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Neural Regeneration Research 2022年第7期17卷 1423-1430页

作者： santiago E.Charif M.Florencia Vassallu Lara Salvañal Lionel M.Igaz IFIBIO Houssay Grupo de Neurociencia de SistemasFacultad de MedicinaUniversidad de Buenos Aires-CONICETBuenos AiresArgentina

Protein synthesis is essential for cells to perform life metabolic *** alterations of protein content can lead to particular *** have an intrinsic array of mechanisms and pathways that are activated when protein misfolding,accumulation,aggregation or mislocalization *** of them(like the unfolded protein response)represent complex interactions between endoplasmic reticulum sensors and elongation factors that tend to increase expression of chaperone proteins and/or repress translation in order to restore protein homeostasis(also known as proteostasis).This is even more important in neurons,as they are very susceptible to harmful effects associated with protein overload and proteostatic mechanisms are less effective with *** neurodegenerative pathologies such as Alzheimer’s,Parkinson’s,and Huntington’s diseases,amyotrophic lateral sclerosis and frontotemporal dementia exhibit a particular molecular signature of distinct,unbalanced protein *** amyotrophic lateral sclerosis and frontotemporal dementia,the majority of cases present intracellular inclusions of ubiquitinated transactive response DNA-binding protein of 43 kDa(TDP-43).TDP-43 is an RNA binding protein that participates in RNA metabolism,among other *** of TDP-43(*** and mislocalization)can dramatically affect neurons,and this has been linked to disease *** of amyotrophic lateral sclerosis/frontotemporal dementia TDP-43-related mutations in cellular and animal models has been shown to recapitulate key features of the amyotrophic lateral sclerosis/frontotemporal dementia disease *** variants can be causative of degeneration onset and *** neurodegenerative diseases(including amyotrophic lateral sclerosis and frontotemporal dementia)have no cure at the moment;however,modulating translation has recently emerged as an attractive approach that can be performed at several steps(***

关键词： amyotrophic lateral sclerosis frontotemporal dementia neurodegeneration neurodegenerative diseases protein imbalance protein synthesis modulation proteostasis therapeutical compounds transactive response DNA-binding protein of 43 kDa translation unfolded protein response

Predictive modeling of critical temperatures in magnesium compounds using transfer learning

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Journal of Magnesium and Alloys 2024年第4期12卷 1540-1553页

作者： Surjeet Kumar Russlan Jaafreh Subhajit Dutta Jung Hyeon Yoo santiago Pereznieto Kotiba Hamad Dae Ho Yoon School of Advanced Materials Science&Engineering Sungkyunkwan University Suwon 16419Republic of Korea

This study presents a transfer learning approach for discovering potential Mg-based superconductors utilizing a comprehensive target ***,a large source dataset(Bandgap dataset)comprising approximately∼75k compounds is utilized for pretraining,followed by fine-tuning with a smaller Critical Temperature(T_(c))dataset containing∼300 ***,there is a significant improvement in the performance of the transfer learning model over the traditional deep learning(DL)model in predicting ***,the transfer learning model is applied to predict the properties of approximately 150k *** are validated computationally using density functional theory(DFT)calculations based on lattice dynamics-related ***,to demonstrate the extended predictive capability of the transfer learning model for new materials,a pool of virtual compounds derived from prototype crystal structures from the Materials Project(MP)database is generated.T_(c) predictions are obtained for∼3600 virtual compounds,which underwent screening for electroneutrality and thermodynamic *** Extra Trees-based model is trained to utilize E_(hull)values to obtain thermodynamically stable materials,employing a dataset containing Ehull values for approximately 150k materials for *** with Ehull values exceeding 5 meV/atom were filtered out,resulting in a refined list of potential Mg-based *** study showcases the effectiveness of transfer learning in predicting superconducting properties and highlights its potential for accelerating the discovery of Mg-based materials in the field of superconductivity.

