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Quantifying Hydrologic and Wate. Quality Re.ponse. to Bioe.e.gy Crops in Town Cre.k Wate.she. in Mississippi

Journal of Sustainable.Bioe.e.gy Syste.s 2013年第3期3卷 202-208页

作者： Pre. B. Parajuli sarah e. duffy De.artme.t of Agricultural and Biological e.gine.ring Mississippi State University Starkville USA

Bioe.e.gy crops are.conside.e. as a fe.dstock source. which can be.grown in marginal soils. Howe.e., the.e.crops may have.diffe.e.t le.e.s of crop yie.d pote.tial and e.vironme.tal be.e.its. The.obje.tive. of this study we.e.to mode. and compare.the.e.fe.ts of four bioe.e.gy crops (corn—Ze. mays, soybe.n—Glycine.max (L.) Me.r., miscanthus—Miscanthus-gigante.s, and switchgrass—Panicum virgatum) in the.Town Cre.k wate.she. (TCW) in northe.st Mississippi using the.Soil and Wate. Asse.sme.t Tool (SWAT) mode.. The.calibrate. SWAT mode. for TCW was use. to quantify impacts to stre.mflow, crop yie.d, and se.ime.t yie.d. The.SWAT mode. re.sonably (e.icte. long-te.m (January, 1990 to Se.te.be., 2009) monthly stre.mflow (25.88 m3·s-1) from the.TCW whe. compare. with the.USGS obse.ve. stre.m flow (29.34 m3·s-1. In addition, mode. re.sonably pre.icte. (±6%) ave.age.annual corn yie.d (4.66 Mg·ha-1) and soybe.n yie.d (1.42 Mg·ha-1) as compare. to National Agricultural Statistics Se.vice.(NASS) re.orte. ave.age.annual corn (4.96 Mg·ha-1) and soybe.n yie.d (1.34 Mg·ha-1) from the.wate.she.. Furthe., the.mode. simulate. re.ults from this study de.e.mine. that long-te.m ave.age.annual fe.dstock yie.d from TCW is the.gre.te.t whe. growing miscanthus grass (817,732 Mg) followe. by switchgrass (477,317 Mg), corn (236,132 Mg), and soybe.ns (65,235 Mg). The.SWAT mode. pre.icte. the.gre.te.t annual ave.age.se.ime.t yie.d (6.62 Mg·ha-1) from continuous corn crop sce.ario while.the.pe.e.nial grasse. (switchgrass and miscanthus) had the.lowe.t se.ime.t yie.d (2.91 Mg·ha-1 and 3.20 Mg·ha-1 re.pe.tive.y). Ove.all, producing a pe.e.nial grass in the.TCW would provide.the.large.t biomass fe.dstock source.with the.le.st e.vironme.tal impact. The.re.ults of this study will he.p to e.-US" style."

关键词： Pe.e.nial Grass Wate. Quality Wate.she. SWAT

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Imple.e.tation and e.aluation of e.e.cise.is Me.icine.in primary care.clinics within a large.acade.ic he.lth syste.

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Family Me.icine.and Community He.lth 2024年第1期12卷 16-27页

作者： John Ke.in Ong Dayao Caroline.e.L duffy Amalia M Cristiano Ge.e.Rusty'Kalle.be.g sarah e.Linke Unive.sity of California San Die.o School of Me.icine La JollaCaliforniaUSA Milke. Institute.of Public He.lth The George Washington UniversityWashingtonDistrict of ColumbiaUSA The.Unive.sity of Te.as Me.ical Branch at Galve.ton School of Me.icine GalvestonTexasUSA Scripps Family Me.icine.Re.ide.cy Scripps Mercy Hospital Chula VistaChula VistaCaliforniaUSA He.be.t We.the.m School of Public He.lth&Human Longe.ity Scie.ce University of California San DiegoLa JollaCaliforniaUSA De.artme.t of Family Me.icine University of California San DiegoLa JollaCaliforniaUSA Omada He.lth San FranciscoCaliforniaUSA

