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局部膨胀土作用下隧道稳定性试验研究

西华大学学报（自然科学版） 2023年第1期42卷 24-31,47页

作者：马素健 saqib Ashraf 崔瑛横滨国立大学都市创新研究院日本横滨240-0067

膨胀土在中国分布极为广泛,目前相应的研究主要集中于工程监测以及数值模拟,容易出现代表性数据缺乏,结果与实际差别较大等不足。本文通过自主研发的膨胀土隧道设备进行模型试验,对底部膨胀土和左侧膨胀土对隧道稳定性的影响进行研究,... 详细信息

膨胀土在中国分布极为广泛,目前相应的研究主要集中于工程监测以及数值模拟,容易出现代表性数据缺乏,结果与实际差别较大等不足。本文通过自主研发的膨胀土隧道设备进行模型试验,对底部膨胀土和左侧膨胀土对隧道稳定性的影响进行研究,探究膨胀作用下隧道的力学响应特征以及围岩变形分布规律,得出如下结论:底部和一侧膨胀作用结束后隧道的环向压力分别达到97.23和37.75 kPa,位于膨胀土对侧位置处的压力几乎为0 kPa,呈现时间正相关和距离负相关现象,底部分布膨胀土情况下扰动范围较大,而一侧分布破坏较为集中;膨胀作用对于隧道的影响是荷载和应变缓冲的共同作用下的非线性相关变化,在膨胀时间为1/5时将出现首次应变缓冲,环向压力增幅迅速减小;当隧道底部分布均匀膨胀土层时可以将膨胀土层看作受弯结构研究隧道的力学特征;不同部位膨胀土作用下的围岩变形将产生剧烈剪切破坏带,根据膨胀土分布位置分别出现单边剪切和双边剪切。

关键词：模型试验膨胀土隧道工程力学特征

Identification of potential P. falciparum transketolase inhibitors: pharmacophore design, in silico screening and docking studies

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Journal of Biophysical Chemistry 2010年第2期1卷 96-104页

作者： Shweta Joshi Alok Ranjan Singh Uzma saqib Prakash Chandra Misra Mohammad Imran Siddiqi Jitendra Kumar Saxena 不详

Transketolase, the most critical enzyme of the non-oxidative branch of the pentose phosphate pathway, has been reported as a novel target in Plasmodium falciparum as it has least homology with the human host. Homology model of P. falciparum transketolase (PfTk) was constructed using the crystal structure of S. cervisiae transketolase as a template, and used for the identification and prioritization of potential compounds targeted against Plasmodium falciparum transketolase. The docking studies with fructose-6-phosphate and thiamine pyrophosphate showed that His31, Asp473, Ser388, Arg361 and His465 formed hydrogen bonds with fructose-6-phosphate while pyrimidine ring of coenzyme interacted with conserved residues of protein viz., Leu121, Glu415, Gly119. The major interacting residues involved in binding of oxythiamine pyrophosphate were similar to cofactor binding site of PfTk. An integrated pharmacophore, co-factor ThDP and substrate fructose-6-pho- sphate, based virtual screening of a small mo- lecule database retrieved eight and thirteen compounds respectively. When screened for their activity against P. falciparum transketolase, one compound in case of ThDP and three compounds in case of fructose-6-phosphate based screening were found active against PfTk. Identification of these novel and chemically diverse inhibitors provides initial leads for optimization of more potent and efficacious drug candidates to treat malarial infection.

关键词： Plasmodium Falciparum Transketolase

Use of Impella cardiac axial flow pump for cardiogenic shock(A newer alternative)-How good is the evidence?

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BIOCELL 2022年第5期46卷 1139-1150页

