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A randomized controlled trial of Promoting Physical Activity in Regional and Remote Cancer Survivors(PPARCS)

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Journal of Sport and Health Science 2024年第1期13卷 81-89页

作者： sarah J.Hardcastle Chloe Maxwell-Smith Vinicius Cavalheri Terry Boyle Marta Leyton Román Cameron Platell Michael Levitt Christobel Saunders Frank Sardelic Sophie Nightingale Jacob McCormick Craig Lynch Paul A.cohen Max Bulsara Dana Hince Sport and Physical Activity Research Centre Sheffield Hallam UniversitySheffieldS102BPUK Institute for Health Research The University of Notre DameFremantleWA 6959Australia Curtin School of Population Health Curtin UniversityPerthWA 6845Australia Curtin School of Allied Health Curtin UniversityPerthWA 6845Australia Allied Health South Metropolitan Health ServiceMurdochWA 6150Australia Australian Centre for Precision Health University of South AustraliaAdelaideSA 5001Australia Department of Didactics of Musical Plastic and Body ExpressionUniversity of ExtremaduraCaceres 10071Spain St.John of God Subiaco Hospital PerthWA 6008Australia Department of Surgery University of MelbourneMelbourneVIC 3010Australia Tamara Private Hospital TamworthNSW 2340Australia Peter MacCallum Cancer Centre MelbourneVIC 3000Australia College of Health and Medicine Australian National UniversityCanberraACT 2600Australia Division of Obstetrics and Gynaecology Medical SchoolUniversity of Western AustraliaPerthWA 6009Australia

Background:Physical activity(PA)is important for cancer *** of remotely delivered interventions are needed to assist in reaching under-served non-metropolitan cancer *** objective of this study was to ascertain whether wearable technology,coupled with health coaching was effective in increasing PA in breast and colorectal cancer survivors living in regional and remote areas in ***:Cancer survivors from 5 states were randomized to intervention and control *** participants were given a Fitbit Charge 2TMand received up to 6 telephone health coaching *** participants received PA print *** assessments at baseline and 12 weeks measured moderate-to-vigorous PA(MVPA),light PA,and sedentary ***:Eighty-seven participants were recruited(age=63±11 years;74(85%)female).There was a significant net improvement in MVPA of 49.8 min/week,favoring the intervention group(95%confidence interval(95%CI):13.6-86.1,p=0.007).There was also a net increase in MVPA bouts of 39.5 min/week(95%CI:11.9-67.1,p=0.005),favoring the intervention *** groups improved light PA and sedentary behavior,but there were no between-group ***:This’s the first study to demonstrate that,when compared to standard practice(i.e.,PA education),a wearable technology intervention coupled with distance-based health coaching,improves MVPA in non-metropolitan cancer *** results display promise for the use of scalable interventions using smart wearable technology in conjunction with phone-based health coaching to foster increased PA in geographically disadvantaged cancer survivors.

关键词： Behavior change Exercise Health disparities Oncology Wearable technology

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宫腔镜下病灶粉碎术治疗宫内病变

妇产与遗传（电子版） 2012年第2期2卷 46-51页

作者： sarah cohen James A.Greenberg 周静哈佛医学院布里格姆妇女医院微创外科哈佛医学院布里格姆妇女医院妇产与生殖科福克纳医院妇科布里格姆妇女医院妇产科南方医科大学南方医院妇产科广州510515

随着技术的发展,宫腔镜的应用范围已得到很大扩展。现代宫腔手术镜以不同尺寸光学元件、流入、流出及工作通道为基础,可在清晰显示子宫腔的同时手术切除宫腔内病变,如息肉和肌瘤。本综述对比了不同宫腔镜治疗方案的相对优缺点,着眼于最... 详细信息

随着技术的发展,宫腔镜的应用范围已得到很大扩展。现代宫腔手术镜以不同尺寸光学元件、流入、流出及工作通道为基础,可在清晰显示子宫腔的同时手术切除宫腔内病变,如息肉和肌瘤。本综述对比了不同宫腔镜治疗方案的相对优缺点,着眼于最新的宫腔镜技术——宫腔镜下粉碎术,以及这项新技术如何与妇科医生现有的医疗设备相兼容。

关键词：宫腔镜下粉碎术平滑肌瘤子宫内膜息肉

Alleviative effects of Cannabis flower on migraine and headache

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Journal of Integrative Medicine 2020年第5期18卷 416-424页

