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Systemic Inflammation Response Index and weight loss as prognostic factors in metastatic pancreatic cancer: A concept study from the PANTHEIA-SEOM trial

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 386-397页

作者： Vilma Pacheco-Barcia sara Custodio-Cabello Fatima Carrasco-Valero Magda Palka-Kotlowska Axel Mariño-Mendez Alberto Carmona-Bayonas Javier Gallego A J Muñoz Martín Paula Jimenez-Fonseca Luis Cabezon-Gutierrez Department of Medical Oncology Hospital Universitario de TorrejonMadrid 28850Spain Department of Internal Medicine Hospital Universitario de TorrejonMadrid 28850Spain Department of Medical Oncology Hospital Universitario Central de AsturiasOviedo 33011Spain Department of Medical Oncology Hospital Universitario Morales MeseguerUniversity of MurciaMurcia 30001Spain Department of Medical Oncology Hospital General Universitario de ElcheElche 03202Spain Department of Medical Oncology Hospital General Universitario Gregorio MarañónUniversidad Complutense MadridMadrid 28007Spain Universidad Francisco de Vitoria Madrid 28223Spain

BACKGROUND The prognostic value of the Systemic Inflammation Response Index(SIRI)in advanced pancreatic cancer is recognized,but its correlation with patients´nutritional status and outcomes remains *** To study the prognostic significance of SIRI and weight loss in metastatic pancreatic *** The PANTHEIA-Spanish Society of Medical Oncology(SEOM)study is a multicentric(16 Spanish hospitals),observational,longitudinal,non-interventional initiative,promoted by the SEOM Real World-Evidence work *** pilot study sought to analyze the association between weight loss and inflammatory status as defined by *** cohort stems from a proof-of-concept pilot study conducted at one of the coordinating *** with pathologically confirmed metastatic pancreatic adenocarcinoma,treated from January 2020 to January 2023,were *** index was calculated using the product of neutrophil and monocyte counts,divided by lymphocyte counts,obtained within 15 days before initiation *** study evaluated associations between overall survival(OS),SIRI and weight *** A total of 50 patients were included.66%of these patients were male and the median age was 66 *** sites:36%liver,12%peritoneal carcinomatosis,10%lung,and 42%multiple *** the first line palliative chemotherapy treatments:50%received gemcitabine plus nab-paclitaxel;28%,modified fluorouracil,leucovorin,irinotecan and oxaliplatin,and 16%were administered gemcitabine.42%had a weight loss>5%in the three months(mo)preceding diagnosis.21 patients with a SIRI≥2.3×10^(3)/L exhibited a trend towards a lower median OS compared to those with a SIRI5%weight loss before diagnosis,the median OS was 6 mo,in contrast to 19 mo for those who did not experience such weight loss(P=0.003).Patients with a weight loss>5%showed higher SIRI *** difference was statistically significant(P<0.000).For pat

关键词： Pancreatic cancer Nutrition Prognostic factor Inflammation Advanced cancer Systemic inflammatory response index Weight loss

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The Impact of Psychosocial Influences on Chronic Wound Healing

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Open Journal of Medical Psychology 2024年第3期13卷 39-57页

作者： Kelly Frasier Vivian Li sara Christoforides Kathleen Daly Alexandra Loperfito Karina Stech Milena Dragovic Nuvance Health/Vassar Brothers Medical Center Poughkeepsie NY USA Lake Erie College of Osteopathic Medicine New York NY USA Medical College of Georgia Augusta University Augusta GA USA Edward Via College of Osteopathic Medicine Blacksburg VA USA Lewis Katz School of Medicine Temple University Philadelphia PA USA College of Osteopathic Medicine California Health Sciences University Clovis CA USA

This comprehensive review explores the intricate dynamics between psychosocial factors and chronic wound healing processes, specifically focusing on prevalent conditions such as pressure ulcers, diabetic foot ulcers, and venous leg ulcers. By examining the roles of psychiatric conditions, including depression, anxiety, and post-traumatic stress disorder (PTSD), this paper illuminates how these factors intricately influence wound healing dynamics, including mechanisms of pain perception and inflammatory responses. Furthermore, we evaluate the effectiveness of integrated biopsychosocial interventions, which encompass a holistic approach to wound care, thereby enhancing healing outcomes for dermatology patients. Future studies should focus on investigating the specific psychosocial determinants that significantly influence wound healing, exploring novel therapeutic strategies, and implementing personalized interventions to meet the unique needs of each patient. Such endeavors hold promise in advancing the fields of psychodermatology and wound management, fostering a deeper understanding and application of psychosocial considerations in dermatological care.

