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Persistent diarrhea with petechial rash-unusual pattern of light chain amyloidosis deposition on skin and gastrointestinal biopsies:A case report

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World Journal of Clinical Cases 2022年第28期10卷 10252-10259页

作者： Shawna E Bilton Nikhil Shah Diana Dougherty sarah simpson Alex Holliday Farhad Sahebjam Douglas J Grider Department of Basic Science Education Virginia Tech Carilion School of MedicineRoanokeVA 24016United States Department of Internal Medicine Carilion ClinicRoanokeVA 24016United States Gastroenterology and Hepatology Section Department of Internal MedicineCarilion ClinicRoanokeVA 24016United States Dermatology Section Department of Internal MedicineCarilion ClinicRoanokeVA 24016United States Dominion Pathology Associates RoanokeVA 24018United States

BACKGROUND Amyloidosis is a rare disease characterized by extracellular deposition of misfolded protein aggregated into insoluble *** involvement in systemic amyloidosis is common,but is often subclinical or presents as vague and nonspecific *** is rare for gastrointestinal symptoms to be the main presenting symptom in patients with systemic amyloidosis,causing it to be undiagnosed until late-stage *** SUMMARY A 53 year-old man with diarrhea,hematochezia,and weight loss presented to a community *** with biopsy at that time was suspicious for Crohn *** to worsening symptoms including nausea,vomiting,and a new petechial rash,an abdominal fat pad biopsy was *** biopsy showed papillary and adnexal dermal amyloid deposition,in a pattern usually seen with cutaneous ***,Cytokeratin 5/6 was negative,excluding cutaneous *** patterns of nodular amyloidosis,subcutaneous amyloid deposits and perivascular amyloid were not *** Acid-Schiff stain was negative for lipoid proteinosis,Congo red was positive for apple green birefringence on polarization and amyloid typing confirmed amyloid light chain *** endoscopic biopsies of the gastrointestinal tract showed amyloid deposition from the esophagus to the rectum,in a pattern usually seen in serum amyloid A in the setting of chronic inflammatory diseases,including severe inflammatory bowel *** marrow biopsy showed kappa-restricted plasma cell *** Described is an unusual presentation of primary systemic amyloidosis,highlighting the risk of misdiagnosis with subsequent significant organ dysfunction and high mortality.

关键词： Light chain amyloidosis Diarrhea Endoscopy Petechial rash Plasma cell dyscrasia Case report

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探秘全球最大稀土矿区

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环球科学 2011年第11期 72-79页

作者：莎拉·辛普森（sarah simpson）王昊明（翻译）《科学美国人》编辑部不详

地质学家在阿富汗地区发现了大量重要矿物。其中包括相当数量的稀土矿石。这项发现不仅能满足高科技产业对稀土元素日益增长的需求，还可以帮助这个国家饱经战乱的人民逐步摆脱依靠种植罂粟维生的现状。

关键词：稀土元素矿区高科技产业地质学家阿富汗

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迷恋家园的水生动物

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科学（中文版） 2001年第4期 9-9页

作者： simpson,sarah 郑忆石

新证据表明，幼鱼和幼虾十分恋家，这可能成为挽救珊瑚礁生物多样性的关键线索。

关键词：水生动物生活习性珊瑚礁生物多样性

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Laser ablation(in situ)Lu-Hf dating of magmatic fluorite and hydrothermal fluorite-bearing veins

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Geoscience Frontiers 2023年第6期14卷 142-154页

作者： Stijn Glorie Jacob Mulder Martin Hand Adrian Fabris Alexander simpson sarah Gilbert Department of Earth Sciences University of AdelaideSA 5005Australia Geological Survey of South Australia Department for Energy and MiningAdelaideSA 5005Australia Adelaide Microscopy University of AdelaideSA 5005Australia

Fluorite(CaF_(2))is a common hydrothermal mineral,which precipitates from fluorine-rich fluids with an exceptional capacity to transport metals and Rare Earth Elements(REEs).Hence,the ability to date fluorite has important implications for understanding the timing of metal transport in hydrothermal *** we present,for the first time,fluorite Lu-Hf dates from fluorite-carbonate veins from the Olympic Cu-Au Province in South *** fluorite dates were obtained in situ using the recently developed LA-ICP-MS/MS Lu-Hf dating method.A fluorite-calcite age of 1588±19 Ma was obtained for the Torrens Dam prospect,consistent with the timing of the formation of the nearby Olympic Dam iron-oxide copper gold Breccia *** in the overlying Neoproterozoic successions were dated at 502±14 Ma,indicating a temporal link between Cu-sulphide remobilisation and the Delamerian ***,we present a multi-session reproducible date for magmatic fluorite from a monzogranite in the Pilbara Craton(Lu-Hf age of 2866±19 Ma).This age is consistent with a garnet Lu-Hf age from the same sample(2850±12 Ma)and holds potential to be developed into a secondary reference material for future fluorite Lu-Hf dating.

