检索结果-南通市图书馆

Long noncoding RNAs in prostate cancer： overview and clinical implications

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2016年第4期18卷 568-574页

作者： Bhavna malik Felix Y Feng Department of Radiation Oncology University of Michigan Ann Arbor Michigan USA Department of Radiation Oncology Urology and Medicine University of California at San Francisco USA Helen Diller Family Comprehensive Cancer Center University of California at San Francisco USA

Prostate cancer is the second most common cause of cancer mortality among men in the United States. While many prostate cancers are indolent, an important subset of patients experiences disease recurrence after conventional therapy and progresses to castration-resistant prostate cancer （CRPC）, which is currently incurable. Thus, there is a critical need to identify biomarkers that will distinguish indolent from aggressive disease, as well as novel therapeutic targets for the prevention or treatment of CRPC. In recent years, long noncoding RNAs （IncRNAs） have emerged as an important class of biological molecules. LncRNAs are polyadenylated RNA species that share many similarities with protein-coding genes despite the fact that they are noncoding （not translated into proteins）. They are usually transcribed by RNA polymerase II and exhibit the same epigenetic signatures as protein-coding genes. LncRNAs have also been implicated in the development and progression of variety of cancers, including prostate cancer. While a large number of IncRNAs exhibit tissue- and cancer-specific expression, their utility as diagnostic and prognostic biomarkers is just starting to be explored. In this review, we highlight recent findings on the functional role and molecular mechanisms of IncRNAs in the progression of prostate cancer and evaluate their use as potential biomarkers and therapeutic targets.

关键词： biomarker long noncoding RNAs (IncRNAs) prostate cancer

Evaluation of Clinician Training in Autism Screening, Care Management, and Patient Education

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Pediatrics 2024年第3期14卷 488-513页

作者： Belinda O’Hagan Julie White Ilana Hardesty Rachel Amgott Candice Bangham Xinyang Liu Alyson Codner Amy Ursitti Alana Chandler sarah Foster Marilyn Augustyn Jacey Greece Division of Developmental and Behavioral Pediatrics Department of Pediatrics Boston Medical Center Boston United States of America Boston University Chobanian & Avedisian School of Medicine Boston United States of America Department of Community Health Sciences Boston University School of Public Health Boston United States of America

Objective: The demand for pediatric developmental evaluations has far exceeded the workforce available to perform them, which creates long significant wait times for services. A year-long clinician training using the Extension for Community Healthcare Outcomes (ECHO®) model with monthly meetings was conducted and evaluated for its impact on primary care clinicians’ self-reported self-efficacy, ability to administer autism screening and counsel families, professional fulfillment, and burnout. Methods: Participants represented six community health centers and a hospital-based practice. Data collection was informed by participant feedback and the Normalization Process Theory via online surveys and focus groups/interviews. Twelve virtual monthly trainings were delivered between November 2020 and October 2021. Results: 30 clinicians participated in data collection. Matched analyses (n = 9) indicated statistically significant increase in self-rated ability to counsel families about autism (Pre-test Mean = 3.00, Post-test Mean = 3.89, p = 0.0313), manage autistic patients’ care (Pre-test Mean = 2.56, Post-test Mean = 4.11, p = 0.0078), empathy toward patients (Pre-test Mean = 2.11, Post-test Mean = 1.22, p = 0.0156) and colleagues (Pre-test Mean = 2.33, Post-test Mean = 1.22, respectively, p = 0.0391). Unmatched analysis revealed increases in participants confident about educating patients about autism (70.59%, post-test n = 12 vs. 3.33%, pre-test n = 1, p = 0.0019). Focus groups found increased confidence in using the term “autism”. Conclusion: Participants reported increases in ability and confidence to care for autistic patients, as well as empathy toward patients and colleagues. Future research should explore long-term outcomes in participants’ knowledge retention, confidence in practice, and improvements to autism evaluations and care.

