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有害废物对价值评估的影响

经济资料译丛 2008年第2期 37-47页

作者： Myles b.Hoffert Frederick W.Morgan 李俭（译）纪益成（指导老师）不详底特律城市的财务部厦门大学评估研究中心 361005

《全面环境反应和清除责任综合法》于1980年正式颁布，该法案又被称为CERCLA或superfund法。该法案对受污染的财产和所有相关的当事人产生了深远的影响。1986年，该法作为CERCLA的修正和附加的Superfund修订重新授权法（sara）饿得以颁布。

关键词：价值评估有害废物综合法当事人授权法法案

An R-Smad from Haemonchus contortus(Hc-DAF-8) mediates development via the TGF-β signalling pathway

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An R-Smad from Haemonchus contortus(Hc-DAF-8) mediates devel...

Wnt genes in colonic polyposis predisposition

中国畜牧兽医学会兽医寄生虫学分会第一届青年科学家学术论...

作者： Fangfang Li Robin b.Gasser Jianan Shan Wenda Di Li He Caixian Zhou Chunqun Wang Yanqin Zhou Rui Fang Junlong Zhao Min Hu State Key Laboratory of Agricultural Microbiology Key Laboratory for the Development of Veterinary ProductsMinistry of AgricultureCollege of Veterinary MedicineHuazhong Agricultural University Melbourne Veterinary School Faculty of Veterinary and Agricultural SciencesThe University of Melbourne

Proteins of the Smad family are essential cellular mediators of the transforming growth factor-β(TGF-β) superfamily that directly transmit incoming signals from the cell surface receptors to the *** spite of their functional importance,almost nothing is known about Smad proteins in parasitic *** the present study,we identified a homologueofDAF-8 representing the receptor-regulated Smad(R-Smad) subfamily of the free-living nematode Caenorhabditis elegans,called Hc-DAF-8,in the parasitic nematode Haemonchus *** features of Hc-DAF-8(502 amino acids),including conserved R-Smad domains,and characteristic residues in the L3 loop involved in Smad-anchoring for receptor activation(sara),are consistent with a TGF-β type I receptor-activated *** Hc-daf-8 gene was transcribed in all developmental stages of *** studied,with a high level in fourth-stage(L4) females and the highest level in adult *** ***,this protein was localised to the platymyarian muscular cells,intestine and reproductive system of L4 and adult *** assessment showed that Hc-daf-8 was able to rescue gene function in a daf-8 deficient mutant strain of ***,leading to a resumption of normal development in this free-living worm.A specific inhibitor of human Smad3(SIS3) was shown to affect *** development in *** together,these results suggest that Hc-DAF-8,encoded by the gene Hc-daf-8,is an important cellular mediator of *** development via the TGF-βsignalling *** findings underpin future explorations of this pathway in *** and other important parasitic nematodes.

关键词： Haemonchus contortus R-Smads TGF-β signalling pathway Development Gene rescue Specific inhibitor of human Smad3(SIS3)

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Genes & Diseases 2023年第3期10卷 753-757页