作者： RAFIQ AHMED BHAT SYED MANZOOR ALI YOOSUF ALI ASHRAF MUHAMMAD HUSSENBOCUS AKANKSHA RATHI JAVAID AKHTER BHAT ABDUL ALEEM KHAN SYED MAQBOOL RAJA saqib IQBAL MD MONOWARUL ISLAM YONGSHENG QU YOU ZHANG YUXIAO SUN WENTAO XIAO ABHISHEK TIBREWAL CHUANYU GAO Zhengzhou University People’s Hospital Department of CardiologyFuwai Central China Cardiovascular HospitalZhengzhouChina Department of Cardiology Super Speciality DivisionGovernment Medical CollegeSrinagarIndia Department of Rheumatology and Immunology Nanjing Drum Tower Hospital Clinical College of Nanjing Medical UniversityNanjingChina Department of Community Medicine Vedanta Institute of Medical SciencesPalgharIndia State Key Laboratory of Crop Genetics and Germplasm Enhancement Nanjing Agricultural UniversityNanjingChina Department of Orthopaedics Nanjing First HospitalNanjing Medical UniversityNanjingChina Department of Paediatrics Batra Hospital and Medical Research CentreNew DelhiIndia Zhengzhou University First Affiliated Hospital ZhengzhouChina Department of Community Medicine Institute of Biostatistics and EpidemiologyGurgaonIndia

The adverse outcomes of a ventricular heart failure(left,right or biventricular)caused by cardiogenic shock are aggravated by lung oedema and organ mal *** advances in medical sciences,revascularisation and mechanical hemodynamic support have proved ineffective in reducing the mortality rate in such patients.A thorough study of the data available about cardio-vascular diseases reveals that the application of conventional methods of treatment are least helpful to practically restore normal functions of heart when it experiences end-stage systolic ventricular ***,to overcome the challenges and find alternatives to address this issue,percutaneous ventricular support devices/machines were designed and successfully *** devices have revolutionized the treatment of ventricular heart failures and are now in use all over the *** this review paper a newer mechanical circulatory support(MCS)device,Impella,has been discussed and compared with a few other devices like Intra-aortic Balloon Pump(IABP),Extracorporeal Circulation(ECLS)and Veno-arterial Extracorporeal Membrane Oxygenation(VA-ECMO).This article studies the challenges being faced during the treatment of cardiogenic shock,and thoroughly discusses the use and effectiveness of Impella Cardiac Axial Pump in each *** can be said that mechanical circulatory support(MCS)device use during percutaneous coronary intervention(PCI)should be individualized based on multiple factors with a recommended use in patients with the greatest potential benefit and a relatively low risk of device-related *** current literature suggests that the outcomes of use of Impella and other mechanical circulatory support devices like IABP and VA-ECMO are *** there seem to be a few advantages of Impella over the others,sufficiently powered,multi-centric,randomised control trials are needed to establish its superiority.

关键词： Cardiogenic shock Hemodynamic support Impella Cardiac Axial Pump IABP VA-ECMO

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2022 年金砖峰会开启合作新征程

当代世界 2022年第7期 45-48页

作者： [印度]穆罕默德·萨奇布印度中国经济文化促进会

2022年6月23日晚,中国国家主席习近平在北京以视频方式主持金砖国家领导人第十四次会晤并发表题为《构建高质量伙伴关系开启金砖合作新征程》的重要讲话。本次金砖峰会敏锐分析了当前全球形势和时代问题,对金砖国家和世界发展提出了面... 详细信息

2022年6月23日晚,中国国家主席习近平在北京以视频方式主持金砖国家领导人第十四次会晤并发表题为《构建高质量伙伴关系开启金砖合作新征程》的重要讲话。本次金砖峰会敏锐分析了当前全球形势和时代问题,对金砖国家和世界发展提出了面向未来、务实可行的建议。金砖国家迈出了合作新征程的关键一步,其合作成果也必将惠及所有国家和人民。

关键词：全球形势金砖国家伙伴关系金砖合作合作成果新征程金砖峰会面向未来

Somatic embryogenesis in wild relatives of cotton (Gossypium Spp.)

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2006年第4期7卷 291-298页

作者： RAO Abdul Qayyum HUSSAIN S. Sarfraz SHAHZAD M. saqib BOKHARI S. Yassir Abbas RAZA M. Hashim RAKHA Allah MAJEED A. SHAHID A. Ali SALEEM Zafar HUSNAIN Tayyab RIAZUDDIN S. Institution Centre of Excellence in Molecular Biology University of the Punjab Lahore 53700 Pakistan

Wild cotton species can contribute a valuable gene pool for agronomically desirable cultivated tetraploid cultivars. In order to exploit diploid cotton a regeneration system is required to achieve transformation based goals. The present studies aimed at optimizing the conditions for regeneration of local varieties as well as wild species of cotton. Different callus induction media were tested with varying concentrations of hormones in which sucrose was used as nutritional source. Different explants (hypo-cotyls, cotyledon, root) were used to check the regeneration of both local cotton plants and wild relatives using T & G medium, BAP medium, CIM medium, EMMS medium, and cell suspension medium. Different stages of embryogenicity such as early torpedo stage, late torpedo stage, heart stage, globular stage and cotyledonary stage were observed in wild relatives of cotton. The results of this study pave the way for establishing future transformation methods.

