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Enhancement of leukocyte adhesion after percutaneous irradiation in rats with hepatocellular carcinoma

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World Journal of Gastroenterology 2005年第13期11卷 1991-1994页

作者： sasa-Marcel Maksan Eduard Schmidt Eduard Ryschich Wolfgang Harms Jan Schmidt Department of Surgery Department of Radiation Therapy

AIM: To evaluate the effects of percutaneous radiation on leukocyte-endothelium interaction (LEI) in experimental hepatocellular carcinoma (HCC). METHODS: Twelve ACI rats underwent HCC-inoculation, six of which on day 12 received low-dose external radiation and six did not. After 12 h intravital microscopy was performed. RESULTS: LEI was significantly reduced in tumor tissue. However,irradiation of liver sinusoids and tumor tissue with 6 Gy led to a significant activation of leukocyte adhesion in the tumor with a marked increase of the proinflammatory cytokine TNF-α. CONCLUSION: The findings indicate that the immune-logical tumor-endothelial barrier can be overcome by external irradiation.

关键词： Radiation Hepatocellular carcinoma Immune response Animal model

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杏子川地区长6储层压裂液原位置换原油

钻井液与完井液 2024年第3期41卷 396-404页

作者：柏浩周福建吴俊霖丁志远杨飒飒盛连奇姚二冬中国石油大学(北京)油气资源与探测国家重点实验室北京102249

杏子川地区延长组长6储层具有含油饱和度低、油湿性强,非均质性强(渗透率为0.10~1.0 mD)等特征。常规压裂液体系润湿改性能力弱、渗吸置换效果差,亟需研究具有渗吸提采功能的压裂液。借助了核磁共振T_(2)谱手段,测试了不同组成和配比的... 详细信息

杏子川地区延长组长6储层具有含油饱和度低、油湿性强,非均质性强(渗透率为0.10~1.0 mD)等特征。常规压裂液体系润湿改性能力弱、渗吸置换效果差,亟需研究具有渗吸提采功能的压裂液。借助了核磁共振T_(2)谱手段,测试了不同组成和配比的化学剂对长6储层岩心内微-纳孔径原油的动用能力,并探究了压裂液原位置换原油的影响因素及其渗吸机理。结果表明:带负电的阴离子试剂AX-2更适合动用长6低含油饱和度储层,0.10%AX-2渗吸采收率大于30%,纳米小孔与微米大孔动用程度分别为42.08%与22.62%;将表面活性剂AX-2复配成为10 nm尺寸的纳米乳液AX-1,抗吸附能力更强,动用效果更佳,纳米孔与微米孔动用程度可提升至58.26%与29.70%;界面张力为1.5 mN/m时AX-1最适合动用长6储层原油,此时液体具有较高的渗吸动力与原油剥离能力。优选体系复配后现场压裂稳定,试油效果良好,平均日产油量超过26 t。

关键词：低含油饱和度纳米乳液核磁T2谱渗吸置换长6砂岩

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临兴气田致密砂岩气藏压裂后产水机理

新疆石油地质 2024年第1期45卷 81-87页

作者：石雪峰游利军葛岩胡云亭马立涛王艺钧郭飒飒中海油能源发展股份有限公司工程技术分公司天津300452 西南石油大学油气藏地质及开发工程全国重点实验室成都610500

鄂尔多斯盆地临兴气田致密砂岩气藏是陆上天然气开发的重点对象,由于构造条件复杂、物性致密以及气水关系复杂,压裂后多数气井持续产水,且井间产水量差异大,研究压裂后束缚水饱和度变化原因,对制定合理的控水采气措施、提高气井采收率... 详细信息

鄂尔多斯盆地临兴气田致密砂岩气藏是陆上天然气开发的重点对象,由于构造条件复杂、物性致密以及气水关系复杂,压裂后多数气井持续产水,且井间产水量差异大,研究压裂后束缚水饱和度变化原因,对制定合理的控水采气措施、提高气井采收率具有重要意义。选取鄂尔多斯盆地临兴气田典型致密砂岩样品,通过气驱法研究了储集层物性、生产压差及压裂液对束缚水饱和度的影响。结果表明:Ⅰ类储集层基质与裂缝间的束缚水饱和度之差为13.32%~18.36%,Ⅱ类储集层为28.28%~34.19%,Ⅲ类储集层为39.10%~48.15%,水力压裂缝网显著提高了储集层水相渗流能力;水力压裂缝网使得水相渗流通道增多,生产压差增大、渗流压耗降低及水湿程度减弱是导致储集层束缚水能力减弱、压裂后气井产水的主要机理。可从控制压裂改造规模、优化生产制度、调整助排剂加量及注入时机等方面来提高高含水致密砂岩气藏压裂后控水采气效果,延缓气井见水时间,减小产水规模。

关键词：鄂尔多斯盆地临兴气田致密砂岩气藏水力压裂束缚水饱和度可动水

Bioactive hyaluronic acid fragments inhibit lipopolysaccharideinduced inflammatory responses via the Toll-like receptor 4 signaling pathway

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Frontiers of Medicine 2021年第2期15卷 292-301页

