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Impact of preoperative antibiotics and other variables on integrated microbiome-host transcriptomic data generated from colorectal cancer resections

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World Journal of Gastroenterology 2021年第14期27卷 1465-1482页

作者： sarah a malik Chencan Zhu Jinyu Li Joseph F LaComb Paula I Denoya Igor Kravets Joshua D Miller Jie Yang Melissa Kramer W Richard McCombie Charles E Robertson Daniel N Frank Ellen Li Department of Medicine Renaissance School of MedicineStony Brook UniversityStony BrookNY 11794United States Department of Applied Mathematics and Statistics Stony Brook UniversityStony BrookNY 11794United States Stony Brook Cancer Center Biostatistics and Bioinformatics Shared Resource Stony Brook UniversityStony BrookNY 11794United States Department of Pathology Renaissance School of MedicineStony Brook UniversityStony BrookNY 11794United States Department of Surgery Renaissance School of MedicineStony Brook UniversityStony BrookNY 11794United States Department of Family Population and Preventive MedicineStony Brook UniversityStony BrookNY 11794United States Cold Spring Harbor Laboratory Cancer Center Sequencing Technologies and Analysis Shared Resource Cold Spring HarborNY 11724United States Department of Medicine University of Colorado Anschutz Medical CampusAuroraCO 80045United States

BACKGROUND Integrative multi-omic approaches have been increasingly applied to discovery and functional studies of complex human ***-term preoperative antibiotics have been adopted to reduce site infections in colorectal cancer(CRC)*** hypothesize that the antibiotics will impact analysis of multi-omic datasets generated from resection samples to investigate biological CRC risk *** To assess the impact of preoperative antibiotics and other variables on integrated microbiome and human transcriptomic data generated from archived CRC resection *** Genomic DNA(gDNA)and RNA were extracted from prospectively collected 51 pairs of frozen sporadic CRC tumor and adjacent non-tumor mucosal samples from 50 CRC patients archived at a single medical center from *** 16S rRNA gene sequencing(V3V4 region,paired end,300 bp)and confirmatory quantitative polymerase chain reaction(qPCR)assays were conducted on *** sequencing(IPE,125 bp)was performed on parallel tumor and non-tumor RNA samples with RNA Integrity Numbers scores≥*** PERMANOVA detected significant effects of tumor vs nontumor histology(P=0.002)and antibiotics(P=0.001)on microbialβ-diversity,but CRC tumor location(left vs right),diabetes mellitus vs not diabetic and Black/African Ancestry(AA)vs not Black/AA,did not reach *** mixed models detected significant tumor vs nontumor histology*antibiotics interaction terms for 14 genus level *** confirmed increased Fusobacterium abundance in tumor vs nontumor groups,and detected significantly reduced bacterial load in the(+)antibiotics *** coordinate analysis of the transcriptomic data showed a clear separation between tumor and nontumor *** expressed genes obtained from separate analyses of tumor and nontumor samples,are presented for the antibiotics,CRC location,diabetes and Black/AA race *** Recent adoption of additional preoperative antibiotics as sta

关键词： Colorectal cancer Antibiotics African Continental Ancestry Group Diabetes mellitus 16S rRNA gene RNA-sequencing

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Blood biomarkers of Alzheimer’s disease:important considerations for use in clinical practice

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Neural Regeneration Research 2025年第1期20卷 205-206页

作者： sarah Fullam Sean O’Dowd Antoinette O’Connor Department of Neurology Tallaght University HospitalDublinIreland Academic Unit of Neurology Trinity College DublinIreland

Introduction:Fluid and positron emission tomography(PET)biomarkers that enable the detection of the hallmark proteins of Alzheimer’s disease(AD)(amyloid and tau)have revolutionized our approach to the diagnosis of *** evolution of AD diagnostic criteria to include biological characterization(Alzheimer’s Association Working Group,2023)provides an appropriate framework to reduce levels of clinico-pathologic mismatch and improve in-vivo diagnostic *** the therapeutic landscape for neurodegenerative disease evolves,it is increasingly incumbent on clinicians to provide timely,and pathologically precise diagnoses for ***,the expensive and invasive nature of these tests limits their scalability.

