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Effects of butternut squash extract on dentate gyrus cell proliferation and spatial learning in male adult rats

Neural Regeneration Research 2011年第24期6卷 1855-1859页

作者： Mohsen Marzban sara soleimani asl Hassan Fallah Huseini Mahdi Tondar Samira Choopani Mehdi Mehdizadeh M.Sc of Anatomical Sciences Tehran University of Medical Sciences Anatomical Department Medicine FacultyHamedan University of Medical Sciences Institute of Medicinal Plants Jihad University (ACECR)Tehran Young Researcher Club Tehran Physiological & Pharmacological Department Pasture InstituteTehran Research Institute for Islamic and Complementary Medicine (RICM) Tehran University of Medical SciencesTehran Anatomical Department Medicine FacultyTehran University of Medical SciencesTehran

Previous studies reported that some plants, including butternut squash, exert positive effects on the brain. However, few studies have examined the effects of butternut squash on learning, memory, and neurogenesis. This study studied the effects of butternut squash extract on spatial learning and cell proliferation in the dentate gyrus of healthy male rats. Thirty-five male Wistar rats were intraperitoneally injected with 0, 50, 100, 200 and 400 mg/kg butternut squash extract once daily for 2 months. After the last administration, rat＇s spatial memory was studied using the Morris water maze. Finally, rats were sacrificed and hippocampal sections were prepared for light microscopy and bromodeoxyuridine immunohistochemistry studies. The results revealed that escape latency and swim distance decreased in all treatment groups compared with the control rats, and that the number of bromodeoxyuridine-positive cells in the dentate gyrus was significantly increased in the treatment groups compared with the controls. These findings suggest that butternut squash extract improves the learning and memory abilities of male rats, and increases the proliferation of dentate gyrus cells.

关键词： butternut squash spatial learning and memory cell proliferation dentate gyrus

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Non-acute effects of different doses of 3, 4-methylenedioxymethamphetamine on spatial memory in the Morris water maze in Sprague-Dawley male rats

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Neural Regeneration Research 2011年第22期6卷 1715-1719页

作者： sara soleimani asl Mohammad Hassan Farhadi Nasser Naghdi Samira Choopani Alireza Samzadeh-Kermani Mehdi Mehdizadeh Anatomical Department Medicine Faculty Tehran University of Medical SciencesTehran *** Tehran Province Iran Substance Abuse and Dependence Research Center University of Social Welfare and Rehabilitation SciencesTehran *** Tehran Province Iran Physiological & Pharmacological Department Pasture Institute Tehran 13164 Tehran Province Iran Chemistry Department Faculty of Sciences Zabol UniversityZabol *** Sistan Baloochestan Province Iran Cellular & Molecular Research Center Tehran University of Medical SciencesTehran *** Tehran Province Iran

3, 4-methylenedioxymethamphetamine （MDMA; also known as ＇ecstasy＇） has been shown to impair learning and spatial memory in adult and neonatal rats. Many studies have focused on the acute effects of MDMA on memory. In the present study, we intraperitoneally administered MDMA （0, 5, 10, 20 mg/kg） to adult male rats to investigate the effects of different doses on rat spatial memory in the Morris water maze, body temperature, and mortality, twice a day, for 7 successive days. The results indicated that MDMA impaired spatial memory dose-dependently, with the highest dose （20 mg/kg） exerting the strongest effects. In addition, MDMA also caused hyperthermia and increased mortality in rats

关键词： 3, 4-methylendioxymethamphetamine Morris water maze spatial memory neural regeneration

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Effects of nitric oxide on the prefrontal cortex in stressed rats

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Neural Regeneration Research 2010年第14期5卷 1096-1099页

作者： Batoul Ebadi Mehdi Mehdizadeh Arezoo Nahavandi Tabandeh Shariati sara soleimani asl Hamdolah Delaviz Department of Radiology Iran University of Medical Sciences Cellular and Molecular Research Center Department of AnatomyIran University of Medical Sciences Department of Physiology Iran University of Medical Sciences Department of Anatomy Hammedan University of Medical Sciences Department of Anatomy Yasuj University of Medical Sciences

