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Oryza CLIMtools:A ge.ome.e.vironme.t association re.ource.re.e.ls adaptive.role. for he.e.otrime.ic G prote.ns in the.re.ulation of rice.agronomic traits

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Plant Communications 2024年第4期5卷 145-165页

作者： Ange. Fe.re.o-Se.rano David Chakravorty Kobie.j.Kirve. sarah M.Assmann Biology De.artme.t Pennsylvania State University208 Mueller LaboratoryUniversity ParkPA 16802USA Inte.colle.e.Graduate.De.re. Program in Bioinformatics and Ge.omics Pennsylvania State University208 Mueller LaboratoryUniversity ParkPA 16802USA

Mode.n crop varie.ie. display a de.re. of mismatch be.we.n the.r curre.t distributions and the.suitability of the.local climate.for the.r *** addre.s this issue.we.pre.e.t Oryza CLIMtools(https://***/CLIMtools/oryza_v1.0/),the.irst re.ource.for pan-ge.ome.pre.iction of climate.associate. ge.e.ic variants in a crop *** CLIMtools consists of inte.active.we.-base. database. that e.able.the.use. to(1)e.plore.the.local e.vironme.ts of traditional rice.varie.ie.(landrace.)in South-e.st Asia and(2)inve.tigate.the.e.vironme.t by ge.ome.associations for 658 Indica and 283 j.ponica rice.landrace.acce.sions colle.te. from ge.re.e.e.ce. local e.vironme.ts and include. in the.3K Rice.Ge.nome. *** de.onstrate.the.value.of the.e.re.ource. by ide.tifying an inte.play be.we.nflowe.ing time.and te.pe.ature.in the.local e.vironme.t that is facilitate. by adaptive.natural variation in OsHD2 and disrupte. by a natural variant in *** quantitative.trait locus analysis has sugge.te. the.impor-tance.of he.e.otrime.ic G prote.ns in the.control of agronomic ***,we.analyze. the.climate.associations of natural variants in the.diffe.e.t he.e.otrime.ic G prote.n *** ide.tifie. a coordi-nate. role.of G prote.ns in adaptation to the.pre.ailing pote.tial e.apotranspiration gradie.t and re.e.le. the.r re.ulation of ke. agronomic traits,including plant he.ght and se.d and panicle.*** conclude.by highlighting the.prospe.t of targe.ing he.e.otrime.ic G prote.ns to produce.climate.re.ilie.t crops.

关键词： Oryza sativa rice G by e adaptation flowe.ing time GWAS OsHD2 OsSOC1 he.e.otrime.ic G pro-te.n OsRGA1 d1 OsGS3 OsDe.1 OsGGC2

De.ign and synthe.is of synthe.ic promote.s for consiste.cy of ge.e.e.pre.sion across growth phase. and scale.in ***

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Synthe.ic and Syste.s Biote.hnology 2024年第2期9卷 330-339页

作者： Kristin V.Pre.ne.l Omar Me.he. sarah M.Cole.an Nicholas j.Morse.Hal S.Alpe. McKe.ta De.artme.t of Che.ical e.gine.ring The University of Texas at Austin200E Dean Keeton St.Stop C0400AustinTX78712USA Institute.for Ce.lular and Mole.ular Biology The University of Texas at Austin2500 Speedway AvenueAustinTX78712USA

Me.abolic e.gine.ring and synthe.ic biology e.de.vors be.e.it from promote.s that pe.form consiste.tly(or robustly)with re.pe.t to ce.lular growth phase.e.pone.tial and stationary)and fe.me.tation scale.microtite. plate.,tube.,flasks,and biore.ctors).Howe.e.,ne.rly all e.doge.ous promote.s(e.pe.ially in Saccharomyce. ce.e.isiae.do not pe.form in this *** this work,a hybrid promote. e.gine.ring strate.y is le.e.age. to cre.te.nove. synthe.ic promote.s with robustne.s across the.e.*** a multi-dime.sional RNA-se. datase.,promote.s with spe.ific phase.de.e.de.cie. we.e.*** e.riche. with functional transcription factors we.e.ide.tifie. using Me.e.*** motif-containing fragme.ts could impart activity de.e.de.ce.in the.opposing ***,we.obtain two ne. promote.s with high and consiste.t e.pre.sion across both phase. by incre.sing the.e.pone.tial phase.activity of the.starting stationary-phase.scaffold by 38 and 23-fold ***,we.show that the.e.promote.s function consiste.tly across various laboratory growth scale. ove. time.in a microtite. plate.and in ***,this work pre.e.ts and validate. a ne. strate.y for e.gine.ring promote.s in *** with high le.e.s of e.pre.sion that are.robust to ce.lular growth phase.and the.scale.of the.culture.

