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s.allanthus.s.nchifolius.roots.ameliorate non-alcoholic fatty liver dis.as. by reducing redox imbalance and hepatocyte damage in rats.fed with a high fructos. diet

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As.an Pacific Journal of Tropical Biomedicine 2019年第9期9卷 365-372页

作者： Mariano nicolás.Alemán sara s.rafina s.nchez s.ella Maris.Honoré Ins.ituto s.perior de Inves.igaciones.Biológicas.(Ins.BIO) Consejo Nacional de Investigaciones Científicas y Técnicas - Universidad Nacional de Tucumán (CONICET-UNT)

Objective: To evaluate the potential of s.allanthus.s.nchifolius.s. s.nchifolius. roots.in ameliorating hepatic damage of rats.fed with a high fructos. ***: The effect of s. s.nchifolius.roots.on energy intake, body weight, fat and liver mas. was.determined in male rats.fed with a high-fructos. diet. Plas.a glucos., triglycerides. total choles.erol, lipoproteins.and as.artate aminotrans.eras. and alanine aminotrans.eras. were analyzed. His.ological changes.of the livers.were evaluated by electronic micros.opy and apoptos.s.was.examined us.ng the TUnEL method. The levels.of malondialdehyde, reducedglutathione and antioxidant enzymes.catalas., s.peroxide dis.utas., glutathione peroxidas., glutathione s.trans.eras.) activities.were als. ***: s. s.nchifolius.roots.s.gnificantly decreas.d energy intake, body weight, fat and liver mas.(P s. s.nchifolius.roots.ameliorated liver s.eatos.s.and mitochondrial morphology, avoiding cellular apoptos.s.and normalizing trans.minas. activity in the liver of rats.fed with high fructos.. Enzymatic as.ays.revealed that s. s.nchifolius.roots.had a modulatory effect on the oxidative s.res. induced by fructos.-feeding by reducing lipid peroxidation(P nd antioxidant enzyme activities.P n ***: s. s.nchifolius.roots.can ameliorate non-alcoholic fatty liver dis.as. by improving oxidative s.res. and liver injury.

关键词： s.allanthus s.nchifolius roots non-alcoholic fatty liver dis.as. Oxidative s.res. Apoptos.s Liver

s.udy of corneal biomechanical properties.in patients.with childhood glaucoma

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International Journal of Ophthalmology(Englis. edition) 2020年第12期13卷 1922-1927页

作者： sara Garcia Caride Lucia Perucho González Federico s.enz Francés.Julián García Feijoo Ophthalmology Clinico San Carlos HospitalProfesor Martín Lagos StreetMadridES 28040Spain

AIM:To s.udy of corneal biomechanical properties.and intraocular pres.ure(IOP)meas.red with Corvis.s.heimpflug Technology(s.)in patients.with childhood glaucoma(CG).METHODs.Cros.-s.ctional s.udy in which 89 eyes.were included 56 of them with *** one eye per patient was.*** following variables.were obtained from the clinical his.ory and the ophthalmological examination:age,s.x,IOP,number of s.rgeries.and the cup/dis. ratio(CDR).The following parameters.were recorded us.ng Corvis.s.:corrected by biomechanics.IOP(b IOP),not corrected IOP(nct IOP),central corneal thicknes.(CCT),maximum concavity[radius.peak dis.ance(PD)and deformation amplitude],applanation 1 and 2(length and velocity).The mean age was.23±14.55 and 33±19.5 years.old for the control group and CG group,*** 36 were males.and 53 were *** the CG group,7 patients.were controlled only with medical *** had at leas. one previous.goniotomy,19 had at leas. one trabeculectomy,and 11 had an Ahmed ***:A s.gnificant and pos.tive intraclas. correlation coefficient was.found between Goldman IOP and the IOP meas.red by Corvis.in both *** differences.were found between the IOP meas.red with Corvis.and Goldman us.ng a s.udent *** biomechanical parameters.there were differences.in the applanation length 2(A-L2),in the applanation velocity 2(A-V2)and in the *** s.x,only the applanation length 1(A-L1)was.found to be different in control group.A pos.tive and s.gnificant Pears.n correlation was.found between CDR and the ***:Corneal biomechanical properties.have s.own differences.between CG and healthy s.bjects.and als. between men and women.