BACKGROUND： Nitric oxide （NO） exhibits both protective and detrimental effects in the central nervous system. OBJECTIVE： To investigate the effect of NO on the prefrontal cortex in neonatal stressed rats. DESIGN, TIME AND SETTING： A randomized, controlled, animal study was performed at the Anatomical Department of Iran University of Medical Sciences from May 2007 to August 2008. MATERIALS; Forty-eight male, Wistar rats were obtained from Pasteur＇s Institute, Tehran, Iran. METHODS： Rat stress models were established by immobilization and randomly received intraperitoneal injection of 2 mL physiological saline, L-arginine （200 mg/kg） as a NO precursor, N（G）-nitro-L-arginine methyl ester （20 mg/kg）, or subcutaneous injection of 7-nitroindazole （25 mg/kg） as a NO synthase inhibitor. MAIN OUTCOME MEASURES： After the rats were treated for 4 weeks, the frontal cortex was harvested for histological observation and NO detection. RESULTS： Subcutaneous administration of N（G）-nitro-L-arginine methyl ester or 7-nitroindazole resulted in significantly lower prefrontal cortex thickness and NO production compared with subcutaneous administration of L-arginine （P 〈 0.05）. Prefrontal cortex thickness significantly increased in rats following L-arginine treatment, compared with physiological saline intervention （P 〈 0.05）. CONCLUSION： NO exhibited protective effects on the prefrontal cortex of stressed rats.

关键词： nitric oxide prefrontal cortex thickness nerve cell stress rats neural regeneration

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This pain drives me crazy:Psychiatric symptoms in women with interstitial cystitis/bladder pain syndrome

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World Journal of Psychiatry 2024年第6期14卷 954-984页

作者： Marianna Mazza Stella Margoni Giuseppe Mandracchia Guglielmo Donofrio Alessia Fischetti Georgios D Kotzalidis Giuseppe Marano Alessio Simonetti Delfina Janiri Lorenzo Moccia Ilaria Marcelli Greta Sfratta Domenico De Berardis Ottavia Ferrara Evelina Bernardi Antonio Restaino Francesco Maria Lisci Antonio Maria D'Onofrio Caterina Brisi Flavia Grisoni Claudia Calderoni Michele Ciliberto Andrea Brugnami sara Rossi Maria Chiara Spera Valeria De Masi Ester Maria Marzo Francesca Abate Gianluca Boggio Maria Benedetta Anesini Cecilia Falsini Anna Quintano Alberto Torresi Miriam Militenda Giovanni Bartolucci Marco Biscosi sara Ruggiero Luca Lo Giudice Giulia Mastroeni Elisabetta Benini Luca Di Benedetto Romina Caso Francesco Pesaresi Francesco Traccis Luca Onori Luca Chisari Leonardo Monacelli Mariateresa Acanfora Eleonora Gaetani Monia Marturano sara Barbonetti Elettra Specogna Francesca Bardi Emanuela De Chiara Gianmarco Stella Andrea Zanzarri Flavio Tavoletta Arianna Crupi Giulia Battisti Laura Monti Giovanni Camardese Daniela Chieffo Antonio Gasbarrini Giovanni Scambia Gabriele Sani Department of Neurosciences Fondazione Policlinico Universitario A Gemelli IRCCSUniversita Cattolica del Sacro CuoreRome 00168Italy Department of Psychiatry UniversitàCattolica del Sacro CuoreRome 00168Italy Department of Neurosciences Section of PsychiatryFondazione Policlinico Universitario Agostino Gemelli IRCCSUniversitàCattolica del Sacro CuoreRome 00168Italy Mental Health NHSASL 4 TeramoTeramo 64100Italy Medical and Surgical Sciences UniversitàCattolica del Sacro CuoreRome 00168Italy Division of Gynecologic Oncology UniversitàCattolica del Sacro CuoreRome 00168Italy UOS Psicologia Clinica Governo ClinicoFondazione Policlinico Universitario Agostino Gemelli IRCCSRome 00168Italy CEMAD Digestive Disease Center Fondazione Policlinico Universitario A.Gemelli-IRCCSRome 00168Italy Department of Woman and Child Health Catholic UniversityRome 00168Italy UOC Psichiatria Clinica e d’Urgenza Dipartimento di Scienze Dell’InvecchiamentoNeurologicheOrtopediche e Della Testa-colloFondazione Policlinico Universitario Agostino Gemelli IRCCSRome 00168Italy

BACKGROUND Interstitial cystitis/bladder pain syndrome(IC/BPS)is an at least 6-mo noninfectious bladder inflammation of unknown origin characterized by chronic suprapubic,abdominal,and/or pelvic *** the term cystitis suggests an inflammatory or infectious origin,no definite cause has been *** occurs in both sexes,but women are twice as much *** To systematically review evidence of psychiatric/psychological changes in persons with IC/*** Hypothesizing that particular psychological characteristics could underpin IC/BPS,we investigated in three databases the presence of psychiatric symptoms and/or disorders and/or psychological characteristics in patients with IC/BPS using the following strategy:("interstitial cystitis"OR"bladder pain syndrome")AND("mood disorder"OR depressive OR antidepressant OR depression OR depressed OR hyperthymic OR mania OR manic OR rapid cyclasterisk OR dysthymiasterisk OR dysphoriasterisk).RESULTS On September 27,2023,the PubMed search produced 223 articles,CINAHL 62,and the combined PsycLIT/PsycARTICLES/PsycINFO/Psychology and Behavioral Sciences Collection search *** on *** produced 14 studies,of which none had available *** were peer-reviewed articles reporting psychiatric/psychological symptoms in patients with IC/BPS,i.e.63 articles spanning from 2000 to October *** studies identified depression and anxiety problems in the IC/BPS population,along with sleep problems and the tendency to *** Psychotherapies targeting catastrophizing and life stress emotional awareness and expression reduced perceived pain in women with IC/*** concepts should be considered when implementing treatments aimed at reducing IC/BPS-related pain.