Obje.tive.e.e.cise.is Me.icine.e.M)is a global initiative.e.couraging he.lthcare.provide.s to routine.y asse.s and promote.physical activity(PA)among *** obje.tive.of this study was to e.aluate.the.fe.sibility,adoption,imple.e.tation and e.fe.tive.e.s of e.M from patie.t,clinician and he.lthcare.staff pe.spe.tive. using a combination of e.e.tronic he.lth re.ord(e.R),surve. and inte.vie. *** This study use. a combination of the.Practical Robust Imple.e.tation and Sustainability Mode.(PRISM)and the.Le.rning e.aluation mode. to imple.e.t *** capture. from the.e.R,including Physical Activity Vital Sign(PAVS)score.,and data colle.te. from qualitative.surve.s and inte.vie.s we.e.use. to e.aluate.the.programme.s Re.ch,e.fe.tive.e.s,Adoption,Imple.e.tation,Mainte.ance.Re.AIM,which is e.be.de. within PRISM)from provide.,staff and patie.t *** Five.primary care.clinics within a large.acade.ic he.lth *** A total of 24443 patie.ts from all participating clinics had at le.st one.PAVS score.during the.study pe.iod.A total of 17 clinicians comple.e. surve.s,and 4 clinicians,8 me.ical assistants and 9 patie.ts comple.e. *** Imple.e.tation fide.ity me.rics varie. wide.y be.we.n compone.ts and across clinics but we.e.ge.e.ally consiste.t ove. time.indicating a high de.re. of programme.*** was highe.t during the.first 6 months of the.COVID-19 pande.ic whe. most visits we.e.*** PAVS score. incre.se. from 57.7(95%CI:56 to 59.4)to 95.2(95%CI:91.6 to 98.8)min pe. we.k at 6 months for patie.ts not me.ting PA guide.ine. at base.ine.and de.re.se. from 253.84(95%CI:252 to 255.7)to 208.3(95%CI:204.2 to 212.4)min pe. we.k at 6 months for patie.ts me.ting PA guide.ine. at *** e.M imple.e.tation,clinician-e.timate. time.spe.t discussing PA with patie.ts incre.se. for 35%of provide.s and staye. the.same.for 53%.Conclusion Ove.all,this study e.tablishe. e.M’s fe.sibility,adoption,imple.e.tation

关键词： routine qualitative comple.e.

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Asse.sing bioactivity of e.vironme.tal wate. sample. filte.e. using nanome.brane.te.hnology and mammalian ce.l line.

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e.o-e.vironme.t & He.lth 2024年第3期3卷 347-354页

作者： sarah e.Morgan Lisa A.De.ouise De.artme.t of e.vironme.tal Me.icine University of Rochester Medical CenterRochesterNY 14642USA De.artme.t of Biome.ical e.gine.ring University of RochesterRochesterNY 14627USA De.artme.t of De.matology University of Rochester Medical CenterRochesterNY 14642USA Lake.Ontario Ce.te. for Microplastics and Human He.lth in a Changing e.vironme.t University of Rochester Medical CenterRochesterNY 14642USA

This proje.t re.orts on the.use.of a nove. nanome.brane.filte.ing te.hnology to isolate.and analyze.the.bioactivity of microplastic(MP)-containing de.ris from Lake.Ontario wate. *** MPs are.a comple. mixture.of polyme.s and sorbe. che.icals that are.pe.siste.t and can e.hibit a wide.range.of toxic *** human e.posure.to MPs is unavoidable.it is ne.e.sary to characte.ize.the.r bioactivity to asse.s pote.tial he.lth *** work se.ks to quantify MP pre.e.ce.in the.ne.rshore.wate.s of Lake.Ontario and be.in to characte.ize.the.bioactivity of the.filtrate.containing *** utilize. silicon nitride.SiN)nanome.brane.te.hnology to isolate.de.ris size. be.we.n 8 and 20μm from lake.wate. sample. colle.te. at various time. and *** we.e.ide.tifie. with Nile.re. ***-base. assays we.e.conducte. dire.tly on the.filte.e. de.ris to te.t for ce.l viability,aryl hydrocarbon re.e.tor(AhR)activity,and inte.le.kin 6(IL-6)le.e.s as a me.sure.of proinflammatory *** sample. containe. *** of the.isolate. de.ris impacte. ce.l ***,AhR activity and IL-6 le.e.s varie. ove. ***,no associations we.e.obse.ve. be.we.n the.amount of plastic and *** diffe.e.ce. in activity are.like.y due.to variations in the.physioche.ical prope.tie. of de.ris be.we.n *** re.ults highlight the.ne.d for incre.se. sampling to fully characte.ize.the.bioactivity of MPs in human ce.ls and to e.ucidate.the.role.that sample.physioche.ical and spatiote.poral prope.tie. play in this activity.

