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The exploitation of epichloae endophytes for agricultural benefit

Fungal Diversity 2013年第3期60卷 171-188页

作者： Linda J.Johnson Anouck c.M.de Bonth Lyn R.Briggs John R.caradus sarah c.finch Damien J.Fleetwood Lester R.Fletcher David E.Hume Richard D.Johnson Alison J.Popay Brian A.Tapper Wayne R.Simpson christine R.Voisey Stuart D.card AgResearch Ltd Grasslands Research CentreTennent DrivePalmerston North 4442New Zealand AgResearch Ltd Ruakura Research CentreEast StreetHamilton 3214New Zealand AgResearch Ltd Lincoln Research CentreCorner Springs Road and Gerald StreetLincoln 8140New Zealand AgResearch Laboratory of Structural Biology School of Biological SciencesUniversity of Auckland3a Symonds StreetAuckland 1142New Zealand Grasslanz Technology Ltd Tennent DrivePalmerston North 4474New Zealand

Epichloae endophytes of family clavicipitaceae(comprising genera Epichloëand Neotyphodium)are fungal symbionts of Pooideae *** associations formed,range from mutually beneficial to antagonistic and the nature of this relationship is dependent upon the importance of vertical(via host seeds)versus horizontal(ascospore mediated)transmission of the *** endophytes can enhance their hosts’survival through protection from abiotic and biotic stresses and can thus be utilized in an agricultural ***-safe grass-endophyte associations that confer bio-protective properties for increased pasture persistence and productivity have been developed and *** of the crucial drivers underpinning the selection of epichloae strains for commercial development is endophyte derived *** potential of next generation endophytes is determined by testing a number of attributes such as agronomic fitness,animal and food safety as well as compatibility with host plants of *** research supports these activities by focusing on elucidating mechanisms of compatibility between host and fungal symbiont,as well as investigating other molecular drivers of symbiosis such as siderophore mediated iron-uptake,fungal signalling,fungal growth in host plants and fungal secondary *** review weaves together the different strands of multidisciplinary research aimed at ultimately exploiting epichloae endophytes for increased pasture performance.

关键词： Epichloë Neotyphodium Pooideae Symbiosis Secondary metabolite Toxicology

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抗肥胖症药物市场需求旺盛

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Engineering 2024年第1期32卷 4-6页

作者： sarah c.P.Williams Senior Technology Writer

In early September 2023,when its market cap jumped to 428 billion USD,a valuation topping the estimated 2022 gross domestic product of its Scandinavian home country,the drugmaker Novo Nordisk(Bagsværd,Denmark)briefly eclipsed the French luxury brand conglomerateLMVH(Paris,France)as Europe's most valuable company[1].The reason for the company's soaring worth?Its already best-selling weight loss drug Wegovy was being released to patients in the United Kingdom.

关键词： market French briefly

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实验室培养肉进入顾客餐桌——机遇与挑战并存

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Engineering 2024年第3期34卷 3-5页

作者： sarah c.P.Williams Senior Technology Writer

In the summer of 2023,two US restaurants added a novel item to their menus:chicken grown in a lab(Fig.1)[1,2].The first to receive regulatory approval for commercial sale,the lab-grown—or"cultivated"—meat starts as a few real chicken cells that are grown in vats of liquid and nutrients until they become pieces large enough to shape into nuggets and strips.

关键词：实验室培养 approval restaurant

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Protocol for the development and validation of a clinical measurement tool for fear of disease progression and recurrence in cardiac patients

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chronic Diseases and Translational Medicine 2024年第3期10卷 195-204页

作者： sarah T.clarke Michael Le Grande Barbara M.Murphy Robert Hester Alun c.Jackson Melbourne School of Psychological Sciences University of MelbourneParkvilleVictoriaAustralia Australian centre for Heart Health MelbourneVictoriaAustralia centre on Behavioral Health University of Hong KongPokfulamHong KongChina