作者： Na You sasa Chu Binggang Cai Youfang Gao Mizhou Hui Jin Zhu Maorong Wang Department of Infectious Disease The People’s Hospital of BozhouBozhou 236800China Department of Infectious Disease The People’s Hospital of LinyiLinyi 276000China Department of Infectious Disease The People’s Hospital of YanchengYancheng 224000China AnRuipu Biological Products Research Co. Ltd.Hangzhou 310019China Huadong Medical Institute of Biotechniques Nanjing 210002China Institute of Liver Disease Jinling HospitalNanjing 210002China

The high-and the low-molecular weight hyaluronic acids(HMW-HA and LMW-HA,respectively)showed different biological activities in ***,the role of LMW-HA in inflammatory response is *** this study,we aimed to investigate the effect of bioactive hyaluronan(B-HA)on lipopolysaccharide(LPS)-induced inflammatory responses in human macrophages and mice.B-HA was produced from HA treated with glycosylated recombinant human hyaluronidase *** THP-1 cells were induced to differentiate into ***-1-derived macrophages were treated with B-HA,LPS,or B-HA+*** mRNA expression and the production of inflammatory cytokines were determined using quantitative real-time PCR and enzyme-linked immunosorbent *** phosphorylation levels of proteins in the nuclear factor-kB(NF-kB),mitogen-activated protein kinase(MAPK),and IRF-3 signaling pathways were measured using Western *** in vivo efficacy of B-HA was assessed in a mouse model of LPS-induced *** showed that B-HA inhibited the expression of TNF-α,IL-6,IL-1,and IFN-β,and enhanced the expression of the antiinflammatory cytokine IL-10 in LPS-induced inflammatory responses in THP-1-derived macrophages and in vivo.B-HA significantly suppressed the phosphorylation of the TLR4 signaling pathway proteins p65,IKKα/β,IkBα,JNK1/2,ERK1/2,p38,and *** conclusion,our results demonstrated that the B-HA attenuated the LPSstimulated inflammatory response by inhibiting the activation of the TLR4 signaling pathway.B-HA could be a potential anti-inflammatory drug in the treatment of inflammatory disease.

关键词： bioactive hyaluronan lipopolysaccharide inflammatory cytokines TLR4 human macrophages

An experimental methodology for the concurrent characterization of multiple parameters influencing nanoscale friction

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Friction 2020年第3期8卷 577-593页

作者： Marko PERCIC sasa ZELENIKA Igor MEZIC Robert PETER Niksa KRSTULOVIC University of Rijeka Faculty of EngineeringVukovarska 58Rijeka 51000Croatia University of Rijeka Centre for Micro-and Nanosciences and TechnologiesRadmile Marej&ie 2Rjeka 51000 Croatia Department of Mechanical Engineering UC Santa BarbaraSanta BarbaraCA 93105USA University of Rijeka Department of PlysicsRadmile Matejtic 2Rijeka 51000Croatia Institute of Plnysics Bijenicka 46Zagreb 1000Croatia

A structured transdisciplinary method for the experimental determination of friction in the nanometric domain is proposed in this *** dependence of nanoscale friction on multiple process parameters on these scales,which comprise normal forces,sliding velocities,and temperature,was studied via the lateral force microscopy *** procedure used to characterize the stiffness of the probes used,and especially the influence of adhesion on the obtained results,is thoroughly *** analyzed thin films were obtained by using either atomic layer or pulsed laser *** developed methodology,based on elaborated design of experiments algorithms,was successfully implemented to concurrently characterize the dependence of nanoscale friction in the multidimensional space defined by the considered process *** enables the establishment of a novel methodology that extends the current state-of-the-art of nanotribological studies,as it allows not only the gathering of experimental data,but also the ability to do so systematically and concurrently for several influencing variables at ***,in turn,creates the basis for determining generalizing correlations of the value of nanoscale friction in any multidimensional experimental *** developments create the preconditions to eventually extend the available macro-and mesoscale friction models to a true multiscale model that will considerably improve the design,modelling and production of MEMS devices,as well as all precision positioning systems aimed at micro-and nanometric accuracy and precision.

关键词： nanoscale friction lateral force microscopy experimental determination methodology multivariate space contact mechanics

The Genetic and Biochemical Mechanisms Underlying Cereal Seed Dormancy

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Phyton-International Journal of Experimental Botany 2023年第4期92卷 1203-1214页

作者： sasa Jing Yuan Tian Heng Zhang John THancock Ying Zhu Ping Li Shanghai Key Laboratory of Bio-Energy Crops Research Center for Natural ProductsPlant Science CenterSchool of Life SciencesShanghai UniversityShanghai200444China State Key Laboratory for Managing Biotic and Chemical Treats to the Quality and Safety of Agro-products Research Center for Crop Molecular Breeding at Zhejiang ProvinceInstitute of Virology and BiotechnologyZhejiang Academy of Agricultural ScienceHangzhou310021China Department of Applied Sciences University of the West of EnglandBristolBS161QYUK

The crop seeds have been a staple food for humans,and seed yield is important for sustaining agriculture development and enhancing human adaptability to food *** phenomenon of pre-harvest sprouting(PHS),caused by seed dormancy deficiency,and the phenomenon of low seedling emergence caused by seed deep dormancy,will lead to a reduction in agricultural ***,it is particularly important to understand the regulation mechanisms of seed *** are many studies on the regulation of seed dormancy in rice,but there are few studies on the regulation of seed dormancy in other crops,and the research on its mechanism is not thorough *** this paper,we comprehensively summarize the regulation mechanisms of cereal seed dormancy,including rice,barley and wheat,discussing the integral mechanism of seed *** information should provide new insights for developing versatile cultivated lines to improve crop yield and economic benefits.

