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Te.racycline.inducible.prote.n e.pre.sion in pancre.tic cance. ce.ls: e.fe.ts of CapG ove.e.pre.sion

丛书名：汽车碰撞修复协会(I-CAR)培训教材

1998年

作者：（美）詹姆斯 e.杜菲（Jame. e.duffy）李杰等译

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World Journal of Gastroe.te.ology 2011年第15期17卷 1947-1960页

作者： sarah Tonack Sabina Pate. Me.di Jalali Taoufik Ne.jadi Rosalind e.Je.kins Christophe. Goldring John Ne.ptole.os e.thne.Coste.lo Live.pool CR-UK Ce.tre Department of Molecular and Therapeutic Cancer MedicineUniversity of Liverpool Liverpool L69 3GA United Kingdom MRC Ce.tre.forDrug Safe.y Scie.ce Department of Pharmacology and Therapeutics School of Biomedical Sciences University of Liverpool L69 3GA United Kingdom National Institute.for He.lth Re.e.rch Pancre.tic Biome.ical Re.e.rch Unit Liverpool L69 3GA United Kingdom

AIM: To e.tablish stable.te.racycline.inducible.pancre.tic cance. ce.l line.. Me.HODS: Suit-2, MiaPaca-2, and Panc-1 ce.ls we.e.transfe.te. with a se.ond ge.e.ation re.e.se.te.racycline.controlle. transactivator prote.n (rtTA2S-M2), unde. the.control of e.the. a cytome.alovirus (CMV) or a chicke. β-actin promote., and the.re.ulting clone. we.e.***: Use.of the.chicke. (β-actin) promote. prove. supe.ior for both the.production and mainte.ance.of doxycycline.inducible.ce.l line.. The.syste. prove. ve.satile. e.abling transie.t inducible.e.pre.sion of a varie.y of ge.e., including GST-P, CYP2e., S100A6, and the.actin capping prote.n, CapG. To de.e.mine.the.physiological utility of this syste. in pancre.tic cance. ce.ls, stable.inducible.CapG e.pre.sors we.e.e.tablishe.. Ove.e.pre.se. CapG was localise. to the.cytoplasm and the.nucle.r me.brane. but was not obse.ve. in the.nucle.s. High CapG le.e.s we.e.associate. with e.hance. motility, but not with change. to the.ce.l cycle. or ce.lular prolife.ation. In CapG-ove.e.pre.sing ce.ls, the.le.e.s and phosphorylation status of othe. actin-moduating prote.ns (Cofilin and e.rin/Radixin) we.e.not alte.e.. Howe.e., pre.iminary analyse. sugge.t that the.le.e.s of othe. ce.lular prote.ns, such as ornithine.aminotransfe.ase.and e.olase. are.alte.e. upon CapG induction. CONCLUSION: We.have.ge.e.ate. pancre.tic-cance. de.ive. ce.l line. in which ge.e.e.pre.sion is fully controllable.

关键词： Pancre.tic cance. ce.ls Te.racycline.inducible CapG Suit-2 Panc-1 MiaPaCa-2

Lymphocyte.phe.otype. in wild-caught rats sugge.t pote.tial me.hanisms unde.lying incre.se. immune.se.sitivity in post-industrial e.vironme.ts

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Ce.lular & Mole.ular Immunology 2012年第2期9卷 163-174页

作者： Ashle. M Trama Zoie.e.Holzkne.ht Anitra D Thomas Kue.-Ying Su Se.n M Le. e.ily e.Foltz sarah e.Pe.kins Shu S Lin William Parke. De.artme.t of Surge.y Duke University Medical Center Durham NC 27710 USA Cardiff School of Bioscie.ce. Cardiff CFIO 3AX UK De.artme.t of Immunology Duke University Medical Center Durham NC 27710 USA

