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Assessing the dynamics and impact of cOVID-19 vaccination on disease spread:A data-driven approach

Infectious Disease Modelling 2024年第2期9卷 527-556页

作者： Farhad Waseel George Streftaris Bhuvendhraa Rudrusamy sarat c.dass School of Mathematical and computer Sciences Heriot-Watt University MalaysiaPutrajayaMalaysia School of Mathematical and computer Sciences Heriot-Watt UniversityEdinburghUnited Kingdom School of Engineering and Physical Sciences Heriot-Watt University MalaysiaPutrajayaMalaysia Maxwell Institute for Mathematical Sciences United Kingdom Faculty of Mathematics Kabul UniversityKabulAfghanistan

The cOVID-19 pandemic has significantly impacted global health,social,and economic situations since its emergence in December *** primary focus of this study is to propose a distinct vaccination policy and assess its impact on controlling cOVID-19 transmission in Malaysia using a Bayesian data-driven approach,concentrating on the year *** employ a compartmental Susceptible-Exposed-Infected-Recovered-Vaccinated(SEIRV)model,incorporating a time-varying transmission rate and a data-driven method for its estimation through an Exploratory Data Analysis(EDA)*** no vaccine guarantees total immunity against the disease,and vaccine immunity wanes over time,it is critical to include and accurately estimate vaccine efficacy,as well as a constant vaccine immunity decay or wane factor,to better simulate the dynamics of vaccine-induced protection over *** on the distribution and effectiveness of vaccines,we integrated a data-driven estimation of vaccine efficacy,calculated at 75%for Malaysia,underscoring the model's realism and relevance to the specific context of the *** Bayesian inference framework is used to assimilate various data sources and account for underlying uncertainties in model *** model is fitted to real-world data from Malaysia to analyze disease spread trends and evaluate the effectiveness of our proposed vaccination *** findings reveal that this distinct vaccination policy,which emphasizes an accelerated vaccination rate during the initial stages of the program,is highly effective in mitigating the spread of cOVID-19 and substantially reducing the pandemic peak and new *** study found that vaccinating 57–66%of the population(as opposed to 76%in the real data)with a better vaccination policy such as proposed here is able to significantly reduce the number of new infections and ultimately reduce the costs associated with new *** study contributes to the development of a robust and informati

关键词： Bayesian inference SEIRV cOVID-19 Vaccination policy Importance sampling Malaysia Data-driven

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DEVELOPMENT OF A cATALYST FOR SOLUTION OF POLY(VINYL ALcOHOL) IN NON-AQUEOUS MEDIUM

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chinese Journal of Polymer Science 2008年第4期26卷 501-506页

作者： Prafulla chetri Narendra Nath dass Neelotpal Sen Sarma Material Science Division IASSTPaschim BoragaonGuwahati-781035AssamIndia

chloro ethane dimethyl sulfoxide,c_2H_5cl·DMSO(EcI·DMSO)was prepared by interaction of acrylic acid with *** acid in dimethyl sulfoxide(DMSO)and subsequent decarboxylation with H_2O_2 *** formation of the compound was confirmed by spectral and analytical methods;the molecular weight was determined by cryoscopic *** solubility of poly(vinyl alcohol)(PVA)in different solvents or mixed solvents at 40℃,50℃and 60℃temperature in the presence of 0.01% of Ec1·-DMSO was *** tu...

关键词： chloro ethane dimethyl sulfoxide Poly(vinyl alcohol) catalyst Solubility

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Stability of freeze-dried pH-responsive dextrin nanogels containing doxorubicin

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Asian Journal of Pharmaceutical Sciences 2016年第5期11卷 648-654页

作者： Somkamol Manchun crispin R.dass Pornsak Sriamornsak Department of Pharmaceutical Technology Faculty of PharmacySilpakorn UniversityNakhon Pathom 73000Thailand Pharmaceutical Biopolymer Group(PBiG) Faculty of PharmacySilpakorn UniversityNakhon Pathom 73000Thailand School of Pharmacy Faculty of Health SciencesCurtin UniversityPerth 6845Australia curtin Health Innovation Research Institute of Ageing and chronic Disease Bentley 6102Australia

