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Hepatitis C virus-associated pruritus: Etiopathogenesis and therapeutic strategies

World Journal of Gastroenterology 2017年第5期23卷 743-750页

作者： Youssef Alhmada Denis Selimovic Fadi Murad sarah-lilly hassan Youssef Haikel Mossaad Megahed Matthias Hannig Mohamed hassan Department of Pathology University of Mississippi Medical Center Graduate School of Dental Medicine Depart-ment of Restorative DentistryDivision of Oral Health ScienceHokkaido University Clinic of Operative Dentistry Periodontology and Preventive DentistrySaarland University Department of Surgery Tulane University School of Medicine Clinic of Dermatology University Hospital of Aachen Institut National de la Santéet de la RecherchéMédicale Department of Operative Dentistry and Endodontics Dental FacultyUniversity of Strasbourg

In addition to its contributing role in the development of chronic liver diseases, chronic hepatitis C virus(HCV) infection is associated with extrahepatic manifestations, particularly, cutaneous-based disorders including those with pruritus as a symptom. Pruritus is frequently associated with the development of chronic liver diseases such as cholestasis and chronic viral infection, and the accumulation of bile acids in patients' sera and tissues as a consequence of liver damage is considered the main cause of pruritus. In addition to their role in dietary lipid absorption, bile acids can trigger the activation of specific receptors, such as the G protein-coupled bile acid receptor(GPBA/ TGR5). These types of receptors are known to play a crucial role in the modulation of the systemic actions of bile acids. TGR5 expression in primary sensory neurons triggers the activation of the transient receptor potential vanilloid 1(TRPV1) leading to the induction of pruritus by an unknown mechanism. Although the pathologic phenomenon of pruritus is common, there is no uniformly effective therapy available. Understanding the mechanisms regulating the occurrence of pruritus together with the conduction of large-scale clinical and evidence-based studies, may help to create a standard treatment protocol. This review focuses on the etiopathogenesis and treatment strategies of pruritus associated with chronic HCV infection.

关键词：丙肝病毒瘙痒 Cholestasis 自体毒素 Lysophosphatidic 酸 PI3 kinase

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An Online Fake Review Detection Approach Using Famous Machine Learning Algorithms

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Computers, Materials & Continua 2024年第2期78卷 2767-2786页

作者： Asma hassan Alshehri Department of Computer Sciences College of Computer Engineering and SciencesPrince Sattam bin Abdulaziz UniversityAl KharjSaudi Arabia

Online review platforms are becoming increasingly popular,encouraging dishonest merchants and service providers to deceive customers by creating fake reviews for their goods or *** Sybil accounts,bot farms,and real account purchases,immoral actors demonize rivals and advertise their *** academic and industry efforts have been aimed at detecting fake/fraudulent product or service evaluations for *** primary hurdle to identifying fraudulent reviews is the lack of a reliable means to distinguish fraudulent reviews from real *** paper adopts a semi-supervised machine learning method to detect fake reviews on any website,among other *** reviews are classified using a semi-supervised approach(PU-learning)since there is a shortage of labeled data,and they are ***,classification is performed using the machine learning techniques Support Vector Machine(SVM)and Nave *** performance of the suggested system has been compared with standard works,and experimental findings are assessed using several assessment metrics.

关键词： Security fake review semi-supervised learning ML algorithms review detection

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Distributed Hybrid Model Predictive Secondary Control of DC Microgrids with Random Communication Disorders

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Journal of Modern Power Systems and Clean Energy 2024年第3期12卷 925-935页

作者： Meysam Yaribeygi Zeinab Karami Qobad Shafiee hassan Bevrani the Department of Electrical Engineering K.N.Toosi University of TechnologyTehranIranand he is now with the Sportradar CompanyTrondheimNorway the Department of Engineering Cybernetics(ITK) Norwegian University of Science and Technology(NTNU)TrondheimNorway the Smart/Micro Grids Research Center Department of Electrical EngineeringUniversity of KurdistanSanandajIran

A reliable and robust communication network is essential to exchange information between distributed generators(DGs)and accurately calculate their control actions in microgrids(MGs).However,the integration of the communication network and MGs poses challenges related to the flexibility,availability,and reliability of the ***,random communication disorders such as time delays and packet loss can negatively impact the system ***,it is essential to design a suitable secondary controller(SC)with a fast dynamic response to restore voltage and appropriate powersharing,while ensuring that the effects of random communication disorders are *** this regard,an optimal distributed hybrid model predictive secondary control method is presented in this *** simulations are carried out in a mixed simulation environment based on MATLAB and OMNET++,by considering IEEE 802.11(Wi Fi)using the recently developed Internet networking(INET)*** the implemented application layer,the recovery Unit is responsible for reducing the impact of random communication *** effectiveness and performance of the proposed method in comparison with a conventional model predictive control are verified by simulation results.