The.immune.syste.s of wild rats and of laboratory rats can be.n utilize. as mode.s of the.human immune.syste. in pre.industrial and post-industrial socie.ie., re.pe.tive.y. In this study, lymphocyte.phe.otype. in wild rats we.e.broadly characte.ize., and the.re.ults we.e.compare. to those.obtaine. by us and by othe.s using ce.ls de.ive. from various strains of laboratory rats. Although not e.pe.te., the.production of re.ulatory T ce.ls was not appare.tly diffe.e.t in wild rats compare. to laboratory rats. On the.othe. hand, diffe.e.ce. in e.pre.sion of marke.s involve. in comple.e.t re.ulation, adhe.ion, signaling and maturation sugge.t incre.se. comple.e.t re.ulation and de.re.se. se.sitivity in wild-caught rats compare. to laboratory rats, and point toward comple. diffe.e.ce. be.we.n the.maturation of T ce.ls. The.re.ults pote.tially le.d insight into the.pathoge.e.is of post-industrial e.ide.ics of alle.gy and autoimmune.dise.se.

关键词： alle.gy autoimmunity biome hygie.e immune.re.ulation

Lions, hye.as and mobs （oh my!）

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Curre.t Zoology 2017年第3期63卷 313-322页

作者： Ke.na D.S. Le.MANN Tracy M. MONTGOMe.Y sarah M. MACLACHLAN Je.na M. PARKe.C livia S. SPAGNUOLO Ke.se. J. VANDe.e.e.ING Patrick S. BILLS Kay e. HOLe.AMP De.artme.t of Inte.rative.Biology Michigan State University 288 Farm Lane Room 203 East Lansing MI 48824 USA e.ology Evolutionary Biology and Behavior Michigan State University 293 Farm Lane Room 103 East Lansing MI 48824 USA De.artme.t of Fish Wildlife and Conservation Biology Colorado State University 1474 Campus Delivery Fort Collins CO 80523 USA Conse.vation e.ology and e.vironme.tal Informatics School of Natural Resources and Environment University of Michigan 440 Church St. Ann Arbor MI 48109 USA Institute.for Cybe. e.able. Re.e.rch Michigan State University Biomedical & Physical Sciences Building 567 Wilson Road Room 1440 East Lansing MI 48824 USA

Unde.standing the.factors that facilitate.the.e.e.ge.ce.of coope.ation among organisms is ce.tral to the.study of social e.olution. Spotte. hye.as Crocuta crocuta fre.ue.tly coope.ate.to mob lions Panthe.a le., approaching the.lions as a tightknit group while.vocalizing loudly in an atte.pt to ove.whe.m the. and drive.the. away. Whe.e.s coope.ative.mobbing be.avior has be.n we.l docume.te. in birds and some.mammals, to our knowle.ge.it has ne.e. be.n de.cribe. during inte.actions be.we.n 2 ape. pre.ators. Using a 27-ye.r datase., we.characte.ize.lion-hye.a e.coun- te.s, asse.s rate. of mobbing be.avior obse.ve. during the.e.inte.actions, and inquire.whe.he. mobbing re.ults in succe.sful acquisition of food. Lions and hye.as inte.acte. most ofte. at fre.h kills, e.pe.ially as pre. size.and the.numbe. of hye.as pre.e.t incre.se.. Posse.sion of food at the.be.inning of an inte.action positive.y affe.te. re.e.tion of that food by e.ch pre.ator spe.ie.. The.pre.e.ce.of male.lions incre.se. the.probability of an inte.spe.ific inte.action but de.re.se. the.like.ihood of hye.as obtaining or re.aining posse.sion of the.food. Hye.a mobbing rate. we.e.highe.t at fre.h kills, but lowe. whe. adult male.lions we.e.pre.e.t. The.occurre.ce.of mobbing was pre.icte. by an incre.se.in the.numbe. of hye.as pre.e.t. Whe.he. or not mobbing re.ulte. in acquisition of food from lions was pre.icte. by an incre.se.in the.numbe. of mobs forme. by the.hye.as pre.e.t, sugge.ting that coope.ation among hye.as e.hance. the.r fitne.s.

关键词： compe.ition coope.ation hye.a lion mobbing sociality.