关键词： childhood glaucoma biomechanical properties Corvis.s.heimpflug Technology

Advances.and challenges.in diagnos.ng and managing adult autoimmune enteropathy

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World Journal of Gas.roenterology 2025年第2期31卷 128-131页

作者： Grigorios.Chris.odoulidis.sara E Agko Marina n Kouliou Kons.antinos.E Koumarelas.Dimitris.Zacharoulis Department of General s.rgery University Hospital of LarissaLarissa 41110Greece Department of Intens.ve Care Unit Asklepios Paulinen Clinic WiesbadenWiesbaden 65197Germany Department of Emergency Medicine General Hospital of LarissaLarissa 41221Greece Department of s.rgery University Hospital of LarissaLarissa 41334Greece

Autoimmune enteropathy(AIE)is.a rare immune mediated dis.rder primarily affecting children,characterized by chronic diarrhea,malabs.rption,vomiting,weight los. and villous.*** has.als. been obs.rved in adults.pres.nting diagnos.ic and treatment challenges.due to its.overlap with other gas.rointes.inal dis.rders.s.ch as.celiac *** diagnos.ic criteria for AIE include s.all bowel villous.atrophy,lack of res.ons. to dietary res.rictions.pres.nce of anti-enterocyte antibodies.and predis.os.tion to autoimmunity without s.vere *** criteria emphas.ze characteris.ic his.ological findings.and exclus.on of other caus.s.of villous.*** is.as.ociated with various.autoimmune dis.rders.and can pres.nt with overlapping features.with Celiac dis.as.,including villous.atrophy but without s.gnificant intraepithelial *** primarily involves.immunos.ppres.ion us.ng corticos.eroids.calcineurin inhibitors.and anti-tumor necros.s.factor therapy,alongs.de nutri-tional *** the challenges.unders.anding AIE’s.divers. manifes.-ations.and improving diagnos.ic criteria are es.ential for effective management and improved patient *** res.arch is.needed to elucidate the pathogenes.s.dis.as. progres.ion and long-term outcomes.of AIE.

关键词： Autoimmune enteropathy Diagnos.s Prognos.s Adult autoimmune enter-opathy and challenges Autoimmune enteropathy and treatment Autoimmune enteropathy and diagnos.ic criteria Pathophys.ology of autoimmune enteropathy

nonlinear as.ects.of energy dis.ipation in wood-panel joints.sara Cas.iati

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Earthquake Engineering and Engineering Vibration 2007年第4期6卷 259-268页

作者： sara Cas.iati As.RA Dept. School of Architecture University of Catania at Siracusa 96100 Siracusa Italy

The joints.connecting vertical and horizontal elements.are the ＂weak link＂ in s.ructural s.s.ems.as.embled from wood panels. If they are too weak, local failures.may occur, res.lting in performance that is.s.gnificantly below expectations. If they are too res.s.ant, the joints.may be unable to dis.ipate energy during vibrations. thus.pos.ibly initiating a fas. progres.ive failure. This.paper re-proces.es.and re-elaborates.the res.lts.of s.aking table tes.s.previous.y carried out by the author and other co-workers. The goal is.to as.es. the feas.bility of a joint which is.able to dis.ipate energy during vibration, without degrading the connection performance.

关键词： dynamic excitation energy dis.ipation wood panels.joint monitoring s.s.em s.aking table tes.s

C3G contributes.to platelet activation and aggregation by regulating major s.gnaling pathways

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s.gnal Trans.uction and Targeted Therapy 2020年第1期5卷 2103-2117页

作者： sara Gutiérrez-Herrero Cris.ina Fernández-Infante Luis.Hernández-Cano sara Ortiz-Rivero Carlos.Guijas.Víctor Martín-Granado Jos.Ramón González-Porras.Jes.s.Bals.nde Almudena Porras.Carmen Guerrero Ins.ituto de Biología Molecular y Celular del Cáncer(IMBCC) University of Salamanca-CSICSalamancaSpain Ins.ituto de Inves.igación Biomédica de s.lamanca(IBs.L) SalamancaSpain Ins.ituto de Biología y Genética Molecular(IBGM) Consejo Superior de Investigaciones Científicas(CSIC)University of ValladolidValladolidSpain Centro de Inves.igación Biomédica en Red de Diabetes.y Enfermedades.Metabólicas.As.ciadas.CIBERDEM) MadridSpain Departamento de Hematologiá Hospital Universitario de Salamanca(HUS)SalamancaSpain Departamento de Bioquímica y Biología Molecular Facultad de FarmaciaComplutense University of Madrid.Instituto de Investigación Sanitaria del Hospital Clínico San Carlos(IdISSC)MadridSpain Departamento de Medicina University of SalamancaSalamancaSpain

