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世界核心医学期刊文摘（神经病学分册） 2005年第6期1卷 3-4页

作者： saposnik g. Young.B. Silver B. 黄卫东 Stroke Service London Health Sciences Centre University of Western Ontario 339 Windermere Rd London Ont. N6A 5A5 Canada Dr.

Context: The focus of thrombolytic therapy in acute stroke has been on favorable outcome at 3 months. Few studies have analyzed outcome at 24 hours. An early and reliable prediction of poor outcome has implications for clinical manag.ment and discharg. planning. Abstract:Objective: To evaluate predictors of lack of improvement at 24 hours after receiving.alteplase and their relationship with poor outcome at 3 months. Desig., Setting. and Participants: Prospective cohort of consecutive patients with acute stroke who received alteplase and were admitted to a university hospital from January 1999 to March 2003. Participants were recruited from 2 academic centers in a major city in Ontario and 33 affiliated hospitals from 7 counties. Main Outcome Measures: Lack of improvement defined as a difference between the National Institutes of Health Stroke Scale score at baseline and at 24 hours of 3 points or less. Poor outcome at 3 months defined by a modified Rankin Scale score of 3 to 5 or death. Results: Among.216 patients with acute stroke who were treated with alteplase, 111 (51.4% ) had a lack of improvement at 24 hours. After adjusting.for ag., sex, and stroke severity, baseline g.ucose level on admission (odds ratio [OR] 2.89; 95% confidence interval [CI], 1.40- 5.99 for a g.ucose level > 144 mg.dL [ > 8 mmol/L]), cortical involvement (OR, 2.66; 95% CI, 1.36- 5.20), and time to treatment (OR, 1.01; 95% CI, 1.0- 1.02 for each 1 minute increase in time to treatment) were independent predictors of lack of improvement. At 3 months, 43 patients (20.2% ) had died; of the 170 survivors, 75 patients (44% ) had poor outcomes. After adjusting.for ag., sex, and stroke severity, lack of improvement at 24 hours was an independent predictor of poor outcome (OR, 12.9; 95% CI, 5.7- 29.6)- and death (OR, 7.5; 95% CI, 2.9- 19.6). Patients with a lack of improvement had long.r leng.hs of hospitalization (14.5 vs 9.6 days; P=.02). Conclusions: Among.patients with acute stroke treated with

关键词：急性脑卒中急性卒中阿替普酶队列研究预后研究出院计划血糖浓度大学医院附属医院时基线

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出生日期是否与易发血管事件相关

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世界核心医学期刊文摘(神经病学分册) 2006年第12期 30-31页

作者： saposnik g. Baiberg.nova A. Dang.J. Hachinski V. 郭俊 Dr.Department of Medicine St.Michael's HospitalUniversity of Toronto55 Queen Street ETorontoOnt.M5C 1R6United States

OBJECTIVE:To examine the influence of birthdays on the onset and course of vascular events such as stroke,TIA,and acute myocardial infarction(AMI).METHODS:This population-based study included all emerg.ncy department(ED)admissions due to ischemic stroke,TIA,or AMI from April 2002 to March 2004 in Ontario,*** cases were identified throug. the National Ambulatory Care Reporting.*** of daily and weekly numbers of events were centered on the patient's birthday and the week of the *** analyses include binomial tests and log.stic ***:During.the study period,there were 24,315 ED admissions with acute stroke,16,088 with TIAs,and 29,090 with *** observed number of vascular events during.the birthday was hig.er than the expected daily number of visits for stroke(87 vs 67;p = 0.009),TIA(58 vs 44;p = 0.02),and AMI(97 vs 80;p = 0.027)but not for selected control conditions(asthma,appendicitis,head trauma).Vascular events were more likely to occur on birthday(242 vs 191;odds ratio [OR] = 1.27).No sig.ificant differences were observed during.the birthday week for any of the *** log.stic reg.ession showed that birthday vascular events were more likely to occur in patients with a history of hypertension(OR = 1.88;95%CI 1.09 to 3.24).Sensitivity analyses with alternative definitions of birthday week did not alter the ***:Stress associated with birthdays may trig.er vascular events in patients with predisposing.conditions.

关键词：血管出生日期 TIA

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最佳出院计划:重组组织型纤溶酶原激活剂治疗急性卒中后长时间住院的临床预测因素

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世界核心医学期刊文摘（神经病学分册） 2005年第6期1卷 59-60页

作者： saposnik g. Webster F. O’ Callag.an C. Hachinski V. 邓剑平 Stroke Service Office 7- GE5 London Health Sciences Center 339 Windermere Rd London Ont. N6A 5A5 Canada Dr.

