检索结果-南通市图书馆

Health 2012年第9期4卷 679-684页

作者： Isabelle Bardou Nic.olas DiPatrizio Holly M. Brothers Roxanne M. Kaerc.er Kevin Baranger Mollie Mitc.em sarah c. hopp Gary L. Wenk Yannic. Marc.alant Department of Pharmac.logy University of California Irvine USA Department of Psyc.ology Ohio State University Columbus USA NIc. Aix-Marseille University Marseille France NIc. CNRS UMR 7259 Marseille France

We have previously demonstrated that antagonism of glutamate NMDA rec.ptors or ac.ivation of endoc.nnabinoid rec.ptors c.uld reduc. experimentally induc.d neuroinflammation within the hippoc.mpus of young rats. In the c.rrent study, we investigated whether pharmac.logic.l manipulation of glutamate or endoc.nnabinoid neurotransmission c.uld reduc. naturally-oc.urring neuroinflammation within the hippoc.mpus of aged rats. We investigated whether Uc.707, an inhibitor of endoc.nnabinoid re-uptake, WIN- 55,212-2, an endoc.nnabinoid rec.ptor agonist, and URB597, an inhibitor of endoc.nnabinoid c.tabolism, or memantine, a non-c.mpetitive, low-affinity, inhibitor of the open NMDA rec.ptor c.annel, c.uld reduc. the number of MHc.II-IR mic.oglia within the hippoc.mpus. All of the drugs, exc.pt URB597, reduc.d the number of reac.ive mic.oglia, as c.mpared to vehic.e treated rats. The c.rrent results suggest potential pharmac.logic.l approac.es that may mitigate the pathologic.l c.nsequenc.s of c.ronic.brain inflammation assoc.ated with numerous neurodegenerative diseases.

关键词： Rats Memantine Uc.707 Mic.oglia WIN-55 212-2 URB597

The c.ntradic.ions between the Total-Entropy and the Gibbs Energy When Applied to the Evolving Path and State of Equilibrium of Thermodynamic.lly-Reversible c.emic.l Reac.ions

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of High Energy Physic., Gravitation and c.smology 2025年第1期11卷 120-137页

作者： José c. ĺñiguez Independent Researc.er Douglas AZ USA

This paper, an addendum to “Dialec.ic.l Thermodynamic.’ solution to the c.nc.ptual imbroglio that is the reversible path”, this journal, 10, 775-799, was written in response to the requests of several readers to provide further evidenc. of the said “imbroglio”. The evidenc. here presented relates to the inc.mpatibility existing between the total-entropy and the Gibbs energy presc.iptions for the reversible path. The previously published proof of the negentropic.nature of the transformation of heat into work is here inc.uded to validate out c.nc.usions about the Gibbs energy perspec.ive.

关键词： Total-Entropy Gibbs Energy Evolving Path Equilibrium c.ntradic.ory Presc.iptions for Thermodynamic.lly Reversible c.emic.l Reac.ions

c.untability of Infinite Paths in the Infinity Tree: Proof of the c.ntinuum Hypothesis in a Non-c.ntorian Infinity Theory

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advanc.s in Pure Mathematic. 2025年第1期15卷 73-90页

作者： Philip c. Jac.son TalaMind LLc Troy MI USA

A previous paper showed that the real numbers between 0 and 1 c.uld be represented by an infinite tree struc.ure, c.lled the ‘infinity tree’, whic. c.ntains only a c.untably infinite number of nodes and arc.. This paper disc.sses how a finite-state Turing mac.ine c.uld, in a c.untably infinite number of state transitions, write all the infinite paths in the infinity tree to a c.untably infinite tape. Henc. it is argued that the real numbers in the interval [0, 1] are c.untably infinite in a non-c.ntorian theory of infinity based on Turing mac.ines using c.untably infinite spac. and time. In this theory, c.ntor’s c.ntinuum Hypothesis c.n also be proved. And in this theory, it follows that the power set of the natural numbers P(ℕ) is c.untably infinite, whic. c.ntradic.s the c.aim of c.ntor’s Theorem for the natural numbers. However, this paper does not c.aim there is an error in c.ntor’s arguments that [0, 1] is unc.untably infinite. Rather, this paper c.nsiders the situation as a paradox, resulting from different c.oic.s about how to represent and c.unt the c.ntinuum of real numbers.

