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Selective Pituitary Resistance to Thyroid Hormone: Clinical Hyperthyroidism with High TSH on Levothyroxine Administration in I-131 Ablated “Graves Disease”

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Open Journal of Endocrine and metabolic Diseases 2022年第8期12卷 177-183页

作者： Ravi moghe sarah Exley Udaya m. Kabadi Des moines University Des Moines USA Broadlawns medical Center Des Moines USA University of Iowa Iowa City USA

Resistance to Thyroid Hormone (RTH) is a rare form of hormone resistance secondary to changes in the genes encoding thyroid hormone receptors. The two subtypes, Pituitary RTH (PRTH) and Generalized RTH (GRTH), cause clinically distinguishable patient presentations. In PRTH, typically only the pituitary gland is resistant to thyroid hormone (TH) while the rest of the body maintains sensitivity. Selective pituitary resistance to thyroid hormone results in dysregulation of thyroid hormone homeostasis with clinical presentation as either euthyroid or hyperthyroidism. PRTH is characterized by elevated thyroid hormone levels with an elevated or inappropriately normal TSH concentration. Herein we describe a case report of a 70-year-old woman who complained of weight loss of over 35 lbs., palpitations, jitters, hair loss, diarrhea, fatigue, muscle weakness, etc. over 6 months, thus, indicating the presence of iatrogenic hyperthyroidism while receiving levothyroxine 175 ug daily prescribed by her primary care provider because of a reported history of “Graves disease” treated by radioactive iodine ablation of the thyroid several years ago. The daily dose of levothyroxine had been increased gradually at an interval of 3 months over a year because of persistent elevation of serum TSH level. Laboratory tests revealed markedly elevated Free T4, Free T3 and TSH levels, along with low concentrations of all lipid fractions, serum creatinine and urea nitrogen levels, indicating TSH induced hyperthyroidism or PRTH. Further testing documented a mutation of thyroid hormone receptor beta gene 2 confirming presence of PRTH. We believe that the initial diagnosis of Graves Disease was erroneous and I-131 ablation further confounded and missed the diagnosis of PRTH. Thus, the purpose of this report is to report a patient with PRTH and describe potential pitfalls in diagnosis and management of this rare disorder.

关键词： Pituitary Thyroid Hormone Resistance Iatrogenic Hyperthyroidism Graves’ Disease

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Arabidopsis CAmTA Transcription Factors Regulate Pipecolic Acid Biosynthesis and Priming of Immunity Genes

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molecular Plant 2020年第1期13卷 157-168页

作者： Yongsig Kim sarah J.Gilmour Lumen Chao Sunchung Park michael F.Thomashow mSU-DOE Plant Research Laboratory Michigan State UniversityEast LansingMl 48824USA mSU Plant Resilience Institute Michigan State UniversityEast LansingMl 48824USA Department of Plant Soil and Microbial SciencesMichigan State UniversityEast LansingMl 48824USA Present address:U.S.Department of Agriculture Agricultural Research Service1636 East Alisal St.SalinasCA 93905USA

The Arabidopsis thaliana Calmodulin-binding Transcription Activator(CAmTA)transcription factors CAmTA1,CAmTA2,and CAmTA3(CAmTA123)serve as master regulators of salicylic acid(SA)-mediated immunity,repressing the biosynthesis of SA in healthy ***,we show that CAmTA123 also repress the biosynthesis of pipecolic acid(Pip)in healthy *** of CAmTA123 function resulted in the induction of AGD2-like defense response protein 1(ALD1),which encodes an enzyme involved in Pip *** of ALD1 resulted in the accumulation of high levels of Pip,which brought about increased levels of the SA receptor protein NPR1 without induction of NPR1 expression or requirement for an increase in SA ***-mediated induction of ALD1 and genes regulating the biosynthesis of SA—CBP60g,SARD1,PAD4,and EDS1—was largely dependent on ***,Pip-mediated increase in NPR1 protein levels was associated with priming of Pip and SA biosynthesis genes to induction by low levels of *** together,our findings expand the role for CAmTA123 in regulating key immunity genes and suggest a working model whereby loss of CAmTA123 repression leads to the induction of plant defense genes and initiation of SAR.