关键词： Microplastics SiN nanome.brane. Lake.Ontario Aryl hydrocarbon re.e.tor(AhR)activity IL-6 le.e.s Bioactivity

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Ste.oidal scaffold de.orations in Solanum alkaloid biosynthe.is

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Mole.ular Plant 2024年第8期17卷 1236-1254页

作者： Rosalind Lucie. Mohame. O.Kamile.n Yoko Nakamura Sofiia Se.e.iuk Ranjit Barbole.Je.s Wurlitze. Maritta Kune.t sarah He.nicke.sarah e.O'Connor Prashant D.Sonawane De.artme.t of Natural Product Biosynthe.is Max Planck Institute for Chemical Ecology07745 JenaGermany Re.e.rch Group Biosynthe.is and NMR Max Planck Institute for Chemical Ecology07745 JenaGermany Bioche.ical Scie.ce. Division CSIR-National Chemical LaboratoryPune 411008MaharashtraIndia

Ste.oidal glycoalkaloids(SGAs)are.spe.ialize. me.abolite. produce. by hundre.s of Solanum spe.ie.,including important ve.e.able.crops such as tomato,potato,and *** it has be.n known that SGAs play important role. in de.e.se.in plants and“anti-nutritional"e.fe.ts(e.g.,toxicity and bitte.ne.s)to humans,many of the.e.mole.ule. have.docume.te. anti-cance.,anti-microbial,antiinflammatory,anti-viral,and anti-pyre.ic *** the.e.α-solasonine.andα-solamargine.isolate. from black nightshade.Solanum nigrum)are.re.orte. to have.pote.t anti-tumor,anti-prolife.ative.and anti-inflammatory ***,α-solasonine.andα-solamargine.along with the.core.ste.oidal aglycone.solasodine.are.the.most wide.pre.d SGAs produce. among the.Solanum ***,it is still unknown how plants synthe.ize.the.e.bioactive.ste.oidal *** comparative.me.abolomictranscriptome.guide. approach,biosynthe.ic logic,combinatorial e.pre.sion in Nicotiana be.thamiana,and functional re.ombinant e.zyme.assays,he.e.we.re.ort the.discove.y of 12 e.zyme. from *** that conve.ts the.starting chole.te.ol pre.ursorto solasodine.aglycone.and the.downstre.mα-solasonine.α-solamargine.and malonyl-solamargine.SGA *** furthe. ide.tifie. six e.zyme. from cultivate. e.gplant that catalyze.the.production ofα-solasonine.α-solamargine.and malonyl-solamargine.SGAs from solasodine.aglycone.via glycosylation and atypical malonylation *** work provide. the.ge.e.tool box and platform for e.gine.ring the.production of high-value.ste.oidal bioactive.mole.ule. inhe.e.ologoushosts usingsynthe.icbiology.

关键词： ste.oidal glycoalkaloids Solanum biosynthe.ic pathway α-solamargine malonyl-solamargine spe.ialize. me.abolite.

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Line.r e.doscopic ultrasound:Curre.t use. and future.pe.spe.tive. in me.iastinal e.amination

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World Journal of Gastroe.te.ology 2024年第33期30卷 3803-3809页

作者： e.ad Gadour sarah Al Ghamdi Bogdan Miute.cu Hossam e.Shaaban Ze.nab Hassan Ayme. Almuhaidb Husse.n H Okasha De.artme.t of Gastroe.te.ology and He.atology King Abdulaziz National Guard HospitalAhsa 36428Saudi Arabia De.artme.t of Inte.nal Me.icine Zamzam University CollegeSchool of MedicineKhartoum 11113Sudan De.artme.t of Me.icine Division of GastroenterologyKing Abdulaziz UniversityJeddah 3646Saudi Arabia De.artme.t of Gastroe.te.ology and He.atology Victor Babes University of Medicine and PharmacyTimisoara 300041Romania Advance. Re.ional Re.e.rch Ce.te. in Gastroe.te.ology and He.atology Victor Babes University of Medicine and PharmacyTimisoara 300041Romania De.artme.t of Inte.nal Me.icine.and Gastroe.te.ology NhtmriCairo 11796Egypt De.artme.t of Inte.nal Me.icine Stockport Hospitals NHS Foundation TrustManchester SK27JEUnited Kingdom De.artme.t of Gastroe.te.ology King Faisal Specialist Hospital and Research CenterRiyadh 11211Saudi Arabia De.artme.t of Inte.nal Me.icine Division of Gastroenterology and HepatologyKasr Al-Aini School of MedicineCairo UniversityCairo 11562Egypt

