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Glycemic Response of Type 2 Diabetics to Raisins

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Food and Nutrition Sciences 2012年第8期3卷 1162-1166页

作者： Ted Wilson Jared A. Anderson Kristine F. Andersen Rachael A. Heimerman Megan M. Larson Michelle R. Freeman sarah E. baker Department of Biology Winona State University Winona MN 55987

Background: Raisins are a nutritious fruit snack containing fiber, antioxidants, and potassium. Diabetics tend to have low fruit intakes, possibly due to concerns about glycemic response. Aim: This study sought to characterize the utility of raisins as a way to improve fruit consumption by type 2 diabetics. Methods: Fasting type 2 diabetics randomly received 100 Calorie servings of bananas (BA;103.1 g), white bread (WB;40.2 g), raisins (RA;30.3 g), or Thompson seedless grapes (TG;112.4 g) on each of four separate lab visits in single cross-over fashion. Blood glucose (n = 15) and plasma insulin (n = 7) were measured before and 30, 60, 120 minutes after snack consumption. Results: Relative to baseline, blood glucose peaked significantly at 30 minutes for TG, RA and WB at 204.6 ± 16.2, 180.5 ± 12.7, and 176.2 ± 12.2 mg/dL, respectively, the 30 minute value for BA (173.2 ± 11.6 mg/dL) approached significance (p = 0.12). At 30 minutes, the blood glucose values for BA and TG differed significantly, at all other times no significant differences were observed, and all values returned to near baseline 120 minutes after consumption. Postprandial plasma insulin increased for all treatments, though not significantly. Conclusion: The extended shelf life and portability of raisins may make them an attractive choice for improving fruit consumption in type 2 diabetics.

关键词： Diabetes Glycemic Response Raisin Grape Bread Banana Fruit

Glycemic Response of Type 2 Diabetics to Raisins

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Food and Nutrition Sciences（食品与营养科学） 2012年第8期

作者： Ted Wilson Jared A. Anderson Kristine F. Andersen Rachael A. Heimerman Megan M. Larson Michelle R. Freeman sarah E. baker

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山毛榉最后的时光

英语学习 2010年第7期 32-34页

作者： sarah baker 吴悠（选注）

那棵毛榉倒下以前，我们以为自己会难舍它的树荫；而失去它之后，我们惊奇地发现，原来阳光是那么地美。

关键词：《山毛榉最后的时光》学习方法英语学习阅读

Middle Kingdom Wanderlust

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城市漫步（GBA版） 2023年第3期 34-37页

作者： Alistair baker-Brian 不详

When sarah Keenlyside first arrived in Beijing in 2005,she perhaps couldn't have imagined the Chinese capital would become her *** having first arrived in the city to work in media,she would later go on to found her o... 详细信息

关键词： travel Middle capital

Neck dissection does not add to morbidity or mortality of laryngectomy

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2019年第4期5卷 215-221页

作者： Christopher C.Xiao sarah A.Imam Shaun A.Nguyen Marc P.Camilon Andrew B.baker Terry A.Day Eric J.Lentsch Department of Otolaryngology-Head and Neck Surgery Kaiser PermanenteNorthern CaliforniaOaklandCA94612USA Department of Health and Human Performance The CitadelCharlestonSC29409USA Department of Otolaryngology-Head and Neck Surgery Medical University of South CarolinaCharlestonSC29425USA Oregon Health&Science University Ear Nose&ThroatPortlandOR97239USA

Objectives:To examine the national rates of complications,readmission,reoperation,death and length of hospital stay after *** explore the risks of neck dissection with laryngectomy using ***:The American College of Surgeons National Quality Improvement Program(ACS-NSQIP)database was reviewed *** database was analyzed for patients undergoing laryngectomy with and without neck ***,perioperative complication,reoperation,readmission,and death variables were ***:754 patients who underwent total laryngectomy during this time were *** analysis showed average age was 63 years old,566(75.1%)were white,and 598(79.3%)were *** these patients,520(69.0%)included a neck dissection while 234(31.0%)did *** comparing patients who received a neck dissection to those who did not,there were no significant differences in median length of hospital stay(12.5 days w/vs.13.3 days w/o,P=0.99),rates of complication(40%w/vs.35%w/o,P=0.23),reoperation(13.5%w/vs.14%w/o,P=0.81),readmission(14%w/vs.18%w/o,P=0.27),and death(1.3%w/vs.1.3%w/o,P>0.99).Furthermore,neck dissection did not increase the risk of complication(P=0.23),readmission(P=0.27),reoperation(P=0.81),death(P=0.94),or lengthened hospital stay(P=0.38).Conclusions:Concurrent neck dissection does not increase postoperative morbidity or mortality in patients undergoing total *** results may help physicians make decisions regarding concurrent neck dissection with total laryngectomy.

