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Effect of tacrolimus in idiopathic membranous nephropathy： a meta-analysis

Chinese Medical Journal 2014年第14期127卷 2693-2699页

作者： santosh, thapa Liu Hong Liu Bicheng Southeast Univ Sch Med Zhongda Hosp Inst Nephrol Nanjing 210009 Jiangsu Peoples R China

Background The efficacy and safety of immunosuppression for idiopathic membranous nephropathy （IMN） are still controversial. Recent studies showed tacrolimus is effective in the treatment of IMN. To evaluate the efficacy and safety of tacrolimus （TAC） for IMN, we conducted a meta-analysis of published medical literatures. Methods Studies addressing the effect of tacrolimus in IMN were searched on PUBMED, EMBASE, The Cochrane Library, and ClinicalTrials.gov （March 2013）. Trials comparing tacrolimus with corticosteroid versus control group （cyclophosphamide with corticosteroid） were included. The quality of the studies was assessed using Jadad method. Statistical analyses were performed using Review Manager 5.2 and the results were summarized by calculating the risk ratio （RR） for dichotomous data or the mean difference （MD） for continuous data with 95% confident interval （CI）. Results A total of four studies （259 patients） were included. It was shown that therapy with tacrolimus plus corticosteroid had a higher complete remission rate compared to therapy with cyclophosplamide plus corticosteroid （RR=1.53, 95% CI： 1.05-2.24, P 〈0.05）, but not significant on total remission, partial remission and adverse effects. Also, no significant alterations were observed in proteinuria and serum albumin level between the two groups. During the entire follow-up period, serum creatinine level remained stable in both groups without ±50% increase in its level. Conclusions TAC is more effective than cyclophosphamide （CTX） by achieving complete remission in patients with IMN. Multi-ethnic RCTs are needed to evaluate its long-term efficacy and safety. Chin Med J 2014;127 （14）： 2693-2699

关键词： tacrolimus idiopathic membranous nephropathy meta-analysis

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Lipolysis supports bone formation by providing osteoblasts with endogenous fatty acid substrates to maintain bioenergetic status

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Bone Research 2023年第4期11卷 876-894页

作者： Ananya Nandy Ron C.M.Helderman santosh thapa Shobana Jayapalan Alison Richards Nikita Narayani Michael P.Czech Clifford J.Rosen Elizabeth Rendina-Ruedy Department of Medicine Division of Clinical PharmacologyVanderbilt University Medical CenterNashvilleTN 37232USA Program in Molecular Medicine University of Massachusetts Chan Medical SchoolWorcesterMA 01605USA Maine Medical Center Research Institute ScarboroughMEUSA Molecular Physiology and Biophysics Vanderbilt UniversityNashvilleTN 37232USA

Bone formation is a highly energy-demanding process that can be impacted by metabolic disorders.Glucose has been considered the principal substrate for osteoblasts,although fatty acids are also important for osteoblast function.Here,we report that osteoblasts can derive energy from endogenous fatty acids stored in lipid droplets via lipolysis and that this process is critical for bone formation.As such,we demonstrate that osteoblasts accumulate lipid droplets that are highly dynamic and provide the molecular mechanism by which they serve as a fuel source for energy generation during osteoblast maturation.Inhibiting cytoplasmic lipolysis leads to both an increase in lipid droplet size in osteoblasts and an impairment in osteoblast function.The fatty acids released by lipolysis from these lipid droplets become critical for cellular energy production as cellular energetics shifts towards oxidative phosphorylation during nutrient-depleted conditions.In vivo,conditional deletion of the ATGL-encoding gene Pnpla2 in osteoblast progenitor cells reduces cortical and trabecular bone parameters and alters skeletal lipid metabolism.Collectively,our data demonstrate that osteoblasts store fatty acids in the form of lipid droplets,which are released via lipolysis to support cellular bioenergetic status when nutrients are limited.Perturbations in this process result in impairment of bone formation,specifically reducing ATP production and overall osteoblast function.

关键词： endogenous maintain osteoblast

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Al-induced proteomics changes in tomato plants over-expressing a glyoxalase I gene

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Horticulture Research 2020年第1期7卷 2114-2128页

作者： Xudong Sun Hui Li santosh thapa Sasikiran Reddy Sangireddy Xiaobo Pei Wei Liu Yuping Jiang Shaolan Yang Dafeng Hui Sarabjit Bhatti Suping Zhou Yong Yang Tara Fish Theodore W.Thannhauser Department of Agricultural and Environmental Sciences College of AgricultureTennessee State University3500 John A Merritt BlvdNashvilleTN 37209USA College of Horticulture Shandong Agricultural UniversityTaianShandongP.R.China R.W.Holley Center for Agriculture and Health USDA-ARSCornell UniversityIthacaNY 14853USA