关键词： Arabidopsis thaliana pipecolic acid salicylic acid plant immunity priming CAmTA transcription factors

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Civil-GIS incorporated approach for water resource management in a developed catchment for urban-geomorphic sustainability:Tallowa Dam,southeastern Australia

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International Soil and Water Conservation Research 2016年第4期4卷 304-313页

作者： Ali K.m.Al-Nasrawi Brian G.Jones Yasir m.Alyazichi sarah m.Hamylton mohammed T.Jameel Ali Faraj Hammadi School of Earth and Environmental Sciences University of WollongongNSW 2522Australia School of Civil Mining&Environmental EngineeringUniversity of WollongongNSW 2522Australia School of mechanical Materials and Mechatronics EngineeringUniversity of WollongongNSW 2522Australia

Damming rivers causes two main problems affecting a river's geomorphic ecosystem and its water *** Tallowa Dam on the Shoalhaven River in southeastern NSW,Australia,provides a case study to find the best sustainable solutions to avoid these *** project uses a civil-infrastructure idea to design a grid of collector pipes from the reservoir bottom *** data analysis using ArcGIS 10.2 is used to determine the best grid location for the pipes in the *** and sediment samples have been analysed for grain size,heavy metal and organic matter *** dam has led to a significant decline in sediment transport and water discharge to the lower reaches of the river which has resulted in greater erosion of sediment and higher salinity rates within the lower river and coastal *** quality in the reservoir has been affected by increased sediment accumulation,particularly mud,which has increased the amount of heavy metal and nutrient pollution that could eventually affect the water users.A proposed solution is to use over-storage water to remove accumulated sediment from the base of the dam through a net of collector pipes controlled by automechanical gates,instead of flowing over the top of the *** would maximize the volume of upstream sediment and contained pollutants that can be released from the reservoir into the downstream river ecosystems as well as providing better water quality and a longer water storage time.

关键词： Water quality Geomorphology Pollutants Civil-infrastructure GIS-detection

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Growth mechanisms of Ag and Cu nanodendrites via Galvanic replacement reactions

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Progress in Natural Science:materials International 2021年第1期31卷 141-151页

作者： Jialu Chen Jemima J.Davies Alister S.Goodfellow sarah m.D.Hall Helena G.Lancaster Xinyu Liu Cameron J.Rhodes Wuzong Zhou School of Chemistry University of St Andrews

Dendritic silver and copper crystals were produced via Galvanic replacement reactions on zinc and aluminum plates, respectively. The growth orientations of these metals were determined using electron microscopy. The results showed that a fast crystal growth associated with a high concentration of metal cations led to kinetically controlled growth along the axes of the cubic close-packed structures. However, a slow growth rate resulted in thermodynamically controlled growth along the [111] axis. The crystal growth was not found to rely upon the direct deposition of metal cations at crystallographic sites on crystal facets, but instead, hydrated metal cations deposited on the crystal surface to form an amorphous coating layer, followed by the reduction of metal cations and crystallization at the crystal/coating interface. Twin defects and stacking faults were often observed across the whole particle and commonly observed1/3{422} diffraction spots were explained by stacking faults rather than by the possible presence of any superstructures. The present work offers evidences to claim that both the crystal growth rate and Coulomb interaction between negatively charged crystal surface and metal cations play an important role in the formation of metal dendrites in replacement reactions.

关键词： Silver nanodendrite Copper nanodendrite Electron microscopy Stacking fault Crystal growth

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Chondrogenic potential of mesenchymal stem cells from horses using a magnetic 3D cell culture system

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World Journal of Stem Cells 2021年第6期13卷 645-658页

作者： Joice Fülber Fernanda R Agreste sarah R T Seidel Eric D P Sotelo Ângela P Barbosa Yara m michelacci Raquel Y A Baccarin Departamento de Clínica médica Medicina Veterinária e ZootecniaUniversidade de São PauloSão Paulo 05506-270Brazil Departamento de Bioquímica Escola Paulista de MedicinaUniversidade Federal de São PauloSão Paulo 04044-020Brazil