Backg.ound and Purpose - The leng.h of stay (LOS) is the main cost- determining.factor for inpatients with acute stroke. Althoug. studies have identified variables associated with LOS, few have analyzed predictors of long.r stay after receiving.thrombolytic therapy for acute stroke. Methods - We studied all consecutive acute stroke patients receiving.intravenous recombinant tissue plasminog.n activator (rtPA) admitted to the London Health Sciences Center, in London, Ontario, Canada, from 1999 to 2003. Long.r stay was defined as LOS ≥ 7days after admission. Demog.aphic as well as baseline clinical, laboratory, and imag.ng.variables were analyzed to identify predictors of LOS. Sig.ificant variables were entered into a multivariate log.stic reg.ession analysis. Results - Among.216 acute stroke patients receiving.rtPA, the median LOS was 6 days. LOS was >7 days in 102 (49% ) patients. Ag. ≥ 70 (odds ratio [OR], 2.2; 95% CI, 1.2 to 4.0), lack of improvement at 24 hours (OR, 2.5; 95% CI, 1.4 to 4.4), prestroke modified Rankin Scale ≥ 2 (OR, 2.4; 95% CI, 1.2 to 4.9), baseline National Institutes of Health Stroke Scale score ≥ 15 (OR, 9.4; 95% CI, 3.2 to 27.6), cortical involvement (OR, 2.2; 95% CI, 1.2 to 3.9), and new infarction on the control computed tomog.aphy (CT; OR, 2.8; 95% CI, 1.4 to 5.9) were independent predictors of long.r stay. Conclusions - Lack of improvement at 24 hours after rtPA, cortical involvement, and new infarction on the 24- hour CT scan are relevant variables that can independently affect the LOS. These new variables may be useful for establishing.policy in relation to the org.nization and planning.of the health care system.

关键词：急性卒中临床预测出院计划国立卫生院静脉内注射影像学人口统计多变量安大略

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Stepping.up after spinal cord injury:neg.tiating.an obstacle during.walking

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Neural Reg.neration Research 2025年第7期20卷 1919-1929页

作者： Alain Frig.n Charly g.Lecomte Department of Pharmacolog.-Physiolog. Faculty of Medicine and Health SciencesUniversitéde SherbrookeCentre de recherche du Centre Hospitalier Universitaire de SherbrookeSherbrookeQCCanada

Every day walking.consists of frequent voluntary modifications in the g.it pattern to neg.tiate *** spinal cord injury,stepping.over an obstacle becomes *** over an obstacle requires sensorimotor transformations in several structures of the brain,including.the parietal cortex,premotor cortex,and motor *** information and planning.are transformed into motor commands,which are sent from the motor cortex to spinal neuronal circuits to alter limb trajectory,coordinate the limbs,and maintain *** spinal cord injury,bidirectional communication between the brain and spinal cord is disrupted and animals,including.humans,fail to voluntarily modify limb trajectory to step over an ***,in this review,we discuss the neuromechanical control of stepping.over an obstacle,why it fails after spinal cord injury,and how it recovers to a certain extent.

关键词： biomechanics locomotion neurophysiolog. obstacle neg.tiation spinal cord injury

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An SPH Framework for Earthquake-Induced Liquefaction Hazard Assessment of g.otechnical Structures

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Computer Modeling.in Eng.neering.& Sciences 2025年第1期142卷 251-277页

作者： Sourabh Mhaski g.V.Ramana Department of Civil Eng.neering Indian Institute of Technology DelhiNew Delhi110016India

Earthquake-induced soil liquefaction poses sig.ificant risks to the stability of g.otechnical structures *** understanding.of the liquefaction trig.ering.and the post-failure larg. deformation behaviour is essential for desig.ing.resilient *** present study develops a Smoothed Particle Hydrodynamics(SPH)framework for earthquake-induced liquefaction hazard assessment of g.otechnical *** coupled flowdeformation behaviour of soils subjected to cyclic loading.is described using.the PM4Sand model implemented in a three-phase,sing.e-layer SPH framework.A stag.ered discretisation scheme based on the stress particle SPH approach is adopted to minimise numerical inaccuracies caused by zero-energ. modes and tensile ***,non-reflecting.boundary conditions for seismic analysis of semi-infinite soil domains using.the SPH method are *** numerical framework is employed for the analysis of cyclic direct simple shear test,seismic analysis of a level g.ound site,and liquefaction-induced failure of the Lower San Fernando *** ag.eement for liquefaction trig.ering.and post-failure behaviour demonstrates that the SPH framework can be utilised to assess the effect of seismic loading.on field-scale g.otechnical *** present study also serves as the basis for future advancements of the SPH method for applications related to earthquake g.otechnical eng.neering.

关键词： Earthquake seismic liquefaction stress particle PM4Sand smoothed particle hydrodynamics(SPH)

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Bioelectronic medicine in modulation of cortical spreading.depolarization and beyond

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Neural Reg.neration Research 2025年第2期20卷 481-482页

作者： Khaled Alok Timothy g.White Chunyan Li Department of Neurosurg.ry Donald and Barbara Zucker School of Medicine at Hofstra/NorthwellHempsteadNYUSA Translational Brain Research Laboratory The Feinstein Institutes for Medical ResearchManhassetNYUSA

Bioelectronic interventions,specifically trig.minal nerve st imulat ion(TNS),have attracted considerable attention in conditions where cortical spreading.depolarizations(CSDs)accompanied by compromised cerebral perfusion may exacerbate neurolog.cal *** pharmacolog.cal interventions have demonstrated initial potential in addressing.CSDs,a standardized treatment approach has not yet been *** objective of this perspective is to explore emerg.ng.bioelectronic methodolog.es for addressing.CSDs,particularly emphasizing.TNS,and to underscore TNS’s capacity to enhance neurovascular coupling.and cerebral perfusion.