Infe.tion doe. not incre.se.long-te.m mortality in patie.ts with acute.se.e.e.alcoholic he.atitis tre.te. with corticoste.oids

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World Journal of Gastroe.te.ology 2017年第11期23卷 2052-2059页

作者： Ashwin D Dhanda Ashish Sinha Vicky Hunt sarah Sale.m Matthe. e.Cramp Pe.e. L Collins Institute.of Translational and Stratifie. Me.icine Plymouth University Peninsula Schools of Medicine and Dentistry South We.t Live. Unit Plymouth Hospitals NHS Trust De.artme.t of Live. Me.icine University Hospitals Bristol NHS Foundation Trust

AIM To de.e.mine.whe.he. infe.tion in patie.ts with acute.se.e.e.alcoholic he.atitis(AAH) tre.te. with corticoste.oids is associate. with incre.se. *** Conse.utive.patie.ts with AAH we.e.tre.te. with ste.oids and re.ruite. to the.study. Clinically re.e.ant infe.tions(body te.pe.ature.> 38 ℃ or e.than 4 h, ascitic ne.trophil count > 0.25 ×109/L, consolidation on che.t radiograph or clinically re.e.ant positive.microbiological culture.of bodily fluid) we.e.re.orde. prospe.tive.y. Clinical and laboratory parame.e.s we.e.re.orde. and survival at 90 d and 6 mo was de.e.mine.. Univariate.analysis of factors associate. with 90-d mortality was pe.forme. and significant variable. include. in a multivariate.*** Se.e.ty-two patie.ts we.e.include. in the.final analysis(me.n age.47.9 ye.rs, 26% fe.ale. me.n discriminant function 53.0). Ove.all mortality in the.group occurre. in 15(21%), 23(32%) and 31(43%) at day 28, day 90 and 1 ye.r re.pe.tive.y. 36(50%) had a clinically re.e.ant infe.tion during the.r hospitalisation(23 afte. initiation of ste.oids). The.me.ian time.to de.e.opme.t of incide.t infe.tion afte. comme.ce.e.t of ste.oids was 10 d. The.commone.t site.of infe.tion was ascite.(31%) and bacte.ae.ia(31%) followe. by urinary tract(19%) and re.piratory tract(8%). Forty-one.se.arate.organisms we.e.isolate. in 33 patie.ts; the.most fre.ue.t ge.us was e.che.ichia(22%) and e.te.ococcus(20%). Infe.tion was not associate. with 90-d or 1 ye.r mortality but was associate. with highe. cre.tinine. mode. for e.d-stage.live. dise.se.and Lille.score. Base.ine.ure. was the.only inde.e.de.t pre.ictor of 90-d *** Clinically re.e.ant infe.tions are.common in patie.ts with AAH but are.not associate. with incre.se. 90-d or 1 ye.r mortality.

关键词： Alcoholic he.atitis e.che.ichia Infe.tion Lille.score Corticoste.oids

Pe.iope.ative.Use.of Me.hotre.ate.and Tumor Ne.rosis Factor α Inhibitors Combination The.apy Is Not Like.y to Incre.se.Post-Ope.ative.Infe.tion Rate.in the.National Ve.e.ans He.lth Administration Administrative.Database.

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Ope. Journal of Rhe.matology and Autoimmune.Dise.se. 2019年第1期9卷 1-13页

作者： Hsin-Hsuan Juo Ande.s Pe.k sarah e. Monse.l Be.nard Ng De.artme.t of Me.icine Division of Rheumatology University of Washington VA Puget Sound Healthcare System Seattle USA The.Se.ttle.Arthritis Clinic University of Washington Medicine Northwest Hospital Seattle USA De.artme.t of Biostatistics University of Washington Seattle USA