BACKGROUND mesenchymal stem cells(mSCs)represent a promising therapy for the treatment of equine joint diseases,studied due to their possible immunomodulatory characteristics and regenerative ***,the source of most suitable mSCs for producing cartilage for regenerative processes in conjunction with biomaterials for an enhanced function is yet to be *** To compare the chondrogenicity of mSCs derived from synovial fluid,bone marrow,and adipose tissue of horses,using the aggrecan *** mSCs from ten horses were cultured,phenotypic characterization was done with antibodies CD90,CD44 and CD34 and were differentiated into *** 3D cell culture system in which biocompatible nanoparticles consisting of gold,iron oxide,and poly-L-lysine were added to the cells,and they were forced by magnets to form one *** microspheroids were exposed to a commercial culture medium for 4 d,7 d,14 d,and 21 *** extraction was performed,and aggrecan was quantified by enzyme-linked immunosorbent *** sulfate and aggrecan in the microspheroids were identified and localized by *** All cultured cells showed fibroblast-like appearance,the ability to adhere to the plastic surface,and were positive for CD44 and CD90,thus confirming the characteristics and morphology of *** soluble protein concentrations were higher in the microspheroids derived from adipose *** aggrecan concentration and the ratio of aggrecan to soluble proteins were higher in microspheroids derived from synovial fluid than in those derived from bone marrow,thereby showing chondrogenic *** from all sources expressed aggrecan and keratan sulfate when observed using confocal immunofluorescence *** sources of mSCs can synthesize aggrecan,however,mSCs from synovial fluid and adipose tissue have demonstrated better biocompatibility in a 3D environment,thus suggesting chondrogenic superiority

关键词： Cellular therapy Chondrocytes Aggrecan Keratan sulfate

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Fast and Accurate Detection of masked Faces Using CNNs and LBPs

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Computer Systems Science & Engineering 2023年第12期47卷 2939-2952页

作者： sarah m.Alhammad Doaa Sami Khafaga Aya Y.Hamed Osama El-Koumy Ehab R.mohamed Khalid m.Hosny Department of Computer Sciences College of Computer and Information SciencesPrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia Computer Science Department Sinai UniversityArishNorth SinaiEgypt Department of Information Technology Faculty of Computers and InformaticsZagazig UniversityZagazigEgypt

Face mask detection has several applications,including real-time surveillance,biometrics,*** face masks is also helpful for crowd control and ensuring people wear them *** monitoring personnel,it is impossible to ensure that people wear face masks;automated systems are a much superior option for face mask detection and *** paper introduces a simple and efficient approach for masked face *** architecture of the proposed approach is very straightforward;it combines deep learning and local binary patterns to extract features and classify themasmasked or *** proposed systemrequires hardware withminimal power consumption compared to state-of-the-art deep learning *** proposed system maintains two *** first,this work extracted the local features of an image by using a local binary pattern descriptor,and then we used deep learning to extract global *** proposed approach has achieved excellent accuracy and high *** performance of the proposed method was tested on three benchmark datasets:the realworld masked faces dataset(RmFD),the simulated masked faces dataset(SmFD),and labeled faces in the wild(LFW).Performancemetrics for the proposed technique weremeasured in terms of accuracy,precision,recall,and *** indicated the efficiency of the proposed technique,providing accuracies of 99.86%,99.98%,and 100%for RmFD,SmFD,and LFW,***,the proposed method outperformed state-of-the-art deep learning methods in the recent bibliography for the same problem under study and on the same evaluation datasets.

关键词： Convolutional neural networks face mask detection local binary patterns deep learning computer vision social protection Keras OpenCV TensorFlow Viola-Jones

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A New Look at Generalized means

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Applied mathematics 2016年第6期7卷 468-472页

作者： sarah m. Tooth John A. Dobelman Department of Statistics Rice University Houston TX USA

Since antiquity, the relationships between 2-tuples and their Pythagorean means have been represented in geometric forms. In this paper, we extend the practice to generalized power means through new representations, and also to 3-tuples. These geometric forms give rise to new algebraic expressions for summary statistics of 2- and 3-tuples.