关键词： Psychosocial Factors Chronic Wound Healing Biopsychosocial Interventions Psychiatric Conditions Dermatology Patients

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Preliminary Palynostratigraphic Data on the Middle Albian-Lower Cenomanian of the Tarfaya Basin, Southwest Morocco

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Open Journal of Geology 2024年第4期14卷 548-568页

作者： Khaoula Chafai Touria Hssaida Wafaa Maatouf Mohamed Z. Yousfi sara Chakir Soukaina Jaydawi Hanane Khaffou Department of Geology Faculty of Sciences Ben M&#8217Sik University Hassan II Casablanca Morocco Department of Petroleum Laboratory Office National des Hydrocarbures et des Mines Rabat Morocco Department of Geology Faculty of Sciences Dhar El Mahraz Sidi Mohamed Ben Abdellah University Fes Morocco Department of Geology Faculty of Sciences Mohammed V University Rabat Morocco

The Tarfaya-Laayoune-Boujdour basin is of great interest to oil exploration;on this aspect, there has been exploration by the Moroccan National Office of Hydrocarbons and Mining, which has shown indices of oil and/or gas recorded in most wells drilled in the Moroccan Atlantic margin. FD-1 well, object of this study, is one of these wells located in the offshore Tarfaya-Laayoune-Boujdour basin. A palynological examination of the processed samples revealed the existence of organic palynomorphs, well conserved and rich in dinoflagellate cysts. The latter are composed of worldwide marker taxa of high stratigraphic resolutions. Thus, the middle upper Albian (3408 - 3408.5 m) is determined by the presence of Cribroperidinium tensiftense, Tehamadinium coummia, Spiniferella cornuta, Chichaouadinium vestitum, Dinopterygium alatum and Litosphaeridium arundum. The upper Albian (3406.5 - 3408 m) is characterized by the FOs of marker taxa: Cyclonephelium chabaca, Cribroperidinium auctificum and Chichaouadinium vestitum. Lastly, the upper Albian-lower Cenomanian transition is defined between 3404 m and 3406.50 m, as suggested by the FOs of Chichaouadinium boydii, Dinopterygium tuberculatum, Sepispinula ancorifera, Litosphaeridium conispinum, Prolixosphaeridium conulum and Xenascus ceratioides.

关键词： Morocco Tarfaya-Laayoune-Boujdour Basin Albian-Cenomanian Transition Dinoflagellate Cysts Palynostratigraphy

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Extracellular vesicles as tools and targets in therapy for diseases

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Signal Transduction and Targeted Therapy 2024年第3期9卷 872-912页

作者： Mudasir A.Kumar Sadaf K.Baba Hana Q.Sadida sara Al.Marzooqi Jayakumar Jerobin Faisal H.Altemani Naseh Algehainy Mohammad A.Alanazi Abdul-Badi Abou-Samra Rakesh Kumar Ammira S.Al-Shabeeb Akil Muzafar A.Macha Rashid Mir Ajaz A.Bhat Watson-Crick Centre for Molecular Medicine Islamic University of Science and TechnologyAwantiporaKashmir 192122India Department of Human Genetics-Precision Medicine in Diabetes Obesity and Cancer ProgramSidra MedicineDohaQatar Qatar Metabolic Institute Academic Health SystemHamad Medical CorporationDohaQatar Department of Medical Laboratory Technology Prince Fahad Bin Sultan Chair for Biomedical ResearchFaculty of Applied Medical SciencesUniversity of TabukTabukSaudi Arabia School of Biotechnology Shri Mata Vaishno Devi UniversityKatraIndia

Extracellular vesicles(EVs)are nano-sized,membranous structures secreted into the extracellular *** exhibit diverse sizes,contents,and surface markers and are ubiquitously released from cells under normal and pathological *** serum is a rich source of these EVs,though their isolation from serum proteins and non-EV lipid particles poses *** vesicles transport various cellular components such as proteins,mRNAs,miRNAs,DNA,and lipids across distances,influencing numerous physiological and pathological events,including those within the tumor microenvironment(TME).Their pivotal roles in cellular communication make EVs promising candidates for therapeutic agents,drug delivery systems,and disease *** in cancer diagnostics,EV detection can pave the way for early identification and offers potential as diagnostic ***,various EV subtypes are emerging as targeted drug delivery tools,highlighting their potential clinical *** need for non-invasive biomarkers to monitor biological processes for diagnostic and therapeutic purposes remains *** into the unique composition of EVs could unlock advanced diagnostic and therapeutic avenues in the *** this review,we discuss in detail the roles of EVs across various conditions,including cancers(encompassing head and neck,lung,gastric,breast,and hepatocellular carcinoma),neurodegenerative disorders,diabetes,viral infections,autoimmune and renal diseases,emphasizing the potential advancements in molecular diagnostics and drug delivery.