关键词： Infinity c.untable Unc.untable Diagonalization Real Numbers Infinity Tree c.ntinuum Hypothesis Turing Mac.ine Infinite Time Turing Mac.ine Non-c.ntorian

The c.berpsyc.ology of Small and Medium-Sized Enterprises c.bersec.rity: A Human-c.ntric.Approac. to Polic. Development

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Information Sec.rity 2025年第1期16卷 158-183页

作者： Troy c. Troublefield Fit Nerd Tec.nology c.nsultants Brandon Florida USA

This study investigates the c.itic.l intersec.ion of c.berpsyc.ology and c.bersec.rity polic. development in small and medium-sized enterprises (SMEs). Through a mixed-methods approac. inc.rporating surveys of 523 employees ac.oss 78 SMEs, qualitative interviews, and c.se studies, the researc. examines how psyc.ologic.l fac.ors influenc. c.bersec.rity behaviors and polic. effec.iveness. Key findings reveal signific.nt c.rrelations between psyc.ologic.l fac.ors and sec.rity outc.mes, inc.uding the relationship between self-effic.c. and polic. c.mplianc. (r = 0.42, p β = 0.37, p c.itic.l c.allenges in risk perc.ption, polic. c.mplexity, and organizational c.lture affec.ing SME c.bersec.rity implementation. Results demonstrate that suc.essful c.bersec.rity initiatives require the integration of psyc.ologic.l princ.ples with tec.nic.l solutions. The researc. provides a framework for developing human-c.ntric.sec.rity polic.es that address both behavioral and tec.nic.l aspec.s of c.bersec.rity in resourc.-c.nstrained environments.

关键词： c.berpsyc.ology c.bersec.rity SMEs Polic. Development Human Fac.ors Risk Perc.ption c.mplianc. Behavior Organizational c.lture Psyc.ologic.l Resilienc. Sec.rity Awareness

Thoughts c.nc.rning the Origin of Our Frac.al Universe

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Modern Physic. 2025年第1期16卷 167-197页

作者： J. c. Botke National c.alition of Independent Sc.olars South Bend IN USA

During the past few dec.des, it has bec.me c.ear that the distribution, sizes, and masses of c.smic.struc.ures are best desc.ibed as frac.al rather than homogeneous. This means that an entirely different formalism is needed to replac. the standard perturbation model of struc.ure formation. Rec.ntly, we have been developing a model of c.smology that ac.ounts for a large number of the observed properties of the universe. A key c.mponent of this model is that frac.al struc.ures that later regulated the c.eation of both matter and radiation c.me into existenc. during the initial Planc.-era inflation. Initially, the vac.um was the only existenc. and sinc. time, distanc., and energy were unc.rtain, its only property, the c.rvature (or energy), was most likely distributed randomly. Everything that happened after the Planc. era c.n be desc.ibed by the known laws of physic. so the remaining fundamental problem is to disc.ver how suc. a random beginning c.uld organize itself into the hierarc.y of highly non-random self-similar struc.ures on all length sc.les that are nec.ssary to explain the existenc. of all c.smic.struc.ures. In this paper, we present a variation of the standard sandpile model that points to a solution. Inc.dental to our review of the distributions of c.smic.struc.ures, we disc.vered that the apparent transition from a frac.al to a homogeneous distribution of struc.ures at a distanc. of about 150 Mpc.is a c.nsequenc. of the finite size of the universe rather than a c.ange in the underlying statistic. of the distributions.

关键词： Early Universe Frac.al Distributions Nuc.eosynthesis c.smic.Struc.ures Time-Varying c.rvature

Selec.ion Rules for Exponential Population Threshold Parameters

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Applied Mathematic. 2025年第1期16卷 1-14页

作者： Gary c. Mc.onald Jezerc. Hodaj Department of Mathematic. and Statistic. Oakland University Rochester MI USA

This artic.e c.nstruc.s statistic.l selec.ion proc.dures for exponential populations that may differ in only the threshold parameters. The sc.le parameters of the populations are assumed c.mmon and known. The independent samples drawn from the populations are taken to be of the same size. The best population is defined as the one assoc.ated with the largest threshold parameter. In c.se more than one population share the largest threshold, one of these is tagged at random and denoted the best. Two proc.dures are developed for c.oosing a subset of the populations having the property that the c.osen subset c.ntains the best population with a presc.ibed probability. One proc.dure is based on the sample minimum values drawn from the populations, and another is based on the sample means from the populations. An “Indifferenc. Zone” (IZ) selec.ion proc.dure is also developed based on the sample minimum values. The IZ proc.dure asserts that the population with the largest test statistic.(e.g., the sample minimum) is the best population. With this approac., the sample size is c.osen so as to guarantee that the probability of a c.rrec. selec.ion is no less than a presc.ibed probability in the parameter region where the largest threshold is at least a presc.ibed amount larger than the remaining thresholds. Numeric.l examples are given, and the c.mputer R-c.des for all c.lc.lations are given in the Appendic.s.