关键词： Autism Spectrum Disorder Program Evaluation Case-Based Training Provider Burnout Continuing Medical Education

Long-term outcomes of titanium-nitride-oxide coated stents and drug-eluting stents in acute coronary syndrome:A systematic review and meta-analysis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Cardiology 2024年第5期16卷 293-305页

作者： Muhammad Ahmed Ali Fahim Afia Salman Hira Anas Khan Syed Muhammad Hasan Muskan FatimaBhojani sarah Aslam Amna Zia Ul Haq Vishal Reddy Bejugam Beena Muntaha Nasir Wajiha Gul Abdul Moeed Abdelrahman S Abdalla Muhammad Majid Muhammad Sohaib Asghar Md Al Hasibuzzaman Department of Internal Medicine Dow University of Health SciencesKarachi 74200Pakistan Department of Internal Medicine North Central Bronx HospitalBronxNY 10467United States Department of Urology Center for Academic MedicineStanford University School of MedicinePalo AltoCA 33872United States Department of Cardiovascular Imaging Cleveland ClinicClevelandOH 44195United States Division of Nephrology and Hypertension Mayo Clinic RochesterRochesterMN 55905United States Institute of Nutrition and Food Science University of DhakaDhaka 1000Bangladesh

BACKGROUND In severe cases of coronary artery disease,percutaneous coronary intervention provide promising *** stent used could be a drug-eluting stent(DES)or a titanium-nitride-oxide coated stent(TiNOS).AIM To compare the 5-year effectiveness and safety of the two stent *** The following systematic review and meta-analysis was conducted in accordance with the preferred reporting items for systematic reviews and meta-analysis guidelines,and PubMed/MEDLINE,Scopus,and Cochrane Central were searched from inception till August *** outcomes were major adverse cardiac events(MACE),cardiac death,myocardial infarction(MI),cardiac death or MI,and ischemia-driven total lesion revascularization(ID-TLR).RESULTS Four randomized controlled trials(RCT),which analyzed a sum total of 3045 patients with acute coronary syndrome(ACS)after a median follow-up time of 5 years were *** statistically insignificant,an increase in the ID-TLR was observed in patients receiving TiNOSs vs *** addition,MI,cardiac death and MI,and definite stent thrombosis(DST)were significantly decreased in the TiNOS *** analysis revealed no significant results with meta-regression presenting non-ST elevated MI(NSTEMI)as a statistically significant covariate in the outcome of *** TiNOS was found to be superior to DES in terms of MI,cardiac death or MI,and DST outcomes,however,the effect of the two stent types on ID-TLR and MACE was not significant.A greater number of studies are required to establish an accurate comparison of patient outcomes in TiNOS and DES.

关键词： Stents Drug-eluting Major adverse cardiac events All-cause death Meta-analysis

An Optimal Analysis for 3D Flow of Prandtl Nanofluid with Convectively Heated Surface

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Communications in Theoretical Physics 2019年第12期71卷 1485-1492页

作者： malik Zaka Ullah Metib Alghamdi Department of Mathematics Faculty of ScienceKing Abdulaziz UniversityJeddah 21589Saudi Arabia Department of Mathematics Faculty of ScienceKing Khalid UniversityAbha 61413Saudi Arabia

In this paper,the magnetohydrodynamic 3 D flow of Prandtl nanoliquid subject to convectively heated extendable surface has been discussed.A linear stretching surface makes the *** and Brownian motion impacts are *** transfer for convective procedure is *** liquid is taken electrically conducted through applied magnetic *** non-dimensional variables lead to strong nonlinear ordinary differential *** obtained nonlinear differential systems are solved through optimal homotopic *** quantities like skin friction coefficients and Nusselt number are explored via *** is observed that effects of Hartman parameter and Biot number on temperature and concentration are quite *** temperature and concentration are enhanced for larger values of Hartman parameter and Biot number.