Induction of non-specific toxicities by doxorubicin(DOX) has restricted conventional DOXbased chemotherapy. p H-responsive dextrin nanogels(DNGs) have been fabricated in order to incorporate and deliver DOX to specific(targeted) sites. However, adequate stability studies of DOX-loaded DNGs are required for selection of storage conditions. The aim of this study was therefore to evaluate the accelerated(25 °c/60% RH) and long-term(5 °c) stability of DNGs prepared with formaldehyde(FDNGs) and glyoxal(GDNGs) as cross-linker by determining the change in their physicochemical properties. The mean diameter decreased with time during long-term storage. The drug content between freshly prepared(initial day) and after storage at 5 °c for 180 days of DOX-loaded FDNGs and DOX-loaded GDNGs was not significantly different(p > 0.05), but decreased after storage under the accelerated condition. The release of DOX from all DNGs was pH-dependent. However, DNGs kept under the accelerated condition showed higher amount of DOX release than those stored at 5 °c and the freshly prepared ones. The results indicate that the stability of DNGs could be improved by their storage at 5 °c.

关键词： Stability Nanogels Dextrin

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Synthesis, antimicrobial and anti-inflammatory activities of some novel 5-substituted imidazolone analogs

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chinese chemical Letters 2016年第5期27卷 707-710页

作者： Ashwani Kumar Dhingra Bhawna chopra Rameshwar dass Sanjeev Kumar Mittal Guru Gobind Singh college of Pharmacy Yamuna Nagar 135001 Haryana India Department of Pharmacy IK Gujral Punjab Technical University Jalandhar 144001 Punjab India Department of Industrial chemistry Guru Nanak Khalsa College Yamuna Nagar 135001 Haryana India IEc School of Pharmacy IEC University Baddi 173205 Himachal Pardesh India

In view of potent antimicrobial and anti-inflammatory activities exhibited by S-substituted imidazolones, a variety of novel imidazolone analogs 3a-I were synthesized by the condensation of different substituted oxazolones I with various aromatic amines 2. All the synthesized compounds were screened for in vitro activities against a panel of Gram-positive and Gram-negative bacteria and the yeast-like pathogenic fungus candida albicans. Several analogs produced good or moderate activities particularly against the tested Gram-positive bacteria Micrococcus luteus and Gram-negative bacteria Pseudornonas aeruginosa and, Meanwhile, compounds 3b and 3c displayed marked antifungal activity against c. albicans. In addition, the in vivo anti-inflammatory activity of the synthesized compounds was determined using the carrageenin-induced paw oedema method in rats. Two of S-substituted imidazo/one derivatives, 3k and 3d show good anti-inflammatory activity. The structures of all the newly svnthesized compounds were elucidated using IR, 1H NMR and 13c NMR.

关键词： Oxazolones Imidazolones Antimicrobial activity Anti-inflammatory activity

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Acute hepatitis of unknown etiology in an adult female:A case report

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World Journal of clinical cases 2023年第22期11卷 5288-5295页

作者： Lucinda dass Alexandra Marie Malabanan Pacia Mahgol Hamidi Department of clinical Studies St.George's UniversityTrue Blue 00000Grenada Department of Internal Medicine Jersey City Medical CenterJersey CityNew Jersey 07307United States

BAcKGROUND Acute liver injury(ALI)refers to inflammation of the hepatic parenchyma without hepatic encephalopathy that lasts less than 6 *** the etiology is unknown,Acute Hepatitis of Unknown Origin(AHUO)can present as a diagnostic and treatment *** in the adult population is unusual and poorly *** has an incidence between 11%and 75%.currently,no treatment guidelines *** no identified cause,treatment is often blind,and the wrong treatment plan may have unintended *** SUMMARY We present the case of a 58-year-old woman who presented to the emergency room for elevated liver function tests(LFTs).Her symptoms started 10 d prior to admission and included nausea,vomiting,jaundice,decreased appetite,weight loss of 10 lbs,and dark *** denied drinking alcohol or taking any hepatotoxic agents,including acetaminophen,statins,vitamins,or *** was admitted to the hospital,and an etiologic work-up was carried *** initial bloodwork revealed elevated liver enzymes(alanine aminotransferase 2500 U/L,aspartate aminotransferase 3159 U/L,and alkaline phosphatase 714 U/L)and elevated total bilirubin of 6.4 mg/*** tested negative for common infectious etiologies such as hepatotropic viruses A,B,c,and *** infective work-up revealed negative serology for cytomegalovirus,Epstein-Barr virus,herpes simplex virus 1&2,and human immunodeficiency *** autoanti-body test results were negative,including anti-smooth muscle antibody,anti-mitochondrial antibody,and anti-liver kidney microsome 1 *** resonance cholangiopancreatography ruled out biliary causes of elevated LFTs,and her core liver biopsy proved *** the course of her hospital stay,the patient's LFTs improved with supportive care and without *** Idiopathic hepatitis makes treatment *** can leave patients feeling confused and ***,educating the patient thoroughly for shared decision-making and manag

