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The challenging management of malignant ureteral obstruction:Analysis of a series of 188 cases

Current Urology 2024年第1期18卷 34-42页

作者： Alberto Artiles Medina Inés Laso García Fernando González Tello sara álvarez r.dr.guez Manuel Hevia Palacios Marina Mata Alcaraz César Mínguez Ojeda Fernando Arias Funez Victoria Gómez Dos Santos Francisco Javier Burgos revilla Department of Urology Hospital Universitario Ramón y CajalMadridSpain Department of radiology Hospital Universitario Ramón y CajalMadridSpain

Background:Malignant ureteral obstruction(MUO)is a common condition that complicates the course of advanced *** aims of this study are to analyze the causes,management,and survival of patients with obstructive nephropathy due to malignant ureteric obstruction and to determine prognostic ***,we studied the complications and outcomes in patients who underwent urinary *** and methods:A retrospective study was conducted on patients with computed tomography-confirmed MUO between January 2016 and November ***,clinical,radiological,laboratory,and management data were *** curves were estimated using the Kaplan-Meier method,and univariate and multivariate Cox proportional hazards models were used to test the association between parameters and ***:A total of 188 patients were *** mean age was 69.01 years(SD,14.95 years),and the majority(54.8%)were *** most common mechanism leading to MUO was compression by a pelvic mass(36.9%),and the 3 most frequent tumors causing MUO were prostate(17.6%),bladder(16.5%),and rectal cancer(11.7%).Forty-seven patients(25%)underwent urinary diversion:23(48.9%)underwent double-J stenting and 21(44.7%)underwent percutaneous *** most common reason for urinary diversion was acute kidney injury(53.3%).recovery of renal function was observed in 55.8%of the patients after urinary *** most frequently identified complications after urinary diversion were urinary tract infection(24.4%),hematuria(17.0%),and urinary sepsis(14.9%).The median survival after hydronephrosis diagnosis was 6.43 months(interquartile range,1.91-14.81 months).In patients who underwent urinary decompression,the median survival after urinary diversion was 8.67 months(interquartile range,2.99-17.28 months).In the multivariate analysis,a lower grade of hydronephrosis and cancer cachexia negatively impacted ***:Cancer patients with MUO have a poor pro

关键词： Hydronephrosis Ureteral obstruction Neoplasms Urinary diversion Survival Prognosis

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Cementite Characterization with Chromium and Vanadium Contents Using Indentation Technique

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Journal of Iron and Steel research International 2015年第4期22卷 366-370页

作者： John Jairo COrONADO sara Aida r.dr.guez research Group of Fatigue and Surfaces School of Mechanical EngineeringUniversity of Valle

Cast irons with some kinds of cementite with different chromium and vanadium contents were character- ized. Fracture toughness was determined by using an indentation technique, along with microhardness and elastic modulus. The results show that at the load of 1 N, microhardness of the cementite with 5.1% Cr is 10.53 GPa, the microhardness for cementite with 9.2% Cr increased to 11.25 GPa and for cementite with 4.5% V the microhard- ness is 9.18 GPa. The cementite with 9.2% Cr presented the highest elastic modulus of 230.4 GPa and the cement- ire with 4% V presented the lowest value of 201.32 GPa. Cementite with 5.1% Cr presented higher fracture tough- ness than cementite with 9.2% Cr; however, cementite with 4.5% V presented the highest fracture toughness of 2.74 MPa ·m1/2 and the lowest brittleness index of 3.35 μm-1/2.

关键词： cementite microhardness elastic modulus fracture toughness indentation technique

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The nucleolus as a genomic safe harbor for strong gene expression in Nannochloropsis oceanica

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Molecular Plant 2022年第2期15卷 340-353页

作者： Christian Südfeld Ana Pozo-r.dr.guez sara A.Manjavacas Díez renéH.Wijffels Maria J.Barbosa sarah D'Adamo Wageningen University Bioprocess EngineeringPO Box 166700 AA WageningenNetherlands Faculty of Biosciences and Aquaculture Nord University8049 BodøNorway

Microalgae are used in food and feed,and they are considered a potential feedstock for sustainably pro-duced chemicals and ***,production of microalgal-derived chemicals is not yet economically *** engineering could bridge the gap to industrial application and facilitate the production of novel products from ***,we report the discovery of a novel gene expression system in the oleaginous microalga Nannochloropsis that exploits the highly efficient transcriptional activity of rNA po-lymerase I and an internal ribosome entry site for *** identified the nucleolus as a genomic safe harbor for Pol I transcription and used it to construct transformant strains with consistently strong trans-gene *** new expression system provides an outstanding tool for genetic and metabolic en-gineering of microalgae and thus will probably make substantial contributions to microalgal research.

