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Prospects for improving pregnancy rates in ART:Genetic and nongenetic approaches

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Prospects for improving pregnancy rates in ART:Genetic and n...

中华医学会第六次全国生殖医学学术会议

作者： Joe Leigh simpson Research and Grants and Globol Programs March of Dimes Foundation Molecular and Human Genetics Florido International UniversityMiomiFL

Improving pregnancy rates in assisted reproductive technologies(ART)underlies many scientific investigations in reproductive *** progress has been made,resulting in universal increase in pregnancy *** is a concurrent ...

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你不知道的JavaScript

作者： (美)Kyle simpson

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在毕业典礼上

疯狂英语（初中天地） 2006年第9期 54-56页

作者： Tom simpson 小虎

当我还是高中一年级学生的时候,一天,我看见班里的一个同学正从学校走回家,他名叫凯尔。他好像要把自己所有的书捧回家。我心想:“为什么会有人在星期五把自己全部的书都带回家呢?他一定是个书呆子。”我已经把自己的周末安排得很充实(... 详细信息

当我还是高中一年级学生的时候,一天,我看见班里的一个同学正从学校走回家,他名叫凯尔。他好像要把自己所有的书捧回家。我心想:“为什么会有人在星期五把自己全部的书都带回家呢?他一定是个书呆子。”我已经把自己的周末安排得很充实(明天下午我要跟朋友一起开派对和踢足球),于是我耸耸肩,继续走我的路。

关键词：毕业典礼

Estrogen deficiency reversibly induces telomere shortening in mouse granulosa cells and ovarian aging in vivo

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Protein & Cell 2011年第4期2卷 333-346页

作者： Sharyn Bayne He Li Margaret E.E.Jones Alex R.Pinto Michelle van Sinderen Ann Drummond Evan R.simpson Jun-Ping Liu Department of Immunology Central Eastern Clinical SchoolMonash UniversityVictoria 3800Australia Prince Henry’s Institute of Medical Research Clayton VIC 3168Australia Current address:Research Services M459The University of Western Australia35 Stirling HighwayCRAWLEY WA 6009Australia Current address:Murdoch Children’s Research Institute Royal Children’s HospitalParkvilleVic 3052Australia

Estrogen is implicated as playing an important role in aging and tumorigenesis of estrogen responsive tissues;however the mechanisms underlying the mitogenic actions of estrogen are not fully *** we report that estrogen deficiency in mice caused by targeted disruption of the aromatase gene results in a signi-ficant inhibition of telomerase maintenance of telomeres in mouse ovaries in a tissue-specific *** inhibition entails a significant shortening of telomeres and compromised proliferation in the follicular granulosa cell compartment of *** expression analysis showed decreased levels of proto-oncogene c-Myc and the telomerase catalytic subunit,telomerase reverse transcriptase(TERT),in response to estrogen *** replacement therapy led to increases in TERT gene expression,telomerase activity,telomere length and ovarian tissue growth,thereby reinstating ovary development to normal in four *** data demonstrate for the first time that telomere maintenance is the primary mechanism mediating the mitogenic effect of estrogen on ovarian granulosa cell proliferation by upregulating the genes of c-Myc and TERT in *** deficiency or over-activity may cause ovarian tissue aging or tumorigenesis,respectively,through estrogen regulation of telomere remodeling.

关键词： estrogen telomerase reverse transcriptase(TERT) telomeres ovary mice

不同发育阶段血吸虫表面抗原的表达和免疫学功能

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国外医学（寄生虫病分册） 1991年第3期18卷 113-114页

作者： simpson AJG 蔡银龙

长期以来,人们普遍认为暴露在寄生虫表面的抗原是保护性免疫反应重要的靶。但是显而易见,血吸虫的保护性抗原并非都是表面抗原,也不是所有表面抗原都是保护性免疫的靶。作者提出,决定表面抗原免疫学功能的因素之一可能是不同发育阶段的... 详细信息

长期以来,人们普遍认为暴露在寄生虫表面的抗原是保护性免疫反应重要的靶。但是显而易见,血吸虫的保护性抗原并非都是表面抗原,也不是所有表面抗原都是保护性免疫的靶。作者提出,决定表面抗原免疫学功能的因素之一可能是不同发育阶段的表达。

关键词：血吸虫表面抗原表达

Imaging of gaucher disease

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World Journal of Radiology 2014年第9期6卷 657-668页

作者： William L simpson George Hermann Manisha Balwani Department of Radiology Icahn School of Medicine at Mount Sinai Department of Genetics and Genomic Sciences Icahn School of Medicine at Mount Sinai

Gaucher disease is the prototypical lysosomal storage *** results from the accumulation of undegrad-ed glucosylceramide in the reticuloendothelial system of the bone marrow,spleen and liver due to deficiency of the enzyme *** leads to he-matologic,visceral and skeletal *** up of glucosylceramide in the liver and spleen results in *** normal bone marrow is re-placed by the accumulating substrate leading to many of the hematologic signs including *** visceral and skeletal manifestations can be visualized with vari-ous imaging modalities including radiography,com-puted tomography,magnetic resonance imaging(MRI)and radionuclide *** to the development of enzyme replacement therapy,treatment was only ***,once intravenous enzyme replace-ment therapy became available in the 1990s it quickly became the standard of *** replacement therapy leads to improvement in all *** and hematologic manifestations respond more quickly usually within a few months or *** skel-etal manifestations take much longer,usually several years,to show *** recent years newer treatment strategies,such as substrate reduction thera-py,have been under *** plays a key role in both initial diagnosis and routine monitoring of patient on treatment particularly volumetric MRI of the liver and spleen and MRI of the femora for evaluating bone marrow disease burden.

