atmosphere. The goal was the grafting of reactive nitrogen-containing functional groups on the plastic surfaces in order to increase the adhesive strength.

关键词： Plasma modification functionalization functional groups atmospheric pressure plasma oxygen-free atmosphere.

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AC1000雷达创造技术新标杆

汽车与配件 2014年第10期 34-36页

作者： sascha Heinrichs-Bartscher TRW汽车集团

电频和电子技术的发展造就了AC1000,这一进步将使带雷达的安全系统也进入到寻常车辆中.TRW的AC1000雷达系列,能帮助汽车制造商旗下所有种类的车型都获得NCAP的最高评级,包括过去对高精技术的成本敏感性很高的微型车.AC1000是？？GHz的... 详细信息

电频和电子技术的发展造就了AC1000,这一进步将使带雷达的安全系统也进入到寻常车辆中.TRW的AC1000雷达系列,能帮助汽车制造商旗下所有种类的车型都获得NCAP的最高评级,包括过去对高精技术的成本敏感性很高的微型车.AC1000是？？GHz的可变雷达系列,其能够实现的功能包括车道变换辅助、盲点探测、路口交通警示、侧面碰撞、行人探测和前部碰撞预警等.传感器也可以与车辆动力系统、制动和电动助力转向系统集成,实现自动紧急制动（AEB）和交通阻塞辅助.

关键词：电子技术雷达电动助力转向系标杆侧面碰撞紧急制动汽车制造商安全系统

Cryo-EM structure of the plant 26S proteasome

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Plant Communications 2022年第3期3卷 116-126页

作者： Susanne Kandolf Irina Grishkovskaya Katarina Belacic Derek L.Bolhuis sascha Amann Brent Foster Richard Imre Karl Mechtler Alexander Schleiffer Hemant D.Tagare Ellen D.Zhong Anton Meinhart Nicholas G.Brown David Haselbach Research Institute of Molecular Pathology(IMP) Vienna BioCenter(VBC)Campus-Vienna-BioCenter 11030 ViennaAustria Department of Radiology and Biomedical Imaging Yale UniversityNew HavenCT 06510USA Department of Pharmacology and Lineberger Comprehensive Cancer Center University of North Carolina School of MedicineChapel HillNC 27599USA Computer Science and Artificial Intelligence Laboratory Massachusetts Institute of TechnologyCambridgeMA 02139USA Vienna BioCenter PhD Program Doctoral School of the University at Vienna and Medical University of ViennaVienna BioCenter(VBC)ViennaAustria Institute of Physical Chemistry University of FreiburgAlbertstraße 21Freiburg 79104Germany CIBSS Centre for Integrative Biological Signalling Studies University of FreiburgFreiburgGermany

Targeted proteolysis is a hallmark of *** is especially important in long-lived cells that can be found in higher eukaryotes,like *** task is mainly fulfilled by the ubiquitin–proteasome ***,proteolysis by the 26S proteasome is vital to development,immunity,and cell *** the yeast and animal proteasomes are well characterized,there is only limited information on the plant *** determined the first plant 26S proteasome structure from Spinacia oleracea by single-particle electron cryogenic microscopy at an overall resolution of 3.3 A°.We found an almost identical overall architecture of the spinach proteasome compared with the known structures from mammals and ***,we noticed a structural difference in the proteolytic active b1 ***,we uncovered an unseen compression state by characterizing the proteasome’s conformational *** suspect that this new conformation of the 20S core protease,in correlation with a partial opening of the unoccupied gate,may contribute to peptide release after *** data provide a structural basis for the plant proteasome,which is crucial for further studies.

关键词： 26S proteasome spinach UPS cryo-EM conformational landscape

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如何让城市变得“聪明”

世界建筑导报 2014年第4期29卷 14-15页

作者： saschaHaselmayer 徐云涛

世界上有55.7万个地方政府花了世界GDP总值的10%,也就是4.5万亿美元。这些地方政府无需参与国防建设,也不用参加国家级的基础设施建设。他们花钱的目的只有一个就是努力为市民提供更好的服务、从而提升市民的生活质量。因此他们每天所... 详细信息

世界上有55.7万个地方政府花了世界GDP总值的10%,也就是4.5万亿美元。这些地方政府无需参与国防建设,也不用参加国家级的基础设施建设。他们花钱的目的只有一个就是努力为市民提供更好的服务、从而提升市民的生活质量。因此他们每天所作出的任何细小决定都为人们的生活带来改变,但问题是这些决定真的有效吗?sascha Haselmayer和他的朋友表示质疑。在他们调查了全世界许多地方政府怎样获得信息和如何作出决定的过程之后,最终他们决定创立一个机构CITYMART。这个机构的目标只有一个:让政府的决策更聪明更有效率并找到最佳的解决方式。而他们的准则很简单:让政府公开自己希望解决的问题,当然也就必须同时公布预算。他们已经和全世界83个城市进行了有效的合作,"让对的方案遇到对的城市"。而这样做的结果不仅改变了政府的效率,也改变了社会的气氛。下面就是sascha Haselmayer和CITYMART的故事。

关键词：城市地方政府基础设施建设生活质量国防建设世界国家级有效率