关键词： Nannochloropsis gene expression nucleolus rNA polymerase I IrES aIrES

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Targeting galectin-3 to counteract spike-phase uncoupling of fast-spiking interneurons to gamma oscillations in Alzheimer’s disease

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Translational Neurodegeneration 2023年第1期12卷 801-823页

作者： Luis Enrique Arroyo-García sara Bachiller rocío ruiz Antonio Boza-Serrano Antonio r.dr.guez-Moreno Tomas Deierborg Yuniesky Andrade-Talavera AndréFisahn Neuronal Oscillations Laboratory Division of NeurogeriatricsCenter for Alzheimer ResearchDepartment of NeurobiologyCare Sciences and SocietyKarolinska Institutet17164 SolnaSweden Experimental Neuroinflammation Laboratory Department of Experimental Medical ScienceLund UniversityBMC B1122184 LundSweden Clinical Unit of Infectious Diseases Microbiology and ParasitologyInstitute of Biomedicine of Seville(IBiS)Virgen del Rocío University HospitalCSICUniversity of SevilleSevilleSpain Department of Biochemistry and Molecular Biology University of SevilleCalle Profesor García González Nº241012 SevilleSpain Laboratory of Cellular Neuroscience and Plasticity Department of PhysiologyAnatomy and Cellular BiologyUniversidad Pablo de OlavideCarretera de Utrera Km-141013 SevilleSpain Department of Biosciences and Nutrition NeoKarolinska Institutet14183 HuddingeSweden

Background Alzheimer’s disease(AD)is a progressive multifaceted neurodegenerative disorder for which no disease-modifying treatment *** is central to the pathology progression,with evidence suggesting that microglia-released galectin-3(gal3)plays a pivotal role by amplifying neuroinflammation in ***,the possible involvement of gal3 in the disruption of neuronal network oscillations typical of AD remains *** Here,we investigated the functional implications of gal3 signaling on experimentally induced gamma oscillations ex vivo(20-80 Hz)by performing electrophysiological recordings in the hippocampal CA3 area of wild-type(WT)mice and of the 5×FAD mouse model of *** addition,the recorded slices from WT mice under acute gal3 application were analyzed with rT-qPCr to detect expression of some neuroinflammation-related genes,and amyloid-β(Aβ)plaque load was quantified by immunostaining in the CA3 area of 6-month-old 5×FAD mice with or without Gal3 knockout(KO).results Gal3 application decreased gamma oscillation power and rhythmicity in an activity-dependent manner,which was accompanied by impairment of cellular dynamics in fast-spiking interneurons(FSNs)and pyramidal *** found that the gal3-induced disruption was mediated by the gal3 carbohydrate-recognition domain and prevented by the gal3 inhibitor TD139,which also prevented Aβ42-induced degradation of gamma ***-more,the 5×FAD mice lacking gal3(5×FAD-Gal3KO)exhibited WT-like gamma network dynamics and decreased Aβplaque *** We report for the first time that gal3 impairs neuronal network dynamics by spike-phase uncoupling of FSNs,inducing a network performance ***,our findings suggest gal3 inhibition as a potential therapeutic strategy to counteract the neuronal network instability typical of AD and other neurological disorders encompassing neuroinflammation and cognitive decline.

关键词： Galectin-3 Gamma oscillations Neuronal network dynamics Fast-spiking interneurons Alzheimer’s disease models Neuroinflammation TD139 Hippocampus

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FNDC4 and FNDC5 reduce SArS-CoV-2 entry points and spike glycoprotein S1-induced pyroptosis, apoptosis, and necroptosis in human adipocytes

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Cellular & Molecular Immunology 2021年第10期18卷 2457-2459页