关键词： Geometry Power means Pythagorean means Outliers

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Skeletal muscle as a therapeutic target for delaying type 1 diabetic complications

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World Journal of Diabetes 2015年第17期6卷 1323-1336页

作者： Samantha K coleman Irena A Rebalka Donna m D'Souza Thomas J Hawke Department of Pathology and molecular medicine McMaster University

Type 1 diabetes mellitus(T1Dm) is a chronic autoimmune disease targeting the pancreatic beta-cells and rendering the person hypoinsulinemic and hyperglycemic. Despite exogenous insulin therapy, individuals with T1 Dm will invariably develop long-term complications such as blindness, kidney failure and cardiovascular disease. Though often overlooked, skeletal muscle isalso adversely affected in T1 Dm, with both physical and metabolic derangements reported. As the largest metabolic organ in the body, impairments to skeletal muscle health in T1 Dm would impact insulin sensitivity, glucose/lipid disposal and basal metabolic rate and thus affect the ability of persons with T1 Dm to manage their disease. In this review, we discuss the impact of T1 Dm on skeletal muscle health with a particular focus on the proposed mechanisms involved. We then identify and discuss established and potential adjuvant therapies which, in association with insulin therapy, would improve the health of skeletal muscle in those with T1 Dm and thereby improve disease managementultimately delaying the onset and severity of other longterm diabetic complications.

关键词： Type 1 diabetes mellitus Skeletal muscle Exercise

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Latent Profiles of Social media Users, STI Knowledge, and Condom Use among African American Young Adults

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Social Networking 2020年第1期9卷 1-10页

作者： Chakema Carmack Lycinda Rodriguez Taylor m. coleman megan Heath Tiffany Ewere Psychological Health & Learning Sciences Department University of Houston Houston TX USA

The abundance of social networking platforms has increased the frequency and the availability for which individuals communicate with one another. The feasibility and accessibility to go online to find sexual partners pose opportunity for contracting sexually transmitted infections (STI) in the absence of safe sexual practices. Low condom use has been reported among young adults who seek sexual partners online. African American young adults have some of the highest rates of infection for certain STIs. In order to mitigate the incidence and prevalence of STIs in at-risk populations, sexually active young adults must use condoms consistently and correctly during sexual activities. The present study sought to uncover the heterogeneity within African American young adults regarding their online networking utilization, STI knowledge, and sexual risk behavior. African American young adults (N = 236), ages 18 - 23, completed private online survey administration. Using latent class analysis, three classes were identified: Social Network Communicators (43%;N = 101), Social Networking Daters (36%;N = 83), and media Sharers (21%;N = 52). Social Networking Daters exhibited the highest probability of using online dating sites daily, low STI knowledge, and a zero probability of consistent condom use. All three groups exhibited relatively low STI knowledge. Furthermore, having a history of STI increased the likelihood of being classified into the Social Networking Daters class relative to the other classes. Findings highlight the need to capitalize upon online platforms for African American young adults who utilize online dating sites and other online environments.

关键词： Social Networking Condom Use Online Dating Sexual Behavior Latent Class Analysis

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Syndromic craniosynostosis associated with microdeletion of chromosome 19p13.12-19p13.2

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Genes & Diseases 2015年第4期2卷 347-352页

作者： sarah m.Lyon Darrel Waggoner Sara Halbach Erik C.Thorland Leila Khorasani Russell R.Reid Pritzker School of medicine University of ChicagoUnited States Department of Human Genetics and Pediatrics University of Chicago5841 S.Maryland AveM/C 0077ChicagoIL 60637United States Lab medicine&Pathology 200 First St SWHilton 970RochesterMN 55905-0001United States Department of Surgery University of Chicago5841 S.Maryland AveM/C 0077ChicagoIL 60637United States

Craniosynostosis,a condition in which the cranial sutures prematurely fuse,can lead to elevated intracranial pressure and craniofacial abnormalities in young *** surgical intervention is the only therapeutic option for patients with this *** has been associated with a variety of different gene mutations and chromosome *** we describe three cases of partial deletion of chromosome *** of the cases present with syndromic craniosynostosis while one has metopic ridging.A review of the genes involved in the rearrangements between the three cases suggests several gene candidates for *** and DAND5,BmP regulators involved in osteoblast differentiation,and mORG1,a mediator of osteoclast dysregulation may play a role in abnormal cranial vault ***,CACNA1A,a gene that when mutated is associated with epilepsy and CC2D1A,a gene associated with non-syndromic mental retardation may contribute to additional phenotypic features seen in the patients we *** addition,these findings further support the need for genetic testing in cases of syndromic craniosynostosis.

关键词： Chromosome 19 Craniofacial syndrome Craniosynostosis microarray microdeletion

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