关键词： Cotton Callus Somatic embryogenic Wild species Cell suspension culture

随机PWM可降低噪声并减少三相逆变器应用中的辐射

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中国电子商情 2019年第4期 33-36页

作者： Aamir Hussain Chughtai Muhammad saqib Dialog半导体公司

大多数传统PWM方案会生成预定的谐波含量。这可能会在实际应用中产生许多问题,如噪声、无线电干扰和机械振动。在需要减轻对环境和其他设备的干扰的应用中,例如工业电机驱动器、牵引驱动器、电动汽车,传统的PWM方案因自身原因不能高效... 详细信息

大多数传统PWM方案会生成预定的谐波含量。这可能会在实际应用中产生许多问题,如噪声、无线电干扰和机械振动。在需要减轻对环境和其他设备的干扰的应用中,例如工业电机驱动器、牵引驱动器、电动汽车,传统的PWM方案因自身原因不能高效地运行,需要添加如EMI滤波器等附加设备。有一种方法可以应对这些问题,就是增加传统PWM方案的开关频率。不过,这会导致开关损耗显著增加。

关键词： PWM 应用噪声逆变器无线电干扰辐射随机机械振动

Dynamic variations in COVID-19 with the SARS-CoV-2 Omicron variant in Kazakhstan and Pakistan

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Infectious Diseases of Poverty 2023年第2期12卷 115-115页

作者： Qianqian Cui Zhengli Shi Duman Yimamaidi Ben Hu Zhuo Zhang Muhammad saqib Ali Zohaib Baikadamova Gulnara Mukhanbetkaliyev Yersyn Zengyun Hu Shizhu Li School of Mathematics and Statistics Ningxia University Yinchuan China Chinese Academy of Sciences Key Laboratory of Special Pathogens and Biosafety Wuhan Institute of Virology Chinese Academy of Sciences Wuhan China State Key Laboratory of Desert and Oasis Ecology Xinjiang Institute of Ecology and Geography Chinese Academy of Sciences Ürümqi China Research Center for Ecology and Environment of Central Asia Chinese Academy of Sciences Ürümqi China University of Chinese Academy of Sciences Beijing China College of Geography and Remote Sensing Sciences Xinjiang University Ürümqi China Department of Clinical Medicine and Surgery Faculty of Veterinary Science University of Agriculture Faisalabad Faisalabad Pakistan Department of Microbiology Faculty of Veterinary and Animal Sciences The Islamia University of Bahawalpur Bahawalpur Pakistan Veterinary Medicine Department Kazakh Agrotechnical University Astana Kazakhstan National Institute of Parasitic Diseases Chinese Centre for Disease Control and Prevention (Chinese Centre for Tropical Diseases Research) NHC Key Laboratory of Parasite and Vector Biology WHO Collaborating Centre for Tropical Diseases National Centre for International Research On Tropical Diseases Shanghai China

Background The ongoing coronavirus disease 2019(COVID-19)pandemic caused by the severe acute respiratory syndrome-coronavirus 2(SARS-CoV-2)and the Omicron variant presents a formidable challenge for control and prevention worldwide,especially for low-and middle-income countries(LMICs).Hence,taking Kazakhstan and Pakistan as examples,this study aims to explore COVID-19 transmission with the Omicron variant at different contact,quarantine and test *** A disease dynamic model was applied,the population was segmented,and three time stages for Omicron transmission were established:the initial outbreak,a period of stabilization,and a second *** impact of population contact,quarantine and testing on the disease are analyzed in five scenarios to analysis their impacts on the *** statistical metrics are employed to quantify the model’s performance,including the correlation coefficient(CC),normalized absolute error,normalized root mean square error and distance between indices of simulation and observation(DISO).Results Our model has high performance in simulating COVID-19 transmission in Kazakhstan and Pakistan with high CC values greater than 0.9 and DISO values less than *** with the present measures(baseline),decreasing(increasing)the contact rates or increasing(decreasing)the quarantined rates can reduce(increase)the peak values of daily new cases and forward(delay)the peak value times(decreasing 842 and forward 2 days for Kazakhstan).The impact of the test rates on the disease are *** the start time of stage Ⅱ is 6 days,the daily new cases are more than 8 and 5 times the rate for Kazakhstan and Pakistan,respectively(29,573 vs.3259;7398 vs.1108).The impact of the start times of stageⅢon the disease are contradictory to those of stageⅡ.Conclusions For the two LMICs,Kazakhstan and Pakistan,stronger control and prevention measures can be more effective in combating ***,to reduce Omicron transmission,strict management

