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Long-term physical,mental and social health effects of COVID-19 in the pediatric population:a scoping review

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World Journal of Pediatrics 2022年第3期18卷 149-159页

作者： Madeline Borel Luyu Xie Olivia Kapera Adrian Mihalcea Jeffrey Kahn sarah E.Messiah School of Public Health University of Texas Health Science CenterDallas Campus2777 N Stemmons FwyDallasTX 75207USA Center for Pediatric Population Health University of Texas Health School of Public Health and Children’s Health System of TexasDallasTXUSA School of Public Health University of Texas Health Science CenterAustin CampusAustinTXUSA School of Public Health University of Texas Health Science CenterHouston CampusHoustonTXUSA Department of Pediatrics University of Texas Southwestern Medical CenterDallasTXUSA Children’s Health System of Texas DallasTXUSA

Background The majority of coronavirus disease 2019(COVID-19)symptom presentations in adults and children appear to run their course within a couple of ***,a subgroup of adults has started to emerge with effects lasting several months or more after initial infection,which raises questions about the long-term physical,mental and social health effects of COVID-19 in the pediatric *** purpose of this review was to determine these impacts well into the second year of the *** A search was conducted using PubMed,Web of Science,Science Direct,and Cochrane between 11/1/2019 and 9/1/*** inclusion criteria were as follows:(1)COVID-19 illness and symptoms in children;(2)severe acute respiratory syndrome coronavirus 2 in children;(3)English language;and(4)human studies *** The few studies that have documented long-term physical symptoms in children show that fatigue,difficulty in concentrating(brain fog),sleep disturbances,and sensory problems are the most reported *** studies examining the impact of COVID-19 in pediatric populations have focused on initial clinical presentation,and symptoms,which are similar to those in adult *** addition,COVID-19 has had a moderate impact on children and adolescents’social environment,which may exacerbate current and future physiological,psychological,behavioral,and academic *** There are limited studies reporting long physical symptoms of COVID-19 in the pediatric ***,pediatric COVID-19 cases are underreported due to low rates of testing and symptomatic infection,which calls for more longitudinal *** who have experienced COVID-19 illness should be monitored for long physiological,psychological,behavioral,and academic outcomes.

关键词： Adolescents Children Coronavirus disease 2019(COVID-19) Long-COVID symptoms

Effects of progesterone on T-type-Ca^(2+)-channel expression in Purkinje cells

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Neural Regeneration Research 2022年第11期17卷 2465-2471页

作者： Annika Eickhoff Jonas Tjaden sarah Stahlke Matthias Vorgerd Verena Theis Veronika Matschke Carsten Theiss Department of Cytology Institute of AnatomyRuhr-University BochumBochumGermany Department of Neurology Neuromuscular Center RuhrgebietUniversity Hospital BergmannsheilRuhr-Universität BochumBochumGermany

Plasticity of cerebellar Purkinje cells(PC)is influenced by progeste rone via the classical progeste rone receptors PR-A and PR-B by stimulating dendritogenesis,spinogenesis,and synaptogenesis in these *** PC cultures were used to analyze progeste rone effects at a molecular level on the voltage-gated T-type-Ca^(2+)-channels Ca_(v)3.1,Ca_(v)3.2,and Ca_(v)3.3 as they helped determine neuronal plasticity by regulating Ca^(2+)-influx in neuronal *** results showed direct effects of progesterone on the mRNA expression of T-type-Ca^(2+)-channels,as well as on the protein kinases A and C being involved in downstream signaling pathways that play an important role in neuronal *** the mRNA expression studies of T-type-Ca^(2+)-channels and protein kinases of the signaling cascade,laser microdissection and purified PC cultures of diffe rent maturation stages were *** staining was also performed to characte rize the localization of T-type-Ca^(2+)-channels in *** rimental progesterone treatment was performed on the purified PC culture for 24 and 48 *** results show that progesterone increases the expression of Ca_(v)3.1 and Ca_(v)3.3 and associated protein kinases A and Cin PC at the mRNA level within 48 hours after treatment at *** effects extend the current knowledge of the function of progesterone in the central nervous system and provide an explanatory approach for its influence on neuronal plasticity.

关键词： Ca_(v)3.1 Ca_(v)3.2 Ca_(v)3.3 neuronal plasticity progesterone protein kinase A protein kinase C Purkinje cells rat cerebellum T-type-Ca^(2+)-channels

Effects of mindfulness-based interventions on depressive symptoms in patients with substance use disorders:a systematic review and meta-analysis

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Frontiers of Nursing 2023年第2期10卷 145-162页

作者： Chuntana Reangsing Sasinun Pusuwun Suneerat Boonsin sarah Oerther School of Nursing Mae Fah Laung UniversityChiangrai 57100Thailand School of Nursing University of PhayaoPhayao 56000Thailand Boromarajonani College of Nursing Saraburi Faculty of NursingPraboromarajchanok InstituteMinistry of Public HealthSaraburi 18000Thailand Trudy Busch Valentine School of Nursing Saint Louis UniversityMO 63104USA

