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Artificial Intelligence in Gastroenterology 2021年第5期2卷 124-132页

作者： sarah el-nakeep Mohamed el-nakeep Gastroenterology and Hepatology Unit Internal Medicine DepartmentFaculty of MedicineAinShams UniversityCairo 11591Egypt Master of Science in electrical Engineering"electronics and Communications" Electronics and Electrical Engineering DepartmentFaculty of EngineeringAin Shams UniversityCairo 11736Egypt Bachelor of Science in electronics and electrical Communications Electronics and Communications and Computers DepartmentFaculty of EngineeringHelwan UniversityCairo 11736Egypt

This minireview discusses the benefits and pitfalls of machine learning,and artificial intelligence in upper gastrointestinal endoscopy for the detection and characterization of *** have reviewed the literature for relevant publications on the topic using PubMed,IEEE,Science Direct,and Google Scholar *** discussed the phases of machine learning and the importance of advanced imaging techniques in upper gastrointestinal endoscopy and its association with artificial intelligence.

关键词： Artificial intelligence Upper gastrointestinal endoscopy Esophageal cancer,Gastric cancer,Barrett’s esophagus

Molecular and genetic markers in hepatocellular carcinoma:In silico analysis to clinical validation(current limitations and future promises)

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World Journal of Gastrointestinal Pathophysiology 2022年第1期13卷 1-14页

作者： sarah el-nakeep Gastroenterology and Hepatology Unit Department of Internal MedicineFaculty of MedicineAin Shams UniversityCairo 11591Egypt

Hepatocellular carcinoma(HCC)is the second cause of cancer-related *** diagnosis of HCC depends mainly on-fetoprotein,which is limited in its diagnostic and screening *** is an urgent need for a biomarker that detects early HCC to give the patients a chance for curative *** targets of therapy could enhance survival and create future alternative curative *** silico analysis provides both;discovery of biomarkers,and understanding of the molecular pathways,to pave the way for treatment *** review discusses the role of in silico analysis in the discovery of biomarkers,molecular pathways,and the role the author has contributed to this area of *** also discusses future aspirations and current limitations.A literature review was conducted on the topic using various databases(PubMed,Science Direct,and Wiley Online Library),searching in various reviews,and editorials on the topic,with overviewing the author’s own published and unpublished *** review discussed the steps of the validation process from in silico analysis to in vivo validation,to incorporation into clinical practice *** addition,reviewing the recent lines of research of bioinformatic studies related to *** conclusion,the genetic,molecular and epigenetic markers discoveries are hot areas for HCC *** will enhance our ability to accomplish this understanding in the near *** face certain limitations that we need to overcome.

关键词： Hepatocellular carcinoma In silico analysis Bioinformatics Biomarkers Molecular pathways Genetics Epigenetics

Cyanidin 3-glucoside modulated cell cycle progression in liver precancerous lesion,in vivo study

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World Journal of Gastroenterology 2021年第14期27卷 1435-1450页

作者： Marwa Matboli Amany H Hasanin Reham Hussein sarah el-nakeep Eman K Habib Rawan ellackany Lobna A Saleh Department of Biochemistry Ain Shams Faculty of MedicineCairo 11318Egypt Department of Clinical Pharmacology Ain Shams Faculty of MedicineCairo 11381Egypt Department of General Internal Medicine Ain Shams Faculty of MedicineCairo 11381Egypt Department of Anatomy&Embryology Ain Shams Faculty of MedicineCairo 11318Egypt Department of Undergraduate Faculty of MedicineModern University for Technology and InformationCairo 11381Egypt

BACKGROUND Cyanidin-3-O-glucoside(cyan)exhibits antioxidant and anticancer *** cell cycle proteins and antimitotic drugs might be promising therapeutic targets in hepatocellular *** To investigate the effect of cyan administration on cell cycle in hepatic precancerous lesion(PCL)induced by diethylnitrosamine/2-acetylaminofluorene(DEN/2-AAF)in Wistar *** In vivo,DEN/2-AAF-induced hepatic PCL,rats were treated with three doses of cyan(10,15,and 20 mg/kg/d,for four consecutive days per week for 16 wk).Blood and liver tissue samples were collected for measurement of the followings;alpha fetoprotein(AFP)liver function and RNA panel differential expression was evaluated via real time polymerase chain *** examination of liver sections stained with H&E and immunohistochemical study using glutathione S-transferase placental(GSTP)and proliferating cell nuclear antigen(PCNA)antibodies were *** Cyan administration mitigated the effect of DEN/2-AFF induced PCL,decreased AFP levels,and improved liver ***,treatment with cyan dose dependently decreased the long non-coding RNA MALAT1 and tubulin gamma 1 mRNA expressions and increased the levels of miR-125b,all of which are involved in cell cycle and mitotic spindle *** note,cyan decreased GSTP foci percent area and PCNA positively stained *** Our results indicated that cyan could be used as a potential therapeutic agent to inhibit liver carcinogenesis in rat model via modulation of cell cycle.