作者： Gema Frühbeck Victoria Catalán Víctor Valentí rafael Moncada Javier Gómez-Ambrosi sara Becerril Camilo Silva Piero Portincasa Javier Escalada Amaia r.dr.guez Metabolic research Laboratory Clínica Universidad de NavarraPamplonaSpain CIBEr Fisiopatología de la Obesidad y Nutrición(CIBErOBN) Instituto de Salud Carlos IIIMadridSpain Obesity and Adipobiology Group Instituto de Investigación Sanitaria de Navarra(IdiSNA)PamplonaSpain Department of Endocrinology and Nutrition Clínica Universidad de NavarraPamplonaSpain Department of Surgery Clínica Universidad de NavarraPamplonaSpain Department of Anesthesia Clínica Universidad de NavarraPamplonaSpain Department of Biomedical Sciences and Human Oncology Clinica Medica“A.Murri”University of Bari Medical SchoolPoliclinico HospitalBariItaly.

A sedentary lifestyle and obesity are important risk factors for severe COVID-19 complications and death[1,2].Excessive adipose tissue(AT)might contribute to more extensive viral spread with increased shedding,immune activation,and cytokine amplification[3].Several factors secreted by contracting muscle,termed myokines,mediate the beneficial effects of exercise in a wide range of diseases,including obesity[4].Thus,we conducted a study to explore the potential role of myokines of the fibronectin type III domain-containing family,FNDC4 and FNDC5,in mechanisms underlying the increased susceptibility to COVID-19 complications in obesity.

关键词： FNDC5 obesity FND

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Detection of hyper-conserved regions in hepatitis B virus X gene potentially useful for gene therapy

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World Journal of Gastroenterology 2018年第19期24卷 2095-2107页

作者： Carolina González David Tabernero Maria Francesca Cortese Josep Gregori rosario Casillas Mar riveiro-Barciela Cristina Godoy sara Sopena Ariadna rando Marcal Yll rosa Lopez-Martinez Josep Quer rafael Esteban Maria Buti Francisco r.dr.guez-Frías Liver Pathology Unit Departments of Biochemistry and MicrobiologyHospital Universitari Vall d’HebronUniversitat Autònoma de BarcelonaBarcelona 08035Spain Liver Unit Liver Disease Laboratory-Viral HepatitisVall d’Hebron Institut Recerca-Hospital Universitari Vall d’HebronUniversitat Autònoma de BarcelonaBarcelona 08035Spain Centro de Investigación Biomédica en red de Enfermedades Hepáticas y Digestivas(CIBErehd) Instituto de Salud Carlos IIIMadrid 28029Spain roche Diagnostics SL Sant Cugat del Vallès 08174Spain Liver Unit Department of Internal MedicineHospital Universitari Vall d'HebronUniversitat Autònoma de BarcelonaBarcelona 08035Spain

AIM To detect hyper-conserved regions in the hepatitis B virus(HBV) X gene(HBX) 5' region that could be candidates for gene *** The study included 27 chronic hepatitis B treatmentnaive patients in various clinical stages(from chronic infection to cirrhosis and hepatocellular carcinoma, both HBeA g-negative and HBeA g-positive), and infected with HBV genotypes A-F and H. In a serum sample from each patient with viremia > 3.5 log IU/m L, the HBX 5' end region [nucleotide(nt) 1255-1611] was PCramplified and submitted to next-generation sequencing(NGS). We assessed genotype variants by phylogenetic analysis, and evaluated conservation of this region by calculating the information content of each nucleotide position in a multiple alignment of all unique sequences(haplotypes) obtained by NGS. Conservation at the HBx protein amino acid(aa) level was also *** NGS yielded 1333069 sequences from the 27 samples, with a median of 4578 sequences/sample(2487-9279, IQr 2817). In 14/27 patients(51.8%), phylogenetic analysis of viral nucleotide haplotypes showed a complex mixture of genotypic variants. Analysis of the information content in the haplotype multiple alignments detected 2 hyper-conserved nucleotide regions, one in the HBX upstream non-coding region(nt 1255-1286) and the other in the 5' end coding region(nt 1519-1603). This last region coded for a conserved amino acid region(aa 63-76) that partially overlaps a Kunitz-like *** Two hyper-conserved regions detected in the HBX 5' end may be of value for targeted gene therapy, regardless of the patients' clinical stage or HBV genotype.