作者： sarah SStith Jegason PDiviant Franco Brockelman Keenan Keeling Branden Hall Storri Lucern Jacob M.Vigil Deparment of Economics Faculy of Economics.University of New MexicoAlbuiquerqueNew Mexico 87131USA Department of Psychology Sudent of Psychologv.University of New Mexico.AlbuquerqueNew Mexico 87131.USA Morebetter Ltd.Sofwure Developer HatsvileMaryland 20781USA Department of Psycholog Faculy of Psychology.University of New MexicoAlbuquerqueNew Mexico 87131USA

Objective: Few studies to date have measured the real-time effects of consumption of common and commercially available Cannabis products for the treatment of headache and migraine under naturalistic conditions. This study examines, for the first time, the effectiveness of using dried Cannabis flower, the most widely used type of Cannabis product in the United States, in actual time for treatment of headache-and migraine-related pain and the associations between different product characteristics and changes in symptom intensity following Cannabis ***: Between 06/10/2016 and 02/12/2019, 699 people used the Releaf Application to record realtime details of their Cannabis use, including product characteristics and symptom intensity levels prior to and following self-administration;data included 1910 session-level attempts to treat headache-(1328 sessions) or migraine-related pain(582 sessions). Changes in headache-or migraine-related pain intensity were measured on a 0–10 scale prior to, and immediately, following Cannabis ***: Ninety-four percent of users experienced symptom relief within a two-hour observation window. The average symptom intensity reduction was 3.3 points on a 0–10 scale(standard deviation = 2.28,cohen's d = 1.58), with males experiencing greater relief than females(P < 0.001) and a trend that younger users(< 35 years) experience greater relief than older users(P = 0.08). Mixed effects regression models showed that, among the known(i.e., labeled) product characteristics, tetrahydrocannabinol levels 10% and higher are the strongest independent predictors of symptom relief, and this effect is particularly prominent in headache rather than migraine sufferers(P < 0.05), females(P < 0.05) and younger users(P < 0.001). Females and younger users also appear to gain greater symptom relief from flower labeled as ‘‘C. indica" rather than ‘‘C. sativa" or other hybrid ***: These results suggest that whole dried Cannabis flowe

关键词： Migraine Headache Cannabis Marijuana Symptom management

Determining the utility of standard hospital microbiology testing: Comparing standard microbiology cultures with DNA sequence analysis in patients with chronic sinusitis

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2019年第2期5卷 82-87页

作者： sarah K.Rapoport Alyssa J.Smith Maxwell Bergman Kelly A.Scriven Itzhak Brook Suzette K.Mikula Medstar Georgetown University Hospital Department of OtolaryngologyHeadεt Neck SurgeryWashington DCUSA Mayo Clinic Department of OtolaryngologyHeadεt Neck SurgeryRochesterMNUSA Georgetown University Medical School Washington DCUSA Medstar Georgetown University Hospital Department of Pediatricsεt Infectious DiseasesWashington DCUSA

Objective:To demonstrate DNA sequencing analysis (DNAsa) of sinus cultures in patients with CRS is a reliable method of detecting pathogens in polymicrobial CRS ***:After obtaining Institutional Review Board approval for this prospective cohort study,we selected a random sample of 50 patients with CRS at Medstar Georgetown University Hospital between September 2016 and March *** defined CRS as a history of rhinosinusitis refractory to maximal medical therapy and prior endoscopic sinus *** demonstrating active purulence in a sinus cavity were prospectively selected to undergo standard hospital cultures (SHC) and DNAsa *** identified in both methods were compared for each ***:Specimens were obtained from 29 female and 16 male patients with a mean age of 50 years.A total of 45 cultures were included in our final analysis;five cultures were excluded after inappropriate laboratory *** from these patients were compared and ***'s weighted kappa analysis showed agreement between the two testing methods in identifying predominant *** detected 31.9% more microorganisms compared to SHC (P < 0.05).When multiple microorganisms were detected,DNAsa yielded more positive results compared to SHC (P < 0.05).Conclusions:DNAsa detects all microorganisms identified by SHC as well as predominant microorganisms not detected by *** molecular pathogen identification may be more reliable for identifying multiple microorganisms as compared to standard culture techniques that identify only one or two *** recalcitrant cases of CRS,DNAsa may provide better guidance in selection of appropriate antimicrobial treatment.

