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Neural Regeneration Research 2021年第12期16卷 2349-2352页

作者： Asit kumar santosh kumar Department of Pharmaceutical Sciences University of Tennessee Health Science CenterMemphisTNUSA

Traumatic brain injury is a sudden trauma or blow on the head,and severe traumatic brain injury is a major cause of death and disability *** acute and chronic consequences following traumatic brain injury can lead to progressive secondary neurodegenerative changes and cognitive *** date,there is no effective pharmaceutical products for the treatment to reduce secondary damage after brain *** discovery of extracellular vesicles has attracted considerable scientific attention due to their role in cell-to-cell *** vesicles have shown their potential to carry not only biological molecules but also as a drug delivery *** a carrier of molecular information,extracellular vesicles have been involved in physiological functions as well as in the modulation of immune ***,we aim to provide new insights into the contrasting role of extracellular vesicles in the propagation of inflammatory responses after brain *** a carrier of pro-inflammatory molecules,their role as functional mediators in the pathophysiology of brain injury is discussed,addressing the inhibition of the extracellular vesicle pathway as an anti-inflammatory or neuroprotective approach to improve the outcome of both acute and chronic inflammation following brain ***,we summarize therapeutic strategies to diminish the risk the neurodegeneration post brain injury and propose that neutral sphingomyelinase inhibitors could be used as potentially useful therapeutic agents for the treatment of brain injury associated neuroinflammation.

关键词： brain injury ceramide extracellular vesicles microglia neuroinflammation neuroprotection neutral sphingomyelinase

Thermo-Magneto-Electric Currents with Dynamical Magnetization Inhomogeneities

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Communications in Theoretical Physics 2011年第9期56卷 504-512页

作者： santosh kumar Kudtarkar Centre for Mathematical Modelling FLAME150/7Jaideep BungalowBaner-Balewadi RoadBanerPune 411 045India

We study the effect of potential and thermal gradient induced non-equilibrium magnetization in quasi1-d itinerant magnets.A semi-phenomenological theory is employed in conjunction with the drift-diffusion model forthis *** the methods of non-equilibrium thermodynamics,we derive the transport currents correspondingto charge,heat,and magnetization flows in the presence of non-equilibrium magnetization *** is shown howtime-dependent magnetic textures give rise to charge and thermal currents even in the absence of external potential andthermal gradients through spin *** presence of dynamical textures also affect the thermodynamic parametersof the *** an application,we consider the case of a helimagnet.

关键词： current and temperature driven spin pumping thermoelectric thermomagnetic

Modeling of All-Optical Even and Odd Parity Generator Circuits Using Metal-Insulator-Metal Plasmonic Waveguides

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Photonic Sensors 2017年第2期7卷 182-192页

作者： Lokendra SINGH Amna BEDI santosh kumar Photonics Lab Department of Electronics and Communication Engineering DIT University Dehradun-248009 India

Plasmonic metal-insulator-metal （MIM） waveguides sustain excellent property of confining the surface plasmons up to a deep subwavelength scale. In this paper, linear and S-shaped MIM waveguides are cascaded together to design the model of Mach-Zehnder interferometer （MZI）. Nonlinear material has been used for switching of light across its output ports. The structures of even and odd parity generators are projected by cascading the MZIs. Parity generator and checker circuit are used for error correction and detection in an optical communication system. Study and analysis of proposed designs are carried out by using the MATLAB simulation and finite-difference- time-domain （FDTD） method.

关键词： Plasmonics MIM waveguides Mach-Zehnder interferometer nonlinear process FDTD method

Peraluminous A-type granites formed through synchronous fractionation,magma mixing,mingling,and undercooling:evidence from microgranular enclaves and host Mesoproterozoic Kanigiri granite pluton,Nellore Schist Belt,southeast India

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Acta Geochimica 2023年第4期42卷 603-636页

作者： Ch.Narshimha santosh kumar Department of Geology Centre of Advanced StudyKumaun UniversityNainital 263001India