关键词： Reaction-cell ICP-MS In-situ geochronology Fluorite-calcite veins Iron oxide copper-gold Critical mineral exploration Rare Earth Elements

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In situ Lu–Hf phosphate geochronology:Progress towards a new tool for space exploration

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Geoscience Frontiers 2022年第3期13卷 164-167页

作者： Stijn Glorie Thomas Burke Martin Hand Alexander simpson sarah Gilbert Benjamin Wade Department of Earth Sciences The University of AdelaideSA 5005 AdelaideAustralia Adelade Microscopy The University of AdelaideSA 5005 AdelaideAustralia

Geochronology is fundamental to understanding planetary ***,as space exploration continues to expand,traditional dating methods,involving complex laboratory processes,are generally not realistic for unmanned space ***-style planetary exploration missions require dating methods that can(1)rapidly resolve age information on small samples,(2)be applied to minerals common in mafic rocks,and(3)be based on technologies that could be installed on future rover *** demonstrate the application of rapid in situ microanalytical Lu–Hf phosphate geochronology using samples of pallasite meteorites,which are representative examples of the deep interiors of differentiated planetoids that are generally difficult to *** pallasites were dated by laser ablation tandem mass-spectrometry(LA-ICP-MS/MS),demonstrating a rapid novel method for exploring planetary *** formation ages for individual pallasites agree with traditional methods and have<2%uncertainty,opening an avenue of opportunity for remote micro-analytical space exploration.

关键词： Pallasite meteorites Lu-Hf geochronology Laser ablation tandem mass-spectrometry Micro-analytical planetary exploration

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In situ apatite and carbonate Lu-Hf and molybdenite Re-Os geochronology for ore deposit research:Method validation and example application to Cu-Au mineralisation

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Geoscience Frontiers 2024年第5期15卷 339-354页

作者： Alexander simpson Stijn Glorie Martin Hand sarah E.Gilbert Carl Spandler Marija Dmitrijeva Greg Swain Angus Nixon Jacob Mulder Carsten Münker Department of Earth Sciences University of AdelaideSA 5005Australia Mineral Exploration Cooperative Research Centre University of AdelaideSA 5005Australia Adelaide Microscopy University of AdelaideSA 5005Australia Fortescue Level 287Adelaide TerraceEast PerthWA 6005Australia Institute of Geology und Mineralogy University of Köln50674 KölnGermany British Geological Survey NottinghamUK

The development of laser ablation inductively coupled plasma quadrupole tandem mass spectrometry(LA-ICP-Q-MS/MS)opens new opportunities to rapidly date a variety of hydrothermal *** we present in situ Lu-Hf and Re-Os dates for hydrothermal apatite and molybdenite,*** further report the first in situ Lu-Hf dates for bastnäsite,dolomite,and siderite,and assess their potential for constraining ore deposit *** method validation,we report isotope-dilution Lu-Hf dates for apatite reference material Bamble-1(1102±5 Ma)and calcite reference material ME-1(1531±7 Ma),enabling improved accuracy on matrix-matched calibration for LA-ICP-MS/MS Lu-Hf *** new methods are applied to the Vulcan Iron-Oxide Copper-Gold(IOCG)prospect in the Olympic Cu-Au Province of South *** deposits have been difficult to accurately date,given the general lack of reliable mineral geochronometers that are cogenetic with IOCG *** apatite Lu-Hf dates and molybdenite Re-Os dates demonstrate that mineralisation at Vulcan largely occurred at ca.1.6 Ga,contemporaneous with the world class Olympic Dam *** data also indicates that the Lu-Hf system in apatite is more robust than the U-Pb system for determining the timing of primary apatite formation in an IOCG *** further demonstrate that dolomite can retain Lu-Hf growth ages over an extended time period(>1.5 billion years),providing constraints on the timing of primary ore mineral crystallisation during brecciation and IOCG ***,late Neoproterozoic(ca.589–544 Ma)and Carboniferous(ca.334±7 Ma)Lu-Hf dates were obtained for texturally late Cubearing carbonate veins,illustrating that the carbonate Lu-Hf method allows direct dating of Cu remobilisation *** has important implications for mineral exploration as the remobilised Cu may have been transferred to younger deposits hosted in Neoproterozoic sedimentary basins overlaying the Olympic IOCG provi

关键词： Reaction-cell ICP-MS In-situ geochronology Lu-Hf Re-Os Iron Oxide Copper Gold Metal fluids