作者： Isabel Quintana Mariona Terradas Pilar Mur Iris b.A.Wte Paske Sophia Peters Isabel Spier Verena Steinke-Lange Claudia Maestro David Torrents Montserrat Puiggròs Romina Royo Raul Tonda Genís Parra Davide Piscia Sergi beltrán Matilde Navarro Virginia Piñol Joan brunet Noemi Gonzalez-Abuin Gemma Aiza Anna Sommer Yasmijn van Herwaarden Galuh Astuti Elke Holinski-Feder Nicoline Hoogerbrugge Richarda Mde Voer Stefan Aretz Gabriel Capellá Laura Valle Hereditary Cancer Program Catalan Institute of OncologyOncobell ProgramIDIBELLHospitalet de LlobregatBarcelona 08908Spain Centro de Investigación biomédica en Red de Cáncer(CIbERONC) Madrid 28029Spain Department of Human Genetics Radboud Institute for Molecular Life SciencesRadboud University Medical CenterGA Nijmegen 6525the Netherlands Member of SOLVE-RD ERN-GENTURIS Institute of Human Genetics Medical FacultyUniversity of BonnBonn 53127Germany National Center for Hereditary Tumor Syndromes University Hospital BonnBonn 53127Germany Medizinische Klinik Und Poliklinik IV Campus InnenstadtKlinikum Der Universität MünchenMunich 80336Germany MGZ-Medizinisch Genetisches Zentrum Munich 80335Germany Life Sciences Department Barcelona Supercomputing Center(BSC)Barcelona 08034Spain ICREA Barcelona 08010Spain CNAG-CRG Centre for Genomic Regulation(CRG)Barcelona Institute of Science and TechnologyBarcelona 08028Spain Universitat Pompeu Fabra(UPF) Barcelona 08002Spain Department of Genetics Microbiology and StatisticsSchool of BiologyUniversitat de Barcelona(UB)Barcelona 08028Spain Gastroenterology Unit Hospital Universitario de Girona Dr Josep TruetaGirona 17007Spain Catalan Institute of Oncology IDIBGiGirona 17007Spain Department of Gastroenterology and Hepatology Radboud University Medical CenterGA Nijmegen 6525the Netherlands Department of Human Genetics Radboud University Medical CenterGA Nijmegen 6525the Netherlands

Much of the genetic predisposition to polyposis,and particularly to serrated polyposis(SP),remains *** germline pathogenic variants in RNF43,a tumor suppressor that exerts negative feedback in the Wnt/β-catenin signaling pathway,have been causally linked to some SP cases(bMP/TGF-β,or Wnt signaling,being the latter associated with adenomatous and serrated polyposis phenotypes.2 based on this observation,we evaluated the presence and role of germline variants in those pathways in unsolved polyposis patients.

关键词： polyposis suppressor colorectal

Nature：大规模研究揭示生命所必需的基因

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现代生物医学进展 2016年第31期16卷 I0002-I0003页