Introduction: One in two cardiac patients fear having another heart event or their heart condition getting worse. Research in other chronic illnesses demonstrates that screening for fear of progression and recurrence is vital for adequately addressing such concerns in clinical care. The current project aims to develop and validate a measure for fear of progression and recurrence in cardiac ***: The Fear of cardiac Recurrence and Progression Scale (FcRP) will be developed through a multistep process. An initial item pool will be generated through a review of the literature and existing measures and consultation with and feedback from key informants. The item pool will be tested in a sample of over 250 adults who have ever had an acute coronary event, undergone cardiac surgery, or a chronic cardiac condition. Exploratory factor analysis will be used to identify the underlying factors, and Rasch analysis will be used to reduce the number of items. A short form version of the FcRP will be developed for use as a brief screening tool, informed by clinical relevance and Rasch psychometric ***: While many cardiac patients experience fears related to the progression or recurrence of their illness, there remains the need for a validated tool with which these concerns can be identified and measured. It is expected that the design and validation of the FcRP will aid identification of cardiac patients suffering from clinically significant levels of fear of progression and recurrence and facilitate the design of tailored psychological interventions to target these fears.

关键词： anxiety cardiac anxiety cardiac recovery cardiac rehabilitation depression fear of progression fear of recurrence psychological measurement psychosocial screening

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Spatial dynamics and Palestinian resilience:The lifestyle of Al-Kurshan Bedouins in Bethlehem District

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Frontiers of Architectural Research 2024年第3期13卷 439-458页

作者： Maha Samman sarah Mitwassi Abdel Rahman Kaloti Department of Architecture Faculty of EngineeringAl-Quds UniversityJerusalemPalestine

This study explores the role of Bedouins in preserving Palestinian land through their own means of community resilience through the concept of“Art of being”and its entailed“Arts of presence and persistence”.This is examined through the correlation between Bedouin lifestyle and the spatial distribution of structures within“Al-Kurshan”Bedouin clan in Area c in the West *** on a mixed qualitative and spatial methodologies,information was gathered through semi-structured interviews with Al-Kurshan Bedouins and employees of organizations supporting Bedouins,on-site observation,and analyses of maps and photos,in addition to drawings and *** spatial distribution of Bedouin built structures is analyzed in relation to landscape and climate,social aspects within the families,and available service and sectorial *** analyses give insight on how Bedouins struggle against adopting other *** study shows that the Bedouins are slowly forced to negotiate their semi-nomadic lifestyle,but resist giving up their right to exist against the threat of forced *** maintain their“Art of being”which partly represents their own way of safeguarding Palestinian lands from *** study contributes to the wider discussion of spatial dynamics of Bedouins and their community resilience within the Palestinian geopolitical context.

关键词： Bedouin everyday life Spatial distribution community resilience Art of being Palestine Area c

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comparison of fungal vs bacterial infections in the medical intensive liver unit:cause or corollary for high mortality?

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World Journal of Hepatology 2024年第3期16卷 379-392页

作者： sarah Khan Hanna Hong Stephanie Bass Yifan Wang Xiao-Feng Wang Omar T Sims christine E Koval Aanchal Kapoor christina c Lindenmeyer Department of Internal Medicine Cleveland ClinicClevelandOH 44195United States cleveland clinic Lerner college of Medicine Cleveland ClinicClevelandOH 44195United States Department of Pharmacy Cleveland ClinicClevelandOH 44195United States Department of Quantitative Health Sciences/Biostatistics Section Cleveland ClinicClevelandOH 44195United States Department of Gastroenterology Hepatology and NutritionCleveland ClinicClevelandOH 44195United States Department of Infectious Disease Cleveland ClinicClevelandOH 44195United States Department of critical care Medicine Cleveland ClinicClevelandOH 44195United States