This e.itorial e.aborate. on the.curre.t and future.applications of line.r e.doscopic ultrasound(e.S),a substantial diagnostic and the.ape.tic modality for various anatomical *** scope.of e.dosonographic asse.sme.t is broad and,among othe. factors,allows for the.e.aluation of the.me.iastinal anatomy and re.ate. pathologie.,such as me.iastinal lymphade.opathy and the.staging of ce.tral malignant lung ***,e.S asse.sme.t has prove. more.accurate.in de.e.ting small le.ions misse. by standard imaging e.aminations,such as compute. tomography or magne.ic re.onance.*** focus on its curre.t use. in the.me.iastinum,including lung and e.ophage.l cance. staging,as we.l as e.aluating me.iastinal lymphade.opathy and submucosal *** e.itorial also e.plore. future.pe.spe.tive. of e.S in me.iastinal e.amination,including ultrasound-guide. the.apie.,artificial inte.lige.ce.inte.ration,advance.e.ts in me.iastinal modalitie.,and improve. diagnostic approache. for various me.iastinal le.ions.

关键词： Line.r e.doscopic ultrasound Me.iastinal e.amination Lung cance. Compute. tomography Magne.ic re.onance.imaging

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In situ apatite.and carbonate.Lu-Hf and molybde.ite.Re.Os ge.chronology for ore.de.osit re.e.rch:Me.hod validation and e.ample.application to Cu-Au mine.alisation

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Ge.scie.ce.Frontie.s 2024年第5期15卷 339-354页

作者： Ale.ande. Simpson Stijn Glorie.Martin Hand sarah e.Gilbe.t Carl Spandle. Marija Dmitrije.a Gre. Swain Angus Nixon Jacob Mulde. Carste. Münke. De.artme.t of e.rth Scie.ce. University of AdelaideSA 5005Australia Mine.al e.ploration Coope.ative.Re.e.rch Ce.tre University of AdelaideSA 5005Australia Ade.aide.Microscopy University of AdelaideSA 5005Australia Forte.cue Level 287Adelaide TerraceEast PerthWA 6005Australia Institute.of Ge.logy und Mine.alogy University of Köln50674 KölnGermany British Ge.logical Surve. NottinghamUK

The.de.e.opme.t of lase. ablation inductive.y couple. plasma quadrupole.tande. mass spe.trome.ry(LA-ICP-Q-MS/MS)ope.s ne. opportunitie. to rapidly date.a varie.y of hydrothe.mal *** we.pre.e.t in situ Lu-Hf and Re.Os date. for hydrothe.mal apatite.and molybde.ite.*** furthe. re.ort the.first in situ Lu-Hf date. for bastnäsite.dolomite.and side.ite.and asse.s the.r pote.tial for constraining ore.de.osit *** me.hod validation,we.re.ort isotope.dilution Lu-Hf date. for apatite.re.e.e.ce.mate.ial Bamble.1(1102±5 Ma)and calcite.re.e.e.ce.mate.ial Me.1(1531±7 Ma),e.abling improve. accuracy on matrix-matche. calibration for LA-ICP-MS/MS Lu-Hf *** ne. me.hods are.applie. to the.Vulcan Iron-Oxide.Coppe.-Gold(IOCG)prospe.t in the.Olympic Cu-Au Province.of South *** de.osits have.be.n difficult to accurate.y date.give. the.ge.e.al lack of re.iable.mine.al ge.chronome.e.s that are.coge.e.ic with IOCG *** apatite.Lu-Hf date. and molybde.ite.Re.Os date. de.onstrate.that mine.alisation at Vulcan large.y occurre. at ca.1.6 Ga,conte.porane.us with the.world class Olympic Dam *** data also indicate. that the.Lu-Hf syste. in apatite.is more.robust than the.U-Pb syste. for de.e.mining the.timing of primary apatite.formation in an IOCG *** furthe. de.onstrate.that dolomite.can re.ain Lu-Hf growth age. ove. an e.te.de. time.pe.iod(>1.5 billion ye.rs),providing constraints on the.timing of primary ore.mine.al crystallisation during bre.ciation and IOCG ***,late.Ne.prote.ozoic(ca.589–544 Ma)and Carbonife.ous(ca.334±7 Ma)Lu-Hf date. we.e.obtaine. for te.turally late.Cube.ring carbonate.ve.ns,illustrating that the.carbonate.Lu-Hf me.hod allows dire.t dating of Cu re.obilisation *** has important implications for mine.al e.ploration as the.re.obilise. Cu may have.be.n transfe.re. to younge. de.osits hoste. in Ne.prote.ozoic se.ime.tary basins ove.laying the.Olympic IOCG provi

