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Nationwide retrospective study of hepatitis B virological response and liver stiffness improvement in 465 patients on nucleos(t)ide analogue

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World Journal of Gastroenterology 2022年第31期28卷 4390-4398页

作者： Alnoor Ramji Karen Doucette Curtis Cooper Gerald Yosel Minuk Mang Ma Alexander Wong David Wong Edward Tam Brian Conway David Truong Philip Wong Lisa Barrett Hin Hin Ko sarah haylock-jacobs Nishi Patel Gilaad G Kaplan Scott Fung Carla S Coffin Department of Medicine University of British ColumbiaVancouver v6t 1z3Canada Department of Medicine University of AlbertaEdmonton t6g 2r7Canada Department of Medicine The Ottawa Hospital Research InstituteUniversity of OttawaOttawa ON K1H 8L6Canada Department of Medicine University of ManitobaWinnipeg r3e 3j7Canada Department of Medicine University of SaskatchewanSaskatoon s7n 5e5Canada Department of Medicine University Health NetworkToronto m5g 2c4Canada Pacific Gastroenterology Associates Vancouver v6z 2k5Canada Vancouver Infectious Disease Centre Vancouver v6z 2c7Canada Department of Medicine McGill UniversityMontreal h3a 0g4Canada Department of Microbiology and Immunology Dalhousie UniversityHalifax b3h 4r2Canada Cumming School of Medicine University of CalgaryCalgary t2n 1n4Canada

BACKGROUND Hepatitis B virus(HBV)nucleos(t)ide analog(NA)therapy reduces liver disease but requires prolonged therapy to achieve hepatitis B surface antigen(HBsAg)*** is limited North American real-world data using non-invasive tools for fibrosis assessment and few have compared 1st generation NA or lamivudine(LAM)to tenofovir disoproxil fumarate(TDF).AIM To assess impact of NA on virological response and fibrosis regression using liver stiffness measurement(LSM)(i.e.,FibroScan®).METHODS Retrospective,observational cohort study from the Canadian HBV *** collected included demographics,NA,HBV DNA,alanine aminotransferase(ALT),and *** were HBV monoinfected patients,treatment naïve,and received 1 NA with minimum 1 year *** In 465(median 49 years,37%female,35%hepatitis B e antigen+at baseline,84%Asian,6%White,and 9%Black).Percentage of 64(n=299)received TDF and 166 were LAM-treated with similar median duration of 3.9 and 3.7 years,*** mean baseline LSM was 11.2 kPa(TDF)vs 8.3 kPa(LAM)(P=0.003).At 5-year follow-up,the mean LSM was 7.0 kPa in TDF vs 6.7 kPa in LAM(P=0.83).There was a significant difference in fibrosis regression between groups(i.e.,mean-4.2 kPa change in TDF and-1.6 kPa in LAM,P<0.05).The last available data on treatment showed that all had normal ALT,but more TDF patients were virologically suppressed(<10 IU/mL)(n=170/190,89%)vs LAM-treated(n=35/58,60%)(P<0.05).None cleared *** In this real-world North American study,approximately 5 years of NA achieves liver fibrosis regression rarely leads to HBsAg loss.

关键词： Nucleos(t)ide analog therapy Functional cure Hepatitis B virus surface antigen loss Fibrosis regression Liver stiffness measurement Transient elastography

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Nasal endoscopy protocols in the era of COVID-19

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2020年第S1期6卷 S33-S35页

作者： Jacob Fried sarah A.Imam Joshua A.Lee Shaun A.Nguyen jacobs School of Medicine at University of Buffalo BuffaloNYUSA Department of Otolaryngology-Head and Neck Surgery Medical University of South CarolinaCharlestonSCUSA Department of Health and Human Performance The CitadelCharlestonSCUSA

Introduction COVID-19,the respiratory illness caused by the novel SARSCoV-2 virus has rapidly emerged as a serious global health *** of March 12,2020,the World Health Organization(WHO)has declared this virus a pandemic.1 In the United States,there have been 35,841 cases diagnosed and 465 deaths,with both prevalence and mortality continuing to escalate.2 The WHO and has enacted various protocols for healthcare institutions internationally in an attempt to slow the spread of disease,3 including adjustments for procedures performed by *** paper aims to review the current literature pertaining to adjustments in nasal endoscopy protocols and appropriate precautions in the era of COVID-19.

关键词： endoscopy mortality respiratory

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Emerging roles of circular RNAs in retinal diseases

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Neural Regeneration Research 2022年第9期17卷 1875-1880页

作者： Aneliya Hanineva Karen Sophia Park Joshua J.Wang Margaret M.DeAngelis Michael H.Farkas sarah X.Zhang Department of Ophthalmology and Ross Eye Institute Jacobs School of Medicine and Biomedical SciencesUniversity at BuffaloState University of New YorkBuffaloNYUSA Research Service Veterans Administration Western New York Healthcare SystemBuffaloNYUSA Department of Biochemistry Jacobs School of Medicine and Biomedical SciencesUniversity at BuffaloState University of New YorkBuffaloNYUSA

Retinal disorders are a group of ocular diseases whose onset is associated with a number of aberrant molecular and cellular processes or physical damages that affect retinal structure and function resulting in neural and vascular degeneration in the *** research has primarily focused on delaying retinal disease with minimal success in preventing or reversing neuronal *** this review,we explore a relatively new field of research involving circular RNAs,whose potential roles as biomarkers and mediators of retinal disease pathogenesis have only just *** knowledge of circular RNAs function is limited given its novelty,current evidence has highlighted their roles as modulators of microRNAs,regulators of gene transcription,and biomarkers of disease development and ***,we summarize how circular RNAs may be implicated in the pathogenesis of common retinal diseases including diabetic retinopathy,glaucoma,proliferative vitreoretinopathy,and age-related macular ***,we explore the potential of circular RNAs as novel biomarkers and therapeutic targets for the diagnosis and treatment of retinal diseases.

关键词： age-related macular degeneration circular RNA diabetic retinopathy glaucoma microRNA proliferative vitreoretinopathy retina

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《纽约时报》:暴怒之后的拥抱

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电影世界 2012年第11期 20-20页

作者： Andrew jacobs sarah Lyall

极其多产、享誉世界的中国作家莫言获得了2012年诺贝尔文学奖,中国几乎举国欢腾。两年前,当颁发诺贝尔和平奖的时候,中国政府的反应充满了轻蔑和愤怒。他们谴责该奖项的授予是个"污辱",将其称之为西方的宣传工具。然而本周四,又一名中... 详细信息

极其多产、享誉世界的中国作家莫言获得了2012年诺贝尔文学奖,中国几乎举国欢腾。两年前,当颁发诺贝尔和平奖的时候,中国政府的反应充满了轻蔑和愤怒。他们谴责该奖项的授予是个"污辱",将其称之为西方的宣传工具。然而本周四,又一名中国公民获得了又一项诺贝尔奖,消息传来之时,他们似乎已经淡忘了之前所有这些事实。极其多产、享誉世界的中国作家莫言获得了2012年诺贝尔文学奖,中国几乎举国欢腾。官方的中央电视台(CCTV)

关键词：纽约时报莫言诺贝尔文学奖中国政府诺贝尔奖中国作家共产党文学院作品中国文学

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