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SQL or NoSQL—Practical Aspect and Rational behind Choosing Data Stores

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Journal of Computer and Communications 2024年第8期12卷 1-20页

作者： Sourabh Sethi sarah Panda Digital Experience Infosys Limited New York USA Research and Incubation Microsoft Inc. Seattle USA

Data storage solutions are a crucial aspect of any application, significantly impacting data management and system performance. This article explores the rationale behind utilizing both SQL and NoSQL databases, addressing key questions about when each type is preferable. The background emphasizes the importance of selecting the appropriate database technology to meet specific application requirements. The purpose of this research is to provide a comprehensive guide for choosing between SQL and NoSQL databases based on various factors, including workload characteristics, scalability needs, and consistency requirements. To achieve this, we examine different strategies for implementing SQL and NoSQL databases in large-scale distributed applications and systems. The research method involves a comparative analysis of the features, advantages, and limitations of both database types. We specifically focus on scenarios involving read-heavy versus write-heavy systems and the trade-offs between availability and consistency. The results of this research indicate that SQL databases, with their relational structure and ACID compliance, are ideal for applications requiring complex queries and data integrity. In contrast, NoSQL databases, offering schema flexibility and horizontal scalability, are better suited for managing extensive datasets and high-velocity data ingestion. In conclusion, the selection of a database depends on the specific needs of the application. SQL databases are preferred for transactional systems with complex relationships, while NoSQL databases excel in scenarios demanding flexibility and scalability. The study provides insights into hybrid approaches, leveraging both database types to optimize system performance.

关键词： SQLData Stores NO-SQLData Stores ACID BASE RUM Conjecture

Transforming Digital Experiences: The Evolution of Digital Experience Platforms (DXPs) from Monoliths to Microservices: A Practical Guide

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Journal of Computer and Communications 2024年第2期12卷 142-155页

作者： Sourabh Sethi sarah Panda Infosys Limited New York NY USA Microsoft Inc. Seattle WA USA

The research aims to explore the transition from monolithic Digital Experience Platforms (DXPs) to Microservices-based DXPs, addressing scalability challenges. The study systematically decomposes monolithic structures into Microservices, emphasizing business capability and subdomain decomposition. Concrete insights, challenges, and solutions encountered during this transformation process are presented. The research contributes valuable insights into the challenges and benefits of adopting Microservices in DXPs. Results highlight the importance of architectural patterns and strategic scaling dimensions for improved performance and scalability. The case study on Backbase’s Engagement Banking Platform showcases successful implementation, providing flexibility, integration, and efficient development in the evolving DXP landscape.

关键词： Digital Experience Platforms (DXPs) Microservices Software Evolution Distributed Systems Architectural Patterns

Abomasal infusion of branched-chain amino acids or branched-chain keto-acids alter lactation performance and liver triglycerides in fresh cows

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Journal of Animal Science and Biotechnology 2024年第3期15卷 1145-1157页

作者： Kristen Gallagher Isabelle Bernstein Cynthia Collings David Main Ghayyoor Ahmad sarah Naughton Jayasimha Daddam Vengai Mavangira Mike Vandehaar Zheng Zhou Department of Animal Science Michigan State UniversityEast Lansing 48824USA Department of Veterinary Diagnostic and Production Animal Medicine Ames 50011USA