Objective:We examined the effects of mindfulness-based interventions(MBIs)on depressive symptoms in patients with substance use disorders(SUDs)and explored the moderating effects of participant,method,and intervention ***:We systematically searched 8 databases from their inception till November *** inclusion criteria were primary studies evaluating MBIs in patients with SUDs with depression measured as an outcome,those including a control group,and those written in *** used a random-effects model to compute effect sizes(ESs)using Hedges’g,a forest plot,and Q and I2 statistics as measures of heterogeneity;we also examined moderator ***:Nineteen studies included 1352 participants(age:38.6±7.0 years).Overall,MBIs showed significantly improved depression(g=0.67,95%conﬁdence interval[CI]:0.29,1.05,I2=89%)compared to *** regard to moderators,providing MBIs as an individual plus group intervention had a greater effect(g=2.13)on reducing depressive symptoms than providing MBIs as a group intervention(g=0.64)or an individual intervention only(g=0.33,P=0.034).Using concealed allocation tended to reduce depressive symptoms(g=1.22)as compared to not using concealed allocation(g=0.48,P=0.086).No other quality indicators were demonstrated to have a moderating influence on the value of the ***:MBIs improved depressive symptoms in patients with *** might be used as an adjunctive or alternative to conventional treatment for depressed patients with SUDs.

关键词： depression meditation mindfulness patients with substance use disorders systematic review and meta-analysis

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大规模裁员不应成为惯例

商业周刊（中文版） 2024年第3期 7-7页

作者： sarah Green Carmichael 逸思(译) 不详

大规模裁员很少能带来预期的经济效果,而且会破坏企业与员工之间的信任,“明天9点,你们带名单来我办公室。”道格(Doug)一直在给艾德(Ed)和艾尔维(Alvy)施压,要求裁掉他们这个七拼八凑起来的小部门的一部分人员。两人不想这么做,但母公... 详细信息

大规模裁员很少能带来预期的经济效果,而且会破坏企业与员工之间的信任,“明天9点,你们带名单来我办公室。”道格(Doug)一直在给艾德(Ed)和艾尔维(Alvy)施压,要求裁掉他们这个七拼八凑起来的小部门的一部分人员。两人不想这么做,但母公司陷入了困境,似乎到了非动不可的程度。第二天上午,他们带着写着两个名字的名单来到道格的办公室:他们自己的名字。道格打了退堂鼓。

关键词：母公司裁员企业与员工办公室

Multiphasic scaffolds for the repair of osteochondral defects:Outcomes of preclinical studies

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Bioactive Materials 2023年第9期27卷 505-545页

作者： Rouyan Chen Jasmine sarah Pye Jiarong Li Christopher B.Little Jiao Jiao Li Kolling Institute Faculty of Medicine and HealthThe University of SydneyNSW2065Australia School of Electrical and Mechanical Engineering Faculty of SciencesEngineering and TechnologyThe University of AdelaideSA5005Australia School of Biomedical Engineering Faculty of Engineering and ITUniversity of Technology SydneyNSW2007Australia

Osteochondral defects are caused by injury to both the articular cartilage and subchondral bone within skeletal joints. They can lead to irreversible joint damage and increase the risk of progression to osteoarthritis. Current treatments for osteochondral injuries are not curative and only target symptoms, highlighting the need for a tissue engineering solution. Scaffold-based approaches can be used to assist osteochondral tissue regeneration, where biomaterials tailored to the properties of cartilage and bone are used to restore the defect and minimise the risk of further joint degeneration. This review captures original research studies published since 2015, on multiphasic scaffolds used to treat osteochondral defects in animal models. These studies used an extensive range of biomaterials for scaffold fabrication, consisting mainly of natural and synthetic polymers. Different methods were used to create multiphasic scaffold designs, including by integrating or fabricating multiple layers, creating gradients, or through the addition of factors such as minerals, growth factors, and cells. The studies used a variety of animals to model osteochondral defects, where rabbits were the most commonly chosen and the vast majority of studies reported small rather than large animal models. The few available clinical studies reporting cell-free scaffolds have shown promising early-stage results in osteochondral repair, but long-term follow-up is necessary to demonstrate consistency in defect restoration. Overall, preclinical studies of multiphasic scaffolds show favourable results in simultaneously regenerating cartilage and bone in animal models of osteochondral defects, suggesting that biomaterials-based tissue engineering strategies may be a promising solution.

关键词： Osteochondral defects Tissue engineering Multiphasic scaffolds Biomaterials Animal models

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绿氢产业前景广阔

Engineering 2023年第5期24卷 3-6,I0001页

作者： sarah Derouin Senior Technology Writer

While hydrogen has long been recognized as a promising alternative to fossil fuels,its widespread use as a carrier of energy has mostly not met expectations[1].Now,increasingly practical low-carbon production,coupled with legislated incentives like those included in the US Inflation Reduction Act(IRA),are driving serious reconsideration of hydrogen as a cost-effective,emission-free energy solution.