关键词： Hepatocellular carcinoma therapy Hepatocellular-carcinoma growth Hepatocellular-carcinoma model Hepatocellular-carcinoma size

New stem cell autophagy surrogate diagnostic biomarkers in earlystage hepatocellular carcinoma in Egypt:A pilot study

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World Journal of Hepatology 2021年第12期13卷 2137-2149页

作者： Tarek Yosef Wesam Ahmed Ibrahim Marwa Matboli Amina Ahmed Swilam sarah el-nakeep Gastroenterology and Hepatology Unit Department of Internal MedicineFaculty of MedicineAin Shams UniversityCairo 11591Egypt Department of Biochemistry Faculty of MedicineAin Shams UniversityCairo 11591Egypt Department of Internal Medicine Health Affair DirectorateMinistry of Health and PopulationCairo 11591Egypt

BACKGROUND Stem cell autophagy disruption is responsible for the development of hepatocellular carcinoma(HCC).Many non-coding RNAs are linked to the activation and inhibition of certain *** SQSTM1 gene controls stem cell autophagy as shown in previous *** upregulation of SQSTM1 is associated with the inhibition of autophagy in cancerous stem cells in patients with *** To determine whether serum microRNA,hsa-miR-519d,is linked to SQSTM1 gene and whether they could be used as diagnostic biomarkers for early-stage *** In silico analysis was performed to determine the most correlated genes of autophagy with ***1 and hsa-miR-519d were validated through this pilot clinical *** study included 50 Egyptian participants,who were classified into three subgroups:Group 1 included 34 patients with early-stage HCC,Group 2 included 11 patients with chronic liver disease,and Group 3(control)included 5 healthy *** patients were subjected to full laboratory investigations,including viral markers and alpha-fetoprotein(AFP),abdominal ultrasound,and clinical assessment with the Child–Pugh score ***,the patients with HCC underwent triphasic computed tomography with contrast to diagnose and determine the tumor site,size,and *** real-time polymerase chain reaction was used to assess hsa-miR-519d-3p and SQSTM1 in the serum of all the study *** Hsa-miR-519d-3p was significantly upregulated in patients with HCC compared with those with chronic liver disease and healthy subjects with an area under the curve(AUC)of 0.939,with cutoff value 8.34,sensitivity of 91.2%,and specificity of 81.8%.SQSTM1 was upregulated with an AUC of 0.995,with cutoff value 7.89,sensitivity of 97.1%,and specificity of 100%.AFP significantly increased in patients with HCC with an AUC of 0.794,with cutoff value 7.30 ng/mL,sensitivity of 76.5%,and specificity of 72.7%.CONCLUSION This study is the first to show a direct re

关键词： Autophagy Hepatocellular carcinoma miRNA miR-519d Stem cell SQSTM1

Exploring the role of molecular biomarkers as a potential weapon against gastric cancer: a review of the literature

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World Journal of Gastroenterology 2016年第26期22卷 5896-5908页

作者： Marwa Matboli sarah el-nakeep Nourhan Hossam Alaa Habieb Ahmed EM Azazy Ali E Ebrahim Ziad Nagy Omar Abdel-Rahman Oncology Diagnostic Unit Medical Biochemistry and Molecular Biology Department Faculty of Medicine Ain Shams University Cairo 113331 Egypt Hepatology and Gastroenterology Unit Internal Medicine Department Faculty of Medicine Ain Shams University Cairo 113331 Egypt Armed Forces College of Medicine Cairo 113331 Egypt Clinical Oncology Department Faculty of Medicine Ain Shams University Cairo 113331 Egypt

Gastric cancer(GC) is a global health problem and a major cause of cancer-related death with high recurrence rates ranging from 25% to 40% for GC patients staging Ⅱ-Ⅳ. Unfortunately, while the majority of GC patients usually present with advanced tumor stage; there is still limited evidence-based therapeutic options. Current approach to GC management consists mainly of; endoscopy followed by, gastrectomy and chemotherapy or chemo-radiotherapy. Recent studies in GC have confirmed that it is a heterogeneous disease. Many molecular characterization studies have been performed in GC. Recent discoveries of the molecular pathways underlying the disease have opened the door to more personalized treatment and better predictable outcome. The identification of molecular markers is a useful tool for clinical managementin GC patients, assisting in diagnosis, evaluation of response to treatment and development of novel therapeutic modalities. While chemotherapeutic agents have certain physiological effects on the tumor cells, the prediction of the response is different from one type of tumor to the other. The specificity of molecular biomarkers is a principal feature driving their application in anticancer therapies. Here we are trying to focus on the role of molecular pathways of GC and well-established molecular markers that can guide the therapeutic management.