关键词： COVID-19 Pandemic Omicron Daily new confirmed cases Cumulative confirmed cases Simulation Prediction

Development of 19-plex Y STR system and polymorphism studies in Pakistani population

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Journal of Pharmaceutical Analysis 2008年第4期20卷 267-273页

作者： Faraz Malik Mahmood A. Kayani M. Ansar Obaid Ullah Muhammad Shafeeq Shahid Chohan Yassir Abbas saqib Shazad Ali Raza Rahat Rehman Faizan Raiz Qurat-ul-ain Muhammad Hassan Siddiqi Allah Rakha Zia ur Rehman Zahoor Ahmed Department of Biosciences COMSATS Insitute of Information Technology Islamabad Pakistan Centre of Excellence in Molecular Biology Lahore Pakistan Centre for Advanced Forensic Sciences University of the Punjab Lahore Pakistan National Key Laboratory of Ministry of Health for Forensic Sciences Xi'an Jiaotong University

For the development of 19-plex Y STR system and polymorphism studies in local ethnic populations sixteen markers of non-recombining regions (NRY) of Y chromosome, which show high power of discrimination among individuals, were selected in this study. Blood samples (600) were collected from the males of three most common castes of Pakistani population (Arain, Awan and Rajput) with different parent lineages. Three markers (DYS385a/b, DYS389I/II and YCAIIa/b) among 16 Y STRs are double-targeted regions of the Y chromosome and thus provide two polymorphic peaks for each respective primer set. These 16 Y-STRs were developed into Megaplex system for simultaneous amplification of all markers within the population. The overall power of discrimination observed in focused populations was 60.5%, 66.5% and 55% in Rajput, Awan and Arain casts respectively. This discrimination power will be helpful in human identification for forensic casework studies including sexual assaults and paternity testing.

关键词： STR Pakistani population polymorphism 19-plex Y STR

Recent advances in vaccination of non-responders to standard dose hepatitis B virus vaccine

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World Journal of Hepatology 2015年第24期7卷 2503-2509页

作者： saqib Walayat Zohair Ahmed Daniel Martin Srinivas Puli Michael Cashman Sonu Dhillon Department of Gastroenterology andHepatology University of Illinois PeoriaCampusOSF Saint Francis Medical Center Department of Internal Medicine Universityof Illinois Peoria CampusOSF Saint Francis Medical Center

Hepatitis B virus(HBV) infection is a global health problem. It is estimated there are more than 2 billion individuals exposed to the virus and 250 million are chronically infected. Hepatitis B is the cause of more than 600000 annual deaths due to cirrhosis and hepatocellular carcinoma. An effective vaccine exists and preventative initiatives center around universal vaccination especially in those at highest risk. Effective vaccination algorithms have led to a significant decline in the development of new infections and its devastating consequences. The vaccine is administered intramuscularly in three doses, with 95% showing long lasting serologic immunity. An additional fourth dose or a repeated higher dose three course regimen is given to those that fail to show immunity. Despite these additional regimens, some remain vulnerable to hepatitis B and are deemed nonresponders. Individuals with chronic disease states such as kidney disease, liver disease, diabetes mellitus, as well as those with a genetic predisposition, and those on immunomodulation therapy, have the highest likelihood of non-response. Various strategies have been developed to elicit an immune response in these individuals. These include increased vaccination dose, intradermal administration, alternative adjuvants, alternative routes of administration, co-administration with other vaccines, and other novel therapies. These alternative strategies can show improved response and lasting immunity. In summary, HBV vaccination is a major advance of modern medicine and all individuals at risk should be sought and vaccinated with subsequent adequate titers demonstrated.

关键词： Hepatitis B vaccine Non-responders Intradermal vac