关键词： three-dimensional flow MHD Prandtl fluid nanoparticles optimal homotopy analysis method(OHAM)

Effect of boundary conditions and convection on thermally induced motion of beams subjected to internal heating

在线全文

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第7期8卷 1044-1052页

作者： malik Pravin KADOLI Ravikiran GANESAN N. Department of Mechanical Engineering National Institute of Technology Karnataka Surathkal Srinivasnagar 575025 India Department of Mechanical Engineering Indian Institute of Technology Madras Chennai 600036 India

Numerical exercises are presented on the thermally induced motion of internally heated beams under various heat transfer and structural boundary conditions. The dynamic displacement and dynamic thermal moment of the beam are analyzed taking into consideration that the temperature gradient is independent as well as dependent on the beam displacement. The effect of length to thickness ratio of the beam on the thermally induced vibration is also investigated. The type of boundary conditions has its influence on the magnitude of dynamic displacement and dynamic thermal moment. A sustained thermally induced motion is observed with progress of time when the temperature gradient being evaluated is dependent on the forced convection generated due to beam motion. A finite element method (FEM) is used to solve the structural equation of motion as well as the heat transfer equation.

关键词： Thermal induced oscillations Natural convection Forced convection Finite element analysis

Systemic oncological therapy in breast cancer patients on dialysis

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Oncology 2024年第6期15卷 730-744页

作者： Salman Khan Ghada Araji Ekrem Yetiskul Praneeth Reddy Keesari Fadi Haddadin Zaid Khamis Varun Chowdhry Muhammad Niazi sarah Afif Meekoo Dhar Suzanne El-Sayegh Department of Internal Medicine Northwell Health-Staten Island University HospitalStaten IslandNY 10305United States Department of Hematology and Oncology Northwell Health-Staten Island University HospitalStaten IslandNY 10305United States Department of Internal Medicine CUNY School of MedicineNew YorkNY 10031United States

The advancement of renal replacement therapy has significantly enhanced the survival rates of patients with end-stage renal disease(ESRD)over ***-ever,this prolonged survival has also been associated with a higher likelihood of cancer diagnoses among these patients including breast *** cancer treatment typically involves surgery,radiation,and systemic therapies,with ap-proaches tailored to cancer type,stage,and patient ***,renal replacement therapy complicates systemic therapy due to altered drug clearance and the necessity for dialysis *** review emphasizes the need for opti-mized dosing and administration strategies for systemic breast cancer treatments in dialysis patients,aiming to ensure both efficacy and ***,ch-allenges in breast cancer screening and diagnosis in this population,including soft-tissue calcifications,are highlighted.

关键词： Breast cancer Systemic therapy Renal replacement therapy Dialysis End-stage renal disease Hormone therapy Chemotherapy

Primary carbohydrate metabolism genes participate in heat-stress memory at the shoot apical meristem of Arabidopsis thaliana

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Molecular Plant 2024年第4期17卷 676-676页

作者： Justyna Jadwiga Olas Federico Apelt Maria Grazia Annunziata Sheeba John sarah Isabel Richard Saurabh Gupta Friedrich Kragler Salma Balazadeh Bernd Mueller-Roeber 不详

(Molecular Plant 14,1508-1524,September 62021)After the original publication of the above article,attentive readers identified errors in Figure 4H that needed correction as *** 4H contained the erroneous labels“10 DAP(7 DAT),”which should have each read,“7 DAP(4 DAT).”To avoid any confusion and ensure consistency across our figures,we modified some of the Col-0 images in a corrected version of Figure 4H below to resemble the exact same Col-0 images as in Figure *** details of the changes are as follows:rotation(Col-0 Primed,all timepoints;Col-0 Triggered,3 DAP and 5 DAP;Col-0 Primed/triggered,3 DAP and 5 DAP),replacement(Col-0 Triggered,7 DAP),and different cropping(Col-0 Primed/triggered,7 DAP).