Obje.tive. The.aim of the.study is to asse.s the.risk of post-ope.ative.outcome.in rhe.matoid arthritis (RA) patie.ts continuing ve.sus stopping combination the.apy of me.hotre.ate.(MTX) and hydroxychloroquine.(HCQ) or tumor ne.rosis factor α inhibitors (TNF) prior to surge.y. Me.hods: Using the.Unite. State. Ve.e.ans Affairs (VA) database., we.ide.tifie. surgical proce.ure. in a 17-ye.r cohort of RA patie.ts. Among those.patie.ts, those.on MTX + HCQ or MTX + TNF we.e.ide.tifie.. Post-ope.ative.outcome.variable. include.infe.tion, le.gth of post-ope.ative.hospital stay and de.th. Re.ults: We.ide.tifie. a total of 29,708 surge.ie. in RA patie.ts. Among the., we.ide.tifie. the.most re.e.t e.e.tive.surge.ie. without pre.ope.ative.infe.tion in 16,174 patie.ts. The.e.we.e.783 and 550 patie.ts on MTX + HCQ and MTX + TNF, re.pe.tive.y. The.rate. of post-op infe.tion we.e.5% and 4% for the.MTX + HCQ and MTX + TNF continuing me.ication groups, re.pe.tive.y, similar to the.ge.e.al RA population (5%). Se.sitivity analyse. at various time.points of discontinuation combination the.apie. prior to surge.y did not show significant change.in te.ms of infe.tion. Conclusions: The.pre.ale.ce.of adve.se.outcome.is low. The.proportion of post-ope.ative.infe.tion in continuing and discontinuing me.icine.groups is similar for both MTX + HCQ and MTX + TNF. While.we.we.e.unable.to formally compare.proportions of post-ope.ative.infe.tion among the.two groups, the.e.pre.iminary findings do not support the.hypothe.is that continuing e.the. MTX + TNF or MTX + HCQ combination during pe.iope.ative.pe.iod incre.se. post-ope.ative.infe.tion compare. with discontinuation prior to the.apy.

关键词： Rhe.matoid Arthritis Pe.iope.ative Manage.e.t Outcome Me.hotre.ate and Tumor Ne.rosis Factor Combination The.apy

Burn He.angioma (BH) (Scalde. Pyoge.ic Granuloma) ve.sus Infantile.He.angioma: Re.ort of Six Case. of BH and Its e.fe.tive.The.apy with Oral Propranolol

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Journal of Cosme.ics, De.matological Scie.ce. and Applications 2017年第3期7卷 229-244页

作者： Khalifa e. Sharquie.Adil A. Noaimi sarah K. Radhi De.artme.t of De.matology College of Medicine University of Baghdad Iraqi and Arab Board for Dermatology & Venereology Baghdad Teaching Hospital Medical City Baghdad Iraq De.artme.t of De.matology Baghdad Teaching Hospital Medical City Baghdad Iraq

Infantile.he.angioma and burn he.angioma have.many similaritie. in clinical picture., pathology and tre.tme.t. As infantile.he.angioma appe.rs usually afte. birth and the. rapidly grow within fe. months and the. a statue.state.and the. involute. within fe. ye.rs while.burn he.angioma so calle. burn pyoge.ic granuloma usually appe.rs within days afte. burn with liquid and grow rapidly into many giant angiomatous masse. and the. afte. short time.usually we.ks or months will involute.in more.than 37.5% of case.. He.ce.burn he.angioma and infantile.he.angioma sharing many similar fe.ture. as both are.angiomatous with dramatic rapid prolife.ation of blood ve.se.s that followe. by involution but with diffe.e.t time.pe.iods and both carry CD133 and CD34 for infantile.he.angioma and CD34 for burn he.angioma. Also infantile.he.angioma rapidly re.ponds to syste.ic propranolol and similarly do in case. of burn he.angioma. Accordingly it is more.be.te. scie.tifically to call scalde. pyoge.ic granuloma burn he.angioma. The.obje.tive.of the.pre.e.t re.ort is to re.ie. the.e.conditions and do comparison be.we.n the. and also to re.ord 6 case. of burn he.angioma and its e.fe.tive.the.apy with oral propranolol.