关键词： Superconductivity Critical temperature Transfer learning Crystal structure features Thermodynamic stability

Electro-tribological properties of diamond like carbon coatings

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Friction 2020年第2期8卷 451-461页

作者： Iñigo BRACERAS Iñigo IBÁNEZ santiago DOMINGUEZ-MEISTER Xabier VELASCO Marta BRIZUELA Iñaki GARMENDIA Tecnalia Research&Innovation Mikeletegi Pasealekua 2Donostia-San Sebastian 20009Spain Mechanical Engineering Department University of the Basque Country UPV/EHUPlaza de Europa1Donostia-San Sebastian 20018Spain

Diamond like carbon(DLC)coatings typically present good self-lubricating tribological properties that could be of interest in sliding dielectric contacts in multiple electrical *** this work electro-tribological studies have been performed on several DLC coatings against aluminum in different humidity conditions,in which the coefficients of friction(CoFs)and electrical contact resistance(ECR)were continuously *** show that CoF and ECR data can be linked to the properties of the coatings(thickness,finishing,microstructure,residual stresses,and wettability)and the degradation modes of their tribological and electrical ***,electro-tribological data can provide valuable information about the performance of dielectric coatings,the reasons behind it,and assist in the development of the *** also shows potential for on-line monitoring of coated parts in operation.

关键词： DLC electro-tribology ECR-electrical contact resistance coefficient of friction

Dimensionality reduction of hyperspectral images of vegetation and crops based on self-organized maps

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Information Processing in Agriculture 2021年第2期8卷 310-327页

作者： David ruiz Hidalgo Bladimir Bacca Cortés Eduardo Caicedo Bravo Perception and Intelligent Systems Research Group School of Electrical and Electronic EngineeringUniversidad del ValleSantiago de Cali 76001Colombia

Hyperspectral images are multidimensional massive sets of information that have shown a great potential for different kind of applications as urban mapping,environmental management,vegetation and crops supervision and mineral ***,due to its high dimensional nature and the high variability of the spectral information,the dimensionality reduction process is one of the main challenges in processing hyperspectral *** aim of dimensionality reduction is to eliminate redundant information and simplify the subsequent processes of classification and the search of *** this context,several dimensionality reduction methods have been proposed,but most of them are not flexible enough to deal with the particular features of the hyperspectral *** this way,the use of intelligent methods as neural networks and specially an unsupervised approach as self-organized maps,may improve the dimensionality reduction stage and the final classification *** paper proposes an unsupervised method for the dimensionality reduction of hyperspectral images based on Kohonen self-organized maps,which,compared with other traditional methods such as principal component analysis(PCA)and wavelet decomposition,provides better classification *** results provided in this paper use an RBF(radial basis function)*** average,the proposed method provides a 64%dimensionality reduction and an 88.5%classification *** results suggest that the dimensionality reduction algorithm based on self-organized maps is an efficient approach compared with other popular *** is due to the ability of self-organized maps to automatically detect(self-organizing)relationships within the set of input patterns,which provides flexibility to deal with the special features of the hyperspectral images.

关键词： Dimensionality reduction Hyperspectral images Principal component analysis Radial basis function Remote sensing Self-organized maps Wavelet transform

Polyurethanes from Kraft Lignin without Using Isocyanates

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Journal of Renewable Materials 2018年第4期6卷 413-425页

作者： F.J.santiago-Medina M.C.Basso A.Pizzi L.Delmotte LERMAB University of Lorraine27 rue Philippe Seguin88000 EpinalFrance Department of Physics King Abdulaziz UniversityJeddahSaudi Arabia Material Science Institute of Mulhouse UMR CNRS 7361University of Upper Alsace15 rue Jean StarckyBP 248868057 Mulhouse CedexFrance

The reaction of a desulphurized kraft lignin with hexamethylene diamine and dimethyl carbonate has allowed the development of isocyanate-free polyurethane *** present research work is based on previous studies made with hydrolyzable and condensed tannins,but takes advantage of the higher number of hydroxyl groups present in lignin and their different aliphatic and aromatic *** obtained materials were analyzed by Fourier transform infrared(FTIR)spectroscopy,matrix-assisted laser desorption ionization time-of-flight(MALDI-TOF)mass spectrometry and solid-state cross-polarization/magic angle spinning(CP MAS)13C nuclear magnetic resonance(NMR),which have revealed the presence of urethane *** interpretation of the results has shown a larger number of species than when tannins were used and has indicated the presence of two types of bonds in the new molecules formed:ionic and covalent bonds.

