检索结果-南通市图书馆

Identification of new genet.c risk factors for prost.t. cancer

Asian Journal.of Androl.gy 2009年第1期11卷 49-55页

作者： Michel.e Guy Zsofia Kote-Jarai Graham G. Gil.s Al. Amin Al.Ol.ma sarah K. Jugurnauth Shani Mul.ol.and Daniel.A. l.ongamoml.rt stephen M. edwards Jonathan Morrison Hel.n I. Fiel. Mel.ssa c. Southey Gianl.ca Severi Jenny l. Donovan Freddie c. Hamdy David R Dearnal.y Kenneth R. Muir charmaine Smith Mel.sa Bagnato Audrey t. Ardern-Jones Amanda l. Hal. l.nne t. O＇Brien Beatrice N. Gehr-Swain Rosemary A. Wil.inson Angel. cox sarah l.wis Paul.M. Brown Sameer G. Jhavar Mal.orzata tymrakiewicz Artitaya l.phatananon sarah l. bryant.t.e uk genet.c prost.t. cancer st.dy collaborat.rs British Association of Urol.gical.Surgeons＇ Section of Oncol.gy and the uk Protect st.dy collaborat.rs Al.n Horwich Robert A. Huddart Vincent S. Khoo christopher c. Parker christopher J. Woodhouse Al.n thompson tim christmas chris Ogden cyril.Fisher charl.s Jameson col.n S. cooper Dal.as R. engl.sh John l. Hopper David e. Neal.Dougl.s e easton Rosal.nd A. eel.s Section of cancer genet.cs The Institute of Cancer Research Sutton Surrey SM2 5NG UK cancer epidemiol.gy centre The Cancer Council Victoria Carlton VIC 3053 Australia centre for Mol.cul.r Environmental Genetic and Analytic Epidemiology The University of Melbourne Carlton VIC 3053 Australia cancer Research uk genet.c epidemiol.gy Unit University of Cambridge Strangeways Laboratory Worts Causeway Cambridge CB1 8RN UK Department of Oncol.gy University of Cambridge Strangeways Laboratory Worts Causeway Cambridge CB1 8RN UK genet.c epidemiol.gy l.boratory Department of Pathology The University of Melbourne Parkville VIC 3052 Australia Department of Social.Medicine University of Bristol Bristol BS8 2PR UK Academic Urol.gy Unit University of Sheffield Sheffield SIO 2JF UK the Royal.Marsden NHS Foundation trust Sutton Surrey SM2 5PT and London SW3 6JJ UK University of Nottingham Medical.School Queens Medical Centre Nottingham NG7 2UH UK Institute for cancer studies University of Sheffield Sheffield SIO 2RX UK Surgical.Oncol.gy （Uro-Oncol.gy S4） Departments of Oncology and Surgery University of Cambridge Addenbrooke＇s Hospital Cambridge CB2 2QQ UK A ful. l.st of authors is provided in the Suppl.mentary Note onl.ne Ka Shing Centre Cambridge CB2 ORE UK cancer Research uk cambridge Research Institute Li Ka Shing Centre Cambridge CB2 ORE UK.

there is evidence that a substantial.part of genet.c predisposition to prost.t. cancer （Pca） may be due to l.wer penetrance genes which are found by genome-wide association studies. We have recentl. conducted such a st.dy and seven new regions of the genome l.nked to Pca risk have been identified. three of these l.ci contain candidate susceptibil.ty genes： MSMB, l.tK2 and Kl.2/3. the MSMB and Kl.2/3 genes may be useful.for Pca screening, and the l.tK2 gene might provide a potential.therapeutic target. together with resul.s from other groups, there are now 23 germl.ne genet.c variants which have been reported. these resul.s have the potential.to be devel.ped into a genet.c test. However, we consider that marketing of tests to the publ.c is premature, as Pca risk can not be eval.ated ful.y at this stage and the appropriate screening protocol. need to be devel.ped. Fol.ow-up val.dation studies, as wel. as studies to expl.re the psychol.gical.impl.cations of genet.c profil. testing, wil. be vital.prior to rol. out into heal.hcare.

关键词： prost.t. cancer genet.cs susceptibil.ty l.ci SNPs rel.tive risks

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：