The field and microstructural features coupled with mineral chemical data from microgranular enclave(ME)and host Mesoproterozoic Kanigiri granite(KG)pluton of Nellore Schist Belt(NSB),Southeastern India,have been documented in order to infer the likely processes responsible for the origin and evolution of ME and host KG *** ME and host KG bear the same mineral assemblages barring the KG which does not contain amphibole;however,they are modally *** ME in KG is originated due to multiple intrusions of ME magmas into the crystallizing host KG magma *** and textural features indicate the dynamic magma flow,mingling,and undercooling of the ME against a relatively cooler surface of host KG *** presence of NSB country rock xenoliths and its diffuse boundaries suggest the intrusive relation and marginal assimilation by the intruding KG *** occasional cumulate texture in the ME appears to have formed by the accumulation of early-formed minerals that crystallized rapidly in the ME magma *** ME shows the magmatically deform features developed due to the flowage and erosion by the subsequent intrusions of ME magma pulses into the crystallizing host KG magma *** ME amphiboles show unusual composition as ferro-edenitic hornblende to potassian-hastingsitic hornblende,that crystallized in the subalkaline-alkaline transition,low fO_(2)(reducing to mildly oxidizing)*** unusual extremely low Mg/Mg+Fe^(t)=0.015(avg.)of ME amphiboles may be related to the changing physico-chemical(P,T,fO_(2),and H_(2)O)condition of the ME magma or they might have crystallized in equilibrium with more evolved KG *** KG(FeOt/MgO=37.04,avg.)and ME(FeO~t/MgO=77.72,avg.)biotites are siderophyllite,and buffered between QFM and NNO syn-crystallizing in the water undersaturated(H_(2O)≈3.58 wt.%in KG;≈3.53wt.%in ME),alkaline anorogenic(A-type)host magmas that were emplaced at mid-crustal(4–5 kbar;17 km)***,microtextural and mineral

关键词： Enclave Kanigiri granite Magma mixing-fractionation Nellore schist belt SE India

Thermal Characteristics of Air-Water Spray Impingement Cooling of Hot Metallic Surface under Controlled Parametric Conditions

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Journal of Thermal Science 2016年第3期25卷 266-272页

作者： santosh kumar Nayak Purna Chandra Mishra School of Mechanical Engineering KIIT University

Experimental results on the thermal characteristics of air-water spray impingement cooling of hot metallic surface are presented and discussed in this *** controlling input parameters investigated were the combined air and water pressures,plate thickness,water flow rate,nozzle height from the target surface and initial temperature of the hot *** effects of these input parameters on the important thermal characteristics such as heat transfer rate,heat transfer coefficient and wetting front movement were measured and *** flat plate samples of mild steel with dimension 120 mm in length,120 mm breadth and thickness of 4 mm,6 mm,and 8mm respectively were *** air assisted water spray was found to be an effective cooling media and method to achieve very high heat transfer rate from the *** heat transfer rate and heat transfer coefficients were obtained for the lesser i.e,4 mm thick *** in the nozzle height reduced the heat transfer efficiency of spray *** an inlet water pressure of 4 bar and air pressure of 3 bar,maximum cooling rates670℃/s and average cooling rate of 305.23℃/s were achieved for a temperature of 850℃ of the steel plate.

关键词： air-water spray transient temperature cooling rate plate thickness

Flow past a bluff body subjected to lower subcritical Reynolds number

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Journal of Ocean Engineering and Science 2020年第2期5卷 173-179页

作者： Pankaj kumar santosh kumar Singh Department of Mechanical Engineering SRM Institute of Science and TechnologyKattankulathur 603203India

The paper aimed to study the flow structure at the wake of the bluff body with altered blockage ratio(BR)keeping the fixed aspect ratio(AR).The study was conducted by a finite volume technique using commercial software *** CFD analysis of the bluff body is mainly subjected to the lower subcritical Reynolds number range(5000 to 15,000)along with blockage ratio as an important *** flow parameters such as drag coefficient,pressure,and kinetic energy variations are analyzed here for the Reynolds number(Re)and *** was observed that at fixed Re,t he drag coefficient(C_(D))increases with an increase in the BR while decrease with increasing Re for a fixed value of BR.

关键词： Blockage ratio Bluff body Drag coefficient Reynolds number

Surface-engineered gadolinium oxide nanorods and nanocuboids for bioimaging

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Rare Metals 2021年第4期40卷 848-857页

作者： Nitya Ramesh Chawda santosh kumar Mahapatra Indrani Banerjee School of Nano Sciences Central University of GujaratGandhinagar 382030India Department of Physical Sciences Central University of PunjabBathinda 151001India

Folic acid and D-gluconic acid-capped gadolinium oxide nanorods and nanocuboids were synthesized via co-precipitation *** study of relaxivity factor on the role of capping and morphology for enhancing contrast ability for T_(1) and T_(2) magnetic resonance imaging(MRI) was *** obtained r_(2)/r_(1) ratio for folic acid and D-gluconic acid-capped gadolinium oxide nanorods and nanocuboids was 1.5 and 1.3,*** nanocrystals were characterized and presented with properties such as good dispersity and stability required for standard contrast agent used in *** characterization and the analysis of capping agent for nanocrystals suggest the preferable use of carbohydrate moieties with higher number of hydroxyl functional group reacted with urea and hydrogen peroxide for desired morphology and anisotropic ***-differential thermal analysis(TG-DTA) illustrated the amount of capping,transition temperature from Gd(OH)3 to GdOOH and crystallization temperature from GdOOH to *** nanocrystals would be significant for other biomedical applications such as drug delivery when equipped with well-functionalized drug molecules.