Background Dairy cows are at high risk of fatty liver disease in early lactation,but current preventative measures are not always *** with fatty liver have lower circulating branched-chain amino acid(BCAA)concentra-tions whereas cows with high circulating BCAA levels have low liver triglyceride(TG).Our objective was to determine the impact of BCAA and their corresponding ketoacids(branched-chain ketoacids,BCKA)on production performance and liver TG accumulation in Holstein cows in the first 3 weeks *** Thirty-six multiparous Holstein cows were used in a randomized block design *** were abomasally infused for the first 21 d postpartum with solutions of 1)saline(CON,n=12);2)BCA(67 g valine,50 g leu-cine,and 34 g isoleucine,n=12);and 3)BCK(77 g 2-ketovaline calcium salt,57 g 2-ketoleucine calcium salt,and 39 g 2-ketoisoleucine calcium salt,n=12).All cows received the same *** effects were determined using PROC GLIMMIX in *** No differences were detected for body weight,body condition score,or dry matter intake averaged over the first 21 d *** receiving BCK had significantly lower liver TG concentrations compared to CON(6.60%vs.4.77%,standard error of the mean(SEM)0.49)during the first 3 weeks of *** of BCA increased milk yield(39.5 vs.35.3 kg/d,SEM 1.8),milk fat yield(2.10 vs.1.69 kg/d,SEM 0.08),and lactose yield(2.11 vs.1.67 kg/d,SEM 0.07)compared with *** to CON,cows receiving BCA had lower plasma glucose(55.0 vs.59.2 mg/dL,SEM 0.86)but higherβ-hydroxybutyrate(9.17 vs.6.00 mg/dL,SEM 0.80).Conclusions Overall,BCAA supplementation in this study improved milk production,whereas BCKA supplementa-tion reduced TG accumulation in the liver of fresh cows.

关键词： Branched-chain amino acids Branched-chain ketoacids Fatty liver Fresh cow

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硅硼碳氮陶瓷前驱体聚硼硅氮烷的合成与表征

Journal of Donghua University(English Edition) 2024年第3期41卷 257-262页

作者： malik Hamza 申键唐滋成刘勇东华大学材料科学与工程学院纤维材料改性国家重点实验室上海201620 东华大学高性能纤维及制品教育部重点实验室上海201620

以三氯化硼(BCl3)、三氯硅烷(HSiCl3)和六甲基二硅氮烷(Me6Si2NH)为原料,通过聚合物前驱体转化陶瓷(polymer-derived ceramics,PDCs)法成功合成了硅硼碳氮(SiBNC)陶瓷前驱体--聚硼硅氮烷(PBSZ)。采用傅里叶变换红外光谱、核磁共振、X射... 详细信息

以三氯化硼(BCl3)、三氯硅烷(HSiCl3)和六甲基二硅氮烷(Me6Si2NH)为原料,通过聚合物前驱体转化陶瓷(polymer-derived ceramics,PDCs)法成功合成了硅硼碳氮(SiBNC)陶瓷前驱体--聚硼硅氮烷(PBSZ)。采用傅里叶变换红外光谱、核磁共振、X射线光电子能谱、热重分析和差示扫描量热对PBSZ的结构和热性能进行分析。结果表明,PBSZ结构中存在硅氮硼(Si—N—B)网络和六元硼氮(B—N)环。在氮气中,800℃时PBSZ的陶瓷产率为53.9%。

关键词：硅硼碳氮(SiBNC)陶瓷陶瓷前驱体聚硼硅氮烷(PBSZ) 聚合物前驱体转化陶瓷(PDCs)法

Linear endoscopic ultrasound:Current uses and future perspectives in mediastinal examination

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World Journal of Gastroenterology 2024年第33期30卷 3803-3809页

作者： Eyad Gadour sarah Al Ghamdi Bogdan Miutescu Hossam E Shaaban Zeinab Hassan Aymen Almuhaidb Hussein H Okasha Department of Gastroenterology and Hepatology King Abdulaziz National Guard HospitalAhsa 36428Saudi Arabia Department of Internal Medicine Zamzam University CollegeSchool of MedicineKhartoum 11113Sudan Department of Medicine Division of GastroenterologyKing Abdulaziz UniversityJeddah 3646Saudi Arabia Department of Gastroenterology and Hepatology Victor Babes University of Medicine and PharmacyTimisoara 300041Romania Advanced Regional Research Center in Gastroenterology and Hepatology Victor Babes University of Medicine and PharmacyTimisoara 300041Romania Department of Internal Medicine and Gastroenterology NhtmriCairo 11796Egypt Department of Internal Medicine Stockport Hospitals NHS Foundation TrustManchester SK27JEUnited Kingdom Department of Gastroenterology King Faisal Specialist Hospital and Research CenterRiyadh 11211Saudi Arabia Department of Internal Medicine Division of Gastroenterology and HepatologyKasr Al-Aini School of MedicineCairo UniversityCairo 11562Egypt