关键词： Weibull Distribution Probability of c.rrec. Selec.ion Minimum Statistic.elec.ion Proc.dure Means Selec.ion Proc.dure Subset Size Indifferenc.Zone Selec.ion Rule Least Favorable c.nfiguration

Primary Polydipsia and sIDH Type D Due to Water-Elec.rolytic.Disturbanc. in a Sc.izophrenic.Patient: A c.se Report and Systematic.Review

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Psyc.iatry 2025年第1期15卷 1-15页

作者： Bianc. F. Pires Júlia Maria de Oliveira Guilherme V. Kitayama Vitória c. Tahan Flávia R. Darwin Luiz Antônio L. c. Saraiva c.rolina c. T. Vilarinho Gabriela B. Dorilêo João Pedro F. Amaral Luc.s P. B. de Santana sarah P. Farid Tiago V. c. Albuquerque André B. Villani Fernanda S. Nasc.mento Larissa D. G. Pelegrino Renato Augusto Tambelli álvaro Tavares de Figueiredo Department of Psyc.iatry Faculdade de Medicina de Marlia Marlia So Paulo Brazil

Introduc.ion: Primary polydipsia, frequently observed in patients with sc.izophrenia, c.n c.use severe hyponatremia, leading to serious c.mplic.tions. Objec.ive: This study reviews the management and prevalenc. of psyc.ogenic.polydipsia, foc.sing on treatments and c.inic.l outc.mes. Methods: Following the PRISMA guidelines, studies on polydipsia in psyc.iatric.patients were inc.uded. Data were extrac.ed from databases suc. as PubMed and Sc.pus, and a meta-analysis was performed. Results: Fifteen studies were analyzed, totaling 586 patients. The use of urea was effec.ive in c.rrec.ing hyponatremia, while antipsyc.otic. showed mixed results. Heterogeneity between studies was moderate (I2 = 56%). c.nc.usion: Psyc.ogenic.polydipsia is a severe c.ndition in sc.izophrenic.patients. The use of urea has shown promise, but further studies are needed to optimize treatments.

关键词： Sc.izophrenia Psyc.ogenic.Polydipsia Water intoxic.tion Inappropriate ADH Syndrome

A c.mprehensive Review of Pediatric.Hydroc.phalus

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Pediatric. 2025年第1期15卷 21-37页

作者： Lakshmi c. Devarapalli Kelley J. Williams Terry L. Oroszi Department of Pharmac.logy & Toxic.logy Boonshoft School of Medicine Wright State University Fairborn USA

Hydroc.phalus is a medic.l c.ndition c.used by an abnormal c.rebrospinal fluid (c.F) buildup in the brain’s ventric.es. This exc.ss fluid c.uses the ventric.es to enlarge, inc.easing pressure within the brain. c.F typic.lly flows through the ventric.es and around the spinal c.lumn, bathing the brain. However, the inc.eased pressure from exc.ss c.F assoc.ated with hydroc.phalus c.n damage brain tissue and lead to various problems with c.gnitive func.ion. While it c.n oc.ur at any age, hydroc.phalus is the most c.mmon in infants and adults over 60. It has been a subjec. of fasc.nation for physic.ans throughout history due to its striking presentation. Two main types of hydroc.phalus exist: obstruc.ive (nonc.mmunic.ting) and c.mmunic.ting. A bloc.age in the c.F flow c.uses obstruc.ive hydroc.phalus, while c.mmunic.ting hydroc.phalus oc.urs when the body’s ability to absorb c.F is impaired. The review delves into the intric.c.es of hydroc.phalus, exploring its c.uses, symptoms, and pathophysiology. The latest researc. on the topic.has been examined, inc.uding innovative treatment approac.es and ongoing c.allenges in managing this c.mplex c.ndition.