关键词： Gaucher disease Lysosomal storage dis-ease Enzyme replacement therapy Genetics Medical imaging Magnetic resonance imaging Bone marrow

Use of GIS to Determine Potential Sources of Aquatic Invasive Species Invasions into Western South Dakota Reservoirs

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Natural Resources 2020年第2期11卷 39-45页

作者： Jayne Kylee Ecker Ryan Raben Greg simpson South Dakota Department of Game Fish and Parks Rapid City SD USA

The spread of Aquatic Invasive Species (AIS) is a constant threat for western US waters. The state of South Dakota detected zebra mussels (Dreissena polymorpha) for the first time at Lewis and Clark Reservoir in 2014. Since then, efforts have been towards preventing their further expansion. To determine possible avenues of infestation westward, we used ArcGIS to map the home zip codes of boaters using four western reservoirs (Belle Fourche Reservoir, Pactola Reservoir, Sheridan Lake and Angostura Reservoir). A 60-mile buffer was used to determine spatial relationships of boater zip codes to establish zebra mussel populations and was considered areas of high risk. We found that there were three instances where a boater came from a high-risk area during the study period. Our results show possible pathways for Dreissena expansion into western South Dakota reservoirs. Most notably is that exposure can occur from either an inter- or intra-state vector. This information confirmed that there is a risk of additional water bodies in South Dakota becoming infected. Based on past studies, prevention is the best method in slowing the expansion of zebra mussels in South Dakota. We suggest three actions, strategically placed decontamination stations, continued public awareness efforts and differentiating boat registration tags on watercraft that are near infested water bodies.

关键词： GIS South Dakota Invasive Species Zebra Mussel

Modern Corrosion Mapping of Storage Tank Bottoms--Notable Advancements in Critical Zone Coverage,Inspection Efficiency and Data Integrity

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Journal of Civil Engineering and Architecture 2024年第3期18卷 148-153页

作者： Andrew J.simpson Matthew A.Boat Eddyfi Technologies-Eddyfi UK Ltd Clos Llyn CwmSwansea Enterprise ParkSwanseaSA68QYUK

Every day,an NDT(Non-Destructive Testing)report will govern key decisions and inform inspection strategies that could affect the flow of millions of dollars which ultimately affects local environments and potential risk to *** is a direct correlation between report quality and equipment *** more able the equipment is-in terms of efficient data gathering,signal to noise ratio,positioning,and coverage-the more actionable the report *** results in optimal maintenance and repair strategies providing the report is clear and well ***,when considering tank floor storage inspection it is essential that asset owners have total confidence in inspection findings and the ensuing *** floor inspection equipment must not only be efficient and highly capable,but data sets should be traceable and integrity maintained *** mapping of large surface areas such as storage tank bottoms is an inherently arduous and time-consuming ***(magnetic flux leakage)based tank bottom scanners present a well-established and highly rated method for *** are many benefits of using modern MFL technology to generate actionable *** among these includes efficiency of coverage while gaining valuable information regarding defect location,severity,surface origin and the extent of *** recent advancements in modern MFL tank bottom scanners afford the ability to scan and record data sets at areas of the tank bottom which were previously classed as dead zones or areas not scanned due to physical *** example of this includes scanning the CZ(critical zone)which is the area close to the annular to shell junction *** of these additional dead zones increases overall inspection coverage,quality and *** of the CZ areas allows engineers to quickly determine the integrity of arguably the most important area of the tank *** we discuss notable developments in CZ coverage

关键词： Storage tank tank bottom CZ MFL stars corrosion corrosion-mapping efficiency coverage paperless reporting data traceability

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纺织品测色前试样调湿的重要性及其注意问题

纺织导报 2006年第7期 91-92页

作者： Clay Hile AI simpson Parameter Generation&Control公司 SDL Atlas公司

测色前将纺织试样调节到标准温、湿度很重要。了解影响温度和湿度的参数可确保试样得到恰当的调湿。为了达到真正所需的条件,在设计一个试验间时必须把导致条件偏差的各个方面考虑在内。文章从单点稳定性、均匀性、传感器精确度、调湿... 详细信息

测色前将纺织试样调节到标准温、湿度很重要。了解影响温度和湿度的参数可确保试样得到恰当的调湿。为了达到真正所需的条件,在设计一个试验间时必须把导致条件偏差的各个方面考虑在内。文章从单点稳定性、均匀性、传感器精确度、调湿时间等方面做了讨论。

关键词：分光光度计调湿标准温湿度传感器测色纺织品