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Latest developments on the mechanism of action of membrane disrupting peptides

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Biophysics Reports 2021年第3期7卷 173-184页

作者： sara Pandidan Adam Mechler La Trobe Institute for Molecular Science La Trobe University

Antimicrobial peptides(AMPs) are integral components of the innate immune defence system of all complex organisms including plants, insects, and mammals. They have wide range of antibacterial, antifungal, antiviral, and even anticancer activities, therefore AMPs are attractive candidates for developing novel therapeutic approaches. Cationic α-helical membrane disrupting peptides are perhaps the most widely studied subclass of AMPs due to their common fundamental characteristics that allow for detailed structure-function analysis and therefore offer a promising solution to the threat of multidrug resistant strains of bacteria. The majority of the studies of AMP activity focused on the biological and biophysical aspects of membrane disruption; the understanding of the molecular mechanism of action from the physicochemical point of view forms a relatively small subfield. This review will provide an overview of these works, focusing on the empirical and thermodynamic models of AMP action.

关键词： Antimicrobial peptides (AMPs) Membrane disrupting peptides Empirical models Thermodynamic models

Modification of PES/PU membrane by supercritical CO2 to enhance CO2/CH4 selectivity:Fabrication and correlation approach using RSM

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Chinese Journal of Chemical Engineering 2018年第12期26卷 2503-2515页

作者： Misagh Ahmadi sara Masoumi Shadi Hassanajili Feridun Esmaeilzadeh Chemical and Petroleum Engineefing School Shiraz University71348-51154 ShirazIran

Integrally skinned asymmetric gas separation membranes of polyethersulfone(PES)/polyurethane(PU) blend were prepared using supercritical CO_2(SC-CO_2) as a nonsolvent for the polymer solution. The membrane consisted of a dense and a porous layer, which were conjoined to separate CO_2 from CH_4. The FTIR, DSC, tensile and SEM tests were performed to study and characterize the membranes. The results revealed that an increase in SC-CO_2 temperature causes an increment in permeance and a decrease in membrane selectivity. Furthermore,by raising the pressure, both permeance and selectivity increased. The modified membrane with SC-CO_2 had much higher selectivity, about 5.5 times superior to the non-modified membrane. This higher selectivity performance compared to previous works was obtained by taking the advantages of both using partial miscible blend polymer due to the strong polar–polar interaction between PU PES and SC-CO_2 to fabricate the membrane. The response surface methodology(RSM) was applied to find the relationships between several explanatory variables and CO_2 and CH_4 permeance and CO_2/CH_4 selectivity as responses. Finally, the results were validated with the experimental data, which the model results were in good agreement with the available experimental data.

关键词： Polyethersulfone Polyurethane Membrane Supercritical CO2 RSM Gas separation

Deep inelastic scattering with proton target in the presence of gluon condensation using holography

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Chinese Physics C 2023年第1期47卷 28-37页

作者： sara Tahery 王晓鹏陈旭荣 Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Lanzhou University Lanzhou 730000China University of Chinese Academy of Sciences Bejing 100049China Guangdong Provincial Key Laboratory of Nuclear Science Institute of Quantum MatterSouth China Normal UniversityGuangzhou 510006China

We study the deep inelastic scattering(DIS)of a proton-targeted lepton in the presence of gluon condensation using gauge/gravity *** use a modified AdS5background where the modification parameter c corresponds to the gluon condensation in the boundary ***,by examining the electromagnetic field,we establish that a non-zero c can increase field *** aim is to obtain the acceptable value of c for this *** method is based on setting the mass of the proton as an eigenvalue of the baryonic state equations of the DIS to find the acceptable value of the parameter c on the other side of the ***,in the second step,we calculate wave function equations for the baryonic states where the mass of the proton target requires a value contribution of c as c=0.0120 *** with the electromagnetic field and baryonic states,we derive the holographic interaction action related to the amplitude of the ***,we compute the corresponding structure functions numerically as functions of x and q,which are Bj?rken variables and the lepton momentum transfers,*** the Jlab Hall C data with our theoretical calculations,our results are acceptable.