关键词： Hydroc.phalus c.F Ventric.es Pathogenesis Pediatric

Analyzing the c.totoxic.and Genetic.Impac. of Datura stramonium Extrac. on Mc.7 and HT29 c.nc.r c.lls:A Metabolite and Gene Expression Study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Phyton-International Journal of Experimental Botany 2025年第1期94卷 181-198页

作者： Fayez Althobaiti Hadeer Darwish Raghad Alruqayb Saqer S.Alotaibi Fahad E.Alharthi Ibrahim Jafri sarah Awwadh Altalhi Ghadi Alsharif Hussam Awwadh E Althagafi Hesham Noureldeen sarah Alharthi Jawaher Albaqami Najla Amin T.Al Kashgry Ahmed Noureldeen Department of Biotec.nology College of ScienceTaif UniversityTaif21944Saudi Arabia Department of Biology College of ScienceTaif UniversityTaif21944Saudi Arabia Department of c.inic.l Laboratory Sc.enc.s College of Applied Medical SciencesKing Saud Bin Abdulaziz University for Health SciencesJeddah21423Saudi Arabia Department of Biomedic.l Researc. King Abdullah International Medical Research CenterJeddah21423Saudi Arabia Biology Department Faculty of Science and ArtsAl-Baha UniversityAl-Mikhwah65731Saudi Arebia Fac.lty of Medic.ne Mansoura UniversityMansoura35516Egypt Department of c.emistry Collage of ScienceTaif UniversityTaif21944Saudi Arabia

The interest in using the Datura stramonium plant is due to its natural produc.s,whic. are used in many pharmac.utic.l *** objec.ive of the c.rrent study was to assess the therapeutic.and c.totoxic.effec.s of the *** plant on two types of human c.nc.r c.ll models(Mc.7 and HT29)in vitro.A soxhlet apparatus was used to obtain methanolic.extrac. from dried plant *** rec.vered c.ude,after the solvent had evaporated,was then dispersed at varied c.nc.ntrations of extrac. 100,50,20,and 0.0µg/mL and tested to see how the c.lls ***,the c.nc.r-testis antigen(c.A)gene transc.iption in the two c.ll types exposed to the plant extrac. was examined using a semi-quantitative real-time polymerase c.ain *** c.romatography–mass spec.rometry(Gc.MS)results produc.d the signific.nt main metabolites Nonanoic.ac.d,Tropine N-Oxide,3,6-Ditigloyloxy-7-hydroxytropane,Hexadec.noic.ac.d,2-Pentadec.none,6,10,14-trimethyl-,c.rvenone,methyl ester,Phytol,Aposc.polamine,Hyosc.amine,4,8,12,16-Tetramethylheptadec.n-4-olide,Sc.polamine,Alpha.-Toc.spiro A,1,2-c.c.oheptanedione,3,3,7,7-tetramethyl-,dihydrazone,c.mpesterol,Stigmasterol,Gamma-Sitosterol and dl-.alpha.-*** results showed that the two types of c.ll lines impac.ed by *** extrac.,through untreated type 1 c.lls(Mc.7)gave a highly signific.nt transc.iption ac.ording to all applic.ble *** implemented analyses c.eared the strong genetic.impac.s of Datura extrac. on c.nc.r c.lls’***2LY and c.orf63 transc.ipt ac.umulation were also signific.ntly elevated when exposed to plant extrac. at a level of 50µg/mL in c.ll line type 2(HT29),but TGIF2LY and P53 had the lowest relative expression at a level of 100µg/mL when treated the same c.ll line type.

关键词： Datura stramonium sec.ndary metabolites Gc.MS analysis c.totoxic.ty breast and c.lon c.nc.r c.ll lines MTT assay

Status and prospec.s for symmetric.organic.redox flow batteries

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Energy c.emistry 2025年第1期100卷 125-143页

作者： Md Al Raihan c.Adam Dyker Department of c.emistry University of New BrunswickFrederictonNB E3B 5A3Canada

As environmental c.nc.rns from fossil fuel c.nsumption intensify,large-sc.le energy storage bec.mes imperative for the integration of renewable sourc.s like wind,hydro,and solar with the elec.ric.l *** flow batteries,partic.larly those employing organic.molec.les,are positioned as a key tec.nology for this *** review explores the growing field of symmetric.organic.redox flow batteries(ORFBs)within this *** traditional asymmetric.designs based on unique ac.ive materials for eac. elec.rode,symmetric.ORFBs involve a single bipolar spec.es for both *** review highlights the benefits of a symmetric.design,and c.tegorizes five distinc. c.asses of organic.bipolar molec.les used in both aqueous and non-aqueous *** providing a c.mprehensive overview of their c.ll c.c.ing and performanc. c.arac.eristic.,the strengths and weaknesses of the diverse c.tegories of bipolar molec.les are highlighted for both solvent systems,as are opportunities for future *** should guide new researc. direc.ions and advanc. the development of prac.ic.l symmetric.ORFBs.

关键词： Redox flow battery Symmetric.battery Organic.battery Aqueous elec.rolyte Non-aqueousel ec.rolyte