关键词： Interstitial cystitis/bladder pain syndrome Psychiatric symptoms Psychological symptoms Catastrophizing Anxiety Depression

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Microfacies Patterns and Depositional Environments of the Sarvak Formation in the Abadan Plain, Southwest of Zagros, Iran

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Open Journal of Geology 2016年第3期6卷 201-209页

作者： Shahab soleimani asl Mohsen Aleali Department of Geology Science and Research Branch Islamic Azad University Tehran Iran

The Sarvak Formation is the second major oil-bearing reservoir in the south and south west of Iran. The Middle Cretaceous Sarvak formation in the Zagros Mountains (Zagros Basin) is mainly composed of carbonate sequences. Based on facies studied, thirteen microfacies were recognized in the studied area, which were categorized in the three facies groups: including inner ramp, mid ramp and outer ramp. Evidences such as the gradual changes in the facies (basin slope), the absence of extensive uninterrupted barrier reef, the lack of calciturbidite and gravity sediments as well as the high proportion of grain-supported indicated that the Sarvak Formation was deposited in the ramp like depositional system, particularly on an inner ramp setting. Inner ramp facies group is the principal setting and subdivided to tidal flat, restricted and unrestricted lagoon as well as shoal sub-environments.

关键词： Microfacies Depositional Environments Sarvak Formation Zagros Iran

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DEFINING A NOVEL FIGURE OF MERIT FOR QUALIFYING TCO LAYERS IN SOLAR CELL APPLICATIONS AND SIMULATING THE EFFECTS OF THEM

DEFINING A NOVEL FIGURE OF MERIT FOR QUALIFYING TCO LAYERS I...

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2007世界太阳能大会：太阳能与人类居住

作者： Farzad Behafarid Ali Mohammadi Gheidari Ebrahim asl soleimani ECE Dept University of Tehran P.O.Box 2703 TehranIran

Transparent conductive oxides are widely used in solar cell *** layers have low electrical resistance that can reduce the top contact losses by reducing series resistance and increasing the fill factor of the *** the contrary,due to their conductivity,these layers have higher absorption coefficient than non conductive anti reflection *** interests in preparing of high quality TCO films lead us to defining a novel figure of merit Q for qualifying these layers and predicting the influence of using TCO films on solar cells operation. In this paper,all of the top contact effects such as shadows of contacts,contact resistance,lateral resistance and metal resistance were analytically *** layers mainly affect the lateral and contact *** properties of layers are modeled for solar cell applications by defining a modified average transmission coefficient using the air mass 1.5 and IQE as the weight factors. Considering the electro-optical effects of TCO layers,a novel figure of merit is introduced which is proportional to the efficiency of the cell. Using this figure of merit we are able to optimize the top contact pattern and choose the best values for finger spacing and busbar width. The defined Q is used to qualifying the ITO layers prepared by RF sputtering in TFL laboratory and it shows that the films with RF power of 300w and the mixture pressure 27 mTorr (90% Ar-10% O) and the annealing temperature of 400℃ has the most amount of Q in optimize top contact pattern.

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The Crystallization and Physical Properties of Al-doped ZnO Films

The Crystallization and Physical Properties of Al-doped ZnO ...

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2011 2nd International Conference on Nanotechnology and Biosensors（ICNB 2011）

作者： Seyed manouchehr Hosseini Pilangorgi Fatemeh Dehghan Nayeri Ebrahim asl-soleimani Department of electrical engineering Toyserkan BranchIslamic Azad UniversityToyserkanIran Thin Film laboratory ECE departmentUniversity of TehranTehranIran

In this paper, Al-doped ZnO (AZO) films have been deposited by RF sputtering at room temperature with thickness 300 nm from an Aluminium Zinc Oxide target in Argon 99.99% ambient and without substrate heating with RF power of 300 watt. After deposition, the samples have been annealed at temperatures ranging from 300 to 500 o C in vacuum for 1h. The effect of flow rate of the Argon gas and annealing, on the Structural properties and grain size have been investigated by XRD using Cu(Ka1) radiation (λ= 0.154056 nm) in θ-2θ scan mode. It is shown that the structural properties and grain size of the AZO thin films are dependent on the flow rate of the Argon gas. The experimental results show that good qualities of crystalline structure appeared when AZO film prepared by flow rate of Argon gas 10 SCCM. But the effect of annealing on the structural properties of the AZO thin films is low. A high degree of preferred orientation which depends on the various flow rate of argon gas is exhibited. The θ-2θ scan data of AZO films exhibit a strong 2θ peaks at nearby 34.53°, corresponding to the (002) peaks of AZO. It is indicated that the film is a crystalline with a preferential orientation along c-axis. There is a 2% variation in 2θ peaks of AZO films. (i.e. 34.53°± 2%) have been prepared at various flow rate and annealing temperature.