This editorial elaborates on the current and future applications of linear endoscopic ultrasound(EUS),a substantial diagnostic and therapeutic modality for various anatomical *** scope of endosonographic assessment is broad and,among other factors,allows for the evaluation of the mediastinal anatomy and related pathologies,such as mediastinal lymphadenopathy and the staging of central malignant lung ***,EUS assessment has proven more accurate in detecting small lesions missed by standard imaging examinations,such as computed tomography or magnetic resonance *** focus on its current uses in the mediastinum,including lung and esophageal cancer staging,as well as evaluating mediastinal lymphadenopathy and submucosal *** editorial also explores future perspectives of EUS in mediastinal examination,including ultrasound-guided therapies,artificial intelligence integration,advancements in mediastinal modalities,and improved diagnostic approaches for various mediastinal lesions.

关键词： Linear endoscopic ultrasound Mediastinal examination Lung cancer Computed tomography Magnetic resonance imaging

Circulating tumor DNA and its role in detection, prognosis and therapeutics of hepatocellular carcinoma

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Chinese Journal of Cancer Research 2024年第2期36卷 195-214页

作者： Sana Rashid Yingchuan Sun Umair Ali Khan Saddozai Sikandar Hayyat Muhammad Usman Munir Muhammad Usman Akbar Muhammad Babar Khawar Zhiguang Ren Xinying Ji malik Ihsan Ullah Khan Institute of Molecular Biology and Biotechnology University of LahoreLahore 54590Pakistan Department of Internal Oncology(Section Ⅰ) Xuchang Municipal Central HospitalXuchang 461000China Institute of Translational Medicine Medical CollegeYangzhou UniversityYangzhou 225001China Australian Institute for Bioengineering&Nanotechnology the University of QueenslandBrisbane 4072Australia Gomal Center of Biochemistry and Biotechnology Gomal UniversityDera Ismail Khan 29111Pakistan Applied Molecular Biology and Biomedicine Lab Department of ZoologyUniversity of NarowalNarowal Punjab 51600Pakistan Kaifeng Municipal Key Laboratory for Infection and Biosafety Henan International Joint Laboratory of Nuclear Protein RegulationSchool of Basic Medical SciencesHenan UniversityKaifeng 475004China Faculty of Basic Medical Subjects Shu-Qing Medical College of ZhengzhouZhengzhou 450064China Department of Medicine Huaxian County People's HospitalHuaxian 456400China

Hepatocellular carcinoma(HCC) is considered the fifth most prevalent cancer among all types of cancers and has the third most morbidity value. It has the most frequent duplication time and a high recurrence rate. Recently, the most unique technique used is liquid biopsies, which carry many markers;the most prominent is circulating tumor DNA(ctDNA). Varied methods are used to investigate ctDNA, including various forms of polymerase chain reaction(PCR) [emulsion PCR(ePCR), digital PCR(dPCR), and bead, emulsion, amplification, magnetic(BEAMing) PCR]. Hence ctDNA is being recognized as a potential biomarker that permits early cancer detection,treatment monitoring, and predictive data on tumor burden are subjective to therapy or surgery. Numerous ctDNA biomarkers have been investigated based on their alterations such as 1) single nucleotide variations(either insertion or deletion of a nucleotide) markers including TP53, KRAS, and CCND1;2) copy number variations which include markers such as CDK6, EFGR, MYC and BRAF;3) DNA methylation(RASSF1A, SEPT9, KMT2C and CCNA2);4) homozygous mutation includes ctDNA markers as CDKN2A, AXIN1;and 5) gain or loss of function of the genes, particularly for HCC. Various researchers have conducted many studies and gotten fruitful ***, there are some drawbacks to ctDNA namely low quantity, fragment heterogeneity, less stability, limited mutant copies and standards, and differential sensitivity. However, plenty of investigations demonstrate ctDNA's significance as a polyvalent biomarker for cancer and can be viewed as a future diagnostic, prognostic and therapeutic agent. This article overviews many conditions in genetic changes linked to the onset and development of HCC, such as dysregulated signaling pathways, somatic mutations, single-nucleotide polymorphisms, and genomic instability. Additionally, efforts are also made to develop treatments for HCC that are molecularly targeted and to unravel some of the genetic pathways that f

