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Insulin receptors in the kidneys in health and disease

World Journal of Nephrology 2019年第1期8卷 11-22页

作者： sarojini singh Rajni Sharma Manju Kumari Swasti Tiwari Department of Molecular Medicine and Biotechnology Sanjay Gandhi Postgraduate Institute of Medical Sciences

Insulin is an important hormone that affects various metabolic processes,including kidney *** in insulin's action leads to insulin resistance in the target *** defects in post-receptor insulin signaling,impairment at the receptor level could significantly affect insulin sensitivity of the target *** kidney is a known target of insulin;however,whether the kidney develops "insulin resistance" is *** of the insulin receptor(IR) expression and its function is very well studied in major metabolic tissues like liver,skeletal muscles,and adipose *** physiological relevance of IRs in the kidney has recently begun to be *** credit goes to studies that showed a wide distribution of IR throughout the nephron segments and their reduced expression in the insulin resistance ***,altered renal and systemic metabolism observed in mice with targeted deletion of the IR from various epithelial cells of the kidney has strengthened this *** this review,we recapitulate the crucial findings from literature that have expanded our knowledge regarding the significance of the renal IR in normal-and insulin-resistance states.

关键词： Insulin receptor Insulin resistance Kidney disease Renal sodium reabsorption Gluconeogenesis Proteinuria Systemic blood pressure

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Natural Products Potential and Scope for Modern Cancer Research

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American Journal of Plant Sciences 2013年第6期4卷 1270-1277页

作者： Rajeev Nema Sarita Khare Parul Jain Alka Pradhan Abhishek Gupta Dharmendra singh Center for Microbiology & Bio-Technology Research and Training Institute Bhopal Bhopal India Government of Motilal Vigyan Mahavidyalaya Bhopal India. S.V. Polytechnic College Bhopal India sarojini Naidu Government Girls Post Graduate (Autonomous) College Bhopal India sarojini Naidu Government Girls Post Graduate (Autonomous) College Bhopal India

In the present time Natural products are considered to be symbols of protection in comparison to the synthetic product that are regarded as unsafe to human life and environment. Although a large number of synthetic drugs are being added to the world of present pharmacopoeia, but still no system of medicine in the world has been able to solve all the health problems, which include diseases like Cancer. Therefore the search for innovative therapeutic constituents from plants is genuine and urgent. In India, there is an ocean of knowledge about medicinal plants and rich medicinal flora, but still only a few pearls have been searched as therapeutic agents. There are large numbers of original plants left which have not been investigated thoroughly from modern scientific view or their healing values have not been known. Thus there is an insistent need for systematic phytochemical examination of those plants which have not been investigated scientifically. More research can be done to investigate the unknown and unexplored potential of plants. Further analysis of plants (active compounds) can be carried out by way of making use of different analytical methods such as HPTLC, HPLC, NMR and UV spectrophotometer analysis or computer based drug designing.

关键词： Medicinal Plant Natural Product Cancer Biology

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Comparative study of the results of compound tibial shaft fractures treated by Ilizarov ring fixators and limb reconstruction system fixators

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Chinese Journal of Traumatology 2015年第6期18卷 347-351页

作者： Chandra Prakash Pal Harish Kumar Deepak Kumar K.S. Dinkar Vivek Mittal Naveen Kumar singh Department of Orthopaedics S. N. Medical College AgTa Uttar Pradesh 282002 India

Purpose： llizarov ring fixator and limb reconstruction system （LRS） fixators have been used in the management of complex tibial fractures with severe soft tissue injuries, compound tibial fractures, and infected tibial nonunion for which conventional internal fixation cannot be contemplated. Fracture union and distraction osteogenesis can be done simultaneously with these external fixators, allowing early weight bearing. Several previous studies have shown almost equal results of rail and ring fixators for the compound tibial shaft fractures. Thus we performed a prospective study to evaluate the union rate, functional outcome and amount of limb lengthening after the treatment of compound tibial shaft fractures with or without infected nonunion by ring or LRS fixators. Methods： This prospective study was done at sarojini Naidu Medical College and Hospital, Agra, India and included 32 patients of compound tibial shaft fractures with or without infected nonunion. There were 26 males and 6 females and the average age was 40 years. Patients were randomly divided into two groups （n - 16 for each）： one underwent llizarov fixation and the other received LRS fixation. Cases were followed up for 3-24 months, 6 months on average from September 2012 to October 2014. Functional and radiological outcomes were assessed using the Association for the Study and Application of Methods of llizarov （ASAMI） criteria for both rail and ring fixators. Results： Union was achieved in all cases. Radiological outcome was found excellent in 68.75%, good in 18.75% and fair in 12.50% of cases treated by rail fixators whereas it was excellent in 56.25%, good in 18.75%, fair in 12.50% and poor in 12.50% of cases treated by ring fixators. Functional result was satis- factory in 75.00% of cases treated by rail fixator and 68.75% of cases treated by ring fixators whereas the corresponding rate of unsatisfactory was 25.00% vs. 31.25%. Conclusion： In our short-term assessment, LRS fixators show a better

关键词： Limb reconstruction system fixators Ring fixators Distraction osteogenesis ASAMI criteria

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