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Long-term experience with debulking surgery in extensive hepatic alveolar echinococcosis:A case series and literature review

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Asian Pacific Journal of Tropical Medicine 2022年第10期15卷 468-473页

作者： Mohsen Aliakbarian Marcello Di Martino sara saeidi Department of General Surgery Surgical Oncology Research CenterMashhad University of Medical SciencesMashhadIran Division of Hepatobiliary and Liver Transplantation Surgery.A.O.R.N.Cardarelli NapoliItaly

Objective:To assess the role of debulking surgery in extensive hepatic alveolar echinococcosis(HAE).Methods:Five cases of extensive HAE undergoing debulking surgery with their long-term follow-ups were reported.Additionally,a systematic review was carried out.Results:The average age of patients in the study was(50.8±17.1)years(range 36 to 77 years).Three cases were female.The median follow-up period was 61 months(range 12 to 84 months).Left liver resections were performed in 2 cases and right hemihepatectomies were undertaken in 2 cases.Two patients(cases 2 and 4)developed early surgical complications,while one of them(case 4)who suffered from the recurrent sub-hepatic abscess died at 12 months postoperatively.Conclusions:This study highlights the importance of debulking surgery for the management of complex symptomatic HAE lesions in patients with no curative option available.

关键词： Alveolar echinococcosis Debulking surgery Reduction Palliative Echinoccocosis multilocularis Case series

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Kaempferol and docetaxel diminish side population and down-regulate some cancer stem cell markers in breast cancer cell line MCF-7

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BIOCELL 2017年第2期41卷 33-40页

作者： sara SOLTANIAN HELIA RIAHIRAD ATHAREH PABARJA MOHAMMAD REZA KARIMZADEH KOLSOUM saeidi Department of Biology Faculty of ScienceShahid Bahonar University of KermanKermanIran Department of Medical Genetics Afzalipour School of MedicineKerman University of Medical SciencesKermanIran Student Research Committee Kerman University of Medical SciencesKermanIran Department of Medical Genetics Kerman University of Medical SciencesKermanIran

Cancer stem cells(CSCs)are a small subpopulation of cancer cells whose resistance to chemotherapy and radiotherapy plays a pivotal role in treatment failure,tumor recurrence and metastasis.Today,the ability of many phytochemicals in targeting of CSCs has been identified.Kaempferol is a plant phytoestrogen that was recognized as a useful agent for targeting cancer cells by apoptosis induction,cell cycle arrest and inhibition of angiogenesis,migration,and invasion of cancer cells.In this study,we compared the effect of docetaxel as a common breast cancer chemotherapy drug and kaempferol on MCF-7 breast CSCs.Results showed that both docetaxel and kaempferol caused a dose-dependent reduction in cell proliferation.Rhodamin 123 dye staining and flow cytometry analysis revealed that after docetaxel and kaempferol treatment,SP cells proportion of MCF-7 decreased to 11.83±2.2% and 3±0.25% respectively relative to proportion of untreated control cells(23±3.2%).Moreover,real time PCR results showed that kaempferol treatment of MCF-7 was more effective than docetaxel in down-regulating the CSC-associated markers(i.***.oct4,nanog,abcb1 and aldh1a1).Taken together,these results indicate that kaempferol is an effective anti-CSCs agent,therefore it may be a therapeutic strategy for eradicating breast cancer through the elimination of CSCs.

关键词： Breast cancer Cancer stem like cells Kaempferol Docetaxel

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