关键词： e.doge.ous synthe.ic stationary

Ce.l Wall Microstructure.Analysis Implicate. He.ice.lulose.Polysaccharide. in Ce.l Adhe.ion in Tomato Fruit Pe.icarp Pare.chyma

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Mole.ular Plant 2009年第5期2卷 910-921页

作者： j.se.j. Ordaz-Ortiz susan e. Marcus j. Paul Knox Ce.tre.for Plant Scie.ce. Faculty of Biological Sciences University of Leeds Leeds LS2 9JT United Kingdom

Me.hods de.e.ope. to isolate.intact ce.ls from both unripe.and ripe.tomato fruit pe.icarp pare.chyma have.allowe. the.ce.l biological analysis of polysaccharide.e.itope. at the.surface.of se.arate. ce.ls. The.LM7 pe.tic homogalacturonan e.itope.is a marke. of the.j.nctions of adhe.ion plane. and inte.ce.lular space. in pare.chyma syste.s. The.LM7 e.itope.pe.siste.tly marke. the.forme. e.ge.of adhe.ion plane. at the.surface.of ce.ls se.arate. from unripe.and ripe.e. tomato fruit and also from fruits with the.Cnr mutation. The.LM 11 xylan e.itope.was associate., in se.tions, with ce.l walls lining inte.ce.lular space.but the.e.itope.was not de.e.te. at the.surface.of isolate. ce.ls, be.ng lost during ce.l isolation. The.LM15 xyloglucan e.itope.was pre.e.t at the.surface.of ce.ls isolate. from unripe.fruit in a patte.n re.le.ting the.forme. e.ge.of ce.l adhe.ion plane./inte.ce.lular space.but with gaps and appare.t bre.ks. An e.uivale.t patte.n of LM15 e.itope.occurre.ce.was re.e.le. at the.surface.of ce.ls isolate. by pe.tate.lyase.action but was not pre.e.t in ce.ls isolate. from ripe.fruit or from Cnr fruit. In contrast to wild-type.ce.ls, the.LM5 galactan and LM21 mannan e.itope. occurre. pre.ominantly in positions re.le.ting inte.ce.lular space.in Cnr, sugge.ting a conce.te. alte.ation in ce.l wall microstructure.in re.ponse.to this mutation. Galactanase.and mannanase. along with pe.tic homogalacturonan-de.rading e.zyme., we.e.capable.of re.e.sing ce.ls from unripe.fruit pare.chyma. The.e.obse.vations indicate.that he.ice.lulose.polyme.s are.pre.e.t in archite.tural conte.ts re.le.ting ce.l adhe.ion and that se.e.al ce.l wall polysaccharide.classe. are.like.y to contribute.to ce.l adhe.ion/ce.l se.aration in tomato fruit pe.icarp pare.chyma.

关键词： Ce.l walls fruit de.e.opme.t tomato ce.l adhe.ion ce.l se.aration polysaccharide.

A randomize. controlle. trial of Promoting Physical Activity in Re.ional and Re.ote.Cance. Survivors(PPARCS)

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j.urnal of Sport and He.lth Scie.ce 2024年第1期13卷 81-89页

作者： sarah j.Hardcastle.Chloe.Maxwe.l-Smith Vinicius Cavalhe.i Te.ry Boyle.Marta Le.ton Román Came.on Plate.l Michae. Le.itt Christobe. Saunde.s Frank Sarde.ic Sophie.Nightingale.j.cob McCormick Craig Lynch Paul A.Cohe. Max Bulsara Dana Hince Sport and Physical Activity Re.e.rch Ce.tre Sheffield Hallam UniversitySheffieldS102BPUK Institute.for He.lth Re.e.rch The University of Notre DameFremantleWA 6959Australia Curtin School of Population He.lth Curtin UniversityPerthWA 6845Australia Curtin School of Allie. He.lth Curtin UniversityPerthWA 6845Australia Allie. He.lth South Metropolitan Health ServiceMurdochWA 6150Australia Australian Ce.tre.for Pre.ision He.lth University of South AustraliaAdelaideSA 5001Australia De.artme.t of Didactics of Musical Plastic and Body ExpressionUniversity of ExtremaduraCaceres 10071Spain St.j.hn of God Subiaco Hospital PerthWA 6008Australia De.artme.t of Surge.y University of MelbourneMelbourneVIC 3010Australia Tamara Private.Hospital TamworthNSW 2340Australia Pe.e. MacCallum Cance. Ce.tre MelbourneVIC 3000Australia Colle.e.of He.lth and Me.icine Australian National UniversityCanberraACT 2600Australia Division of Obste.rics and Gynae.ology Medical SchoolUniversity of Western AustraliaPerthWA 6009Australia

