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Orbital Involvement in Multiple Myeloma: A Case Report

Journal of Cancer Therapy 2012年第6期3卷 1052-1054页

作者： sara terenzi Daniela di Cristino Alessandra Murgia Dania Janniello Elisabetta Ponti Barbara Tolu sara Cicchetti Riccardo Santoni Department of Diagnostic Imaging Molecular Imaging Interventional Radiology and Radiotherapy Tor Vergata University General Hospital Rome Italy.

Purpose: To report a retro-orbital localization of Multiple Myeloma (MM) describing its treatment and clinical result. Case report: A 50-years-old male patient with Magnetic Resonance Imaging (MRI) evidence of a retro-orbital mass with exophthalmos, due to the pathological diagnosis of MM, was referred for Radiation Therapy (RT). Discussion: The orbital involvement in Multiple Myeloma is rare and few cases are reported in the literature. The treatment of choice is RT alone with a prescribed dose ranging between 40 Gy and 45 Gy. In our patient the retro-orbital lesion, measuring 26 × 16 mm, was treated with Intensity Modulated Radiotherapy Technique (IMRT) delivering 4400 cGy with conventional fractionation. The treatment was well tolerated, the patient experienced a complete regression of the exophthalmos without any significant side effect.

关键词： Plasma Cell Tumours Multiple Myeloma Tumours of the Orbit Radiation Therapy

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Hypofractioned Radiation Therapy in the Treatment of Partial Breast: 30 Gy in Five Consecutive Fractions

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Journal of Cancer Therapy 2012年第6期3卷 1151-1158页

作者： sara terenzi Rosaria Barbarino Maria Daniela Falco Daniela di Cristino Luana Di Murro Dania Janniello Gianluca Ingrosso Alessandra Murgia Grazia Tortorelli Barbara Tolu Riccardo Santoni Department of Diagnostic Imaging Molecular Imaging Interventional Radiology and Radiotherapy Tor Vergata University General Hospital Viale Oxford Rome Italy.

Background and Purpose: Recent prospective studies have explored the partial breast irradiation (PBI) for patients with early-stage breast cancer using different technical approaches. The purpose of this study is to explore feasibility, tumor control and acute and late toxicity of a specific hypo-fractionated 3D-CRT when treating postmenopausal patients with early breast cancer with partial breast irradiation, using five fractions in five consecutive days. Materials and Methods: Ten patients, aged ≥ 70 underwent breast conservative surgery for invasive breast carcinoma with a complete microscopic resection;no lymphovascular invasion was found and negative axillary node status was assessed. Metal clips were positioned in the surgical bed at the time of surgery. All of the patients provided an informed consent for breast irradiation. Seven patients received Tamoxifen. Of the ten patients, five were treated for left breast disease, and five for right breast disease. The dose fractionation schedule was 3000 cGy delivered to the isocenter in 5 fractions (600 cGy/fr) using 6 MV photons. According to the linear quadratic model and an α/β ratio of 4 Gy this prescription is equivalent to 50 Gy in a standard 2-Gy fractionation schedule. Patients were treated in the supine position. A comercial breast board was used as immobilization device in order to keep the arms of the patient raised. The clinical target volume (CTV) was drawn with a uniform 1-cm three-dimensional margin around the surgical clips. The CTV was limited to 3 mm from the skin surface and 3 mm from the lung-chest wall interface. A three-dimensional margin was added to the CTV to obtain the planning target volume (PTV). The ipsilateral and controlateral breast, the ipsilateral and controlateral lung, heart and spinal cord were contoured as organs at risk (OAR). The treatment was developed using Precise Plan Treatment Planning System and four no-coplanar fields. The constraints used have been: uninvolved breast (

关键词： Breast Cancer Partial Breast Irradiation Hypofractioned

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