关键词： Gastric cancer Molecular therapy Targeted therapy Biomarkers Bioinformatics

Blood biomarkers of Alzheimer’s disease:important considerations for use in clinical practice

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Neural Regeneration Research 2025年第1期20卷 205-206页

作者： sarah Fullam Sean O’Dowd Antoinette O’Connor Department of Neurology Tallaght University HospitalDublinIreland Academic Unit of Neurology Trinity College DublinIreland

Introduction:Fluid and positron emission tomography(PET)biomarkers that enable the detection of the hallmark proteins of Alzheimer’s disease(AD)(amyloid and tau)have revolutionized our approach to the diagnosis of *** evolution of AD diagnostic criteria to include biological characterization(Alzheimer’s Association Working Group,2023)provides an appropriate framework to reduce levels of clinico-pathologic mismatch and improve in-vivo diagnostic *** the therapeutic landscape for neurodegenerative disease evolves,it is increasingly incumbent on clinicians to provide timely,and pathologically precise diagnoses for ***,the expensive and invasive nature of these tests limits their scalability.

关键词： Blood Alzheimer diagnosis

Comparing the demographic data and outcomes of septic shock patients presenting to teaching or non-teaching metropolitan hospitals in the United States

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World Journal of Emergency Medicine 2022年第6期13卷 433-440页

作者： Ralph Bou Chebl Nadim Kattouf Mohamad Assaf Saadeddine Haidar Gilbert Abou Dagher sarah Abdul Nabi Rana Bachir Mazen el Sayed Department of Emergency Medicine American University of BeirutBeirut 11072020Lebanon

BACKGROUND:Studies looking at the effect of hospital teaching status on septic shock related in-hospital mortality are *** aim of this study was to examine the effect of hospital teaching status on mortality in septic shock patients in the United ***:This was a retrospective observational study,using the Nationwide Emergency Department Sample Database(released in 2018).All patients with septic shock were *** sample logistic regression was performed to assess the impact of hospital teaching status on patient ***:A total of 388,552 septic shock patients were included in the *** average age was 66.93 years and 51.7%were *** of the patients presented to metropolitan teaching hospitals(68.2%)and 31.8%presented to metropolitan non-teaching *** shock patients presenting to teaching hospitals were found to have a higher percentage of medical comorbidities,were more likely to be intubated and placed on mechanical ventilation(50.5%vs.46.9%)and had a longer average length of hospital stay(12.47 d vs.10.20 d).Septic shock patients presenting to teaching hospitals had greater odds of in-hospital mortality compared to those presenting to metropolitan non-teaching hospitals(adjusted odd ratio[OR]=1.295,95%confidence interval[CI]:1.256-1.335).CONCLUSION:Septic shock patients presenting to metropolitan teaching hospitals had significantly higher risks of mortality than those presenting to metropolitan non-teaching *** also had higher rates of intubation and mechanical ventilation as well as longer lengths of hospital stay than those in non-teaching hospitals.

关键词： Sepsis Septic shock In-hospital mortality Hospital teaching status United States Epidemiology Outcome

Link between caries,periodontitis,and pregnancy:The role of personalized oral hygiene

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World Journal of Clinical Cases 2025年第6期13卷 51-57页

作者： Melissa Martínez Nieto Martha Leticia De León Rodríguez Francisco Javier Alcaraz Baturoni Alma Alicia Soto Chávez sarah Monserrat LomelíMartínez Periodontics Program Department of Integrated Dentistry ClinicsCentro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajara 44340Mexico Department of Medical and Life Sciences Centro Universitario de la CiénegaUniversidad de GuadalajaraOcotlán 47810JaliscoMexico Master of Public Health Department of Well-being and SustainableCentro Universitario del NorteUniversidad de GuadalajaraColotlán 46200Mexico