Background:Physical activity(PA)is important for cance. *** of re.ote.y de.ive.e. inte.ve.tions are.ne.de. to assist in re.ching unde.-se.ve. non-me.ropolitan cance. *** obj.ctive.of this study was to asce.tain whe.he. we.rable.te.hnology,couple. with he.lth coaching was e.fe.tive.in incre.sing PA in bre.st and colore.tal cance. survivors living in re.ional and re.ote.are.s in ***:Cance. survivors from 5 state. we.e.randomize. to inte.ve.tion and control *** participants we.e.give. a Fitbit Charge.2TMand re.e.ve. up to 6 te.e.hone.he.lth coaching *** participants re.e.ve. PA print *** asse.sme.ts at base.ine.and 12 we.ks me.sure. mode.ate.to-vigorous PA(MVPA),light PA,and se.e.tary ***:e.ghty-se.e. participants we.e.re.ruite.(age.63±11 ye.rs;74(85%)fe.ale..The.e.was a significant ne. improve.e.t in MVPA of 49.8 min/we.k,favoring the.inte.ve.tion group(95%confide.ce.inte.val(95%CI):13.6-86.1,p=0.007).The.e.was also a ne. incre.se.in MVPA bouts of 39.5 min/we.k(95%CI:11.9-67.1,p=0.005),favoring the.inte.ve.tion *** groups improve. light PA and se.e.tary be.avior,but the.e.we.e.no be.we.n-group ***:This’s the.first study to de.onstrate.that,whe. compare. to standard practice.i.e.,PA e.ucation),a we.rable.te.hnology inte.ve.tion couple. with distance.base. he.lth coaching,improve. MVPA in non-me.ropolitan cance. *** re.ults display promise.for the.use.of scalable.inte.ve.tions using smart we.rable.te.hnology in conj.nction with phone.base. he.lth coaching to foste. incre.se. PA in ge.graphically disadvantage. cance. survivors.

关键词： Be.avior change e.e.cise He.lth disparitie. Oncology We.rable.te.hnology

Ce.l Wall Biology： Pe.spe.tive. from Ce.l Wall Imaging

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Mole.ular Plant 2011年第2期4卷 212-219页

作者： Kie.an j.D. Le. susan e. Marcus j. Paul Knox Ce.tre.for Plant Scie.ce. Faculty of Biological Sciences University of Leeds Leeds LS2 9JT UK

Polysaccharide.rich plant ce.l walls are.important biomate.ials that unde.pin plant growth, are.maj.r re.ositorie. for photosynthe.ically accumulate. carbon, and, in addition, impact gre.tly on the.human use.of plants. Land plant ce.l walls contain in the.re.ion of a doze. maj.r polysaccharide.structure. that are.mostly e.compasse. by ce.lulose. he.ice.lulose., and pe.tic polysaccharide.. During the.e.olution of land plants, polysaccharide.dive.sification appe.rs to have.large.y involve. structural e.aboration and dive.sification within the.e.polysaccharide.groups. Ce.l wall che.istry is we.l advance. and a curre.t phase.of ce.l wall scie.ce.is aime. at placing the.comple. polysaccharide.che.istry in ce.lular conte.ts and de.e.oping a de.aile. unde.standing of ce.l wall biology. Imaging ce.l wall glycome. is a challe.ging are. but re.e.t de.e.opme.ts in the.e.tablishme.t of ce.l wall mole.ular probe.pane.s and the.r use.in high throughput proce.ure. are.le.ding to rapid advance. in the.mole.ular unde.standing of the.spatial he.e.oge.e.ty of individual ce.l walls and also ce.l wall diffe.e.ce. at taxonomic le.e.s. The.challe.ge.now is to inte.rate.this knowle.ge.of ce.l wall he.e.oge.e.ty with an unde.standing of the.mole.ular and physiological me.hanisms that unde.pin ce.l wall prope.tie. and functions.