作者： Dickinson, Mary E. Flenniken, Ann M. Ji, Xiao Teboul, Lydia Wong, Michael D. White, Jacqueline K. Meehan, Terrence F. Weninger, Wolfgang J. Westerberg, Henrik Adissu, Hibret baker, Candice N. bower, Lynette brown, James M. Caddle, L. brianna Chiani, Francesco Clary, Dave Cleak, James Daly, Mark J. Denegre, James M. Doe, brendan Dolan, Mary E. Edie, sarah M. Fuchs, Helmut Gailus-Durner, Valerie Galli, Antonella Gambadoro, Alessia Gallegos, Juan Guo, Shiying Horner, Neil R. Hsu, Chih-Wei Johnson, sara J. Kalaga, Sowmya Keith, Lance C. Lanoue, Louise Lawson, Thomas N. Lek, Monkol Mark, Manuel Arschall, Susan M. Mason, Jeremy McElwee, Melissa L. Newbigging, Susan Nutter, Lauryl M. J. Peterson, Kevin A. Ramirez-Solis, Ramiro Rowland, Douglas J. Ryder, Edward Samocha, Kaitlin E. Seavitt, John R. Selloum, Mohammed Szoke-Kovacs, Zsombor Tamura, Masaru Trainor, Amanda G. Tudose, Ilinca Wakana, Shigeharu Warren, Jonathan Wendling, Olivia West, David b. Wong, Leeyean Yoshiki, Atsushi MacArthur, Daniel G. Tocchini-Valentini, Glauco P. Gao, Xiang Flicek, Paul bradley, Allan Skarnes, William C. Justice, Monica J. Parkinson, Helen E. Moore, Mark Wells, sara braun, Robert E. Svenson, Karen L. de Angelis, Martin Hrabe Herault, Yann Mohun, Tim Mallon, Ann-Marie Henkelman, R. Mark brown, Steve D. M. Adams, David J. Lloyd, K. C. Kent McKerlie, Colin beaudet, Arthur L. bucan, Maja Murray, Stephen A. Dept Mol Physiol & biophys Houston TX 77030 USA Toronto Ctr Phenogen Toronto ON M5T 3H7 Canada Mt Sinai Hosp Toronto ON M5G 1X5 Canada Univ Penn Perelman Sch Med Genom & Computat Biol Program Philadelphia PA 19104 USA Med Res Council Harwell Mammalian Genet Unit Harwell OX11 0RD Oxon England Mary Lyon Ctr Harwell OX11 0RD Oxon England Hosp Sick Children Mouse Imaging Ctr Toronto ON M5T 3H7 Canada Wellcome Trust Sanger Inst Wellcome Trust Genome Campus Cambridge CB10 1SA England European bioinformat Inst European Mol Biol Lab Wellcome Trust Genome Campus Cambridge CB10 1SD England Med Univ Vienna Ctr Anat & Cell Biol A-1090 Vienna Austria Hosp Sick Children 555 Univ Ave Toronto ON M5G 1X8 Canada Jackson Lab 600 Main St Bar Harbor ME 04609 USA Univ Calif Davis Mouse Biol Program Davis CA 95618 USA Italian Natl Res Council CNR Inst Cell Biol & Neurobiol Monterotondo Mouse Clin I-00015 Monterotondo Italy Massachusetts Gen Hosp Analyt & Translat Genet Unit Boston MA 02114 USA broad Inst MIT & Harvard Program Med & Populat Genet Cambridge MA 02142 USA German Res Ctr Environm Hlth Helmholtz Zentrum Munchen Inst Expt Genet D-85764 Neuherberg Germany German Mouse Clin D-85764 Neuherberg Germany baylor Coll Med Dept Mol & Human Genet Houston TX 77030 USA Nanjing Univ Nanjing Biomed Res Inst Collaborat Innovat Ctr Genet & Dev SKL Pharmaceut Biotechnol & Model Anim Res Ctr Nanjing 210061 Jiangsu Peoples R China Univ Strasbourg ICS Infrastruct Natl PHENOMIN F-67404 Illkirch Graffenstaden France Univ Strasbourg INSERM CNRS IGBMC F-67404 Illkirch Graffenstaden France RIKEN BioResource Ctr Tsukuba Ibaraki 3050074 Japan Childrens Hosp Oakland Res Inst Oakland CA 94609 USA IMPC San Anselmo CA 94960 USA Tech Univ Munich Sch Life Sci Weihenstephan Chair Expt Genet D-81675 Freising Weihenstephan Germany German Ctr Diabet Res DZD D-85764 Neuherberg Germany Francis Crick Inst Mill Hill Lab Mill Hill London NW1 1AT England Univ Penn Perlman

在哺乳动物基因组中。大约三分之一的基因是生命所必需的。在一项新的研究中，来自美国贝勒医学院等多个机构的研究人员描述了这些基因的大规模发现。以及它将如何影响对哺乳动物发育和人类疾病的理解。相关研究结果在线发表在Nature期... 详细信息

在哺乳动物基因组中。大约三分之一的基因是生命所必需的。在一项新的研究中，来自美国贝勒医学院等多个机构的研究人员描述了这些基因的大规模发现。以及它将如何影响对哺乳动物发育和人类疾病的理解。相关研究结果在线发表在Nature期刊上，论文标题为“High—throughput discovery of novel developmental phenotypes”。

关键词：动物基因组生命哺乳动物研究人员人类疾病医学院

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萨拉的故事

高中生（作文） 2015年第5期 38-38页

作者： Lindsay b. 甜妞

我还记得萨拉六年级时在数学课上的处境：她千方百计想融入我们这帮女生，谈论流行时尚，炫耀新装扮，但没人搭理她。并不是因为萨拉人不好，对我们不友善，而是因为从她跨进教室的那一刻起，她就被贴上了“小胖妞”的标签。

关键词：故事流行时尚数学课六年级装扮

更加全面地认识城镇化、城镇地区和碳循环的关系

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城市与区域规划研究 2017年第3期9卷 245-264页