关键词： DIS AdS/QCD Gluon condensation Proton

Osteopontin and the immune system:another brick in the wall

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Cellular & Molecular Immunology 2018年第4期15卷 405-407页

作者： sara Caputo Matteo Bellone Cellular Immunology Unit Department of ImmunologyTransplantation and Infectious DiseasesSan Raffaele Scientific Institute20132 MilanItaly

The innate and adaptive arms of the immune system are finely tuned to efficiently react to either endogenous or exogenous noxiae that perturb the function of our tissues and organs,thus rapidly returning to homeostasis with minimal collateral *** molecular mechanisms by which this occurs have been only partially *** work by Kanayama et al.1 contributes to the building of this wall of knowledge by adding an important *** show that osteopontin(OPN),a phosphorylated protein of the extracellular matrix(ECM),has a dominant role in balancing lymphoid and myeloid cells during emergency granulopoiesis(that is,an increased cellular output from the bone marrow to meet the acute demand for the respective blood cell type).2 OPN that is produced and released by bone marrow(BM)stromal cells negatively impacts the pool size of hematopoietic stem cells(that is,Lin−Sca-1+c-kit+).

关键词： organs al. endogenous

Stem cell therapy for nerve injury

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World Journal of Stem Cells 2017年第9期9卷 144-151页

作者： sara Sayad Fathi Arash Zaminy Department of Anatomical Sciences School of MedicineGuilan University of Medical Sciences Neuroscience Research Center School of MedicineGuilan University of Medical Sciences

Peripheral nerve injury has remained a substantial clinical complication with no satisfactory treatment *** the great development in the field ofmicrosurgery,some severe types of neural injuries cannot be treated without causing tension to the injured *** current studies have focused on the new approaches for the treatment of peripheral nerve *** cells with the ability to differentiate into a variety of cell types have brought a new perspective to this *** this review,we will discuss the use of three main sources of mesenchymal stem cells in the treatment of peripheral nerve injuries.

关键词： Cell-based therapies Peripheral nerve injury Stem cells Mesenchymal stem cells Bone marrow mesenchymal stem cells Adipose-derived mesenchymal stem cells Umbilical cord mesenchymal stem cells

Hepatitis C in non-hepatic solid organ transplant candidatesand recipients:A new horizon

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World Journal of Gastroenterology 2016年第4期22卷 1650-1663页

作者： sara Belga Karen Elizabeth Doucette Division of Infectious Diseases Department of MedicineUniversity of AlbertaEdmontonAlberta T6G 2G3Canada

Hepatitis C virus(HCV) infection is estimated to affect 130-150 million people globally which corresponds to2%-3% of the total world population. It remains the leading indication for liver transplant worldwide and has been demonstrated to negatively impact both patient and graft survival following non-hepatic organ transplantation. In the era of interferon-based therapy, although treatment and cure of HCV prior to nonhepatic transplant improved survival, tolerability and low cure rates substantially limited therapy. Interferon(IFN)-based therapy following non-hepatic solid organ transplant, due to the risk of allograft rejection, is generally contraindicated. Rapid advances in IFN-free therapy with direct acting antivirals(DAAs) in the last few years have completely changed the paradigm of hepatitis C therapy. Compared to IFN-based regimens, DAAs have less frequent and less severe adverse effects, shorter durations of therapy, and higher cure rates that are minimally impacted by historically negative predictors of response such as cirrhosis, ethnicity, and post-transplant state. Recent studies have shown that liver transplant(LT) recipients can be safely and effectively treated with DAA combination therapies; although data are limited, many of the principles of therapy in LT may be extrapolated to non-hepatic solid organ transplant recipients. Here we review the data on DAA combination therapies in transplantation, discuss the advantages and disadvantages of pre- vs post-transplant HCV therapy and future directions.