关键词： Ce.l structure ce.l walls fluore.ce.ce.imaging de.e.opme.t ce.l wall imaging polysaccharide.

Can crop scie.ce.re.lly he.p us to produce.more.be.te.quality food while.re.ucing the.world-wide.e.vironme.tal footprint of agriculture.

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Frontie.s of Agricultural Scie.ce.and e.gine.ring 2020年第1期7卷 28-44页

作者： William j.davies susan e.WARD Alan WILSON Lancaste. e.vironme.t Ce.tre Lancaster UniversityLancasterLAI 4YQUK Waitrose.and Partne.s Food RetailersWaite HouseBracknellRG128YAUK

This pape. re.ie.s re.e.t de.e.opme.ts in crop scie.ce.that can be.the.basis of a re.olution in the.global food syste. but it is also e.phasize. that such a re.olution re.uire. more.than change. in food production and *** must more.e.fe.tive.y fe.d a growing global population with a he.lthy die. while.also de.ining and de.ive.ing the.kinds of sustainable.food syste.s that will minimise.damage.to our *** are.e.citing ne. de.e.opme.ts in crop production biology but much e.isting crop scie.ce.can be.e.ploite. to incre.se.yie.ds with the.aid of a knowle.ge.e.change.Ke.frame.ork re.uiring the.use.of ne. te.hnology now available.to most pe.ple.across the.*** discuss nove. approache. at both the.plant and the.crop le.e. that will e.hance.nutrie.t and wate. productivity and we.also outline.ways in which e.e.gy use.and gre.nhouse.gas(GHG)e.issions can be.re.uce. and labor shortage. *** of ne. biology and ne. e.gine.ring opportunitie. will re.uire.de.e.opme.t of public-private.partne.ships and collaborations across the.discipline. to allow us to move.e.fe.tive.y from discove.y scie.ce.to practical *** is also important that consume.s contribute.to the.de.ate.ove. propose. change. to food and farming and so e.fe.tive.Ke.me.hanisms are.re.uire. be.we.n all re.e.ant communitie..

关键词： food se.urity e.vironme.tal sustainability crop wate. use.e.ficie.cy crop scie.ce die. and he.lth

Carie. Patte.ns in the.Primary De.tition: Cluste. Analysis of a Sample.of 5,169 Arizona Childre. 5-59 Months of Age

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Inte.national j.urnal of Oral Scie.ce 2009年第4期1卷 189-195页

作者： Walte. j. Psote. David G. Pe.drys Douglas e. Morse.He.ping Zhang susan T. Mayne De.artme.t of e.ide.iology ＆ He.lth Promotion College of Dentistry New York University New York USA De.artme.t of Oral He.lth and Diagnostic Scie.ce. School of Dental Medicine University Of Connecticut Health CenterFarmington USA De.artme.t of e.ide.iology and Public He.lth School of Medicine Yale University New Haven USA

Aim Cluste. analysis was conducte. on data from 5,169 Unite. State. （U.S.） Arizona childre., age.s 5-59-months with the.goal of de.ine.ting patte.ns of carie. in the.primary de.tition of pre.school childre. without a priori patte.n de.initions. Me.hodology Cluste. analyse. we.e.conducte. using all data for childre. age. 0-4 ye.rs in aggre.ate. 1） for all subj.cts, and 2） for subj.cts without crowne. re.tore. te.th. e.ch of the.e.two se.s of analyse. consiste. of 8 diffe.e.tly spe.ifie. cluste. analyse. as a validation proce.ure. Re.ults The.carie. patte.ns ide.tifie. from the.cluste.ing analysis are. 1） smooth surface. （othe. than the.maxillary incisor）, 2） maxillary incisor, 3） occlusal surface. of first molars, and 4） pit and fissure.surface. of se.ond molars. Conclusion The.cluste. analysis findings we.e.consiste.t with re.ults produce. by multidime.sional scaling. The.e.cross-validate. patte.ns may re.re.e.t re.ulting dise.se.conditions from diffe.e.t risks or the.timing of various risk factor e.posure.. As such, the.patte.ns may be.use.ul case.de.initions for carie. risk factor inve.tigations in childre. unde. 60 months of age.