BAcKGROUND Due to development of an immune-dysregulated phenotype,advanced liver disease in all forms predisposes patients to sepsis acquisition,including by opportunistic pathogens such as *** data exists on fungal infection within a medical intensive liver unit(MILU),particularly in relation to acute on chronic liver *** To investigate the impact of fungal infections among critically ill patients with advanced liver disease,and compare outcomes to those of patients with bacterial *** From our prospective registry of MILU patients from 2018-2022,we included 27 patients with culture-positive fungal infections and 183 with bacterial *** compared outcomes between patients admitted to the MILU with fungal infections to bacterial *** was extracted through chart *** All fungal infections were due to candida species,and were most frequently blood *** among patients with fungal infections was significantly worse relative to the bacterial cohort(93%vs 52%,Pcohort developed grade 2 or 3 acute on chronic liver failure(AcLF)(90%vs 64%,P=0.02).Patients in the fungal cohort had increased use of vasopressors(96%vs 70%,P=0.04),mechanical ventilation(96%vs 65%,Pcute kidney injury(78%vs 52%,P=0.014).On MILU admission,the fungal cohort had significantly higher Acute Physiology and chronic Health Evaluation(108 vs 91,P=0.003),Acute Physiology Score(86 vs 65,P=0.003),and Model for End-Stage Liver Disease-Sodium scores(86 vs 65,P=0.041).There was no significant difference in the rate of central line use preceding culture(52%vs 40%,P=0.2).Patients with fungal infection had higher rate of transplant hold placement,and lower rates of transplant;however,differences did not achieve statistical *** Mortality was worse among patients with fungal infections,likely attributable to severe AcLF *** studies examinin

关键词： Fungal Infection Sepsis Acute on chronic liver failure Intensive care

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Macroalgal deep genomics illuminate multiple paths to aquatic,photosynthetic multicellularity

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Molecular Plant 2024年第5期17卷 747-771页

作者： David R.Nelson Alexandra Mystikou Ashish Jaiswal cecilia Rad-Menendez Michael J.Preston Frederik De Boever Diana c.El Assal sarah Daakour Michael W.Lomas Jean-claude Twizere David H.Green William c.Ratcliff Kourosh Salehi-Ashtiani Division of Science and Math New York University Abu DhabiAbu DhabiUAE center for Genomics and Systems Biology(cGSB) New York University Abu DhabiAbu DhabiUAE Biotechnology Research center Technology Innovation InstitutePO Box 9639Masdar CityAbu DhabiUAE culture collection of Algae and Protozoa Scottish Association for Marine ScienceObanScotlandUK National center for Marine Algae and Microbiota Bigelow Laboratory for Ocean SciencesEast BoothbayMEUSA Laboratory of Viral Interactomes GIGA InstituteUniversity of LiegeLiegeBelgium School of Biological Sciences Georgia Institute of TechnologyAtlantaGAUSA

Macroalgae are multicellular,aquatic autotrophs that play vital roles in global climate maintenance and have diverse applications in biotechnology and eco-engineering,which are directly linked to their multicellularity ***,their genomic diversity and the evolutionary mechanisms underlying multicellularity in these organisms remain *** this study,we sequenced 110 macroalgal genomes from diverse climates and phyla,and identified key genomic features that distinguish them from their microalgal *** for cell adhesion,extracellular matrix formation,cell polarity,transport,and cell differentiation distinguish macroalgae from microalgae across all three major phyla,constituting conserved and unique gene sets supporting multicellular *** genes show phylum-and climate-specific expansions that may facilitate niche ***,our study reveals genetic determinants of convergent and divergent evolutionary trajectories that have shaped morphological diversity in macroalgae and provides genome-wide frameworks to understand photosynthetic multicellular evolution in aquatic environments.

关键词： macroalgae multicellularity comparative genomics evolution adhesome endogenous viral elements

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Discoid meniscus:Treatment considerations and updates

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World Journal of Orthopedics 2024年第6期15卷 520-528页

作者： Waleed Albishi Amjad Albaroudi Abdulrahman M Alaseem sarah Aljasser Ibrahim Alshaygy Abdullah Addar Department of Orthopedic Surgery College of MedicineKing Saud UniversityRiyadh 11362Saudi Arabia