关键词： Hepatitis B virus Hepatitis B X gene Hepatitis B X protein Gene therapy Next-generation sequencing HBV conserved regions Small interference rNA

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Segmental Pigmentation Disorder with Congenital Heterochromia Iridis

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Open Journal of Pediatrics 2015年第3期5卷 213-217页

作者： Carmen Madrigal Díez sara r.dr.guez Prado José Héctor Fernández Llaca Primary Paediatric Health Care Centro de Salud Bezana Servicio Cántabro de Salud Spain Department of Opthalmology Hospital de Sierrallana Torrelavega Cantabria Spain Department of Dermatology Hospital Universitario Marqués de Valdecilla Santander Cantabria Spain

We report the case of a 10-year-old girl with congenital complete heterochromia iridis and segmental pigmentation disorder in its hyperpigmented form. We have found no publication that mentions the combination of thes... 详细信息

关键词： Congenital Heterochromia Iridis Segmental Pigmentation Disorder Café-au-Lait Macules

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Alcohol liver disease: A review of current therapeutic approaches to achieve long-term abstinence

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World Journal of Gastroenterology 2015年第28期21卷 8516-8526页

作者： María Luisa Gutiérrez García sara Blasco-Algora Conrado M Fernández-r.dr.guez Service of Gastroenterology Hospital Universitario Fundación

Harmful alcohol drinking may lead to significant damage on any organ or system of the *** liver disease(ALD) is the most prevalent cause of advanced liver disease in *** ALD,only alcohol abstinence was associated with a better long-term ***,current effective therapeutic strategy should be oriented towards achieving alcohol abstinence or a significant reduction in alcohol *** all primary care patients to detect those cases with alcohol abuse has been proposed as population-wide preventive intervention in primary *** has been suggested that in patients with mild alcohol use disorder the best approach is brief intervention in the primary care setting with the ultimate goal being abstinence,whereas patients with moderate-to-severe alcohol use disorder must be referred to specialized care where detoxification and medical treatment of alcohol dependence must be undertaken.

关键词： Alcohol use disorders Alcoholic liver disease Alcohol abstinence Alcohol withdrawal syndrome Alcohol dependence

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Conservation and variability of hepatitis B core at different chronic hepatitis stages

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World Journal of Gastroenterology 2020年第20期26卷 2584-2598页

作者： Marcal Yll Maria Francesca Cortese Mercedes Guerrero-Murillo Gerard Orriols Josep Gregori rosario Casillas Carolina González sara Sopena Cristina Godoy Marta Vila David Tabernero Josep Quer Ariadna rando rosa Lopez-Martinez rafael Esteban Mar riveiro-Barciela Maria Buti Francisco r.dr.guez-Frías Liver Pathology Unit Departments of Biochemistry and MicrobiologyHospital Universitari Vall d'HebronUniversitat Autònoma de BarcelonaBarcelona 08035Spain Liver Unit Liver Disease Laboratory-Viral HepatitisVall d'Hebron Institut Recerca-Hospital Universitari Vall d'HebronUniversitat Autònoma de BarcelonaBarcelona 08035Spain Department of Microbiology Hospital Universitari Vall d'HebronUniversitat Autònoma de BarcelonaBarcelona 08035Spain Centro de Investigación Biomédica en red de Enfermedades Hepáticas y Digestivas Instituto de Salud Carlos ⅢMadrid 28029Spain Liver Unit Department of Internal MedicineHospital Universitari Vall d'HebronUniversitat Autónoma de BarcelonaBarcelona 08035Spain

BACKGrOUND Since it is currently not possible to eradicate hepatitis B virus(HBV)infection with existing treatments,research continues to uncover new therapeutic *** core protein,encoded by the HBV core gene(HBC),intervenes in both structural and functional processes,and is a key protein in the HBV life *** this reason,both the protein and the gene could be valuable targets for new therapeutic and diagnostic ***,alterations in the protein sequence could serve as potential markers of disease *** To detect,by next-generation sequencing,HBC hyper-conserved regions that could potentially be prognostic factors and targets for new *** Thirty-eight of 45 patients with chronic HBV initially selected were included and grouped according to liver disease stage[chronic hepatitis B infection without liver damage(CHB,n=16),liver cirrhosis(LC,n=5),and hepatocellular carcinoma(HCC,n=17)].HBV DNA was extracted from patients’plasma.A region between nucleotide(nt)1863 and 2483,which includes HBC,was amplified and analyzed by next-generation sequencing(Illumina Mi Seq platform).Sequences were genotyped by distance-based discriminant *** and intergroup nt and amino acid(aa)conservation was determined by sliding window *** presence of nt insertion and deletions and/or aa substitutions in the different groups was determined by aligning the sequences with genotype-specific consensus *** Three nt(nt 1900-1929,2249-2284,2364-2398)and 2 aa(aa 117-120,159-167)hyper-conserved regions were shared by all the clinical *** groups showed a similar pattern of conservation,except for five nt regions(nt 1946-1992,2060-2095,2145-2175,2230-2250,2270-2293)and one aa region(aa 140-160),where CHB and LC,respectively,were less conserved(Proup-specific conserved regions were also observed at both nt(2306-2334 in CHB and 1935-1976 and 2402-2435 in LC)and aa(between aa 98-103 in CHB and 28-30 and 5