关键词： diseases sized sizes

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Study of Hygrothermal Behavior of Bio-Sourced Material Treated Ecologically for Improving Thermal Performance of Buildings

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Journal of Renewable Materials 2024年第5期12卷 1007-1027页

作者： Soumia Mounir Miloudia Slaoui Youssef Maaloufa Fatima Zohra El Wardi Yakubu Aminu Dodo sara Ibn-Elhaj Abdelhamid Khabbazi National School of Architecture Agadir New Complex Ibn Zohr AgadirHay dakhla80000Morocco EMDD CERNE2DUniversity Mohammed V in RabatEst SaléSaléMedinaMorocco Physics Department LPMAT LaboratoryFaculty of Sciences Ain ChockHassan II UniversityCasablancaMorocco Architectural Engineering Department College of Engineering Najran UniversityNajran66426Saudi Arabia The Centre of Scientific and Engineering Research Najran UniversityNajranSaudi Arabia

Creating sustainable cities is the only way to live in a clean environment,and this problem can be solved by using bio-sourced and recycled *** this purpose,the authors contribute to the valuation of sheep wool waste as an eco-friendly material to be used in *** paper investigates the thermal,hygrothermal,and biological aspects of sheep wool by testing a traditional *** biological method of aerobic mesophilicﬂora has been *** X was used to determine the chemical composition of the materials ***,thermal characterization has been *** thermal conductivity is above 0.046(W·m^(-1)·K^(-1))and the thermal diffusivity is 1.56.10^(-6) m^(2)·s^(-1).Besides,the energy efﬁciency of using sheep wool in buildings was ***,its humidity behavior was evaluated in different aspects in both winter and *** of biological analyses show the efﬁciency of the treatment by removing the majority of the microorgan-isms:the value of yeast and mildew was reduced from 38.10^(2) to 2.10^(2)(UFC·g^(-1)).In addition to that,sheep wool permits obtaining a low thermal transmittance on the scale of the walls and low cooling needs on the scale of the building with a gain of 45%and 52%,respectively.

关键词： Sustainability sheep wool biological treatment hygrothermal wool behavior hot wire method

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新奥尔良当代艺术中心共享办公室美国新奥尔良

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世界建筑导报 2024年第1期39卷 74-78页

作者：无 Neil Alexander(摄影) sara Essex Bradley(摄影) EDR建筑事务所不详

The Shop是一个综合的联合办公项目,位于新奥尔良市中心,坐落在新奥尔良市当代艺术中心(CAC)的三层和四层。面向科技、艺术和文化事业,The Shop成为发展中的创新工业的创业者中心。这座历史悠久的建筑之前被用做K&B的总部和一个杂货冷饮... 详细信息

The Shop是一个综合的联合办公项目,位于新奥尔良市中心,坐落在新奥尔良市当代艺术中心(CAC)的三层和四层。面向科技、艺术和文化事业,The Shop成为发展中的创新工业的创业者中心。这座历史悠久的建筑之前被用做K&B的总部和一个杂货冷饮店,70年代中期被用作当代艺术中心。顶部两层在过去40年中一直没有被充分利用,The Shop的开发标志着对这一空间的第一次大规模整修。

关键词：联合办公当代艺术中心新奥尔良市美国新奥尔良 Shop 冷饮店办公室杂货

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Influence of Statins and Fibrates Drugs on Bone Health and Regeneration

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Journal of Biomaterials and Nanobiotechnology 2024年第1期15卷 1-24页

作者： Octavio Santiago Ivan Nadir Camal Ruggieri Marina Ribeiro Paulini Valéria Paula Sassoli Fazan João Paulo Mardegan Issa sara Feldman LABOATEM Laboratory of Bone Biology and Tissue Engineering School of Medicine Rosario National University Ros&#225rio Argentina School of Dentistry of Ribeirã o Preto University of S&#227o Paulo (FORP/USP) Ribeir&#227o Preto S&#227o Paulo Brazil School of Medicine of Ribeirã o Preto University of S&#227o Paulo (FMRP/USP) Ribeir&#227o Preto S&#227o Paulo Brazil