Optimal health during pregnancy is crucial for ensuring the well-being of the mother and the developing *** article is focused on the impact of oral health and the role of personalized oral hygiene management in addressing prevalent dental issues among pregnant women,with particular emphasis on periodontal disease and dental *** the high prevalence of these dental problems and their association with obstetric complications such as pre-term birth and low birth weight,many pregnant women do not receive adequate dental *** gap in care is often due to misconceptions about the safety of dental treat-ments during pregnancy and lack of awareness on the part of healthcare *** of the impacts of oral health and personalization of oral hygiene strategies such as tailored education and support,have proven effective in improving oral health in this *** reductions in the incidence of caries and periodontal disease may be achieved by adapting care to the specific needs of each patient,thereby enhancing maternal and fetal health *** of personalized oral hygiene management into maternal health pro-grams and enhancement of ongoing education for pregnant women and healthcare professionals are essential steps in the reduction of pregnancy-related risks and improvement of maternal and neonatal *** Tip:In this article,we reviewed a recent study on the effects of personalized oral hygiene management on the oral health of pregnant women,as discussed in the article by Men et *** study demonstrated that personalized oral hygiene interventions significantly improved oral health outcomes during pregnancy by reducing the prevalence of dental caries and periodontal *** emphasized the importance of individualized oral care programs that integrate education and tailored support,and we highlighted their significance in enhancing maternal and fetal *** approach underscores the need for

关键词： Pregnancy Periodontal disease Periodontitis Dental caries Oral hygiene

The potency of N,N′-diphenyl-1,4-phenylenediamine and adiposederived stem cell co-administration in alleviating hepatorenal dysfunction complications associated with type 1 diabetes mellitus in rats

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BIOCelL 2023年第8期47卷 1885-1895页

作者： HANY M.ABD el-LATEEF SAFA H.QAHL EMAN FAYAD sarah A.ALTALHI IBRAHIM JAFRI el SHAIMAA SHABANA MARWA K.DARWISH REHAB MAHER SAAD SHAABAN SHADY G.el-SAWAH Department of Chemistry College of ScienceKing Faisal UniversityAl-AhsaSaudi Arabia Chemistry Department Faculty of ScienceSohag UniversitySohagEgypt Department of Biology College of ScienceUniversity of JeddahJeddahSaudi Arabia Department of Biotechnology College of ScienceTaif UniversityTaifSaudi Arabia Fellow of Biochemistry Genetic UnitChildren HospitalFaculty of MedicineMansoura UniversityMansouraEgypt Chemistry Department(Biochemistry Branch) Faculty of ScienceSuez UniversitySuezEgypt Department of Clinical Laboratories Sciences College of Applied Medical SciencesShaqra UniversityRiyadhSaudi Arabia Biology Department Faculty of ScienceMansoura UniversityMansouraEgypt Department of Chemistry Organic Chemistry DivisionCollege of ScienceMansoura UniversityMansouraEgypt Zoology Department Faculty of ScienceArish UniversityNorth SinaiEgypt

Background:The increasing occurrence of diabetes mellitus(DM)noted worldwide has considerably elicited concern in the recent *** is associated with elevated vascular complications,morbidity,mortality,and poor quality of *** this context,mesenchymal stem cells(MSCs)have shown significant therapeutic potentialities in managing and curing type 1 DM owing to their self-renewable,immunosuppressive,and differentiation *** investigated the potential action of N,N′-diphenyl-1,4-phenylenediamine(DPPD),a well-known synthetic antioxidant to enhance the therapeutic ability of the adipose-derived stem cells(AD-MSCs)in alleviating kidney and liver complications in diabetic ***:Over the four weeks of experiments,albino male rats(n=36)were split into six test groups:control,DPPD(250 mg/kg,i.p.),STZ-diabetic(D),D+DPPD,D+AD-MSCs(1×10^(6)cell/rat,i.v.),and D+AD-MSCs+DPPD treated ***:Significant declines in the renal and hepatic oxidative stress markers(MDA,ROS,and AGEs)were observed coupled with a significant elevation in many antioxidant marker levels(GSH,SOD,CAT,GPx,HO-1,and TAC)in the diabetic rats treated with either DPPD or AD-MSCs or their co-administered injection compared to the diabetic untreated *** was suggested to be the leading cause of amelioration of the kidney functions(as measured by urea,uric acid,and creatine levels)and liver functions(as evidenced by the levels of AST,ALT,ALP,bilirubin,total proteins,albumin,and globulins).Conclusion:DPPD and AD-MSCs co-administration showed superior results in terms of the enhancement of the relative hepato-renal function,indicating the beneficial role of DPPD supplementation in increasing the therapeutic potential of AD-MSCs.

关键词： Antioxidants Diabetic nephropathy DPPD Oxidative stress Stem cells

Apportioning aldehydes:Quantifying industrial sources of carbonyls

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Journal of Environmental Sciences 2015年第4期27卷 132-134页

作者： sarah A.Styler Leibniz Institute for Tropospheric Research

In their recent Journal of Environmental Sciences publication,Wang and colleagues provide field evidence that industrial activities can contribute substantially to atmospheric carbonyl concentrations（Wang et al.,2015）.These results may helpto explain underestimations of carbonyl emissions in currently available emission inventories,and highlight the need for an improved understanding of industrial sources of this class of compounds.

关键词： Carbonyl compounds Source apportionment Industrial emissions