关键词： Hepatitis B virus Hepatitis B core gene Next-generation sequencing Genetic conservation Amino acid substitution Gene therapy Small interfering rNA

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Characterization of hepatitis B virus X gene quasispecies complexity in mono-infection and hepatitis delta virus superinfection

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World Journal of Gastroenterology 2019年第13期25卷 1566-1579页

作者： Cristina Godoy David Tabernero sara Sopena Josep Gregori Maria Francesca Cortese Carolina González rosario Casillas Mar?al Yll Ariadna rando rosa López-Martínez Josep Quer Gloria González-Aseguinolaza rafael Esteban Mar riveiro-Barciela Maria Buti Francisco r.dr.guez-Frías Liver Pathology Unit Departments of Biochemistry and Microbiology Hospital Universitari Vall d’Hebron Universitat Autònoma de Barcelona Liver Unit Liver Disease Laboratory-Viral Hepatitis Vall d’Hebron Institut Recerca-Hospital Universitari Vall d'Hebron Universitat Autònoma de Barcelona Centro de Investigación Biomédica en red de Enfermedades Hepáticas y Digestivas (CIBErehd) Instituto de Salud Carlos Ⅲ roche Diagnostics SL Centro de Investigación Médica Aplicada (CIMA) Universidad de Navarra Liver Unit Department of Internal MedicineHospital Universitari Vall d’Hebron Universitat Autònoma de Barcelona (UAB)

Hepatitis delta virus(HDV) seems to strongly suppress hepatitis B virus(HBV)replication, although little is known about the mechanism of this interaction. Both these viruses show a dynamic distribution of mutants, resulting in viral quasispecies. Next-generation sequencing is a viable approach for analyzing the composition of these mutant spectra. As the regulatory hepatitis B X protein(HBx) is essential for HBV replication, determination of HBV X gene(HBX)quasispecies complexity in HBV/HDV infection compared to HBV monoinfection may provide information on the interactions between these two *** To compare HBV quasispecies complexity in the HBX 5' region between chronic hepatitis delta(CHD) and chronic HBV mono-infected *** Twenty-four untreated patients were included: 7/24(29.2%) with HBeAgnegative chronic HBV infection(CI, previously termed inactive carriers), 8/24(33.3%) with HBeAg-negative chronic hepatitis B(CHB) and 9/24(37.5%) with CHD. A serum sample from each patient was first tested for HBV DNA *** HBX 5' region [nucleotides(nt) 1255-1611] was then PCr-amplified for subsequent next-generation sequencing(MiSeq, Illumina, United States). HBV quasispecies complexity in the region analyzed was evaluated using incidencebased indices(number of haplotypes and number of mutations), abundancebased indices(Hill numbers of order 1 and 2), and functional indices(mutation frequency and nucleotide diversity). We also evaluated the pattern of nucleotide changes to investigate which of them could be the cause of the quasispecies *** CHB patients showed higher median HBV-DNA levels [5.4 logIU/mL,interquartile range(IQr) 3.5-7.9] than CHD(3.4 logIU/mL, IQr 3-7.6)(P = n.s.)or CI(3.2 logIU/mL, IQr 2.3-3.5)(P reater in CI than CHB. A similar trend was observed in CHD patients, although only Hill numbers of order 2 showed

关键词： Hepatitis B virus Hepatitis delta virus Hepatitis B X gene Next-generation sequencing Viral quasispecies Hepatitis B virus-hepatitis delta virus interaction

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