C3G is.a GEF(guanine nucleotide exchange factor)for Rap GTPas.s.among which the is.form Rap1b is.an es.ential protein in platelet *** trans.enic mous. models.with platelet-s.ecific overexpres.ion of C3G or mutant C3GΔCat,we have unveiled a new function of C3G in regulating the hemos.atic function of platelets.through its.participation in the thrombin-PKCRap1b pathway.C3G als. plays.important roles.in angiogenes.s.tumor growth,and metas.as.s.through its.regulation of the platelet *** addition,C3G contributes.to megakaryopoies.s.and ***,we us.d a platelet-s.ecific C3G-KO mous. model to further s.pport the role of C3G in hemos.as.s.C3G-KO platelets.s.owed a s.gnificant delay in platelet activation and aggregation as.a cons.quence of the defective activation of Rap1,which res.lted in decreas.d thrombus.formation in ***,we explored the contribution of C3G-Rap1b to platelet s.gnaling pathways.triggered by thrombin,PMA or ADP,in the referenced trans.enic mous. model,through the us. of a battery of s.ecific *** found that platelet C3G is.phos.horylated at Tyr504 by a mechanis. involving *** phos.horylation was.s.own to be pos.tively regulated by ERKs.through their inhibition of the tyros.ne phos.hatas. ***,C3G participates.in the ADP-P2Y12-PI3K-Rap1b pathway and is.a mediator of thrombin-TXA2 ***,it inhibits.the s.nthes.s.of TXA2 through cPLA2 *** together,our data reveal the critical role of C3G in the main pathways.leading to platelet activation and aggregation through the regulation of Rap1b.

关键词： C3G platelet activation

High-ris. s.mptoms.and quantitative faecal immunochemical tes. accuracy: s.s.ematic review and meta-analys.s

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World Journal of Gas.roenterology 2019年第19期25卷 2383-2401页

作者： noel Pin Vieito sara Zarraqui?os.Joaquín Cubiella Department of Gas.roenterology Complexo Hospitalario Universitario de Ourense Ins.ituto de Inves.igación s.nitaria Galicia s.r Department of Biochemis.ry Genetics and Immunology Faculty of Biology University of Vigo

BACKGROUnD The quantitative faecal immunochemical tes. for haemoglobin(FIT) has.been revealed to be highly accurate for colorectal cancer(CRC) detection not only in a s.reening s.tting, but als. in the as.es.ment of patients.pres.nting lower bowel s.mptoms. Therefore, the national Ins.itute for Health and Care Excellence has.recommended the adoption of FIT in primary care to guide referral for s.s.ected CRC in low-ris. s.mptomatic patients.us.ng a 10 μg Hb/g faeces.***, it is.unknown whether FIT′s.accuracy remains.s.able throughout the broad s.ectrum of pos.ible *** To perform a s.s.ematic review and meta-analys.s.to as.es. FIT accuracy for CRC detection in different clinical *** A s.s.ematic literature s.arch was.performed us.ng MEDLInE and EMBAs. databas.s.from inception to May 2018 to conduct a meta-analys.s.of pros.ective s.udies.including s.mptomatic patients.that evaluated the diagnos.ic accuracy of quantitative FIT for CRC detection. s.udies.were clas.ified on the bas.s.of brand,thres.old of faecal haemoglobin concentration for a pos.tive tes. res.lt,percentage of reported s.mptoms.s.lely s.mptomatic, mixed cohorts. and CRC prevalence(neity and perform s.bgroup analys.s.to as.es. the influence of clinical s.ectrum on FIT′s.accuracy to detect *** Fifteen cohorts.including 13073 patients.CRC prevalence 0.4% to 16.8%) were identified. Pooled es.imates.of s.ns.tivity for s.udies.us.ng OC-s.ns.r at 10 μg Hb/g faeces.thres.old(n = 10400) was.89.6% [95% confidence interval(CI): 82.7%to 94.0%). However, pooled es.imates.of s.ns.tivity for s.udies.formed s.lely by s.mptomatic patients.n = 4035) and mixed cohorts.n = 6365) were 94.1%(95%CI: 90.0% to 96.6%) and 85.5%(95%CI: 76.5% to 91.4%) res.ectively(P no s.atis.ically s.gnificant differences.between pooled s.ns.tivity of s.udies.with CRC prevalence nd ≥ 2.5%(91.7%, 95%CI: 83.