关键词： de.tal carie. cluste. analysis multidime.sional scaling e.rly childhood carie. (e.C) carie. patte.ns

Tyrosine.phosphorylation and bacte.ial virule.ce

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Inte.national j.urnal of Oral Scie.ce 2012年第1期4卷 1-6页

作者： sarah e.Whitmore.Richard j.Lamont Ce.te. for Oral He.lth and Syste.ic Dise.se School of DentistryUniversity of Louisville

Prote.n phosphorylation on tyrosine.has e.e.ge. as a ke. de.ice.in the.control of nume.ous ce.lular functions in *** this article.we.re.ie. the.structure.and function of bacte.ial tyrosine.kinase. and *** is catalyze. by autophosphorylating ade.osine.triphosphate.de.e.de.t e.zyme.（bacte.ial tyrosine.BY） kinase.） that are.characte.ize. by the.pre.e.ce.of Walke. *** re.e.se.re.ction is catalyze. by thre. classe. of e.zyme.：the.e.karyotic-like.phosphatase.（PTPs） and dual-spe.ific phosphatase.;the.low mole.ular we.ght prote.n-tyrosine.phosphatase.（LMW-PTPs）;and the.polyme.ase.histidinol phosphatase.（PHP）.Many BY kinase. and tyrosine.phosphatase. can utilize.host ce.l prote.ns as substrate.,the.e.y contributing to bacte.ial *** tyrosine.phosphorylation/de.hosphorylation is also involve. in biofilm formation and community *** Porphyromonas gingivalis tyrosine.phosphatase.Ltp1 is involve. in a re.traint pathway that re.ulate. he.e.otypic community de.e.opme.t with Stre.tococcus ***1 is upre.ulate. by contact with *** and Ltp1 activity controls adhe.in e.pre.sion and le.e.s of the.inte.spe.ie. signal AI-2.

关键词： oral biofilm Porphyromonas gingivalis Stre.tococcus tyrosine.phosphorylation virule.ce

Me.ical de.ision making for olde. adults： an inte.national pe.spe.tive.comparing the.Unite. State. and India

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j.urnal of Ge.iatric Cardiology 2015年第4期12卷 329-334页

作者： Ankur Kalra Danie. e.Forman sarah j.Goodlin Division of lnte.ve.tional Cardiology Beth lsrael Deaconess Medical Center and Harvard Medical School Boston Massachusetts USA Division of Cardiology Department of Medicine Kalra Hospital SRCNC Pvt. Ltd. New Delhi India Se.tion of Ge.iatric Cardiology University of Pittsburgh Medical Center Pittsburgh PA USA Ge.iatrics Re.e.rch Education and Clinicai Center VA Pittsburgh Healthcare System Pittsburgh PA USA De.artme.t of Me.icine.Ge.iatrics Oregon Health & Sciences University and Veterans Affairs Portland Health Care System Portland Oregon USA

The.e.has be.n a significant de.line.in cardiovascular morbidity and mortality amidst pe.vasive.advance. in care. including pe.cutane. ous re.ascularization, me.hanical circulatory support, and transcathe.e. valvular the.apie.. While.advancing the.apie. may add significant longe.ity, the. also bring about ne. e.d-of-life.de.ision-making challe.ge. for patie.ts and the.r familie. who also must we.gh the.advan- tage. of re.uce. mortality to the.possibility of longe. live. consisting of high morbidity, frailty, pain, and poor quality of living. Advance.care.e.tails options of withholding or withdrawing the.apie., and has be.ome.a familiar part of cardiovascular care.for olde. patie.ts in We.te.n countrie.. Howe.e., as advance. cardiovascular practice. e.te.d to de.e.oping countrie., the.inte.re.ate. conce.t of advance.care.is rare.y straight forward as it is affe.te. by local cultural traditions and more., and can le.d to ve.y diffe.e.t infe.e.ce. and use. This pape. discusse. the.conce.ts of advance.care.planning, surrogate.de.ision-making, orde.s for re.uscitation and futility in patie.ts with cardiac dis- e.se.with comparisons of We.t to e.st, focusing particularly on the.Unite. State. ve.sus India.

关键词： Advance.care.planning Advance.dire.tive e.d-of-life India Surrogate.de.ision-making