关键词： Acute hepatitis Acute liver injury Idiopathic hepatitis Acute hepatitis of unknown etiology case report

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Absolute copy number differences of Y chromosomal genes between crossbred (Bos taurus×Bos indicus) and Indicine bulls

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Journal of Animal Science and Biotechnology 2013年第4期4卷 257-263页

作者： Ayan Mukherjee Gulshan dass Jagan Mohanarao G Moloya Gohain Biswajit Brahma Tirtha Kumar Datta Sachinandan De Animal Genomics Lab Animal Biotechnology Centre National Dairy Research Institute Department of Veterinary Biochemistry College of Veterinary Sciences & Animal Husbandry Central Agricultural University

Background： The Y chromosome in mammal is paternally inherited and harbors genes related to male fertility and spermatogenesis. The unique intra-chromosomal recombination pattern of Y chromosome and morphological difference of this chromosome between Bos taurus and Bos indicus make it an ideal model for studying structural variation, especially in crossbred （Bos taurus x Bos indicus） bulls. copy Number Variation （cNV） is a type of genomic structural variation that gives information complementary to SNP data. The purpose of this study was to find out copy number differences of four Y chromosomal spermatogenesis-related candidate genes in genomic DNA of crossbred and purebred Indicine bulls. Result： Four Y chromosomal candidate genes of spermatogenesis namely, sex determining gene on Ychromosome （SRY）, DEAD box po/ypeptide 3-Y chromosome （DDX3 Y）, Ubiquidn specific peptidase 9, Y-linked （ usPgY）, testis-specific protein on Y chromosome （TSPY） were evaluated. Absolute copy numbers of Y chromosomal genes were determined by standard curve-based quantitative real time PcR. copy numbers of SRYand TSPYgenes per unit amount of genomic DNA are higher in crossbred than Indicine bulls. However, no difference was observed in DDX3Yand usPgYgene copy numbers between two groups. conclusion： The present study demonstrates that the structural organization of Y chromosomes differs between crossbred and Indicine bulls which are reproductively healthy as observed from analysis of semen attributes. The absolute copy numbers of SRY and TSPY genes in unit mass of genomic DNA of crossbred bulls are significantly higher than Indicine bulls. No alteration in absolute copies ofDDX3Yand usPgYgene was found between the genome of crossbred and Indicine bulls. This study suggests that the DDX3Yand USPgYare likely to be single copy genes in the genome of crossbred and Indicine bulls and variation in Y chromosome length between crossbred and Indicine bulls may be due to the copy number variation of

关键词： Absolute copy SRY DDX3Y usPgY TSPY crossbred

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茴香种子蛋白质水解物和肽的抗氧化和蛋白质保护潜力（英文）

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现代食品科技 2019年第9期35卷 22-29,21页

作者：摩哈娜达斯·莎美拉蔡俊泰黄怀祖拉曼大学理学院马来西亚金宝31900 拉曼大学生物多样性研究中心马来西亚金宝31900

茴香种子是一种可食用的香料,经常用于增进各种烹饪的香气和味道,并且因其药用价值而在不同文化中被珍藏。之前的研究报告提及了与茴香种子相关的各种生物活性。然而,对于来自茴香种子的水解蛋白质知之甚少。在本文中,作者从茴香种子中... 详细信息