关键词： solution driving mostly

Biometric Verification System UsingHyperparameter Tuned Deep Learning Model

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Computer Systems Science & Engineering 2023年第7期46卷 321-336页

作者： Mohammad Yamin Saleh Bajaba sarah B.Basahel E.Laxmi Lydia Department of Management Information Systems Faculty of Economics and AdministrationKing Abdulaziz UniversityJeddah21589Saudi Arabia Department of Business Administration Faculty of Economics and AdministrationKing Abdulaziz UniversityJeddah21589Saudi Arabia Department of Management Information Systems Faculty of Economics and AdministrationKing Abdulaziz UniversityJeddahSaudi Arabia Department of Computer Science and Engineering Vignan’s Institute of Information TechnologyVisakhapatnam530049India

Deep learning(DL)models have been useful in many computer vision,speech recognition,and natural language processing tasks in recent *** models seem a natural fit to handle the rising number of biometric recognition problems,from cellphone authentication to airport security *** approaches have recently been utilized to improve the efficiency of various biometric recognition *** recognition was considered the more reliable and accurate biometric detection method *** recognition has been an active research region in the last few decades due to its extensive applications,from security in airports to homeland security border *** article presents a new Political Optimizer with Deep Transfer Learning Enabled Biometric Iris Recognition(PODTL-BIR)*** presented PODTL-BIR technique recognizes the iris for biometric *** the presented PODTL-BIR model,an initial stage of pre-processing is carried *** addition,the MobileNetv2 feature extractor is utilized to produce a collection of feature *** PODTL-BIR technique utilizes a bidirectional gated recurrent unit(BiGRU)model to recognise iris for biometric ***,the political optimizer(PO)algorithm is used as a hyperparameter tuning strategy to improve the PODTL-BIR technique’s recognition ***-ranging experimental investigation was executed to validate the enhanced performance of the PODTL-BIR *** experimental outcome stated the promising performance of the PODTL-BIR system over other existing algorithms.

关键词： Biometric verification iris recognition political optimizer deep learning feature extraction

Post-operative prevention and monitoring of Crohn’s disease recurrence

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Gastroenterology Report 2022年第1期10卷 217-226页

作者： Kate E.Lee sarah Cantrell Bo Shen Adam S.Faye Department of Medicine Duke University Medical CenterDurhamNCUSA Duke University Medical Center Library&Archives Duke University School of MedicineDurhamNCUSA Center for Inflammatory Bowel Diseases NewYork-Presbyterian/Columbia University Irving Medical CenterNew YorkNYUSA Division of Gastroenterology NYU Grossman School of MedicineNew YorkNYUSA

Crohn’s disease(CD)and ulcerative colitis(UC)are relapsing and remitting chronic inflammatory diseases of the gastrointestinal *** surgery for UC can provide a cure,surgery for CD is rarely *** the past few decades,research has identified risk factors for postsurgical CD recurrence,enabling patient risk stratification to guide monitoring and prophylactic treatment to prevent CD recurrence.A MEDLINE literature review identified articles regarding post-operative monitoring of CD recurrence after resection *** this review,we discuss the evidence on risk factors for postoperative CD recurrence as well as suggestions on post-operative management.

关键词： post-operative Crohn’s management recurrence biologics

Hypertensive emergency versus preeclampsia in a patient with sickle cell disease:a case report

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World Journal of Emergency Medicine 2023年第4期14卷 329-331页

作者： Jigar Patel Juan A Reyes Ivan Berezowski Quincy K Tran sarah E Frasure Ali Pourmand Division of Hospital Medicine Department of Medicinethe George Washington UniversityWashington DC 20037USA Department of Emergency Medicine University of Maryland School of MedicineBaltimore 21201-1544USA Program in Trauma the R Adams Cowley Shock Trauma CenterUniversity of Maryland School of MedicineBaltimore 21201USA Department of Emergency Medicine the George Washington University School of Medicine and Health SciencesWashington DC 20037USA

Sickle cell disease(SCD)is strongly associated with severe preeclampsia and has also been linked to poor pregnancy-related ***,sickle cell nephropathy(SCN)is a common complication of SCD and results in chronic *** patients with SCD who present to the emergency department(ED)with pulmonary edema,hypertension,and proteinuria may suffer from a hypertensive emergency with or without *** prior lab work to determine whether a patient’s proteinuria or kidney dysfunction is new or at baseline,it may be impossible for the emergency physician to determine which diagnosis is more ***,amultidisciplinary approach which involves cardiology,nephrology,medicine and obstetrics consultations should be utilized to help direct *** present the case of a 39-yearold patient with SCD,who was also 26 weeks pregnant,and presented to the ED with markedly elevated blood pressure and *** she was initially admitted to the obstetrics ward for blood pressure management given concern for preeclampsia,she was ultimately diagnosed with hypertensive emergency and sickle cell nephropathy.

关键词： hypertensive admitted markedly