关键词： Laryngectomy Neck dissection Total laryngectomy Complication rates Outcomes

The Fold-Illuminator:A low-cost,portable,and disposable incubator-illuminator device

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Synthetic and Systems Biotechnology 2021年第2期6卷 95-101页

作者： Logan R.Burrington Emran Baryal Katherine Hui Emmett Lambert sarah T.Harding Javin P.Oza Chemistry and Biochemistry Department College of Science and MathCalifornia Polytechnic State UniversitySan Luis ObispoCA93407USA Mechanical Engineering Department College of EngineeringCalifornia Polytechnic State UniversitySan Luis ObispoCA93407USA

Fluorescent reporters have revolutionized modern applications in the fields of molecular and synthetic biology,enabling applications ranging from education to point-of-care *** advancements in these fields have primarily focused on improving reaction conditions,the development of new applications,and the broad dissemination of these ***,field and classroom-based applications have remained limited in part due to the nature of fluorescent signal detection,which often requires the use of costly lab equipment to observe and quantify fluorescence *** without access to laboratory equipment rely on qualitative assessments of fluorescence,a process that remains highly variable from user-to-user even within the same *** overcome this challenge,we have developed a foldable illuminator and incubator device to support field-applications of synthetic biology-based biosensors for education and *** Fold-Illuminator is an affordable,portable,and recyclable device that allows for the visible detection of fluorescent *** Fold-Illuminator’s design allows for assembly in under 10 min,a user can then utilize the optional heating element to incubate biochemical reactions and visualize fluorescence outputs in a defined and light-controlled *** LED strips and light-filtering screens provide modularity to pair with the fluorescence wavelengths of *** user can then unfold the device for convenient storage,transport,or even *** cost for the Fold-Illuminator is$5.58 USD and is compatible with an optional heating element for an additional$3.98 cost,with potential for further reductions in cost for larger ***-source templates for cutting device parts from paper stock are provided for both printing and cutting by hand;cutting can also be achieved with consumer-grade smart cutting machines such as the Cricut®.Combined with the broad applications of fluorescent reporters

关键词： Illuminator Incubator Fluorescent reporter Education Diagnostics Frugal science

美国临床肿瘤学会IV期非小细胞肺癌化疗的临床实践指南更新

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中国肺癌杂志 2010年第3期13卷 171-189页

作者： Christopher G. AZZOLI Sherman baker JR sarah TEMIN William PAO Timothy ALIFF Julie BRAHMER David H. JOHNSON Janessa L. LASKIN Gregory MASTERS Daniel MILTON Luke NORDQUIST David G. PFISTER Steven PIANTADOSI Joan H. SCHILLER Reily SMITH Thomas J. SMITH John R. STRAWN David TRENT Giuseppe GIACCONE 丁燕(翻译) 南娟(翻译) 刘谦(翻译) 周清华(校对) 陈军(校对) From the Memorial Sloan-Kettering Cancer Center New York NY Virginia Commonwealth University Massey Cancer Center Richmond American Society of Clinical Oncology Alexandria Virginia Cancer Center Richmond VA Vanderbilt-Ingram Cancer Center Nashville TN Northwest Oncology & Hematology Associates Coral Springs FL Sidney Kimmel Comprehensive Cancer Center Johns Hopkins University Baltimore National Cancer Institute Bethesda MD Helen F. Graham Cancer Center Newark DE Hematology/Oncology of Indiana PC Indianapolis IN Nebraska Cancer Specialists PC Omaha NE Samuel Oschin Comprehensive Cancer Institute Los Angeles CA University of Texas Southwestern Medical Center Dallas TX British Columbia Cancer Agency Vancouver British Columbia Canada 天津医科大学总医院天津市肺癌研究所天津市肺癌转移与肿瘤微环境重点实验室