关键词： Microgrid model predictive control random communication disorder secondary control

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E-voting system using cloud-based hybrid blockchain technology

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Journal of Safety Science and Resilience 2024年第1期5卷 102-109页

作者： Beulah Jayakumari S lilly Sheeba Maya Eapen Jani Anbarasi Vinayakumar Ravi A.Suganya Malathy Jawahar Department of Information Technology Tagore Engineering College Chennai India School of Computer Science and Engineering SRM Institute of Science and Technology Ramapuram ChennaiIndia Department of Information Technology Jerusalem College of Engineering ChennaiIndia School of Computer Science and Engineering Vellore Institute of Technology Chennai India Center for Artificial Intelligence Prince Mohammad Bin Fahd UniversityKhobarSaudi Arabia Leather Process Technology Division CSIR-Central Leather Research Institute ChennaiIndia

With the invention of Internet-enabled devices,cloud and blockchain-based technologies,an online voting system can smoothly carry out election *** pandemic situations,citizens tend to develop panic about mass gatherings,which may influence the decrease in the number of *** urges a reliable,flexible,transparent,secure,and cost-effective voting *** proposed online voting system using cloud-based hybrid blockchain technology eradicates the flaws that persist in the existing voting system,and it is carried out in three phases:the registration phase,vote casting phase and vote counting phase.A timestamp-based authentication protocol with digital signature validates voters and candidates during the registration and vote casting *** smart contracts,third-party interventions are eliminated,and the transactions are secured in the blockchain ***,to provide accurate voting results,the practical Byzantine fault tolerance(PBFT)consensus mechanism is adopted to ensure that the vote has not been modified or ***,the overall performance of the proposed system is significantly better than that of the existing *** performance was analyzed based on authentication delay,vote alteration,response time,and latency.

关键词： E-voting Cloud Blockchain Smart contract Consensus mechanism

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Existence and numerical approximation of a solution to frictional contact problem for electro-elastic materials

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Applied Mathematics(A Journal of Chinese Universities) 2024年第2期39卷 201-219页

作者： Othman Baiz EL-hassan Benkhira Rachid Fakhar University Ibn Zohr Lab.ESERFP of OuarzazateMorocco University Moulay Ismail Faculty of SciencesLaboratory MACSESTMBP 3103Toulal-MeknesMorocco University Sultan Moulay Slimane Laboratory LS2MEPolydisciplary Faculty of Khouribga25000 KhouribgaMorocco

In this paper,a frictional contact problem between an electro-elastic body and an electrically conductive foundation is *** contact is modeled by normal compliance with finite penetration and a version of Coulomb’s law of dry friction in which the coefficient of friction depends on the *** addition,the effects of the electrical conductivity of the foundation are taken into *** model leads to a coupled system of the quasi-variational inequality of the elliptic type for the displacement and the nonlinear variational equation for the electric *** existence of a weak solution is proved by using an abstract result for elliptic variational inequalities and a fixed point ***,a finite element approximation of the problem is *** some regularity conditions,an optimal order error estimate of the approximate solution is ***,a successive iteration technique is used to solve the problem numerically and a convergence result is established.

关键词： piezoelectric material frictional contact variational Inequality fixed point process finite element method error estimation iteration method

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Sedimentary facies analysis of a thin-bed-dominated turbidite succession in the Miocene Temburong Formation,Kampung Bebuloh,Labuan Island,Malaysia

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Journal of Palaeogeography 2024年第3期13卷 401-429页

作者： Farah Syafira Burhanuddin Meor Hakif Amir hassan Department of Geology Faculty of ScienceUniversiti Malaya50603 Kuala LumpurMalaysia

Thin-bedded turbidites are important hydrocarbon-bearing reservoirs in many mature fields throughout the *** type of turbidite depositional setting strongly influences vertical and horizontal continuity of the ***,distinguishing between lobe and levee associated thin-bedded turbidites remains challenging due to their generally similar facies *** study aims to contribute some insights to this problem by conducting a detailed bed-scale facies analysis on the Early Miocene Temburong Formation exposed at Kampung Bebuloh,Labuan Island,Malaysia,which may uncover features that can help in differentiating between both depositional *** facies are recognized in the Temburong Formation,which are interpreted as low density turbidites(F1-F4),hybrid event beds(F5),and sustained turbidites(F6).Detailed facies and ichnology analysis reveal features which are consistent with a lobe fringe deposit rather than leveeassociated environment interpretation,including tabular bed geometries,presence of hybrid event beds,and the absence of thick-bedded channel-fill *** facies associations are identified and interpreted as representing sub-environments within an overall lobe depositional setting.A diverse trace fossil assemblage,comprising the Nereites ichnofacies is consistent with a deep marine *** identification of the Paleodictyon and Nereites sub-ichnofacies indicates a distal turbidite system setting,most likely lobe *** on the thick accumulation of FA2 and FA3 and no distinct observable vertical trend,the Early Miocene Temburong Formation in Labuan is interpreted as turbidites deposited at the fringes of lobe complexes rather than a single lobe *** works into the Temburong Formation in SW Labuan proposed a middle slope to proximal basin floor setting where the thin-bedded intervals were interpreted as potentially representing either levee deposits or the fringes of confined lobe ***

关键词： Facies analysis Trace fossils Depositional lobes Hybrid event beds Lobe fringe Temburong formation Thin-bedded turbidite