关键词： Chronic rhinosinusitis (CRS) DNA sequencing analysis (DNAsa) Microbiome Molecular sequencing Microbiology culture

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腹腔镜妇科手术中输尿管的损伤

妇产与遗传（电子版） 2012年第4期2卷 55-59页

作者： Elmira Manoucheri sarah L.cohen Evelien M.Sandberg Adam S.Kibel Jon Einarsson 周静马萨诸塞州波士顿布里格姆与妇女医院妇产科微创妇科马萨诸塞州波士顿布里格姆与妇女医院泌尿外科南方医科大学南方医院妇产科广州510515

妇科手术中腹腔镜的引入既是开创性的进步，也是新的挑战。随着越来越多的晚期病例的病理通过腹腔镜的取得，其潜在的并发症也越来越受重视，例如输尿管损伤。1971年，Engel等报道了首例腹腔镜输卵管结扎术中输尿管损伤，术后患者出现... 详细信息

妇科手术中腹腔镜的引入既是开创性的进步，也是新的挑战。随着越来越多的晚期病例的病理通过腹腔镜的取得，其潜在的并发症也越来越受重视，例如输尿管损伤。1971年，Engel等报道了首例腹腔镜输卵管结扎术中输尿管损伤，术后患者出现腰痛，被诊断为右侧输尿管损伤，必须行输尿管膀胱吻合术和Boari皮瓣修复。此后，许多研究致力于预防和处理妇科手术中的输尿管损伤。

关键词：输尿管损伤腹腔镜手术中妇科输尿管膀胱吻合术输卵管结扎术 Engel 术后患者

多不饱和脂肪酸代谢，嘌呤代谢和肌苷作为主要的潜在的独立诊断生物标志物儿童和青少年的抑郁症

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多不饱和脂肪酸代谢，嘌呤代谢和肌苷作为主要的潜在的独立诊断生...

心理疗法治疗儿童青少年焦虑障碍的网络meta分析

中国睡眠研究会第十一届全国学术年会

作者：周新雨刘兰香兰兴会 David cohen 张玉清 Arun V Ravindran 袁帅郑鹏 David Coghill 杨力凝 sarah E Hetrick 蒋晓峰 Jean-Jacques Benoliel Andrea Cipriani 谢鹏重庆医科大学附属第一医院重庆医科大学神经科学研究所重庆医科大学附属儿童医院 H?pital Pitié–Salpétrière 重庆医科大学附属第二医院 University of Toronto 成都市精神病院 University of Melbourne University of Auckland Site Pitie′-Salpe?trie’re Universite′ Pierre et Marie Curie-Paris 6 University of Oxford Oxford Health NHS Foundation Trust

目的儿童青少年重度抑郁症（MDD）是一种在全球范围内以高复发率、高致残率为特点的疾病,但其病理机制尚未得到充分阐明并且有效治疗方式有限。方法利用超高效液相色谱-四极杆飞行时间质谱对血浆进行了代谢组学分析,以寻找儿童青少年抑...

目的儿童青少年重度抑郁症（MDD）是一种在全球范围内以高复发率、高致残率为特点的疾病,但其病理机制尚未得到充分阐明并且有效治疗方式有限。方法利用超高效液相色谱-四极杆飞行时间质谱对血浆进行了代谢组学分析,以寻找儿童青少年抑郁症的潜在生物标志物。我们共招募了134名儿童和青少年,包括52名首发DN-MDD患者（男性/女性:27/25）、32名DT-MDD患者（男性/女性:15/17）和50名HCs患者（男性/女性:27/23）,分别采集其血浆样本进行代谢谱和生物信息学分析。结果发现了几种紊乱的通路与儿童青少年抑郁症密切相关,包括脂肪酸代谢（尤其是多不饱和脂肪酸代谢）和嘌呤代谢,共鉴定出35种代谢物（DN-MDD vs. HCs）, 36种代谢物（DT-MDD vs. HCs）, 6种代谢物（DT-MDD ***-MDD）组间差异具有统计学意义。为进一步探索识别儿童和青少年MDD潜在生物诊断标志物的可能性,我们进行了二元逻辑回归分析,证明肌苷是潜在的MDD独立诊断生物标志物。通过ROC分析,在区分未用药的MDD患者和健康对照组,其ROC曲线下面积达到0.999,并且区分药物治疗后的MDD患者和健康对照组的曲线下面积为0.866。同时,我们还发现了儿童青少年MDD病理生理学与成人MDD不同,后者主要是与色氨酸代谢相关。结论通过代谢组学分析,发现代谢紊乱与儿童青少年MDD的病理机制和诊断生物标志物之间存在紧密联系。

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心理疗法治疗儿童青少年焦虑障碍的网络meta分析