本文旨在为IV期非小细胞肺癌患者的治疗提供更新版推荐。本文资料检索源自2002年以来公布的相关随机试验文献。此指南范围限于化疗与生物治疗。更新委员会对这些文献进行了总结并提供了推荐更新。162篇文献符合标准被纳入参考。本推荐... 详细信息

本文旨在为IV期非小细胞肺癌患者的治疗提供更新版推荐。本文资料检索源自2002年以来公布的相关随机试验文献。此指南范围限于化疗与生物治疗。更新委员会对这些文献进行了总结并提供了推荐更新。162篇文献符合标准被纳入参考。本推荐基于可改善总生存期的治疗方法。仅改善无进展生存期的治疗方法推动了对毒性及生存质量的监测。对于体力状态评分为0分或1分患者的一线治疗,可推荐以铂类为基础的细胞毒性药物的两药联用。对铂类治疗有禁忌的患者,可采用非铂类细胞毒性两药联合。对于体力状态评分为2分的患者,单一细胞毒性药物即可。对于疾病进展或经过4个周期的治疗仍对治疗无反应的患者,应停止一线细胞毒性化疗。即使在6个周期后患者对治疗仍有反应,亦应停止两药细胞毒性化疗。对于伴有明确的表皮生长因子受体(epidermal growth factor receptor,EGFR)突变的患者,可推荐一线采用吉非替尼治疗;对于EGFR突变为阴性或不明确的患者,细胞毒性化疗更佳。除具有特定临床特征的患者外,可推荐贝伐单抗与卡铂-紫杉醇联用。对于通过免疫组化证实EGFR阳性的肿瘤患者,可推荐西妥昔单抗与顺铂-长春瑞滨联用。多西紫杉醇、厄洛替尼、吉非替尼或培美曲塞被推荐作为二线治疗。对于未曾接受过厄洛替尼或吉非替尼治疗的患者,可推荐厄洛替尼作为三线治疗。现有数据不足以推荐常规三线采用细胞毒性药物。已有的证据也不足以推荐常规应用分子标记物选择化疗。

关键词：临床实践指南非小细胞肺癌选择化疗美国临床肿瘤学会细胞毒性药物表皮生长因子受体 receptor 肺癌患者

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疫苗竞赛的领先者

商业周刊（中文版） 2020年第12期 64-69页

作者： Stephanie baker Xia Gordon(插画) Vernon Silver James Paton 冯艳彬(译) 许诺(译) 不详

今年4月,萨拉·吉尔伯特(sarah Gilbert)的三个孩子决定参加一项新冠病毒实验疫苗的人体试验。他们是三胞胎,今年21岁,都在大学读生物化学专业。这是他们的母亲带领牛津大学一个团队研发的疫苗。关于参加人体试验,家里从未郑重其事地讨... 详细信息

今年4月,萨拉·吉尔伯特(sarah Gilbert)的三个孩子决定参加一项新冠病毒实验疫苗的人体试验。他们是三胞胎,今年21岁,都在大学读生物化学专业。这是他们的母亲带领牛津大学一个团队研发的疫苗。关于参加人体试验,家里从未郑重其事地讨论过。

关键词：人体试验吉尔伯特三胞胎牛津大学疫苗生物化学专业病毒

Nature：大规模研究揭示生命所必需的基因

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现代生物医学进展 2016年第31期16卷 I0002-I0003页