关键词： Re.ction-ce.l ICP-MS In-situ ge.chronology Lu-Hf Re.Os Iron Oxide.Coppe. Gold Me.al fluids

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Oryza CLIMtools:A ge.ome.e.vironme.t association re.ource.re.e.ls adaptive.role. for he.e.otrime.ic G prote.ns in the.re.ulation of rice.agronomic traits

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Plant Communications 2024年第4期5卷 145-165页

作者： Ange. Fe.re.o-Se.rano David Chakravorty Kobie.J.Kirve. sarah M.Assmann Biology De.artme.t Pennsylvania State University208 Mueller LaboratoryUniversity ParkPA 16802USA Inte.colle.e.Graduate.De.re. Program in Bioinformatics and Ge.omics Pennsylvania State University208 Mueller LaboratoryUniversity ParkPA 16802USA

Mode.n crop varie.ie. display a de.re. of mismatch be.we.n the.r curre.t distributions and the.suitability of the.local climate.for the.r *** addre.s this issue.we.pre.e.t Oryza CLIMtools(https://***/CLIMtools/oryza_v1.0/),the.irst re.ource.for pan-ge.ome.pre.iction of climate.associate. ge.e.ic variants in a crop *** CLIMtools consists of inte.active.we.-base. database. that e.able.the.use. to(1)e.plore.the.local e.vironme.ts of traditional rice.varie.ie.(landrace.)in South-e.st Asia and(2)inve.tigate.the.e.vironme.t by ge.ome.associations for 658 Indica and 283 Japonica rice.landrace.acce.sions colle.te. from ge.re.e.e.ce. local e.vironme.ts and include. in the.3K Rice.Ge.nome. *** de.onstrate.the.value.of the.e.re.ource. by ide.tifying an inte.play be.we.nflowe.ing time.and te.pe.ature.in the.local e.vironme.t that is facilitate. by adaptive.natural variation in OsHD2 and disrupte. by a natural variant in *** quantitative.trait locus analysis has sugge.te. the.impor-tance.of he.e.otrime.ic G prote.ns in the.control of agronomic ***,we.analyze. the.climate.associations of natural variants in the.diffe.e.t he.e.otrime.ic G prote.n *** ide.tifie. a coordi-nate. role.of G prote.ns in adaptation to the.pre.ailing pote.tial e.apotranspiration gradie.t and re.e.le. the.r re.ulation of ke. agronomic traits,including plant he.ght and se.d and panicle.*** conclude.by highlighting the.prospe.t of targe.ing he.e.otrime.ic G prote.ns to produce.climate.re.ilie.t crops.

关键词： Oryza sativa rice G by e adaptation flowe.ing time GWAS OsHD2 OsSOC1 he.e.otrime.ic G pro-te.n OsRGA1 d1 OsGS3 OsDe.1 OsGGC2

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Comparison of fungal vs bacte.ial infe.tions in the.me.ical inte.sive.live. unit:Cause.or corollary for high mortality?

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World Journal of He.atology 2024年第3期16卷 379-392页

作者： sarah Khan Hanna Hong Ste.hanie.Bass Yifan Wang Xiao-Fe.g Wang Omar T Sims Christine.e.Koval Aanchal Kapoor Christina C Linde.me.e. De.artme.t of Inte.nal Me.icine Cleveland ClinicClevelandOH 44195United States Cle.e.and Clinic Le.ne. Colle.e.of Me.icine Cleveland ClinicClevelandOH 44195United States De.artme.t of Pharmacy Cleveland ClinicClevelandOH 44195United States De.artme.t of Quantitative.He.lth Scie.ce./Biostatistics Se.tion Cleveland ClinicClevelandOH 44195United States De.artme.t of Gastroe.te.ology Hepatology and NutritionCleveland ClinicClevelandOH 44195United States De.artme.t of Infe.tious Dise.se Cleveland ClinicClevelandOH 44195United States De.artme.t of Critical Care.Me.icine Cleveland ClinicClevelandOH 44195United States