A discoid meniscus is a morphological abnormality wherein the meniscus loses its normal‘c’*** most patients are asymptomatic,patients might still present with symptoms such as locking,pain,swelling,or giving *** resonance imaging is usually needed for confirmation of *** on a constellation of factors,including clinical and radiological,different approaches are chosen for the management of discoid *** purpose of this review is to outline the treatment of discoid meniscus,starting from conservative approach,to the different surgical options for this *** PubMed and Google Scholar databases were used for this *** discussing the treatment of discoid meniscus from 2018 to 2023 were *** there were 369 studies retrieved,and after removal of studies using the exclusion criteria,26 studies were included in this *** such as stability,presence of tear,and morphology can help with surgical *** approaches have been used to treat discoid meniscus,where the choice is tailored for each patient ***,factors that may positively impact patient outcomes include male sex,body mass indexconventional approach is partial meniscectomy with or without repair;however,recently,there has been an increased emphasis on discoid-preserving techniques such as meniscoplasty,meniscopexy,and meniscal allograft transplantation.

关键词： Discoid meniscus Saucerization Partial meniscectomy Meniscoplasty Meniscopexy Meniscal allograft transplantation Arthroscopy Knee

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Probing the Galactic Halo with RR Lyrae Stars. VI. The Radial Velocity curve Templates of RRc Stars

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Research in Astronomy and Astrophysics 2024年第7期24卷 121-137页

作者： Yue Huang Min Fang Gaochao Liu Xianzhong Zheng sarah Ann Bird Yang Huang Jianrong Shi Jiangtao Wang Huawei Zhang Haijun Tian Haotong Zhang college of Science China Three Gorges University center for Astronomy and Space Sciences China Three Gorges University Purple Mountain Observatory Chinese Academy of Sciences School of Astronomy and Space Science University of Science and Technology of China School of Astronomy and Space Science University of Chinese Academy of Sciences cAS Key Laboratory of Optical Astronomy National Astronomical Observatories Department of Astronomy School of PhysicsPeking University Kavli Institute for Astronomy and Astrophysics Peking University School of Sciences Hangzhou Dianzi University

We present radial velocity（RV） curve templates of RR Lyrae first-overtone（RRc） stars constructed with the Mg I b triplet and Hα lines using time-domain Medium-Resolution Survey spectra of seven RRc stars from Large Sky Area Multi-Object Fiber Spectroscopic Telescope（LAMOST） Data Release 9. Additionally, we derive the relation between the stellar RV curve amplitudes and g-band light curve amplitudes from Zwicky Transient Facility（ZTF）public survey. For those RRc stars without ZTF g-band light curves, we provide the conversions from the light curve amplitudes in ZTF r-and i-bands, Gaia G-band, and V-band from the All-Sky Automated Survey for Supernovae to those in ZTF g-band. We validate our RV curve templates using the RRc star SV Scl and find the uncertainties of systemic RV are less than 2.11 km s-1and 6.08 km s-1based on the Mg I b triplet and Hα lines,respectively. We calculate the systemic RVs of 30 RRc stars using the RV curve templates constructed with the Mg I b triplet and Hα lines and find the systemic RVs are comparable with each other. This RV curve template will be particularly useful for obtaining the systemic RV of RRc using the LAMOST spectroscopy.

关键词： Stars stars: variables: RR Lyrae techniques: radial velocities

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The terminology of the 2012 Atlanta consensus conference on post-inflammatory collections after acute pancreatitis:An assessment of utilization in practice

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Hepatobiliary & Pancreatic Diseases International 2022年第5期21卷 508-510页

作者： Santhalingam Jegatheeswaran Louise M finch Maya c Siriwardena Ajith K Siriwardena Regional Hepato-Pancreato-Biliary Surgery Unit Manchester Royal InfirmaryOxford RoadManchester M139WLUK Warwick Medical School WarwickUK Faculty of Biology Medicine and HealthUniversity of ManchesterManchesterUK

To the Editor The report of the 1992 Atlanta consensus conference provided a framework for standardization of the terminology for description of acute pancreatitis and its complications[1].Terms such as“pancreatic phlegmon”which had historically been subjected to differential interpretation were discontinued and modern terminology was introduced[1].With subsequent clinical usage and with the accrual of new knowledge it became clear that further changes were necessary.

关键词： pancreatitis acute terminology

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