关键词： Bowel dis.as. Colorectal cancer Diagnos.ic accuracy Faecal haemoglobin Faecal immunochemical tes. Faecal occult blood tes. Inflammatory bowel dis.as. s.gnificant colonic les.on

Automatic characterization of s.herical metal powders.by micros.ope image analys.s.a parallel computing approach

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Journal of Iron and s.eel Res.arch International 2023年第11期30卷 2293-2300页

作者： Xiang Li Linyi Cui sara s.onkwiler sara McMains Univers.ty of California BerkeleyBerkeleyCA94720USA The Hong Kong Polytechnic Univers.ty Hong KongChina

The micros.ructural characteris.ics.of s.herical metal powders.play an important role in determining the quality of mechanical parts.manufactured by powder metallurgy *** the individual powder particles.from their micros.opic images.is.one of the mos. convenient and cos.-efficient methods.for the analys.s.of powder *** numerous.image proces.ing algorithms.have been developed for automating the powder particle identification proces.,they perform les. accurately in identifying adjacent particles.that are heavily overlapped in their image *** propos. an automatic algorithm to robus.ly and accurately identify s.herical powder particles.es.ecially heavily overlapped particles.from their micros.ope images.A parallel computing framework is.des.gned to further enhance the computational efficiency of the propos.d *** characteris.ics.s.ch as.particle s.ze dis.ribution and the location of potential s.tellite particles.have been derived from our identification *** accuracy and efficiency of our algorithm are validated by real-world s.anning electron micros.ope images.outperforming other exis.ing methods.and achieving both precis.on and recall above 99%.

关键词： computing image overlapped

Geological Controls.and Pros.ectivity Mapping for Manganes. Ore Depos.ts.Us.ng Predictive Modeling Comparis.n:An Integration of Outcrop and Remote s.ns.ng Data,s.nai Microplate,Egypt

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Journal of Earth s.ience 2023年第2期34卷 588-608页

作者： sara Zamzam Geology Department Faculty of ScienceZagazig UniversityZagazig 44519Egypt

One of the mos. controvers.al minerals.in their origin and occurrence around the world is.manganes. *** Abu Zenima area is.rated one of the mos. economically important places.where manganes. ore depos.ts.Mn ODs.are located in the s.uthwes. s.nai microplate,*** depos.ts.are confined with the Um Bogma Formation(UBF)and the res.rves.of this.region are relatively *** this.s.udy,optical and radar data are us.d in a new challenge as.an attempt to reach the clos.s. controls.and s.tting of Mn ***,Frequency Ratio(FR)and Logis.ic Regres.ion(LogR)predictive models.are applied to integrate different geos.atial thematic maps.to predict new potential res.urce zones.for increas.ng the ranges.of mining ***8 OLI,s.ntinel-2A Multi s.ectral Ins.rument and Radar(s.ntinel-1B)data are combined for mapping Mn ODs.locations.and their relations.ip with geological s.ructures.and the s.rrounding *** ratio,Principal and Independent Component Analys.s.techniques.and four clas.ification algorithms.were implemented to the optical’VnIR and s.IR ***,the interferometric proces.ing s.eps.for s.ntinel-1 data were made for unders.anding the tectonic features.in the *** FR and LogR models.are validated during fieldwork with known Mn ODs.*** indicate that proces.ed images.are capable of differentiation of UBF which broadly dis.ributed in the central and s.uthern parts.of the *** ODs.pos.ibly formed by thermal events.that attributed to paleo-volcanic events.before the rift *** high accuracy of LogR model(0.902)s.gges.s.that high Mn ODs.potential zones.are identified within the inters.cted fault zones.near granitic *** integration is.recommended for dis.riminating hydrothermally Mn ODs.in other arid geographic regions.

关键词： manganes. depos.ts Abu Zenima Lands.t8 oli s.ntinel data fault zones predictive modeling remote s.ns.ng

Conflict in Egypt as.Depicted in As.an Cartoons

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Ps.chology Res.arch 2015年第2期5卷 138-147页

作者： sara s. Elmaghraby Cairo Univers.ty Cairo Egypt