BACKGROUND Due.to de.e.opme.t of an immune.dysre.ulate. phe.otype.advance. live. dise.se.in all forms pre.ispose. patie.ts to se.sis acquisition,including by opportunistic pathoge.s such as *** data e.ists on fungal infe.tion within a me.ical inte.sive.live. unit(MILU),particularly in re.ation to acute.on chronic live. *** To inve.tigate.the.impact of fungal infe.tions among critically ill patie.ts with advance. live. dise.se.and compare.outcome. to those.of patie.ts with bacte.ial *** From our prospe.tive.re.istry of MILU patie.ts from 2018-2022,we.include. 27 patie.ts with culture.positive.fungal infe.tions and 183 with bacte.ial *** compare. outcome. be.we.n patie.ts admitte. to the.MILU with fungal infe.tions to bacte.ial *** was e.tracte. through chart *** All fungal infe.tions we.e.due.to Candida spe.ie.,and we.e.most fre.ue.tly blood *** among patie.ts with fungal infe.tions was significantly worse.re.ative.to the.bacte.ial cohort(93%vs 52%,Pe.majority of the.fungal cohort de.e.ope. grade.2 or 3 acute.on chronic live. failure.ACLF)(90%vs 64%,P=0.02).Patie.ts in the.fungal cohort had incre.se. use.of vasopre.sors(96%vs 70%,P=0.04),me.hanical ve.tilation(96%vs 65%,Pe.to acute.kidne. injury(78%vs 52%,P=0.014).On MILU admission,the.fungal cohort had significantly highe. Acute.Physiology and Chronic He.lth e.aluation(108 vs 91,P=0.003),Acute.Physiology Score.86 vs 65,P=0.003),and Mode. for e.d-Stage.Live. Dise.se.Sodium score.(86 vs 65,P=0.041).The.e.was no significant diffe.e.ce.in the.rate.of ce.tral line.use.pre.e.ing culture.52%vs 40%,P=0.2).Patie.ts with fungal infe.tion had highe. rate.of transplant hold place.e.t,and lowe. rate. of transplant;howe.e.,diffe.e.ce. did not achie.e.statistical *** Mortality was worse.among patie.ts with fungal infe.tions,like.y attributable.to se.e.e.ACLF *** studie. e.aminin

关键词： Fungal Infe.tion Se.sis Acute.on chronic live. failure Inte.sive.care

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De.ign and synthe.is of synthe.ic promote.s for consiste.cy of ge.e.e.pre.sion across growth phase. and scale.in ***

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Synthe.ic and Syste.s Biote.hnology 2024年第2期9卷 330-339页

作者： Kristin V.Pre.ne.l Omar Me.he. sarah M.Cole.an Nicholas J.Morse.Hal S.Alpe. McKe.ta De.artme.t of Che.ical e.gine.ring The University of Texas at Austin200E Dean Keeton St.Stop C0400AustinTX78712USA Institute.for Ce.lular and Mole.ular Biology The University of Texas at Austin2500 Speedway AvenueAustinTX78712USA

Me.abolic e.gine.ring and synthe.ic biology e.de.vors be.e.it from promote.s that pe.form consiste.tly(or robustly)with re.pe.t to ce.lular growth phase.e.pone.tial and stationary)and fe.me.tation scale.microtite. plate.,tube.,flasks,and biore.ctors).Howe.e.,ne.rly all e.doge.ous promote.s(e.pe.ially in Saccharomyce. ce.e.isiae.do not pe.form in this *** this work,a hybrid promote. e.gine.ring strate.y is le.e.age. to cre.te.nove. synthe.ic promote.s with robustne.s across the.e.*** a multi-dime.sional RNA-se. datase.,promote.s with spe.ific phase.de.e.de.cie. we.e.*** e.riche. with functional transcription factors we.e.ide.tifie. using Me.e.*** motif-containing fragme.ts could impart activity de.e.de.ce.in the.opposing ***,we.obtain two ne. promote.s with high and consiste.t e.pre.sion across both phase. by incre.sing the.e.pone.tial phase.activity of the.starting stationary-phase.scaffold by 38 and 23-fold ***,we.show that the.e.promote.s function consiste.tly across various laboratory growth scale. ove. time.in a microtite. plate.and in ***,this work pre.e.ts and validate. a ne. strate.y for e.gine.ring promote.s in *** with high le.e.s of e.pre.sion that are.robust to ce.lular growth phase.and the.scale.of the.culture.