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An Adaptive Data-driven Method Based on Fuzzy Logic for Determining Power System Voltage Status

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Journal of Modern Power Systems and Clean Energy 2024年第3期12卷 707-718页

作者： Sirwan Shazdeh Hêmin Golpîra hassan Bevrani the SMGRC University of KurdistanSanandajIran Power Systems Modeling&Simulation Lab Department of Electrical EngineeringUniversity of KurdistanKurdistanSanandaj 66177-15175Iran

This paper proposes an adaptive method based on fuzzy logic that utilizes data from phasor measurement units(PMUs) to assess and classify generating-side voltage trajectories. The voltage variable and its associated derivatives are used as the input variables of a fuzzy-logic block. In addition, the voltage trajectory is compared with the pre-selected pilot-bus voltage to make a reliable decision about the voltage operational state. Different types of short-term voltage dynamics are considered in the proposed method. The fuzzy membership functions are determined using a systematic method that considers the current situation of the voltage trajectory. Finally, the voltage status is categorized into four classes to determine appropriate remedial actions. The proposed method is validated on a IEEE 73-bus power system in a MATLAB environment.

关键词： Fuzzy logic fault-induced delayed voltage recovery phasor measurement unit(PMU) short-term voltage stability situational awareness voltage classification

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Suppression of mature TAU isoforms prevents Alzheimer's disease-like amyloid-beta oligomer-induced spine loss in rodent neurons

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Neural Regeneration Research 2024年第8期19卷 1655-1657页

作者： sarah Buchholz Hans Zempel Institute of Human Genetics Faculty of Medicine and University Hospital CologneUniversity of CologneCologneGermany Center for Molecular Medicine Cologne(CMMC) Faculty of Medicine and University Hospital CologneUniversity of CologneCologneGermany

Introduction:TAU isoforms as disease mediators:The microtubule-associated protein TAU is predominantly present in the axons of neurons under physiological *** Alzheimer’s disease(AD)and related tauopathies,TAU also mislocalizes("TAU missorting")to the soma and the dendrites,where it eventually forms aggregates,the so-called neurofibrillary tangles(for review see Zimmer-Bensch and Zempel,2021;Zempel,2023).

关键词： Alzheimer Zimmer tau

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The anti-neoplastic effects of metformin modulate the acquired phenotype of fbroblast cells in the breast cancer-normal fbroblast co-culture system

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Oncology Research 2024年第3期32卷 477-487页

作者： SAMANEH MOSTAFAVI ZUHAIR MOHAMMAD hassan Department of Immunology Faculty of Medical SciencesTarbiat Modares UniversityTehranIran

Intracellular communications between breast cancer and fibroblast cells were reported to be involved in cancer proliferation,growth,and therapy *** hallmarks of cancer fibroblast interactions,consisting of caveolin 1(Cav1)and mono-carboxylate ransporter 4(MCT4)(metabolic coupling markers),along with IL-6,TGFB,and lactate secretion,are considered robust biomarkers predicting recurrence and *** order to promote a novel phenotype in normal fibroblasts,we predicted that breast cancer cells could be able to cause loss of Cavl and increase of MCT4,as well as elevate IL 6 and TGF in nearby nomal *** created a co culture model using breast cancer(4T1)and normal fibroblast(NIH3T3)cell lines cultured under specific experimental conditions in order to directly test our ***,we show that long-term co-culture of breast cancer cells and normal fibroblasts promotes loss of Cavl and gain of MCT4 in adjacent fibroblasts and increase lactate *** results were validated using the monoculture of each group separately as a *** this system,we show that me tformin inhibits IL-6 and TGFB secretion and re expresses Cavl in both ***,MCT4 and lactate stayed high after treatment with *** conclusion,our work shows that co-culture with breast cancer cells may cause signifcant alterations in the phenotype and secretion of normal ***,however,may change this state and affect fibroblasts'acquired ***,mitochondrial inhibition by metformin after 8 days of treatment,signi ficantly hinders tumor growth in mouse model of breast cancer.

关键词： Caveolin 1 Lactic acid Metformin NIH 3T3 cells Neoplasms

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A novel fractional case study of nonlinear dynamics via analytical approach

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Applied Mathematics(A Journal of Chinese Universities) 2024年第2期39卷 276-290页

作者： hassan Khan Adnan Khan Rasool Shah Dumitru Baleanu Department of Mathematics Abdul Wali khan UniversityMardan 23200Pakistan Department of Mathematics Faculty of Arts and SciencesCankaya UniversityAnkara 06530Turkey Institute of Space Sciences Magurele-BucharestRomania

The present work describes the fractional view analysis of Newell-Whitehead-Segal equations,using an innovative *** work is carried with the help of the Caputo operator of fractional *** analytical solutions of some numerical examples are presented to confirm the reliability of the proposed *** derived results are very consistent with the actual solutions to the problems.A graphical representation has been done for the solution of the problems at various fractional-order ***,the solution in series form has the desired rate of convergence and provides the closed-form *** is noted that the procedure can be modified in other directions for fractional order problems.

关键词： Homotopy Perturbation method Shehu transform Newell-Whitehead-Segel Equation Caputo operator

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