作者： Dickinson, Mary E. Flenniken, Ann M. Ji, Xiao Teboul, Lydia Wong, Michael D. White, Jacqueline K. Meehan, Terrence F. Weninger, Wolfgang J. Westerberg, Henrik Adissu, Hibret baker, Candice N. Bower, Lynette Brown, James M. Caddle, L. Brianna Chiani, Francesco Clary, Dave Cleak, James Daly, Mark J. Denegre, James M. Doe, Brendan Dolan, Mary E. Edie, sarah M. Fuchs, Helmut Gailus-Durner, Valerie Galli, Antonella Gambadoro, Alessia Gallegos, Juan Guo, Shiying Horner, Neil R. Hsu, Chih-Wei Johnson, Sara J. Kalaga, Sowmya Keith, Lance C. Lanoue, Louise Lawson, Thomas N. Lek, Monkol Mark, Manuel Arschall, Susan M. Mason, Jeremy McElwee, Melissa L. Newbigging, Susan Nutter, Lauryl M. J. Peterson, Kevin A. Ramirez-Solis, Ramiro Rowland, Douglas J. Ryder, Edward Samocha, Kaitlin E. Seavitt, John R. Selloum, Mohammed Szoke-Kovacs, Zsombor Tamura, Masaru Trainor, Amanda G. Tudose, Ilinca Wakana, Shigeharu Warren, Jonathan Wendling, Olivia West, David B. Wong, Leeyean Yoshiki, Atsushi MacArthur, Daniel G. Tocchini-Valentini, Glauco P. Gao, Xiang Flicek, Paul Bradley, Allan Skarnes, William C. Justice, Monica J. Parkinson, Helen E. Moore, Mark Wells, Sara Braun, Robert E. Svenson, Karen L. de Angelis, Martin Hrabe Herault, Yann Mohun, Tim Mallon, Ann-Marie Henkelman, R. Mark Brown, Steve D. M. Adams, David J. Lloyd, K. C. Kent McKerlie, Colin Beaudet, Arthur L. Bucan, Maja Murray, Stephen A. Dept Mol Physiol & Biophys Houston TX 77030 USA Toronto Ctr Phenogen Toronto ON M5T 3H7 Canada Mt Sinai Hosp Toronto ON M5G 1X5 Canada Univ Penn Perelman Sch Med Genom & Computat Biol Program Philadelphia PA 19104 USA Med Res Council Harwell Mammalian Genet Unit Harwell OX11 0RD Oxon England Mary Lyon Ctr Harwell OX11 0RD Oxon England Hosp Sick Children Mouse Imaging Ctr Toronto ON M5T 3H7 Canada Wellcome Trust Sanger Inst Wellcome Trust Genome Campus Cambridge CB10 1SA England European Bioinformat Inst European Mol Biol Lab Wellcome Trust Genome Campus Cambridge CB10 1SD England Med Univ Vienna Ctr Anat & Cell Biol A-1090 Vienna Austria Hosp Sick Children 555 Univ Ave Toronto ON M5G 1X8 Canada Jackson Lab 600 Main St Bar Harbor ME 04609 USA Univ Calif Davis Mouse Biol Program Davis CA 95618 USA Italian Natl Res Council CNR Inst Cell Biol & Neurobiol Monterotondo Mouse Clin I-00015 Monterotondo Italy Massachusetts Gen Hosp Analyt & Translat Genet Unit Boston MA 02114 USA Broad Inst MIT & Harvard Program Med & Populat Genet Cambridge MA 02142 USA German Res Ctr Environm Hlth Helmholtz Zentrum Munchen Inst Expt Genet D-85764 Neuherberg Germany German Mouse Clin D-85764 Neuherberg Germany Baylor Coll Med Dept Mol & Human Genet Houston TX 77030 USA Nanjing Univ Nanjing Biomed Res Inst Collaborat Innovat Ctr Genet & Dev SKL Pharmaceut Biotechnol & Model Anim Res Ctr Nanjing 210061 Jiangsu Peoples R China Univ Strasbourg ICS Infrastruct Natl PHENOMIN F-67404 Illkirch Graffenstaden France Univ Strasbourg INSERM CNRS IGBMC F-67404 Illkirch Graffenstaden France RIKEN BioResource Ctr Tsukuba Ibaraki 3050074 Japan Childrens Hosp Oakland Res Inst Oakland CA 94609 USA IMPC San Anselmo CA 94960 USA Tech Univ Munich Sch Life Sci Weihenstephan Chair Expt Genet D-81675 Freising Weihenstephan Germany German Ctr Diabet Res DZD D-85764 Neuherberg Germany Francis Crick Inst Mill Hill Lab Mill Hill London NW1 1AT England Univ Penn Perlman

在哺乳动物基因组中。大约三分之一的基因是生命所必需的。在一项新的研究中，来自美国贝勒医学院等多个机构的研究人员描述了这些基因的大规模发现。以及它将如何影响对哺乳动物发育和人类疾病的理解。相关研究结果在线发表在Nature期... 详细信息

在哺乳动物基因组中。大约三分之一的基因是生命所必需的。在一项新的研究中，来自美国贝勒医学院等多个机构的研究人员描述了这些基因的大规模发现。以及它将如何影响对哺乳动物发育和人类疾病的理解。相关研究结果在线发表在Nature期刊上，论文标题为“High—throughput discovery of novel developmental phenotypes”。

关键词：动物基因组生命哺乳动物研究人员人类疾病医学院