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To resect or not to resect?-the dilemma in oligometastatic breast cancer

Hepatobiliary Surgery and Nutrition 2022年第4期11卷 623-625页

作者： sara lonardi Valentina Guarneri Medical Oncology 3 Istituto Oncologico Veneto IOV-IRCCSPaduaItaly Department of Surgery Oncology and GastroenterologyUniversity of PaduaPaduaItaly Medical Oncology 2 Istituto Oncologico Veneto IOV-IRCCSPaduaItaly

Despite the good prognosis of the vast majority of breast cancer cases,about 10%is firstly diagnosed with stage IV,while 20-30%of localized disease treated with curative intent will eventually relapse(1).Hepatic metastases are the third site of relapse,after lymph-nodes and bone,but,due to the early systemic nature of breast cancer,rarely the recurrence is liver-limited.

关键词： breast cancer prognosis

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Targeted therapies in metastatic gastric cancer: Current knowledge and future perspectives

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World Journal of Gastroenterology 2019年第38期25卷 5773-5788页

作者： Antonio Pellino Erika Riello Floriana Nappo Stefano Brignola Sabina Murgioni Selma Ahcene Djaballah sara lonardi Vittorina Zagonel Massimo Rugge Fotios Loupakis Matteo Fassan Department of Oncology Veneto Institute of Oncology IOV-IRCCSPadua 35100Italy Department of Surgery Oncology and GastroenterologyUniversity of PaduaPadua 35100Italy Surgical Pathology&Cytopathology Unit Department of MedicineUniversity of PaduaPadua 35100Italy Veneto Cancer Registry Padua 35100Italy

Gastric cancer(GC)represents a leading cause of cancer related morbidity and mortality worldwide accounting for more than 1 million of newly diagnosed cases and thousands of deaths every *** the last decade,the development of targeted therapies and the optimization of already available chemotherapeutic drugs has expanded the available treatment options for advanced GC and granted better survival expectations to the *** the same time,global efforts have been undertaken to investigate in detail the genomic and epigenomic heterogeneity of this disease,resulting in the identification of new specific and sensitive predictive and prognostic biomarkers and in innovative molecular classifications based on gene expression ***,several randomized studies aimed at exploring new innovative agents,such as immune checkpoint inhibitors,failed to demonstrate clinically meaningful survival ***,it is essential to further improve the molecular characterization of GC subgroups in order to provide researchers and medical oncologists with new tools for patients’selection and stratification in future clinical development programs and subsequent *** aim of the present manuscript is to provide a global overview of the recent molecular classifications from The Cancer Genome Atlas and the Asian Cancer Research Group and to present key promising developments in the field of immunotherapy and targeted therapies in metastatic GC.

关键词： Gastric cancer Personalized medicine Predictive biomarkers Molecular diagnostic The Cancer Genome Atlas Asian Cancer Research Group

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Hepatocellular carcinoma in elderly patients:a concise reviewon systemic therapy with sorafenib

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Hepatoma Research 2015年第1期1卷 58-62页

作者： Lombardi Giuseppe Vitale Alessandro sara lonardi Bellu Luisa Pambuku Ardi Marsico Valentina Crivellari Gino Aliberti Camillo Cillo Umberto Zagonel Vittorina Department of Clinical and Experimental Oncology Medical Oncology 1Veneto Institute of Oncology-IRCCS35128 PaduaItaly Department of Surgery Oncology and GastroenterologyUniversity of Padua35122 PaduaItaly Interventional Oncology Unit Veneto Institute of Oncology-IRCCS35128 PaduaItaly

The treatment of hepatocellular carcinoma(HCC)in elderly patients is *** particular,the effi cacy and safety of sorafenib as a systemic treatment in these patients is still under *** performed a concise review of sorafenib therapy in this ***,it is important to make any decisions on treatment for elderly patients with HCC through a multidisciplinary team that includes experts in the liver *** with good clinical conditions should be treated with sorafenib.

关键词： Hepatocellular carcinoma sorafenib treatment chemotherapy elderly patients

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