作者：帕特里夏·罗梅罗-兰考凯文·格尼凯伦·濑户米哈伊尔·切斯特赖利·杜伦萨拉·休斯露西·赫蒂拉彼得·马科图利奥拉里·贝克南希·格里姆克里斯·肯尼迪伊丽莎白·拉森斯蒂芬妮·平塞特丹·伦福洛兰迪·桑切斯吉娅米·斯雷斯塔安德烈亚·萨兹姆斯基乔舒亚·斯佩林埃莉诺·斯托克斯高雪梅徐瑾顾朝林美国都市未来和大气研究中心亚利桑那州立大学生命科学学院/全球持续力学院耶鲁大学森林与环境研究学院亚利桑那州立大学土木、环境和可持续工程学院美国国家航空航天局喷气推进实验室多伦多环境保护局/多伦多大学波士顿大学地球和环境系纽约城市大学亨特学院地理系明尼苏达大学生物产品和生物系统工程系多伦多大学土木工程系美国科学促进会/美国国家航空航天局加利福尼亚大学环境与可持续发展学院美国大气研究中心/乔治·华盛顿公共政策研究所墨西哥城市与环境学院人口研究中心美国碳循环科学项目办公室德拉华大学公共政策和管理学院清华大学建筑学院

对城镇化、城镇地区和碳循环相关的独立研究，加深了我们对能源和土地使用影响碳循环这一过程的认识。文章将多样化观点综合在一起，作为全面理解城镇化过程、城镇地区及其与碳循环关系的第一步。文章建议，对于不同的城镇化过程、机理... 详细信息

对城镇化、城镇地区和碳循环相关的独立研究，加深了我们对能源和土地使用影响碳循环这一过程的认识。文章将多样化观点综合在一起，作为全面理解城镇化过程、城镇地区及其与碳循环关系的第一步。文章建议，对于不同的城镇化过程、机理和要素，不同的时间、不同的城市乃至跨城市的碳排放时空模式问题，需要在现有研究方法的基础上，应用补充和整合的新型跨学科研究法进行研究。文章呼吁对城镇化和不同位置城市碳影响的研究需要采用更加整体性的方法，其中既包括收入，也包括城市发展路径的其他相互联系的特性，如城市形态、经济功能和制度或治理安排。文章进一步指出城镇化机理和城镇化过程都存在广泛的不确定性，而且两者都与城市社会制度和建成环境系统存在相互关系，它们三者对碳循环均有影响，并且相关碳排量的控制又会对城镇化产生影响。最后，文章还研究了低碳城市转型发展的路径、障碍和局限，建议发展终端到终端、合作、综合的科学意识，从而提高城市转型效率，同时规避转型过程中的障碍。

关键词：城镇化城镇地区碳循环

Observatory science with eXTP

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Science China(Physics,Mechanics & Astronomy) 2019年第2期62卷 97-138页