关键词： Contrast agent Nanomaterials Magnetic resonance imaging Imaging

Local Extreme Complete Trio Pattern for Multimedia Image Retrieval System

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International Journal of Automation and computing 2016年第5期13卷 457-467页

作者： santosh kumar Vipparthi Shyam Krishna Nagar Indian Institute of Technology Banaras Hindu UniversityVaranasi 221005Uttar PradeshIndia Malaviya National Institute of Technology Jaipur 302017RajastanIndia

This paper presents a new feature descriptor, namely local extreme complete trio pattern （LECTP） for image retrieval application. The LECTP extracts complete extreme to minimal edge information in all possible directions using trio values. The LECTP integrates the local extreme sign trio patterns （LESTP） with magnitude local operator （MLOP） for image retrieval. The performance of the LECTP is tested by conducting three experiments on Corel-5 000, Corel-10 000 and MIT-VisTex color databases, respectively. The results after investigation show a significant improvement in terms of average retrieval precision （ARP） and average retrieval rate （ARR） as compared to the other state-of-the art techniques in content based image retrieval （CBIR）.

关键词： Image retrieval (IR) local binary patterns (LBP) average retrieval precision (ARP) average retrieval rate (ARR) database (DB).

Underground void filling by cemented mill tailings

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International Journal of Mining Science and Technology 2013年第6期23卷 893-900页

作者： Choudhary Bhanwar Singh kumar santosh Department of Mining Indian School of Mines

Underground mining always create *** voids can cause subsidence of *** it is always a demand to fill the void in such a manner that the effect of underground mining can be *** filling using mill tailings especially in metal mining is one of the best *** tailings produced in milling process have traditionally been disposed in tailing ponds creating a waste disposal and environmental problems in terms of land degradation,air and water pollution,*** disposal practice is more acute in the metal milling industry where the fine grinding,required for value liberation,results in the production of very fine tailings in large *** paper includes discussions on the effectiveness of different paste mixes with varying cement contents in paste backfilling *** results revealed that material composition and use of super plasticizer strongly influenced the strength of cemented backfill.

关键词： Underground Cemented mill tailings Backfilling Metal mining Super plasticizer

Biomonitoring of endosulfan toxicity in human

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BIOCELL 2022年第7期46卷 1771-1777页

作者： santosh kumar KARN ADITYA UPADHYAY AWANISH kumar Department of Biotechnology Sardar Bhagwan Singh UniversityFormer Sardar Bhagwan Singh Post Graduate Institute of Biomedical Science&ResearchDehradun248161India Department of Biotechnology National Institute of TechnologyRaipur492010India

Chemicals are comprehensively used worldwide to control herbs,weeds,pests,and other competing agents with various growing *** consumption of crops grown with these chemicals(even in small quantities)can upshot into accumulation in the human *** can accidentally inhale these hazardous chemicals if they are in an area where they were *** chemicals can be ingested in a human with contaminated food and *** it causes various adverse effects(chronic toxicity,teratogenic,mutagenic,carcinogenic effect,reproductive,and organ toxicity)on human *** the pool of these chemicals used as pesticides in the environment,exposure of endosulfan to humans has a potential health risk throughout the *** poisoning of endosulfan is reported frequently in society,therefore,this article highlights the toxicological and other harmful properties of endosulfan to humans and emphasized its essential *** quick monitoring and effective hazard evaluation are possible with multiomics technologies and some other analytical *** review summarizes the introduction and mechanism of action of endosulfan along with some other toxic chemicals used in the agriculture work,the toxicity of endosulfan in human/environment,and importantly its biomonitoring(detection of chemicals and their metabolites in a biological sample)in human because biomonitoring is often considered as the most preferred *** could be easily done in human samples(blood,hair,milk,and urine)with a multi-omics approach,which is a quick,reliable,and state-of-the-art technique.

关键词： Endosulfan Agricultural use Toxicity Biomonitoring in human