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Hydroalcoholic extract of licorice(Glycyrrhiza glabra L.) root attenuates ethanol and cerulein induced pancreatitis in rats

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Asian Pacific Journal of Tropical Biomedicine 2019年第10期9卷 424-433页

作者： sarmishta srikantam Geetha Arumugam Department of Biochemistry Bharathi Women’s CollegeBroadwayChennaiIndia Dr.Ambedkar Government Arts College VyasarpadiChennaiIndia

Objective:To evaluate the therapeutic potential of hydroalcoholic extract of licorice root against ethanol and cerulein induced chronic pancreatitis in ***:The phytochemical profile of hydroalcoholic extract of licorice root was determined by high performance liquid chromatography(HPLC)and gas chromatography coupled to mass spectrometry(GC-MS).Chronic pancreatitis was induced in male albino Wistar rats by feeding them a diet containing ethanol(0%-36%of total calories)for 4 weeks and cerulein(20μg/kg ***,i.p.)thrice a week for 3 *** and amylase in serum,lipid peroxides and antioxidants including reduced glutathione,glutathione peroxidase,superoxide dismutase and catalase in pancreas were *** response was measured by myeloperoxidase in the pancreas,caspase-1 and the concentrations of IL-1 as and liver was carried oαand IL-18 in ***,histological evaluation of the ***:Different flavonoids and saponins were identified in the hydroalcoholic extract of licorice root through HPLC and GC-MS.A marked increase in the levels of serum lipase,amylase,lipid peroxides,caspase-1,myeloperoxidase,IL-1 in the levels of antioxidants were observed after ethanoα,and IL-18 and a marked decrease l and cerulein *** with hydroalcoholic extract of licorice root attenuated these *** addition,histological observation confirmed the protective effect of the extract in the pancreas and liver against inflammatory changes induced by ethanol and ***:The licorice root extract attenuates ethanol and cerulein induced pancreatitis in rats probably due to its antioxidant phytonutrients since ethanol and cerulein-induced production of reactive oxygen species contributes to severe inflammation in the pancreas.

关键词： Pancreatitis ROS Inflammation Glycyrrhiza glabra HPLC GC-MS

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