作者： Jean J.M.in 't Zand Enrico bozzo JinLu Qu Xiang-Dong Li Lorenzo Amati Yang Chen Immacolata Donnarumma Victor Doroshenko Stephen A.Drake Margarita Hernanz Peter A.Jenke Thomas J.Maccarone Simin Mahmoodifar Domitilla de Martino Alessandra De Rosa Elena M.Rossi Antonia Rowlinson Gloria Sala Giulia Stratta Thomas M.Tauris Joern Wilms XueFeng Wu Ping Zhou Iván Agudo Diego Altamirano Jean-Luc Atteia Nils A.andersson M.Cristina baglio David R.ballantyne Altan baykal Ehud behar Tomaso belloni Sudip bhattacharyya Stefano bianchi Anna bilous Pere blay Joao braga Sφren brandt Edward F.brown Niccolo bucciantini Luciano burderi Edward M.Cackett Riccardo Campana Sergio Campana Piergiorgio Casella Yuri Cavecchi Frank Chambers Liang Chen Yu-Peng Chen Jér?me Chenevez Maria Chernyakova ChiChuan Jin Riccardo Ciolfi Elisa Costantini Andrew Cumming Antonino D'Aì Zi-Gao Dai Filippo D'Ammando Massimiliano De Pasquale Nathalie Degenaar Melania Del Santo Valerio D'Elia Tiziana Di Salvo Gerry Doyle Maurizio Falanga XiLong Fan Robert D.Ferdman Marco Feroci Federico Fraschetti Duncan K.Galloway Angelo F.Gambino Poshak Gandhi MingYu Ge bruce Gendre Ramandeep Gill Diego G?tz Christian Gouiffès Paola Grandi Jonathan Granot Manuel Güdel Alexander Heger Craig O.Heinke Jeroen Homan Rosario Iaria Kazushi Iwasawa Luca Izzo Long Ji Peter G.Jonker Jordi José Jelle S.Kaastra Emrah Kalemci Oleg Kargaltsev Nobuyuki Kawai Laurens Keek Stefanie Komossa Ingo Kreykenbohm Lucien Kuiper Devaky Kunneriath Gang Li En-Wei Liang Manuel Linares Francesco Longo FangJun Lu Alexander A.Lutovinov Denys Malyshev Julien Malzac Antonios Manousakis Ian McHardy Missagh Mehdipour YunPeng Men Mariano Méndez Roberto P.Mignani Romana Mikusincova M.Coleman Miller Giovanni Miniutti Christian Motch Joonas Nättilä Emanuele Nardini Torsten Neubert Paul T.O'brien Mauro Orlandini Julian P.Osborne Luigi Pacciani Stéphane Paltani Maurizio Paolillo Iossif E.Papadakis biswajit Paul Alberto Pellizzoni Uria Peretz Miguel A.Pérez Torres Emanuele Perinati Chanda Prescod-Weinstein Pablo Reig SRON Netherlands Institute for Space Research Department of Astronomy University of Geneva Key Laboratory for Particle Astrophysics Institute of High Energy PhysicsChinese Academy of Sciences School of Astronomy and Space Science Nanjing University INAF-IASF bologna ASI Via del Politecnico snc INAF-Istituto di Astrofisica e Planetologie Spaziali Institut für Astronomie und Astrophysik Tübingen Universit?t Tübingen NASA Goddard Space Flight Center ICREA&Institute of Space Sciences(IEEC-CSIC) Campus UABCarrer de Can Magrans CSPAR SPA University of Alabama in Huntsville Department of Physics Texas Tech University INAF Osservatorio Astronomico di Capodimonte Leiden Observatory Leiden University Anton Pannekoek Institute University of Amsterdam ASTRON Netherlands Institute for Radio Astronomy Universitat Politecnica de Catalunya(UPC-IEEC) Universitádegli Studi di Urbino‘Carlo bo’ Max-Planck-Institut für Radioastronomie Dr.Karl-Remeis-Sternwarte and Erlangen Centre for Astroparticle Physics(ECAP) Friedrich Alexander Universit?t Erlangen-Nurnberg Purple Mountain Observatory Chinese Academy of Sciences Instituto de Astrofysíca de Andalucia-CSIC Department of Physics and Astronomy University of Southampton IRAP Universitéde ToulouseCNRSUPSCNES Mathematical Sciences and STAG Research Centre University of Southampton New York University Abu Dhabi Center for Relativistic Astrophysics School of PhysicsGeorgia Institute of Technology Physics Department Middle East Technical University Department of Physics Technion-Israel Institute of Technology INAF Osservatorio Astronomico di brera Tata Institute of Fundamental Research Dipartimento di Matematica e Fisica Universitàdegli Studi Roma Tre Instituto de Astrofísica de Canarias Instituto Nacional de Pesquisas Espaciais-INPE National Space Institute Technical University of Denmark(DTU Space) Department of Physics and Astronomy Michigan State University INAF Osservatorio Astrofisico di Arcetri Dipartimento di Fisica Universitádegli Studi di Cagliari Department of Physics and A

In this White Paper we present the potential of the enhanced X-ray Timing and Polarimetry(eXTP) mission for studies related to Observatory Science targets. These include flaring stars, supernova remnants, accreting white dwarfs, low and high mass X-ray binaries, radio quiet and radio loud active galactic nuclei, tidal disruption events, and gamma-ray bursts. eXTP will be excellently suited to study one common aspect of these objects: their often transient nature. Developed by an international Consortium led by the Institute of High Energy Physics of the Chinese Academy of Science, the eXTP mission is expected to be launched in the mid 2020s.

关键词： space research in struments nuclear astrophysics flare stars accretion and accretion disks mass loss and stellar winds cataclysmic binaries X-ray binaries supernova remnants active galactic nuclei X-ray bursts gamma-ray bursts gravitational waves