关键词： Hepatitis C chronic kidney transplantation heart transplantation lung transplantation liver transplantation kidney failure chronic antiviral agents

Pharmacokinetic drug interactions in liver disease:Anupdate

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World Journal of Gastroenterology 2016年第3期22卷 1260-1278页

作者： Pietro Palatini sara De Martin Department of Pharmaceutical and Pharmacological Sciences University of Padova35131 PadovaItaly

Inhibition and induction of drug-metabolizing enzymes are the most frequent and dangerous drugdrug interactions. They are an important cause of serious adverse events that have often resulted in early termination of drug development or withdrawal of drugs from the market. Management of such interactions by dose adjustment in clinical practice is extremely difficult because of the wide interindividual variability in their magnitude. This review examines the genetic, physiological, and environmental factors responsible for this variability, focusing on an important but so far neglected cause of variability, liver functional status. Clinical studies have shown that liver disease causes a reduction in the magnitude of interactions due to enzyme inhibition, which is proportional to the degree of liver function impairment. The effect of liver dysfunction varies quantitatively according to the nature, reversible or irreversible, of the inhibitory interaction. The magnitude of reversible inhibition is more drastically reduced and virtually vanishes in patients with advanced hepatocellular insufficiency. Two mechanisms, in order of importance, are responsible for this reduction: decreased hepatic uptake of the inhibitory drug and reduced enzyme expression. The extent of irreversible inhibitory interactions is only partially reduced, as it is only influenced by the decreased expression of the inhibited enzyme. Thus, for appropriate clinical management of inhibitory drug interactions, both the liver functional status and the mechanism of inhibition must be taken into consideration. Although the inducibility of drugmetabolizing enzymes in liver disease has long been studied, very conflicting results have been obtained, mainly because of methodological differences. Taken together, the results of early animal and human studies indicated that enzyme induction is substantially preserved in compensated liver cirrhosis, whereas no definitive conclusion as to whether it is significant

关键词： Pharmacokinetic interactions Enzymeinhibition Enzyme induction Liver disease Plasmaprotein binding

Wettability alteration analysis of smart water/novel functionalized nanocomposites for enhanced oil recovery

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Petroleum Science 2020年第5期17卷 1318-1328页

作者： sara Habibi Arezou Jafari Zahra F.akhroueian Chemical Engineering Faculty Tarbiat Modares UniversityTehranIran School of Chemical Engineering College of EngineeringInstitute of Petroleum EngineeringUniversity of TehranTehranIran

Smart water flooding,as a popular method to change the wettability of carbonate rocks,is one of the interesting and challenging issues in reservoir *** addition,the recent studies show that nanoparticles have a great potential for application in EOR ***,little research has been conducted on the use of smart water with nanoparticles in enhanced oil *** this study,stability,contact angle and IFT measurements and multi-step core flooding tests were designed to investigate the effect of the ionic composition of smart water containing SO4^2- and Ca^2+ ions in the presence of nanofluid on EOR *** amine/organosiloxane@Al2O3/SiO2(AOAS) nanocomposite previously synthesized using co-precipitation-hydrothermal method has been used ***,for the first time the application of this nanocomposite along with smart water has been studied in this *** show that by increasing the concentrations of calcium and sulfate ions in smart water,oil recovery is improved by 9% and 10%,respectively,compared to *** addition,the use of smart water and nanofluids simultaneously is very effective on increasing oil ***,the best performance was observed in smart water containing two times of sulfate ions concentration(SW2 S) with nanofluids,showing increased efficiency of about 7.5%.

关键词： Smart water Nanofluid Wettability alteration Contact angle Stability Enhanced oil recovery

Advanced imaging in surveillance of Barrett’s esophagus: Is the juice worth the squeeze?

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World Journal of Gastroenterology 2019年第25期25卷 3108-3115页

作者： sara A Cerrone Arvind J Trindade Division of Gastroenterology Long Island Jewish Medical CenterZucker School of Medicine at Hofstra/NorthwellNorthwell Health System

Esophageal cancer is on the *** known precursor lesion is Barrett’s esophagus(BE).Patients with dysplasia are at higher risk of developing esophageal *** the gold standard for surveillance endoscopy involves taking targeted biopsies of abnormal areas as well as random biopsies every 1-2 cm of the length of the Barrett’*** studies have shown that this surveillance can miss dysplasia and *** imaging technologies have been developed that may help detect dysplasia in *** opinion review discusses advanced imaging in BE surveillance endoscopy and its utility in clinical practice.

关键词： Barrett’s esophagus Advanced imaging Chromoendoscopy Endomicroscopy