关键词： Hepatocellular carcinoma circulating tumor DNA biomarkers single nucleotide variations diagnosis prognosis

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实用英语口语生活美语

Disparities across the CREOG Districts —Variations of Wellness and Inclusivity Efforts in Obstetrics & Gynecology Residency Websites between Two Consecutive Years

2024年

主讲人： sarah

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来源：爱迪科森网上报告厅评论

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Advances in Reproductive Sciences 2024年第1期12卷 14-22页

作者： Taylor Gatson Mark Alvarez malik Mays Rachel Coleman Dani Zoorob School of Medicine Louisiana State University (LSU) Health Sciences Center Shreveport USA Department of Obstetrics and Gynecology Louisiana State University (LSU) Health Sciences Center Shreveport USA College of Medicine and Life Sciences University of Toledo Toledo USA

Background: Few studies have focused on the geographic and chronologic assessment of inclusivity and wellness in Obstetrics and Gynecology residency websites across the US. Objective: To identify variations in wellness and inclusivity website depictions across CREOG districts over the past two years. Methods: This is a cross-sectional analysis of the websites of ACGME-accredited OB/GYN residency programs across the United States between April 2022 and April 2023. The assessment was based on a compilation of 22 attributes devised and piloted by 49 medical students. A racially, geographically, and gender-diverse cohort of 11 students performed data collection. Results: A total of 560 websites were analyzed over two years. Wellness efforts remained unchanged in both years (website content, dedicated support personnel, and group activities). In 2023, a reduction in referencing of wellness (22%) and inclusivity (30%) occurred in leadership messaging. However, a 7% increase in the use of inclusive pronouns was noted. A reduction in gender diversity was identified (9% in faculty, 5% in residents), with programs favoring female-only teams. Similarly, a 7% reduction in the number of underrepresented in medicine faculty and residents was noted. A 15% reduction was noted in curricula referencing inclusivity in their mission statement and inclusivity focused research. Conclusions: This study suggests the variations across websites relative to inclusivity and wellness over the past two years. Updated websites may provide an accurate reflection of the offerings of programs and their investment in wellness and inclusivity across the nation.

关键词： Diversity Gynecology Inclusion Obstetrics Residency

Discoid meniscus:Treatment considerations and updates

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World Journal of Orthopedics 2024年第6期15卷 520-528页

作者： Waleed Albishi Amjad Albaroudi Abdulrahman M Alaseem sarah Aljasser Ibrahim Alshaygy Abdullah Addar Department of Orthopedic Surgery College of MedicineKing Saud UniversityRiyadh 11362Saudi Arabia

A discoid meniscus is a morphological abnormality wherein the meniscus loses its normal‘C’*** most patients are asymptomatic,patients might still present with symptoms such as locking,pain,swelling,or giving *** resonance imaging is usually needed for confirmation of *** on a constellation of factors,including clinical and radiological,different approaches are chosen for the management of discoid *** purpose of this review is to outline the treatment of discoid meniscus,starting from conservative approach,to the different surgical options for this *** PubMed and Google Scholar databases were used for this *** discussing the treatment of discoid meniscus from 2018 to 2023 were *** there were 369 studies retrieved,and after removal of studies using the exclusion criteria,26 studies were included in this *** such as stability,presence of tear,and morphology can help with surgical *** approaches have been used to treat discoid meniscus,where the choice is tailored for each patient ***,factors that may positively impact patient outcomes include male sex,body mass index<18.5,age at symptom onset<25 years,and duration of symptoms<24 *** conventional approach is partial meniscectomy with or without repair;however,recently,there has been an increased emphasis on discoid-preserving techniques such as meniscoplasty,meniscopexy,and meniscal allograft transplantation.

关键词： Discoid meniscus Saucerization Partial meniscectomy Meniscoplasty Meniscopexy Meniscal allograft transplantation Arthroscopy Knee