In the medical and dental field, the importance and need for the study of materials and drugs for use as bone grafts or regeneration in injured areas due to the presence of fractures, infections or tumors that cause extensive loss of bone tissue is observed. Bone is a specialized, vascularized and dynamic connective tissue that changes throughout the life of the organism. When injured, it has a unique ability to regenerate and repair without the presence of scars, but in some situations, due to the size of the defect, the bone tissue does not regenerate completely. Thus, due to its importance, there is a great development in therapeutic approaches for the treatment of bone defects through studies that include autografts, allografts and artificial materials used alone or in association with bone grafts. Pharmaceuticals composed of biomaterials and osteogenic active substances have been extensively studied because they provide potential for tissue regeneration and new strategies for the treatment of bone defects. Statins work as specific inhibitors of 3-hydroxy-3-methyl-glutaryl coenzyme A reductase (HMG-CoAreductase). They represent efficient drugs in lowering cholesterol, as they reduce platelet aggregation and thrombus deposition;in addition, they promote angiogenesis, reduce the β-amyloid peptide related to Alzheimer’s disease and suppress the activation of T lymphocytes. Furthermore, these substances have been used in the treatment of hypercholesterolemia and coronary artery disease. By inhibiting HMG-CoAreductase, statins not only inhibit cholesterol synthesis, but also exhibit several other beneficial pleiotropic effects. Therefore, there has been increasing interest in researching the effects of statins, including Simvastatin, on bone and osteometabolic diseases. However, statins in high doses cause inflammation in bone defects and inhibit osteoblastic differentiation, negatively contributing to bone repair. Thus, different types of studies with different conc

关键词： Bone Statins Rosuvastatin Sinvastatin Fibrates Fenofibrate Bone Regeneration

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The challenging management of malignant ureteral obstruction:Analysis of a series of 188 cases

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Current Urology 2024年第1期18卷 34-42页

作者： Alberto Artiles Medina Inés Laso García Fernando González Tello sara Álvarez Rodríguez Manuel Hevia Palacios Marina Mata Alcaraz César Mínguez Ojeda Fernando Arias Funez Victoria Gómez Dos Santos Francisco Javier Burgos Revilla Department of Urology Hospital Universitario Ramón y CajalMadridSpain Department of Radiology Hospital Universitario Ramón y CajalMadridSpain

Background:Malignant ureteral obstruction(MUO)is a common condition that complicates the course of advanced *** aims of this study are to analyze the causes,management,and survival of patients with obstructive nephropathy due to malignant ureteric obstruction and to determine prognostic ***,we studied the complications and outcomes in patients who underwent urinary *** and methods:A retrospective study was conducted on patients with computed tomography-confirmed MUO between January 2016 and November ***,clinical,radiological,laboratory,and management data were *** curves were estimated using the Kaplan-Meier method,and univariate and multivariate Cox proportional hazards models were used to test the association between parameters and ***:A total of 188 patients were *** mean age was 69.01 years(SD,14.95 years),and the majority(54.8%)were *** most common mechanism leading to MUO was compression by a pelvic mass(36.9%),and the 3 most frequent tumors causing MUO were prostate(17.6%),bladder(16.5%),and rectal cancer(11.7%).Forty-seven patients(25%)underwent urinary diversion:23(48.9%)underwent double-J stenting and 21(44.7%)underwent percutaneous *** most common reason for urinary diversion was acute kidney injury(53.3%).Recovery of renal function was observed in 55.8%of the patients after urinary *** most frequently identified complications after urinary diversion were urinary tract infection(24.4%),hematuria(17.0%),and urinary sepsis(14.9%).The median survival after hydronephrosis diagnosis was 6.43 months(interquartile range,1.91-14.81 months).In patients who underwent urinary decompression,the median survival after urinary diversion was 8.67 months(interquartile range,2.99-17.28 months).In the multivariate analysis,a lower grade of hydronephrosis and cancer cachexia negatively impacted ***:Cancer patients with MUO have a poor pro

关键词： Hydronephrosis Ureteral obstruction Neoplasms Urinary diversion Survival Prognosis

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促进慢性阻塞性肺疾病哮喘患者自我监控空气质量的护理干预措施: 整合性综述

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International Journal of Nursing Sciences 2024年第1期11卷 46-56页

作者： Bruna F.Sebastiao Raquel M.Hortelao sara S.Granadas Jose M.Faria Joana R.Pinto Helga Rafael Henriques Nursing School of Lisbon LisbonPortugal Hospital Center of Central Lisbon Portugal CUF Tejo Hospital LisbonPortugal University Hospital Center of Northern Lisbon LisbonPortugal Nursing Research Innovation and Development Centre of Lisbon(CIDNUR)LisbonPortugal

目的哮喘-慢性阻塞性肺疾病肺重叠症(Asthma-chronie obst ructive pulmonary disease overlap,A-CO)患者的生活质量较低,肺功能较差,病情经常加重。由于暴露于污染环境会加重其症状,增加发病率和病死率,环境管理对其至关重要。旨在通... 详细信息