关键词： Burn He.angioma Infantile He.angioma Oral Propranolol

Fusion of spatiote.poral and the.atic fe.ture. of te.tual data for animal dise.se.surve.llance

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Information Proce.sing in Agriculture 2023年第3期10卷 347-360页

作者： sarah Vale.tin Re.aud Lance.ot Mathie. Roche CIRAD F-34398 MontpellierFrance ASTRe Univ MontpellierCIRADINRAEMontpellierFrance Te.IS Univ MontpellierAgroParisTechCIRADCNRSINRAEMontpellierFrance De.arte.e.t de.Biologie Universite de SherbrookeSherbrookeQuebecCanada

Se.e.al inte.ne.-base. surve.llance.syste.s have.be.n cre.te. to monitor the.we. for animal he.lth *** syste.s colle.t a large.amount of ne.s de.ling with outbre.ks re.ate. to animal *** ide.tifying ne.s article. that de.cribe.the.same.outbre.k e.e.t is a ke. ste. to quickly de.e.t re.e.ant e.ide.iological information while.alle.iating manual curation of ne.s *** pape. addre.se. the.task of re.rie.ing ne.s article. that are.re.ate. in e.ide.iological *** tackle.this issue.using te.t mining and fe.ture.fusion *** main obje.tive.of this pape. is to ide.tify a te.tual re.re.e.tation in which two article. that share.the.same.e.ide.iological conte.t are.*** compare. two type. of re.re.e.tations(i.e.,fe.ture.)to re.re.e.t the.docume.ts:(i)morphosyntactic fe.ture.(i.e.,se.e.tion and transformation of all te.ms from the.ne.s,base. on classical te.tual proce.sing ste.s)and(ii)le.icose.antic fe.ture.(i.e.,se.e.tion,transformation and fusion of e.ide.iological te.ms including dise.se.,hosts,locations and date.).We.compare. two type. of te.m we.ghing(i.e.,Boole.n and TF-IDF)for both *** combine.and transform le.icose.antic fe.ture.,we.compare. two data fusion te.hnique.(i.e.,e.rly fusion and late.fusion)and the.e.fe.t of fe.ture. ge.e.alisation,while.e.aluating the.re.ative.importance.of e.ch type.of *** conducte. our analysis using a corpus compose. of a subse. of ne.s article. in e.glish re.ate. to animal dise.se.*** re.ults showe. that the.combination of re.e.ant le.icose.antic(e.ide.iological)fe.ture. using fusion me.hods improve. classical morphosyntactic re.re.e.tation in the.conte.t of dise.se.re.ate. ne.s *** le.icose.antic re.re.e.tation base. on TF-IDF and fe.ture.ge.e.alisation(F-me.sure.0.92,r-pre.ision=0.58)outpe.forme. the.morphosyntactic re.re.e.tation(F-me.sure.0.89,r-pre.ision=0.45),while.re.ucing the.fe.ture. *** the.fe.ture. into lowe. granular

关键词： Animal dise.se.surve.llance Te.t mining Ranking Fusion

Asse.sing the.Impacts of Climate.Change.and Variability on Maize.(Ze. mays) Yie.d ove. Tanzania

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Atmosphe.ic and Climate.Scie.ce. 2021年第3期11卷 569-588页

作者： Amina Abdalla Lukali sarah e. Osima Yunshe.g Lou Kombo Hamad Kai Tanzania Me.e.rological Authority (TMA) Kisauni Zanzibar TMA Ubungo Plaza Dar es Salaam Tanzania De.e.tme.t of Applie. Me.e.rology Nanjing University of Information Science and Technology Nanjing China

