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Phytopharmacological Profile of Jasminum Grandiflorum Linn.(Oleaceae)

Chinese Journal of Integrative Medicine 2016年第4期22卷 311-320页

作者： Mittal Arun sardana satish Pandey Anima Hindu College of Pharmacy SonipatHaryana-(131001)India Department of Pharmaceutical Sciences Birla Institute of TechnologyMesraRanchiJharkhand(835215)India

Plants are the real basis towards animal life and are also central to people＇s livelihood. The contributions of the plants in performing varied religious celebrations and in other multiple beneficiaries like medicine, human happiness as well as in treating deadly diseases can never be neglected. In treating diseases, the plants and their constituents are better choice than any other synthetic chemical. The nature has been kind enough to provide the human beings with various types of medicinal plants and in the real sense these form the storehouse of curing almost all the ailments. Consequently, most of the drugs which are being used in preparing formulations have their origin and roots in the plants which form the chief natural source of medicines. Even in modern era, the plant-derived drugs are being extensively used, either in their original or semi-synthetic form. It is because their natural phytoconstituents are highly innocuous posing relatively fewer or no side effects. Based upon their observations, analysis and experience, our ancestors used many plants for medicinal purposes and thus their efforts need to be supported by scientific evidence. Jasminum grandiflorum Linn. is one of such important plants. It has been extensively used by the tribes all over India to treat different diseases which mainly include body pains, toothache, stomach ache, ulcers, and sexual impotency. Chemistry of the plant revealed the presence of mainly secoiridoids, terpenoids, flavonoids and tannins. Not much scientific support was given to the folklore claims for this plant but some of its traditional uses were investigated like spasmolytic, wound healing, antimicrobial, angiotensin converting enzyme inhibitor, antiulcer and antioxidant activities. This article is the review of research works done on the plant Jasminum grandiflorum Linn. to date. As a part of it the local names, morphology, traditional claims, chemistry and pharmacological activities have been discussed.

关键词： Jasminum grandiflorum Linn. ethnobotany phytochemistry pharmacological activity

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5-Fluorouracil loaded guar gum microspheres for colon delivery： preparation, characterization and in vitro release

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药学学报 2009年第11期44卷 1278-1284页

作者： KAUSHIK Dinesh sardana satish MISHRA DN Department of Pharmaceutics Hindu College of Pharmacy Sonepat-131001 India Department of Pharmaceutical Sciences Guru Jambheswar University of Science and Technology Hisar (Haryana) India

The present investigation is aimed to develop a new formulation containing chemically crosslinked guar gum microspheres loaded with 5-fluorouracil for targeting colorectal cancer. The emulsification polymerization method involving the dispersion of aqueous phase of guar gum in castor oil was used to prepare spherical microspheres. Various processing parameters were studied in order to optimize the formulation. Particle size and surface morphology of the microspheres were determined using optical microscopy and scanning electron microscopy. The in vitro drug release studies performed in simulated gastric fluid (SGF) for 2 h followed by intestinal fluid for 3 h, revealed the retention of the drug inside the microspheres from which only (15.27 ± 0.56) % of the drug was released in 5 h. In vitro release rate studies were also carried out in simulated colonic fluid (SCF) in the presence of rat caecal contents, which showed improved drug release. The drug release from the formulation was found to be (41.6 ± 3.5) % with 2% (w/v) caecal matter in 24 h as compared to control study where (25.2 ± 3.5) % of drug was released. The drug release from the formulation with 2% and 4% rat caecal contents medium after 2 days of enzyme induction was found to be (56.3 ± 4.1) % and (78.9 ± 2.8) % in 24 h respectively. Similarly, (61.3 ± 5.4) % and (90.2 ± 2.9) % drug was released respectively with 2% and 4% rat caecal matter after 4 days of enzyme induction and (72.1 ± 2.9) % and (90.2 ± 3.2) % after 6 days of enzyme induction. In this way, 5-fluorouracil loaded guar gum microspheres have shown promising results in the management of colorectal cancer, warranting thorough in vivo study for scale up technology.

关键词：制剂学药学氟尿嘧啶临床

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Effect of ciprofloxacin and chloramphenicol on humoral immune response elicited by bovine albumin encapsulated in niosomes

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药学学报 2007年第8期42卷 905-909,910页

作者： MADAN Jitender KAUSHIK Dinesh sardana satish MISHRA Dn Department of Pharmaceutics Hindu College of Pharmacy Faculty of Pharmacy Guru Jambheshwar University of Science and Technology

The aim is to evaluate the effect of ciprofloxacin and chloramphenicol on anti-BSA antibody production triggered by bovine albumin encapsulated in non-ionic surfactant vesicle,*** phase evaporation method was adopted to entrap the antigen in colloidal carrier composed of Span 80 and Span 85 followed by simultaneous characterization for particle size,entrapment efficiency and in vitro *** protein content was determined by Bradford method using UV Visible Spectrophotometer at 595 *** immune response was measured in terms of systemic IgG antibody titre by ELISA *** data indicated that 7∶3 molar ratio of Span 80 and cholesterol based niosomal formulation possessed maximum(39.8±2.9)% of soluble *** markedly(P0.05).It is necessary to explore the effect of a vaccine antigen when a candidate is medicated with a therapeutic agent,which might help in programming a new drug management and vaccination programme.

关键词：环丙沙星氯霉素体液免疫 IgG抗体牛蛋白胶囊免疫应答泡囊

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