关键词： Blood Alzheimer diagnosis

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Influence of ellagic acid on prostate cancer cell proliferation:A caspase-dependent pathway

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Asian Pacific Journal of Tropical Medicine 2011年第7期4卷 550-555页

作者： Arshi malik sarah Afaq Mohammad Shahid Kafil Akhtar Abdullah Assiri Department of Clinical Biochemistry College of MedicineKing Khalid UniversityAbhaKingdom of Saudi Arabia Department of Microbiology Jawaharlal Nehru Medical CollegeAligarh Muslim UniversityAligarhIndia Department of Pathology Jawaharlal Nehru Medical CollegeAligarh Muslim UniversityAligarhIndia Interventional Cardiologist College of MedicineKing Khalid UniversityAbhaKingdom of Saudi Arabia

Objective:To evaluate the effect of allagic acid treatment on the cell viability of human prostate cancer ***:Ellagic acid(10-100 mol/L) treatment(48 h) of human prostate carcinoma PC3 cells was found to result in a dose-dependent inhibition of cell growth and apoptosis of PC3 cells as assessed by MTT assay,western *** cytometry and confocal ***:We observed that ellagic acid treatment of PC3 cells resulted in a dose dependent inhibition of cell growth/cell *** ellagic acid caused cell growth inhibition was found to be accompanied by induction of apoptosis,as assessed by the cleavage of poly (ADP-ribose) polymerase(PARP) and morphological ***,induction of apoptosis accompanied a decrease in the levels of antiapoptotic protein Bcl-2 and increase in proapoptotic protein *** shifting the Bax:Bcl-2 ratio in favor of *** acid treatment of PC3 cells was also found to result in significant activation of caspases,as shown by the dose dependent decrease in the protein expression of procaspase-3,-6.-8 and -*** ellagic acid-mediated induction of apoptosis was significantly(80%-90%) inhibited by the caspase inhibitor N-benzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethylketone(Z-VAD-FMK).Thus these data suggested an essential role of caspases in ellagic acid-mediated apoptosis of PC3 ***:It is tempting to suggest that consumption of tropical pigmented fruits and vegetables could be an effective strategy to combat prostate cancer.

关键词： Ellagic acid Apoptosis Prostate cancer Caspases

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Active Queue Management Exploiting the Rate Information in TCP-IP Networks

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IEEE/CAA Journal of Automatica Sinica 2018年第1期5卷 223-231页

作者： Abderrahmane Boudi malik Loudini Laboratoire de la Communication dans les Systemes Informatiques Ecole nationale Superieure d'Informatique ESI Algiers 16309 Algeria IEEE

In this paper, we propose a new mechanism called explicit rate notification(ERN) to be used in end-to-end communications. The ERN scheme encodes in the header of transmission control protocol(TCP) packets information about the sending rate and the round trip time(RTT) of the flows. This new available information to the intermediate nodes(routers) is used to improve fairness, increase utilization, decrease the number of drops, and minimize queueing delays. Thus, it induces a better management of the queue. A comparison of our scheme with preexistent schemes, like the explicit congestion notification scheme, shows the effectiveness of the proposed mechanism.

关键词： Active queue management congestion control fairness transmission control protocol(TCP)

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Pulsed Corona Discharges and Their Applications in Toxic VOCs Abatement

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Chinese Journal of Chemical Engineering 1999年第4期7卷 351-362页

作者： Muhammad Arif malik Salman Akbar malik Applied Chemistry Division PINSTECHPO NiloreIslamabadPakistanDepartment of Biological SciencesQuaid-i-Azam UniversityIslamabadPakistan

Plasma processes are among the emerging technologies for volatile organic compounds (VOCs) abatement[1]. Both thermal plasmas and non-equilibrium plasmas (cold plasmas) are being developed for VOCs cleanup[2,3]. Particularly, pulsed corona discharges offer several advantages over conventional VOCs abatement techniques[4-7]. To optimize the existing technology and to develop it further, there is need to understand the mechanisms involved in plasma chemical reactions. Furthermore, it is strongly desirable to be able to predict the behavior of new VOCs in non-equilibrium plasma environment from the data known for a few representative compounds. Pulsed corona discharge technique is introduced here with citation of relevant literature. Fundamental principles, useful for predicting the VOCs' decomposition behavior, have been worked out from the published literature. Latest developments in the area, targeted to minimize the energy losses, improve the VOCs destruction efficiency and reduce the generation of unwanted organic and inorganic by-products, are presented.

关键词： corona discharges volatile organic compounds air purification water purification nonequilibrium plasma

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Modelling of electronegative collisional warm plasma for plasma-surface interaction process

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Plasma Science and Technology 2021年第4期23卷 48-54页

作者： Rajat DHAWAN Hitendra K malik Plasma Science and Technology Laboratory Department of PhysicsIndian Institute of Technology DelhiNew Delhi—110016India

An electronegative collisional plasma having warm and massive positive ions,non-extensive distributed electrons and Boltzmann distributed negative ions is modelled for the plasma-surface interaction process that is used for the surface *** the sheath formation is evaluated through the Bohm’s criterion,which is found to be modified,and the variation of the sheath thickness and profiles of the density of plasma species and the net space charge density in the sheath region in addition to the electric *** effect of ion temperature,nonextensivity and collisional parameter is examined in greater detail considering the collisional cross-section to obey power-law dependency on the positive ion *** positive ions are found to enter in the sheath region at lower velocities in the collisional plasma compared to the case of collision-less plasma;this velocity sees minuscule reduction with increasing *** increasing ion temperature and collisional parameter lead to the formation of sheath with smaller thickness.

