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Molecular mechanisms underlying the neuroprotection of environmental enrichment in Parkinson’s disease

Neural Regeneration Research 2023年第7期18卷 1450-1456页

作者： Tamara Andrea Alarcón sarah martins presti-silva Ana Paula Toniato Simões Fabiola Mara Ribeiro Rita Gomes Wanderley Pires Department of Physiological Sciences Health Science CenterUniversidade Federal do Espirito SantoVitoriaBrazil Laboratory of Molecular and Behavioral Neurobiology Health Science CenterUniversidade Federal do Espirito SantoVitoriaBrazil Department of Biochemistry and Immunology Institute o Biological SciencesUniversidade Federal de Minas GeraisAvenida Antônio CarlosBelo HorizonteBrazil

Parkinson’s disease is the most common movement disorder,affecting about 1%of the population over the age of 60 ***’s disease is characterized clinically by resting tremor,bradykinesia,rigidity and postural instability,as a result of the progressive loss of nigrostriatal dopaminergic *** addition to this neuronal cell loss,Parkinson’s disease is characterized by the accumulation of intracellular protein aggregates,Lewy bodies and Lewy neurites,composed primarily of the proteinα-*** it was first described almost 200 years ago,there are no disease-modifying drugs to treat patients with Parkinson’s *** addition to conventional therapies,non-pharmacological treatment strategies are under investigation in patients and animal models of neurodegenerative *** such strategies,environmental enrichment,comprising physical exercise,cognitive stimulus,and social interactions,has been assessed in preclinical models of Parkinson’s *** enrichment can cause structural and functional changes in the brain and promote neurogenesis and dendritic growth by modifying gene expression,enhancing the expression of neurotrophic factors and modulating *** this review article,we focus on the current knowledge about the molecular mechanisms underlying environmental enrichment neuroprotection in Parkinson’s disease,highlighting its influence on the dopaminergic,cholinergic,glutamatergic and GABAergic systems,as well as the involvement of neurotrophic *** describe experimental pre-clinical data showing how environmental enrichment can act as a modulator in a neurochemical and behavioral context in different animal models of Parkinson’s disease,highlighting the potential of environmental enrichment as an additional strategy in the management and prevention of this complex disease.

关键词： acetylcholine brain-derived neurotrophic factor dopamine environment enrichment gamma-aminobutyric acid glial cell line-derived neurotrophic factor glutamate molecular mechanisms Parkinson’s disease

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Chemical profile and antimicrobial activity of Secondatia floribunda A. DC(Apocynaceae)

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Asian Pacific Journal of Tropical Biomedicine 2017年第8期7卷 739-749页

作者： Daiany Alves Ribeiro sarah Soares Damasceno Aline Augusti Boligon Irwin Rose Alencar de Menezes Marta Maria de Almeida Souza JoséGalberto martins da Costa Programa de Pós-Graduacao em Etnobiologia e Conservacao da Natureza Universidade Regional do Cariri Departamento de Química Biológica Laboratório de Pesquisas de Produtos NaturaisUniversidade Regional do Cariri Laboratório de Fitoquímica Universidade Federal de Santa Maria Departamento de Química Biológica Laboratório de Farmacologia e Química MolecularUniversidade Regional do Cariri Departamento de Ciências Biológicas Laboratório de Ecologia VegetalUniversidade Regional do Cariri

Objective: To establish the chemical profile, and to evaluate the antibacterial and modulatory activity of the ethanolic extracts of the stalk's inner bark and heartwood of Secondatia ***: Quantification of total plienols and flavonoids was determined by the FolinCiocalteu method and aluminum chloride, respectively. Phenolic compounds were identified and quantified by HPLC-DAD(High Performance Liquid ChromatographyDiodearray Detector) and the Infrared Spectroscopy was performed using the measure by Attenuated Total Reflectance with Fourier Transform(ATR-FTIR). Antibacterial assays for determination of the Minimum Inhibitory Concentration(MIC) and modification of aminoglycosides were performed by ***: Infrared spectra showed similar characteristics, having among its main absorption bands hydroxyl group(OH). The antibacterial activity showed clinically significant results for the strains of Staphylococcus aureus and Escherichia coli. In modulation assay, synergic and antagonistic effect for both extracts was *** extract in combination with antibiotics showed a significant MIC reduction at 19.8%(P<0.0001)-79.3%(P<0.01).Conclusions: This study is the first report of chemical and biological information of Secondatia floribunda suggesting that it is clinically relevant source of a new antibacterial therapy, especially due to the presence of significant levels of phenolic compounds.

关键词：化学作文 HPLC Cinchonain 自然产品修正抵抗

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Assessing the relationship between the rumen microbiota and feed efficiency in Nellore steers

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Journal of Animal Science and Biotechnology 2021年第4期12卷 1645-1661页

作者： Déborah Romaskevis Gomes Lopes Márcio de Souza Duarte Alex J.La Reau Ibrahim Zuniga Chaves Tiago Antônio de Oliveira Mendes Edenio Detmann Cláudia Braga Pereira Bento Maria Eugênia Zerlotti Mercadante sarah Figueiredo martins Bonilha Garret Suen Hilário Cuquetto Mantovani Departamento de Microbiologia Universidade Federal de ViçosaViçosaMG 36570-900Brazil Departamento de Zootecnia Universidade Federal de ViçosaViçosaMinas GeraisBrazil Department of Bacteriology University of Wisconsin-MadisonMadisonWIUSA Departamento de Bioquímia e Biologia Molecular Universidade Federal de ViçosaViçosaMinas GeraisBrazil Instituto de Zootecnia Centro APTA Bovinos de CorteSertãozinhoSão PauloBrazil

Background:Ruminants rely upon a complex community of microbes in their rumen to convert host-indigestible feed into ***,little is known about the association between the rumen microbiota and feed efficiency traits in Nellore(Bos indicus)cattle,a breed of major economic importance to the global beef ***,we compare the composition of the bacterial,archaeal and fungal communities in the rumen of Nellore steers with high and low feed efficiency(FE)phenotypes,as measured by residual feed intake(RFI).Results:The Firmicutes to Bacteroidetes ratio was significantly higher(P<0.05)in positive-RFI steers(p-RFI,low feed efficiency)than in negative-RFI(n-RFI,high feed efficiency)*** differences in bacterial composition from steers with high and low FE were mainly associated with members of the families Lachnospiraceae,Ruminococcaceae and Christensenellaceae,as well as the genus *** community richness was lower(P<0.05)in p-RFI than in n-RFI steers and the genus Methanobrevibacter was either increased or exclusive of p-RFI *** fungal genus Buwchfawromyces was more abundant in the rumen solid fraction of n-RFI steers(P<0.05)and a highly abundant OTU belonging to the genus Piromyces was also increased in the rumen microbiota of highefficiency ***,analysis of rumen fermentation variables and functional predictions indicated similar metabolic outputs for the microbiota of distinct FE ***:Our results demonstrate that differences in the ruminal microbiota of high and low FE Nellore steers comprise specific taxa from the bacterial,archaeal and fungal *** OTUs belonging to the genus Piromyces were identified in animals showing high feed efficiency,whereas among archaea,Methanobrevibacter was associated with steers classified as *** identification of specific RFI-associated microorganisms in Nellore steers could guide further studies targeting the isolation and functional characterization

关键词： Beef cattle ITS1 region Next-generation sequencing RFI Rumen microbiota 16S rRNA gene

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