关键词： e.doge.ous synthe.ic stationary

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Surgical inte.ve.tion combine. with we.ght-be.ring walking training promote. re.ove.y in patie.ts with chronic spinal cord injury:a randomize. controlle. study

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Ne.ral Re.e.e.ation Re.e.rch 2024年第12期19卷 2773-2784页

作者： Hui Zhu Jame. D.Gue.t sarah Dunlop Jia-Xin Xie.Sujuan Gao Zhuojing Luo Joe.e.Springe. Wutian Wu Wise.Young Wai Sang Poon Song Liu Hongkun Gao Tao Yu Dianchun Wang Libing Zhou She.gping Wu Le. Zhong Fang Niu Xiaome. Wang Yanshe.g Liu Kwok-Fai So Xiao-Ming Xu Kunming Tongre. Hospital KunmingYunnan ProvinceChina Ne.rological Surge.y and the Miami Project to Cure ParalysisMiller School of MedicineUniversity of MiamiMiamiFLUSA School of Biological Scie.ce. The University of Western AustraliaPerthWAAustralia Minde.oo Foundation PerthWAAustralia Clinical Ce.te. for Spinal Cord Injury Kunming General Hospital of Chengdu Military CommandKunmingYunnan ProvinceChina De.artme.t of Biostatistics and He.lth Data Scie.ce Indiana University School of MedicineIndianapolisINUSA De.artme.t of Orthope.ic Spinal Surge.y Xijing HospitalFourth Military Medical UniversityXi’anShaanxi ProvinceChina Spinal Cord and Brain Injury Re.e.rch Ce.te. Department of Physical Medicine and RehabilitationUniversity of Kentucky College of MedicineLexingtonKYUSA Guangdong-HongKong-Macao Institute.of CNS Re.e.e.ation Jinan UniversityGuangzhouGuangdong ProvinceChina W.M.Ke.k Ce.te. for Collaborative.Ne.roscie.ce Rutgers UniversityPiscatawayNJUSA Ne.rosurge.y De.artme.t Chinese University of Hong KongPrince of Wales HospitalHong Kong Special Administration RegionChina Spinal Cord and Brain Injury Re.e.rch Group Stark Neurosciences Research InstituteDepartment of Neurological SurgeryIndiana University School of MedicineIndianapolisINUSA

For patie.ts with chronic spinal cord injury,the.co nve.tional tre.tme.t is re.abilitation and tre.tme.t of spinal cord injury complications such as urinary tract infe.tion,pre.sure.sore.,oste.porosis,and de.p ve.n *** is rare.y pe.fo rme. on spinal co rd injury in the.chronic phase.and fe. tre.tme.ts have.be.n prove. e.fe.tive.in chronic spinal cord injury *** of e.fe.tive.the.apie. fo r chronic spinal co rd injury patie.ts is *** conducte. a randomize. controlle. clinical trial in patie.ts with chronic comple.e.thoracic spinal co rd injury to compare.inte.sive.re.abilitation(we.ght-be.ring walking training)alone.with surgical inte.ve.tion plus inte.sive.*** clinical trial was re.iste.e. at ***(NCT02663310).The.goal of surgical inte.ve.tion was spinal cord de.e.he.ing,re.toration of ce.e.rospinal fluid flow,and e.imination of re.idual spinal cord *** found that surgical inte.ve.tion plus we.ght-be.ring walking training was associate. with a highe. incide.ce.of Ame.ican Spinal Injury Association Impairme.t Scale.improve.e.t,re.uce. spasticity,and more.rapid bowe. and bladde. functional re.ove.y than we.ght-be.ring walking training ***,the.surgical proce.ure. and inte.sive.re.abilitation we.e.*** Spinal Injury Association Impairme.t Scale.improve.e.t was more.common in T7-T11 injurie. than in T2-T6 *** combine. with re.abilitation appe.rs to have.a role.in tre.tme.t of chronic spinal cord injury patie.ts.

关键词： chronic spinal cord injury inte.sive.re.abilitation locomotor training ne.rological re.ove.y surgical inte.ve.tion we.ghtbe.ring walking training

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