茴香种子是一种可食用的香料,经常用于增进各种烹饪的香气和味道,并且因其药用价值而在不同文化中被珍藏。之前的研究报告提及了与茴香种子相关的各种生物活性。然而,对于来自茴香种子的水解蛋白质知之甚少。在本文中,作者从茴香种子中分离出总蛋白质,然后使用四种不同的蛋白酶进行酶水解。本文中也报道了水解度,pH和温度曲线。在ABTS自由基清除测定的指引下,作者使用离心过滤,c18反相和强阳离子交换(ScX)来进一步分离碱性蛋白酶消化的蛋白质水解物。与粗水解物相比,纯化水解物的自由基清除潜力增强了4.5倍。通过肽测序进一步分析纯化的ScX级分,本文也鉴定出两个肽序列,其范围为6~8个氨基酸。紧接着,文中也报道了使用白蛋白变性抑制试验来测试茴香肽的蛋白质保护潜力,其中一种茴香肽(EDVDFR)更被测出与纯谷胱甘肽(GSH)相当的Ec50值。总要言之,茴香种子衍生的蛋白质水解物和茴香肽有潜力被进一步开发成促进健康的补充剂或作为食品添加剂用于保存富含蛋白质的食物。

关键词：抗氧化肽酶水解茴香籽蛋白质保护 pH和热稳定性肠稳定性

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A PRELIMINARY STUDY OF THE FOSSIL FLORA OF THE PINGTINGSHAN cOAL FIELD IN cENTRAL HONAN

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Science in china,Ser.A 1954年第3期 323-334页

作者： H.c.SZE Institute of Palaeontology Academia Sinica

The collection and study of the Permian plants in the central Honanhas been occupying the writer’s attention for the past fifteen years. A numberof very interesting fossil plants found from this area have been descrited byDr. c. H. Pan as Pseudorhipidopsis brevicaulis and P. baieroides in *** discovery of such remarkable specimens in the coal field of centralHonan has received a share of the attention it deserves. In 1938, Prof. Gothanexpressed his view in regarding to this occurrence as follows: 'dass auch diecathaysia-Flora noch allerhand Ueberraschendes enthalt, zeigt die Mitteilung

关键词： A PRELIMINARY STUDY OF THE FOSSIL FLORA OF THE PINGTINGSHAN cOAL FIELD IN cENTRAL HONAN

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山西隰县上石炭纪植物并校正松泽勋发表之热河古生代植物化石

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古生物学报 1954年第2期 171-182页

作者：斯行健中国科学院古生物研究所

1952年盛金章同志曾至山西隰县调查煤田地质,仅采得植物化石三种,经研究结果其时代当属於上石炭纪,兹分别述之於下:Lepldodendron oculus-felis(Abbado)Zeiller(图版Ⅰ,图1—2)这一种鳞木系莘夏植物群中最有代表性的重要份子之一。正如... 详细信息

1952年盛金章同志曾至山西隰县调查煤田地质,仅采得植物化石三种,经研究结果其时代当属於上石炭纪,兹分别述之於下:Lepldodendron oculus-felis(Abbado)Zeiller(图版Ⅰ,图1—2)这一种鳞木系莘夏植物群中最有代表性的重要份子之一。正如种名 Lepido-dendron oculus-felis 所表示,此种鳞木,以其猫睛状的叶痕为其特徵。当前的标本,保存异常佳美,叶痕中的三点(当中的一点代表维管束,两旁的两点代表Parichnos 痕)亦甚为明显。日本学者松泽动将此种化石定为 Lepidodendron

关键词：石炭纪上石月阴太原煤田植物化石热河山西

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山西河曲县华夏植物群中的一个盎格兰型的callipteris新种

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古生物学报 1954年第1期 83-94页

作者：斯行健中国科学院古生物研究所

在华夏植物群中是否有盎格兰或库斯纳次克植物群份子存在的问题,是近二、三十年来古植物学家常喜讨论和感兴趣的事。虽然多数学者相信,当着古生代末期西伯利亚的库斯纳次克(Кузнецкий)植物群份子和东亚的华夏植物群份子并无真... 详细信息

在华夏植物群中是否有盎格兰或库斯纳次克植物群份子存在的问题,是近二、三十年来古植物学家常喜讨论和感兴趣的事。虽然多数学者相信,当着古生代末期西伯利亚的库斯纳次克(Кузнецкий)植物群份子和东亚的华夏植物群份子并无真正的互相迁移的事实,但在华夏植物群中,有若干亲缘的、和近似的库斯纳次克型式的种属,是值得合人非常注意的。山西中部太原附近石盒子系地层中所发现的,并且被Halle 教授所描写的Psygmophyllum multipartitum,其和Zalessky 教授所描述的库斯纳次克植物群中的Iniopteris sibirica 相近缘的程度,

关键词：盒子上石下石植物化石 callipteris 山西

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