目的哮喘-慢性阻塞性肺疾病肺重叠症(Asthma-chronie obst ructive pulmonary disease overlap,A-CO)患者的生活质量较低,肺功能较差,病情经常加重。由于暴露于污染环境会加重其症状,增加发病率和病死率,环境管理对其至关重要。旨在通过系统性综述,寻找证据,以指导制订护理干预措施,促进ACO患者对空气质量的自我管理。方法2023年3月 ,系统检索CINAHL、Medline、Academie Search Complete .Scopus、WebofScience、Cochrane图书馆、乔安娜布里格斯研究所(JoannaBriggsInstitute,JBI)循证实践数据库,以及GoogleScholar。对纳人研究进行数据提取和综合,并对护理干预措施进行分类。采用JBI研究质量评估工具进行方法学质量评估。结果共纳入5篇来自不同国家的研究。促进ACO患者自我监控空气质量的干预措施包括:警觉性干预措施(医务人员定期巡诊、进行症状评估),监测干预措施(监测室内外诱发因素) ,教育干预措施(空气质量警报、避免接触过敏原),以及相关政策的影响,如无烟政策和改善空气质量的综合战略。尽管这些研究报告了不同的干预措施,方法质量也存在差异,但这些干预措施显示了预防患者病情恶化、尽量减少急诊就诊和住院治疗的潜力。这些关键点可作为护理干预措施的关键组成部分。结论有必要采取全面措施,让护士参与促进患者自我监控空气质量的多学科团队.提高认识、制订和实施护理干预,从而使ACO患者受益。同时,需要进--步开展研究,以扩大证据基础并完善这些干预措施。

关键词：空气质量哮喘哮喘-慢阻肺重叠慢性病慢性阻塞性肺疾病护理自我管理

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Multi-tissue transcriptomics of a unique monozygotic discordant twin case of severe progressive osseous heteroplasia

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Genes & Diseases 2024年第3期11卷 22-25页

作者： Alberto Gomez-Carballa Maria Jose Curras-Tuala sara Pischedda Miriam Cebey-Lopez Jose Gomez-Rial Irene Rivero-Cale Jacobo Pardo-seco Xabier Bello Sandra Viz-Lasheras Antonio Justicia-Grande Julian Montoto-Louzao Alba Camino-Mera Isabel Ferreiros-Vidal Maximo Fraga Jose RAntunez Rodolfo Gomez Federico Martinon-Torres Antonio Salas Genetics Vaccines and Infections Research Group(GENVIP)Instituto de Investigacion Sanitaria de SantiagoSantiagode CompostelaGalicia 15706Spain Translational Pediatrics and Infectious Diseases Department of PediatricsHospital Clinico Universitario de Santiago de CompostelaServicio Galego de Saude(SERGAS)Galicia 15706Spain Laboratorio de Inmunologia Servicio de Andlisis ClinicosHospital Clinico Universitario de Santiago de CompostelaServicio Galego de Saude(SERGAS)Galicia 15706Spain Unidade de Xenetica Instituto de Ciencias Forenses(INCIFOR)Facultade de MedicinaUniversidade de Santiago de Compostelaand GenPoB Research GroupInstituto de Investigacion SanitariaHospital Clinico Universitario de Santiago de CompostelaServicio Galego de Saude(SERGAS)Galicia 15706Spain Musculoskeletal Pathology Group Instituto de Investigacion Sanitaria de SantiagoServicio Galego de Saude(SERGAS)Santiago de CompostelaGalicia 15706Spain Department of Pathology Hospital Clinico Universitario de Santiago de Compostela(SERGAS)Galicia 15706Spain Unidad Integrada de BiobancosBiomodelos 3D y Modelos Animales IDIS(lnstituto de Investigacion Sanitaria de Santiagode Compostela)Galicia15706Spain Centro de Investigacion Biomedica en Red de Enfermedades Respiratorias(CIBER-ES) MadridSpain

Progressive osseous heteroplasia(POH)is an ultra-rare autosomal dominant disabling disorder characterized by heterotopic ossification(HO).It is caused by heterozygous inactivating mutations in the GNAS(guanine nucleotide-binding protein alpha-stimulating activity polypeptide)***,the molecular mechanisms underlying HO remain poorly *** a treatment for POH is not yet available,the identification of the mechanisms driving POH in affected tissues using gene expression may be of great help to underestand the molecular basis of POH and develop new therapeutic approaches.

关键词： stimulating driving asi

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