关键词： electronegative sheath ion temperature non-extensivity sheath thickness power-law dependency collisions

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Closed-Form Expression for the Exact Period of a Nonlinear Oscillator Typified by a Mass Attached to a Stretched Wire

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Advances in Applied Mathematics and Mechanics 2011年第6期3卷 689-701页

作者： malik Mamode Department of Physics Laboratoire PIMENTEquipe MASCUniversity of La Reunion97400 Saint-DenisFrance

The exact analytical expression of the period of a conservative nonlinear oscillator with a non-polynomial potential,is *** an oscillatory system corresponds to the transverse vibration of a particle attached to the center of a stretched elastic *** result is given in terms of elliptic functions and validates the approximate formulae derived from various approximation procedures as the harmonic balance method and the rational harmonic balance method usually implemented for solving such a nonlinear problem.

关键词： Nonlinear oscillator exact period elliptic integral

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Critical Technical Awakenings

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Journal of Social Computing 2021年第4期2卷 365-384页

作者： Maya malik Momin M.malik the School of Social Work McGill UniversityMontréalH3A 0G4Canada the Institute in Critical Quantitative Computational&Mixed MethodologiesJohns Hopkins UniversityBaltimoreMD 21218USA

Starting with Philip ***’s 1997 essay on“critical technical practice”,we consider examples of writings from computer science where authors describe“waking up”from a previously narrow technical approach to the world,enabling them to recognize how their previous efforts towards social change had been *** use these examples first to talk about the underlying assumptions of a technology-centric approach to social problems,and second to theorize these awakenings in terms of Paulo Freire’s idea of critical ***,understanding these awakenings among technical practitioners as examples of this more general phenomenon gives guidance for how we might encourage and guide critical awakenings in order to get more technologists working effectively towards positive social change.

关键词： critical technical practice critical consciousness perspective transformation education machine learning

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Novel concept of tailorable magnetic field and electron pressure distribution in a magnetic nozzle for effective space propulsion

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Propulsion and Power Research 2023年第1期12卷 59-68页

作者： Lohit malik Department of Manufacturing Processes and Automation Engineering Netaji Subhas University of Technology(formerly Netaji Subhas Institute of Technology)New DelhiIndia Department of Mechanical and Aerospace Engineering Princeton UniversityPrincetonNJ 08540United States

Magnetic nozzle appears to be a practical solution for prolonged space *** efficient handling of the spaceship,an in-flight solution to customize the thrust from the magnetic nozzle is *** a new concept of three-thick coils system is proposed for tailoring the magnetic field in-flight in accordance with electron pressure *** role of peak position of the pressure and its axial gradient is also uncovered for realizing higher *** three-fold increase in thrust is observed when the electron temperature is raised to w2.5 times of its original value at the exit *** set-up is optimized for its best performance and efficient use in the electric space propulsion sector with thrust approaching 5 *** particular,this can contribute to the attitude control or the precision pointing of the spacecraft,the technology for removal of space debris and manipulating the ion momentum flux lost to a wall or unsteady laser produced plasma flow in a magnetic nozzle.

关键词： Tailorable magnetic field Magnetic nozzle Electron pressure Thrust Effective space propulsion

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Tapered coils system for space propulsion with enhanced thrust: a concept of plasma detachment

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Propulsion and Power Research 2022年第2期11卷 171-180页

A concept for plasma detachment in a magnetic nozzle is developed based on the detachment region which is found to decrease with the taper angle of the coils employed in the proposed flexible three coil *** tapering the coils while resulting in the same crosssectional area,the plasma plume outside the throat grows radially that leads to an enhancement in the thrust from 2.67 mN to 5 mN at the final detachment plane for a rise in the taper angle from 0 to 13.The maximum thrust can reach about 9 mN when the middle coil is shifted closer to the right coil along with increasing middle-to-outer-coil diameter(inner)ratio from 1 to *** three-tapered-coils arrangement for a magnetic nozzle turns out to be a robust candidate for space propulsion offering the ability to control plasma detachment and tune thrust in-flight simply via mechanical movements without changing the current.

关键词： Tapered coil Magnetic field topology Magnetic nozzle Thrust Plasma detachment Space propulsion

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