关键词： Crops rice wheat barly dormancy germination ABA GA

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中西药药动学相互作用研究方法回顾与展望

中草药 2024年第6期55卷 1788-1798页

作者：祝颖张洒洒胡子晗林慧孙嘉奇郝琨杜军陈亮杨抒雨郑剑恒何华中国药科大学药物代谢动力学研究中心江苏南京211198 中国药科大学药物科学研究院药物代谢动力学重点实验室江苏南京210009 安利(中国)研发中心有限公司上海201203

中药与化学药的联用可能改变药物的吸收、分布、代谢、排泄过程,引起中西药药动学相互作用,导致药物的药效和不良反应的改变。当前中药的药物相互作用研究方法主要参考了化学药的研究体系,但这些方法是否适用于具有多组分多靶点作用特... 详细信息

中药与化学药的联用可能改变药物的吸收、分布、代谢、排泄过程,引起中西药药动学相互作用,导致药物的药效和不良反应的改变。当前中药的药物相互作用研究方法主要参考了化学药的研究体系,但这些方法是否适用于具有多组分多靶点作用特征的中药仍未可知。通过对化学药的药物相互作用研究方法及其适用条件进行总结,收集并分析现有中西药药物相互作用的临床试验研究结果,探讨了中药药物相互作用体内外不相关的原因,提出了中药的药物相互作用体外研究方法需根据其多组分多靶点的作用特征进行构建,并在此基础上对中药药物相互作用研究方法进行了展望。

关键词：中西药联用药动学药物相互作用药效不良反应

Diabetes Prediction Algorithm Using Recursive Ridge Regression L2

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Computers, Materials & Continua 2022年第4期71卷 457-471页

作者： Milos Mravik T.Vetriselvi K.Venkatachalam Marko Sarac Nebojsa Bacanin sasa Adamovic Department of Computer Science Singidunum UniversityBelgrade11000Serbia Department of Computer science and Engineering K.Ramakrishnan College of TechnologyTrichy621112India Department of Applied Cybernetics Faculty of ScienceUniversity of Hradec Králové50003Hradec KrálovéCzech Republic

At present,the prevalence of diabetes is increasing because the human body cannot metabolize the glucose *** prediction of diabetes patients is an important research *** researchers have proposed techniques to predict this disease through data mining and machine learning *** prediction,feature selection is a key concept in ***,the features that are relevant to the disease are used for *** condition improves the prediction *** the right features in the whole feature set is a complicated process,and many researchers are concentrating on it to produce a predictive model with high *** this work,a wrapper-based feature selection method called recursive feature elimination is combined with ridge regression(L2)to form a hybrid L2 regulated feature selection algorithm for overcoming the overfitting problem of data *** is a major problem in feature selection,where the new data are unfit to the model because the training data are *** regression is mainly used to overcome the overfitting *** features are selected by using the proposed feature selection method,and random forest classifier is used to classify the data on the basis of the selected *** work uses the Pima Indians Diabetes data set,and the evaluated results are compared with the existing algorithms to prove the accuracy of the proposed *** accuracy of the proposed algorithm in predicting diabetes is 100%,and its area under the curve is 97%.The proposed algorithm outperforms existing algorithms.

关键词： Ridge regression recursive feature elimination random forest machine learning feature selection

Disturbance of hepatic and intestinal microcirculation in experimental liver cirrhosis

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World Journal of Gastroenterology 2005年第6期11卷 846-849页

作者： sasa-Marcel Maksan Eduard Ryschich Zilfi (U|¨)lger Martha Maria Gebhard Jan Schmidt Department of Surgery

AIM: To analyze hepatic, mesenteric and mucosal microcirculation and leukocyte-endothelium interaction (LEI) in a rat model with liver ***: Hepatic cirrhosis was induced in Wistar rats by gavage with carbon tetrachloride, and intravital videomicroscopy was performed in liver, mesentery and small intestine mucosa. Special emphasis is given on microcirculatory and morphometric changes during cirrhotic portal ***: LEI was influenced significantly in the cirrhotic liver but not in the gut. Blood flow measurement showed significant differences among liver, main mesenteric vessels and the mucosa. The results of our study indicate that liver cirrhosis leads to alterations in hepatic and mesenteric blood flow but not in mucosal blood ***: The enhanced inflammatory response in hepatic microvessels may be caused by a decrease of antithrombin Ⅲ levels and could be responsible for disturbances of organ pathology.

关键词： Liver cirrhosis Microcirculation Small intestine Liver