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The historyand aspirations of the Oxford English Dictionary:1857-2014 and beyond

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外语教学与研究 2014年第6期46卷 803-816页

作者： John simpson Chief Editor Oxford English Dictionary (1983-2013)

The Oxford English Dictionary(OED)was originally published between 1884 and 1928,but even today we are only scratching the surface of its full potential as a major searchable online *** article looks briefly at how and why the dictionary was originally established in the second half of the nineteenth century,before examining how today's editors are updating its content in the first comprehensive revision programme the dictionary has ever *** remainder of the article investigates the current online site and looks into the future—to see what strategies the dictionary is employing and imagining as it moves away from being a book on computer to becoming a fully-fledged online language resource.

关键词： dictionary briefly beyond examining originally becoming vocabulary today historical speakers

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Collaborating remotely:an evaluation of immersive capabilities on spatial experiences and team membership

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International Journal of Digital Earth 2018年第4期11卷 420-436页

作者： Danielle Oprean Mark simpson Alexander Klippel Department of Architecture The Pennsylvania State UniversityUniversity ParkPAUSA Department of Geography The Pennsylvania State UniversityUniversity ParkPAUSA

Today’s workforce environments are steadily becoming more distributed across the globe,calling for improved ways of facilitating collaborations at a distance,including geo-collaborations or collaborations at critical *** technology is allowing distributed teams to move away from traditional conference rooms,taking collaborations into the field and giving remote teams more information about the *** idea of situating a remote collaborator’s experiences in the field,virtually,promises to enhance the understanding of geographically remote *** technologies in virtual reality(VR)hold promise for providing mobile spatial experiences in real-time,without being tied to fixed hardware,such as systems in conference *** exploratory study using VR technology on remote user experiences in a collaboration was conducted to identify the added value for remote *** findings suggest immersive capabilities improve feelings of presence in the remote locations and perceptions of being in the remote location increase feelings of team membership.

关键词： Presence geo-collaboration virtual reality

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Summary of East Gondwanan Conodont Data through the Ireviken Event at Boree Creek

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Journal of Earth Science 2021年第3期32卷 512-523页

作者： Andrew simpson David Mathieson Jiri Fryda Barbora Frydova Archives and Collections University LibraryMacquarie UniversitySydney NSW 2109Australia Department of Biological Sciences Macquarie UniversitySydney NSW 2109Australia Department of Environmental Geosciences Czech University of Life Sciences Prague16500 PragueCzech Republic

The Ireviken Event was the first Middle Paleozoic event consisting of synchronised faunal,isotopic and facies change to be *** analysis of the conodont faunas throughout the Boree Creek/Borenore Limestone succession in the central western region of the Tasman fold belt of New South Wales(Australia)revealing all five conodont zones that comprise the event is *** some zonal boundaries are precise,allowing direct comparison of stratigraphic intervals on other paleo-continents,some can only be *** data from pre-Ireviken Event strata,in contrast,only permit the identification of a broad Telychian *** identification of Wenlock post-Ireviken Event conodont zones is incomplete due to lithological variability,namely the presence of tuffaceous beds near the top of the formation and an unconformity between the Boree Creek and overlying Borenore *** Boree Creek Formation contains the only example of the Ireviken Event discovered to date from the Tasman fold belt of eastern Gondwanaland.

关键词： conodonts extinction Ireviken Event Silurian Boree Creek eastern Gondwanaland

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Identification of isopeptidase activity in the midgut of insects： Purification, properties and nutritional ecology of a Hofmannophila pseudospretella （Lepidoptera： Oecophoridae） larval enzyme

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Insect Science 2010年第4期17卷 325-334页

作者： Robert M. simpson John T. Christeller Plant and Food Research Institute Tennant Drive Palmerston North 4474 Private Bag 11 030 New Zealand

A γ-glutamyl transpeptidase （isopeptidase） has been purified 580-fold to homogeneity from the midgut of keratinophagous larvae of Hofmannophila pseudospretella. The enzyme is a single polypeptide of molecular mass 80 kDa. The enzyme was identified by its hydrolytic activity against the synthetic substrate, γ-glutamyl-AMC, its molecular mass and inhibition profile compared to other γ-glutamyl transpeptidases. The enzyme is low or absent from most other insect digestive systems apart from other keratinophagous lepidopteran larvae and predatory carabids. While isopepfide bonds are present in high levels of the proteins in the diet of keratinophages, their presence in the diet of predatory beetles has not been established.

关键词： γ-glutamyl transpeptidase Hofmannophila pseudospretella isopeptidase,keratinophagous nutritional ecology

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