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Patients with hematological malignancies and serological signs of prior resolved hepatitis B

World Journal of Gastrointestinal Oncology 2012年第3期4卷 37-45页

作者： Massimo Marignani Elia Gigante Paola Begini Alfredo Marzano Michela di Fonzo Ilaria Deli sara gallina Maria Christina Cox Gianfranco Delle Fave Digestive and Liver Disease Department School of Medicine and Psychology University "Sapienza" Azienda Ospedaliera S. Andrea Via Grottarossa 1035-1039 00189 Rome Italy SCDU of Gastroenterology and Hepatology AO San Giovanni Battista Corso Bramante 88 10125 Torino Italy Haematology Department School of Medicine and Psychology University "Sapienza" Azienda Ospedaliera S. Andrea Via Grottarossa 1035-1039 00189 Rome Italy

Hepatitis B virus (HBV) infection affects a large part of the world population. Within the different virological HBV categories that have been identified, patients with occult HBV infection represent a peculiar group. These individuals harbor a replication competent virus, inhibited in its replicative function. Accordingly, cases of reactivations have been observed in immunosuppressed individuals who lose immunological control over the infection. Patients with hematological malignancies (HM) are treated with intense myeloand immunosuppres-sive chemotherapy regimens which favor HBV reactivation. This event can have severe consequences, such as hepatitis flare, hepatic failure and even death. In addition, it can lead to delays or interruptions of curative treatments, resulting in a decreased disease free and overall survival. In this review, we will examine the event of HBV reactivation in patients with signs of resolved HBV infection undergoing treatment for HM and propose possible management strategies.

关键词： Occult hepatitis B Hematological malignancies Hepatitis B virus Chemotherapy Hepatitis B reactivation

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‘Les liaisons dangereuses’: Hepatitis C, Rituximab and B-cell non-Hodgkin’s lymphomas

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2012年第2期3卷 21-28页

作者： Massimo Marignani Michela di Fonzo Paola Begini Elia Gigante Ilaria Deli Adriano M Pellicelli sara gallina Emanuela de Santis Gianfranco Delle Fave M Christina Cox Department of Digestive and Liver Disease School of Medicine and Psychology University "Sapienza" Azienda Ospedaliera S. Andrea Via Grottarossa 1035-1039 00189 Rome Italy Liver Unit Azienda Ospedaliera San Camillo Forlanini 000149 Rome Italy Department of Haematology School of Medicine and Psychology University "Sapienza" Azienda Ospedaliera S. Andrea Via Grottarossa 1035-1039 00189 Rome Italy

Rituximab has provided a revolutionary contribution to the treatment of B-cell non-Hodgkin’s lymphomas (NHL). A high prevalence of hepatitis C virus (HCV) infection has been described in B-cell NHL patients. Cases of liver dysfunction in HCV-positive patients have been reported with Rituximab-containing regimens. In this paper we review the recent data regarding the effects of Rituximab in NHL patients with HCV infection. We also added a section devoted to improving communication between oncohaematologists and hepatologists. Furthermore, we propose a common methodological ground to study hepatic toxicity emerging during chemotherapy.

关键词： Rituximab B-cell non-Hodgkin’s lymphoma Hepatitis C virus Immunochemotherapy Methodology

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