关键词： AZO sputtering annealing thin film ZnO

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A NEW APPROACH FOR INVESTIGATION OF STRUCTURAL PROPERTIES OF INDIUM TIN OXIDE THIN FILM

A NEW APPROACH FOR INVESTIGATION OF STRUCTURAL PROPERTIES OF...

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2007世界太阳能大会：太阳能与人类居住

作者： A.Mohammadi Gheidari E.asl soleimani W.Shams-Kolahi Thin Film Laboratory ECE DepartmentUniversity of TehranP.O.Box 14395/515TehranIran

It has been proved that the optical and electrical properties of indium tin oxide (ITO) thin film is strongly structural dependent,with the structural properties of the film varies for different film preparation condition. The ITO film has been prepared by RF sputtering and its transmission and conductivity have been optimized by annealing in the atmosphere of N at 400℃.A theoretical model based on the variation of electrical and optical band gap of the film for different preparation condition is developed and its validity has been verified by experimental results.

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Effects of the Mixture of <i>Cichorium intybus</i>L. and <i>Cinnamomum zeylanicum</i>on Hepatic Enzymes Activity and Biochemical Parameters in Patients with Nonalcoholic Fatty Liver Disease

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Health 2014年第11期6卷 1212-1217页

作者： Zeynab Sheybani asl Ali Akbar Malekirad Mohammad Abdollahi Alireza Bakhshipour Hajar Akbari Dastjerdi sara Mostafalou Razieh Yousef Poor Department of Biology Payame Noor University Tehran Iran Faculty of Pharmacy Pharmaceutical Sciences Research Center Tehran University of Medical Science Tehran Iran Facultyof Medicine Zahedan University of Medical Science Zahedan Iran

The prevalence of nonalcoholic fatty liver disease (NAFLD) as a metabolic disorder affecting the liver function is rapidly increasing and there is a need to develop new and more efficient treatment. This study was designed to evaluate the protective effect of Cichorium intybus L. and Cinnamon mixture infusion (2.5 and 0.5 g/100mL and twice/day) on patients with NAFLD. This before-after clinical trial study was performed on 25 patients with NAFLD. They were administered the mixture of extract prepared in special bags twice a day for 30 days. Hepatic and metabolic markers of NAFLD like alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphates (ALP), fasting blood sugar (FBS), cholesterol (chol), triglycerides (TG), high-density lipoprotein (HDL) and low-density lipoprotein (LDL) in plasma and also, fatty liver ultrasonographic grading were determined before and after using the extracts. 30-day treatment with extracts in NAFLD patients resulted in a significant decrease in ALT and AST. FBS, TG and ALP were also decreased after administration of the extracts but not significantly. A significant linear correlation was found between age and ALP, and between gender and liver enzymes. It is concluded that the mixture of Cichorium intybus L. and Cinnamon extracts has some benefits in NAFLD patients making them valuable for future investigations.

关键词： Nonalcoholic Fatty Liver Disease Cichorium intybus L. Cinnamon Liver Enzymes Biochemical Parameters

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BMSCs and CoQ10 Improve Behavioral Recovery and Histological Outcome in Rat Models of Parkinson's Disease

BMSCs and CoQ10 Improve Behavioral Recovery and Histological...

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第六届国际脑血管病高峰论坛

作者： Akram nezhadi Farideh ghazi Homa rassoli Mehrdad bakhtiari Zohreh ataiy sara soleimani Mehdi Mehdizadeh Department of Anatomy Army University of medical sciences(Iran) Department of genetic and biology Iran University of Medical Sciences Department of Anatomy School of MedicineIran University of Medical Sciences Department of Anatomy School of MedicineHamedan University of Medical Sciences Cellular and molecular research center Department of AnatomySchool of MedicineIran University of Medical SciencesTehran-Iran

Objective:The assessment of the ability of combined treatment of bone marrow stromal cells graft(BMSCs) and oral administration of Coenzyme(CoQ 1 O) in rat model of Parkinson disease as a good substitute for common cu... 详细信息

关键词： Coenzyme Q10 Stromal cells derived from Bone marrow Neuroprotective Parkinson’s disease

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