关键词： Figure metabolism Prime

An improved chaotic hybrid differential evolution for the short-term hydrothermal scheduling problem considering practical constraints

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers of Information Technology & Electronic Engineering 2015年第5期16卷 404-417页

作者： Tahir Nadeem malik Salman ZAFAR Saaqib HAROON Electrical Engineering Department University of Engineering and Technology

Short-term hydrothermal scheduling(STHTS) is a non-linear and complex optimization problem with a set of operational hydraulic and thermal constraints. Earlier, this problem has been addressed by several classical techniques; however, due to limitations such as non-linearity and non-convexity in cost curves, artificial intelligence tools based techniques are being used to solve the STHTS problem. In this paper an improved chaotic hybrid differential evolution(ICHDE) algorithm is proposed to find an optimal solution to this problem taking into account practical constraints. A self-adjusted parameter setting is obtained in differential evolution(DE) with the application of chaos theory, and a chaotic hybridized local search mechanism is embedded in DE to effectively prevent it from premature convergence. Furthermore, heuristic constraint handling techniques without any penalty factor setting are adopted to handle the complex hydraulic and thermal constraints. The superiority and effectiveness of the developed methodology are evaluated by its application in two illustrated hydrothermal test systems taken from the literature. The transmission line losses, prohibited discharge zones of hydel plants, and ramp rate limits of thermal plants are also taken into account. The simulation results reveal that the proposed technique is competent to produce an encouraging solution as compared with other recently established evolutionary approaches.

关键词： Valve-point effect Prohibited discharge zones Differential evolution Chaotic sequences Constraint handling

Assessment of Genetic Variation Within Indian Mustard (Brassica juncea) Germplasm Using Random Amplified Polymorphic DNA Markers

在线全文

学校读者我要写书评

暂无评论

Journal of Integrative Plant Biology 2008年第4期50卷 385-392页

作者： Muhammad Ayub Khan malik Ashiq Rabbani Muhammad Munir Saifullah Khan Ajmal Muhammad Azim malik Oilseed Research Program National Agricultural Research Center Park Road Islamabad 45500 Pakistan Institute of Agri-Biotechnology & Genetic Resources National Agricultural Research Center Park Road Islamabad 45500 Pakistan University of Arid Agriculture Rawalpindi Pakistan

Genetic diversity among 45 Indian mustard （Brassica juncea L.） genotypes comprising 37 germplasm collections, five advance breeding lines and three improved cultivars was investigated at the DNA level using the random amplified polymorphic DNA （RAPD） technique. Fifteen primers used generated a total of 92 RAPD fragments, of which 81 （88%） were polymorphic. Of these, 13 were unique to accession ‘Pak85559＇. Each primer produced four to nine amplified products with an average of 6.13 bands per primer. Based on pairwise comparisons of RAPD amplification products, Nei and Li＇s similarity coefficients were calculated to evaluate the relationships among the accessions. Pairwise similarity indices were higher among the oilseed accessions and cultivars showing narrow ranges of 0.77-0.99. An unweighted pair-group method with arithmetic averages cluster analysis based on these genetic similarities placed most of the collections and oilseed cultivars close to each other, showing a low level of polymorphism between the accessions used. However, the clusters formed by oilseed collections and cultivars were comparatively distinct from that of advanced breeding lines. Genetically, all of the accessions were classified into a few major groups and a number of individual accessions. Advanced breeding lines were relatively divergent from the rest of the accessions and formed independent clusters. Clustering of the accessions did not show any pattern of association between the RAPD markers and the collection sites. A low level of genetic variability of oilseed mustard was attributed to the selection for similar traits and horticultural uses. Perhaps close parentage of these accessions further contributed towards their little diversity. The study demonstrated that RAPD is a simple and fast technique to compare the genetic relationship and pattern of variation among the gene pool of this crop.

关键词： Brassica juncea genetic diversity germplasm oilseed mustard Pakistan random amplified polymorphic DNA.