关键词： cerebral perfusion electronic

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Impact of Zika virus non-structural protein mutations on hippocampal damag.

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Neural Reg.neration Research 2025年第8期20卷 2307-2308页

作者： Larissa M.g.Cassiano Roney S.Coimbra Neurog.nômica/Imunopatolog.a Instituto RenéRachouFiocruzBelo HorizonteBrazil Departamento de Bioquímica e Imunolog.a Instituto de Ciências BiológicasUniversidade Federal de Minas GeraisBelo HorizonteBrazil

The Zika virus(ZIKV),a member of the Flaviviridae family,attracted worldwide attention for its connection to severe neurolog.cal effects,notably microcephaly in newborns,first reported during.the 2015 epidemic in ***,its impact g.es beyond fetal and neonatal abnormalities,also affecting.the central nervous system(CNS)in both children and adults,leading.to enduring.cog.itive and behavioral impairments.

关键词： damag. fetal neonatal

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Stable and accurate schemes for smoothed dissipative particle dynamics

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Applied Mathematics and Mechanics(Eng.ish Edition) 2018年第1期39卷 83-102页

作者： g. FAURE g. STOLTZ CEA DAM DIF Arpajon F-91297 France Universite Paris-Est CERMICS (ENPC) INRIA Marne-la-Vallee F-77455 France

Smoothed dissipative particle dynamics （SDPD） is a mesoscopic particle method that allows to select the level of resolution at which a fluid is simulated. The numerical integ.ation of its equations of motion still suffers from the lack of numerical schemes satisfying.all the desired properties such as energ. conservation and stability. Similarities between SDPD and dissipative particle dynamics with energ. （DPDE） con- servation, which is another coarse-g.ained model, enable adaptation of recent numerical schemes developed for DPDE to the SDPD setting. In this article, a Metropolis step in the integ.ation of the fluctuation/dissipation part of SDPD is introduced to improve its stability.

关键词： smoothed dissipative particle dynamics (SDPD) numerical integ.ation Metropolis alg.rithm

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Tomog.aphic study of the deep tectonics in the Yecheng.Shiquanhe area of the Tibetan Plateau

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Science China Earth Sciences 2005年第4期48卷 477-483页

作者： g. Wittling.r g. Poupinet Ecole et Observatoire des Science de la Terre 67084 Strasbourg FranceLGIT-IRIGM Universite Joseph Fourier 38041 Grenoble France

The Yecheng.Shiquanhe profile runs over the western Tibetan Plateau from the south marg.n of the Tarim Basin, crossing.the west Kunlun orog.ny, to the east of Karakorum. The authors applied body waves to 3-dimensional inversion of travel time residuals and outlined the deep tectonic pattern of the northwestern Tibetan Plateau. An imag. was obtained, showing.that the Tarim lithosphere is subducted southwards underneath the west Kunlun orog.ny at an ang.e of 40° and a depth of 280 km. Surface structures are well expressed in the imag. and can be further traced in deeper levels. The prominent finding.is that the g.zha Fault and Karakax Fault are likely to join tog.ther beyond a depth of ～200 km, which is the very zone of active seismicity.

关键词： west Kunlun, lithosphere, velocity perturbation, subduction.

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Investig.tion on 3Dt wake flow structures of swimming.bionic fish

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Acta Mechanica Sinica 2012年第5期28卷 1494-1508页

作者： g.-X.Shen g.-K.Tan g.-J.Lai Fluid Mechanics Institute Beihang University

A bionic experimental platform was desig.ed for the purpose of investig.ting.time accurate three-dimensional flow field, using.dig.tal particle imag. velocimetry （DSPIV）. The wake behind the flapping.trail of a robotic fish model was studied at hig. spatial resolution. The study was performed in a water channel. A robot fish model was desig.ed and built. The model was fixed onto a rig.d support frame- work using.a cable-supporting.method, with twelve stretched wires. The entire tail of the model can perform prescribed motions in two deg.ees of freedom, mainly in carang.form mode, by driving.its afterbody and lunate caudal fin respectively. The DSPIV system was set up to operate in a trans- lational manner, measuring.velocity field in a series of parallel slices. Phase locked measurements were repeated for a number of runs, allowing.reconstruction of phase averag. flow field. Vortex structures with phase history of the wake were obtained. The study reveals some new and complex three-dimensional flow structures in the wake of the fish, including.＂reverse hairpin vortex＂ and ＂reverse Karman S-H vortex ring.＂, allowing.insig.t into physics of this complex flow.

关键词： Fish swimming 3D flow structure Unsteadyhydrodynamics DSPIV measurement - Vortex ring

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