Glyoxalase I(Gly I)is the first enzyme in the glutathionine-dependent glyoxalase pathway for detoxification of methylglyoxal(MG)under stress conditions.Transgenic tomato‘Money Maker’plants overexpressing tomato SlGlyI gene(tomato unigene accession SGN-U582631/Solyc09g082120.3.1)were generated and homozygous lines were obtained after four generations of self-pollination.In this study,SlGlyI-overepxressing line(GlyI),wild type(WT,negative control)and plants transformed with empty vector(ECtr,positive control),were subjected to Al-treatment by growing in Magnavaca’s nutrient solution(pH 4.5)supplemented with 20μM Al3+ion activity.After 30 days of treatments,the fresh and dry weight of shoots and roots of plants from Al-treated conditions decreased significantly compared to the non-treated conditions for all the three lines.When compared across the three lines,root fresh and dry weight of GlyI was significant higher than WT and ECtr,whereas there was no difference in shoot tissues.The basal 5mm root-tips of GlyI plants expressed a significantly higher level of glyoxalase activity under both non-Al-treated and Al-treated conditions compared to the two control lines.Under Al-treated condition,there was a significant increase in MG content in ECtr and WT lines,but not in GlyI line.Quantitative proteomics analysis using tandem mass tags mass spectrometry identified 4080 quantifiable proteins and 201 Al-induced differentially expressed proteins(DEPs)in roottip tissues from GlyI,and 4273 proteins and 230 DEPs from ECtr.The Al-down-regulated DEPs were classified into molecular pathways of gene transcription,RNA splicing and protein biosynthesis in both GlyI and ECtr lines.The Alinduced DEPs in GlyI associated with tolerance to Al3+and MG toxicity are involved in callose degradation,cell wall components(xylan acetylation and pectin degradation),oxidative stress(antioxidants)and turnover of Al-damaged epidermal cells,repair of damaged DNA,epigenetics,gene transcription,and protein translation.A protein–protein association net

关键词： expressing transformed roots

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应用改进的Morgan-Morgan-Finney模型评估土壤侵蚀易感性:以尼泊尔Kulekhani流域为例

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Journal of Resources and Ecology 2024年第1期15卷 182-196页

作者： thapa Rabin JOSHI Rajeev BHATTA Binod GHIMIRE santosh 尼泊尔赫陀达农林大学林业学院尼泊尔Hetauda44107 尼泊尔乌达布尔农林大学自然资源管理学院尼泊尔UdayapurKatari56310

本研究旨在考察Kulekhani流域土地利用与土地覆盖(LULC)动态变化及土壤侵蚀情况,并对2000年至2020年不同LULC类别进行分析。研究结果显示,Kulekhani流域森林土地比例从2000年的60.72%上升至2010年的62.43%,2020年达到64.75%。水域面积... 详细信息

本研究旨在考察Kulekhani流域土地利用与土地覆盖(LULC)动态变化及土壤侵蚀情况,并对2000年至2020年不同LULC类别进行分析。研究结果显示,Kulekhani流域森林土地比例从2000年的60.72%上升至2010年的62.43%,2020年达到64.75%。水域面积有小幅增加,2000年占比为1.07%,2020年增加到1.08%。相应地,荒地面积从0.21%增至0.35%。相反,农业用地比例逐渐减少,2000年为38%,2010年为36.24%,2020年降至33.82%。使用改进的Morgan-Morgan-Finney模型估算土壤流失量显示,2000年到2010年期间,加权平均土壤流失量呈下降趋势,而2010年到2020年期间略微增加。计算得出的土壤流失值分别为2000年8.64 t ha^(-1)yr^(-1)、2010年7.12 t ha^(-1)yr^(-1)和2020年7.30 t ha^(-1)yr^(-1)。土壤侵蚀易感性图表明,2000年到2020年期间,非常低风险的土壤侵蚀区域有所增加,主要集中在森林地区,而农业区域则显示出低到中度的易感性。此外,荒地区域显示出中高度的土壤侵蚀易感性。为解决这些问题,建议未来的努力应包括在荒地地区进行造林计划,在农业区域实施保护耕作方式,并采取适当的道路稳定措施。

关键词：水泥沙土地利用土地覆盖坡度降雨量

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尼中合作进入新阶段——中国支援尼泊尔抗击新冠肺炎疫情纪实

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一带一路报道 2020年第4期 68-73页

作者：圣多什·吉米尔钟晓玉(译) 尼泊尔《共和报》不详

2020年5月13日,中国人民解放军一架满载医疗物资的飞机降落在加德满都特里布万国际机场。当天下午,中国驻尼泊尔大使侯艳琪在尼军队总部向尼泊尔军队参谋长塔帕上将移交了该批医疗物资。中国提供的这批防护服、医用口罩、额温枪等医疗... 详细信息

2020年5月13日,中国人民解放军一架满载医疗物资的飞机降落在加德满都特里布万国际机场。当天下午,中国驻尼泊尔大使侯艳琪在尼军队总部向尼泊尔军队参谋长塔帕上将移交了该批医疗物资。中国提供的这批防护服、医用口罩、额温枪等医疗物资为尼泊尔抗击新冠肺炎疫情提供了巨大帮助。

关键词：医疗物资国际机场加德满都防护服尼泊尔肺炎疫情

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