This study aime. at unde.standing the.impacts of the.se.sonal hydroclimatic variable. on maize.yie.d and de.e.oping of statistical crop mode. for future.maize.yie.d pre.iction ove. Tanzania. The.food se.urity of the.country is basically de.e.mine. by availability of maize. Unfortunate.y, agriculture.ove. the.country is mainly rain fe. he.ce.highly e.dange.e. by the.de.rime.tal conse.ue.ce. of climate.change.and variability. Obse.ve. climate.data was acquire. from Tanzania Me.e.rological Authority (TMA) and Maize.yie.d data from Food and Agriculture.Organization (FAO). The.study use. the.Mann-Ke.dall te.t and Se.’s slope.for tre.d and magnitude.de.e.tion in minimum, maximum te.pe.ature.and rainfall at the.95% confide.ce.le.e.. The.re.ults have.shown that rainfall is de.re.sing ove. the.country and e.pe.ially during the.growing se.son but incre.sing during short rains se.son. Characte.istics of se.sonal climatic variable., cycle.during growing pe.iod we.e.linke. to maize.yie.d, and high (low) yie.d was re.orte. during anomalous we. (dry) growing se.sons. This portrays se.sonal de.e.de.ce.of maize.production. Statistical crop mode. was built by aggre.ating spatial re.ions that have.statistically significant re.ation with maize.yie.d. Re.ults show that, 58.8% of yie.d variance.is linke. to se.sonal hydroclimate.variability. Rainfall e.e.ge. as the.dominant pre.ictor variable.for maize.yie.d since.it accounts for 44.1% of yie.d variance. The.mode.e. and obse.ve. yie.ds e.hibit statistically substantial re.ationship (r = 0.78) he.ce.de.icting high cre.e.ce.of the.built statistical crop mode.. Also, the.re.ults re.e.le. a de.re.sing tre.d in Maize.yie.d with furthe. Le.sing tre.d is proje.te. to proce.d in the.future. This calls for adaptation and imple.e.tation of appropriate.re.ional me.sure. to raise.maize.production in orde. to fe.d the.burge.ning human population amidst climate.change.

关键词： Rainfall Te.pe.ature Climate.Variability Maize.Yie.d Maize.Yie.d Proje.tions Tanzania

Colle.ting Ophiocordyce.s sine.sis:an e.e.ging live.ihood strate.y in the.Garhwal,Indian Himalaya

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Journal of Mountain Scie.ce 2017年第2期14卷 390-402页

作者： Laura CAPLINS sarah J.HALVORSON De.artme.t of Socie.y and Conse.vation College of Forestry and ConservationUniversity of MontanaMissoulaMontana59812USA De.artme.t of Ge.graphy College of Arts and SciencesUniversity of MontanaMissoulaMontana59812USA

In the.Garhwal of Uttarakhand, India, the.Bhotiya, an e.hnically and culturally distinct tribal group, we.e.historically e.gage. in se.sonal migration(i.e. transhumance. to take.advantage.of scarce.mountain re.ource. and trade.re.ations with Tibe.. This live.ihood practice.has all but *** are.adapting to the.e.changing circumstance. by e.gaging in the.colle.tion and sale.of the.valuable.alpine.me.icinal fungus Ophiocordyce.s sine.sis, wide.y known as Cordyce.s. The.colle.tion of this fungus has e.plode., e.e.ging as a lucrative.ye. high-risk live.ihood strate.y for many Bhotiya *** Bhotiyas' historic he.ding and trade.base. inte.actions and knowle.ge.of the.e.alpine.e.vironme.ts whe.e.Cordyce.s are.found unique.y positions the. to acce.s this valuable.biological re.ource. e.se.he.e.in the.Himalayan re.ion, some.house.olds are.e.rning as much as two-thirds of the.r income.from the.colle.tion of Cordyce.s; in China Cordyce.s is now liste. as an e.dange.e. spe.ie. due.to inte.se.ove.-e.ploitation in the.Tibe.an *** pape. se.ks to fill the.void in the.scie.tific lite.ature.on the.social, e.ological and e.onomic aspe.ts of the.e.e.ging Cordyce.s trade.in the.Garhwal. Our study inve.tigate. the.socio-spatial dime.sions of Cordyce.s colle.tion in the.high alpine.me.dows. We.docume.t how a fusion of local knowle.ge.and practice.with alpine.mountain syste.s has se.ve. to re.nvigorate.the.e.onomic inte.rity of mountain communitie. at a time.of rapid socioe.onomic change.and to re.magine.a ne. re.ationship be.we.n alpine.re.ource. and community *** article.offe.s sugge.tions to addre.s the.sustainability of both Cordyce.s colle.tion and live.ihood activitie. which hinge.on this fungus population. We.find a ne.d for(1) community-base. conse.vation me.sure. that are.roote. in(2) se.ure.re.ource.acce.s rights for local communitie. to continue.sustainable.colle.tion and sale.of Cordyce.s and(3) participatory-and scie.ce.base. proc

关键词： Cordyce.s ( Ophiocordyce.s sine.sis) Garhwal Himalaya Live.ihood Alpine.me.dows Bhotiya Sustainability