关键词： Lignin urethanes non-isocyanate polyurethanes MALDI-TOF FTIR

Rectal tone and compliance affected in patients with fecal incontinence after fistulotomy

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World Journal of Gastroenterology 2015年第13期21卷 4000-4005页

作者： Richard Alexander Awad santiago Camacho Francisco Flores Evelyn Altamirano Mario Antonio García Experimental Medicine and Motility Unit Gastroenterology Service U-107Mexico City General HospitalMexico DF06726Mexico

AIM: To investigate the anal sphincter and rectal factors that may be involved in fecal incontinence that develops following fistulotomy(FIAF).METHODS: Eleven patients with FIAF were compared with 11 patients with idiopathic fecal incontinence and with 11 asymptomatic healthy subjects(HS). All of the study participants underwent anorectal manometry and a barostat study(rectal sensitivity, tone, compliance and capacity). The mean time since surgery was 28 ± 26 mo. The postoperative continence score was 14 ± 2.5(95%CI: 12.4-15.5, St Mark's fecal incontinence grading system).RESULTS: Compared with the HS, the FIAF patients showed increased rectal tone(42.63 ± 27.69 vs 103.5 ± 51.13, P = 0.002) and less rectal compliance(4.95 ± 3.43 vs 11.77 ± 6.9, P = 0.009). No significant differences were found between the FIAF patients and the HS with respect to the rectal capacity; thresholds for the non-noxious stimuli of first sensation, gas sensation and urge-to-defecate sensation or the noxious stimulus of pain; anal resting pressure or squeeze pressure; or the frequency or percentage of relaxation of the rectoanal inhibitory reflex. No significant differences were found between the FIAF patients and the patients with idiopathic fecal ***: In patients with FIAF, normal motor anal sphincter function and rectal sensitivity are preserved, but rectal tone and compliance are impaired. The results suggest that FIAF is not due to alterations in rectal sensitivity and that the rectum is more involved than the anal sphincters in the genesis of FIAF.

关键词： Fecal incontinence Anorectal surgery Fistulotomy V

Smart dental materials for antimicrobial applications

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Bioactive Materials 2023年第6期24卷 1-19页

作者： Carolina Montoya Lina Roldan Michelle Yu Sara Valliani Christina Ta Maobin Yang santiago Orrego Department of Oral Health Sciences Kornberg School of DentistryTemple UniversityPhiladelphiaPAUSA Bioengineering Research Group(GIB) Universidad EAFITMedellínColombia Department of Endodontology Kornberg School of DentistryTemple UniversityPhiladelphiaPAUSA Bioengineering Department College of EngineeringTemple UniversityPhiladelphiaPAUSA

Smart biomaterials can sense and react to physiological or external environmental stimuli(e.g.,mechanical,chemical,electrical,or magnetic signals).The last decades have seen exponential growth in the use and development of smart dental biomaterials for antimicrobial applications in *** biomaterial systems offer improved efficacy and controllable bio-functionalities to prevent infections and extend the longevity of dental *** review article presents the current state-of-the-art of design,evaluation,advantages,and limitations of bioactive and stimuli-responsive and autonomous dental materials for antimicrobial ***,the importance and classification of smart biomaterials are ***,the categories of bioresponsive antibacterial dental materials are systematically itemized based on different stimuli,including pH,enzymes,light,magnetic field,and *** each category,their antimicrobial mechanism,applications,and examples are ***,we examined the limitations and obstacles required to develop clinically relevant applications of these appealing technologies.

关键词： Antimicrobial Antibacterial Antifungal Smart dental materials Bioresponsive biomaterials Stimuli-responsive Restorative dentistry Biofilm Antibiofilm Bioactive

Status of Cry1Ac and Cry2Ab2 resistance in field populations of Helicoverpa zea in Texas, USA

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Insect Science 2022年第2期29卷 487-495页

作者： JoséC.santiago González David L.Kerns Graham P.Head Fei Yang Department of Entomology Texas A&M UniversityCollege StationTexasUSA Bayer Crop Science St.LouisMissouriUSA

Helicoverpa zea is a major target pest of Bt corn and Bt ***-evolved resistance of *** to Cry1 and Cry2 proteins has been widely reported in the United *** the frequency of resistance alleles in a target insect is critical for Bt resistance *** multiple cases of practical resistance to Cry proteins having been documented in ***,there are no data on the current status of alleles conferring resistance to Cry1Ac and Cry2Ab2 in field populations of this *** 2018‒2019,a total of 106 F2 families for Cry1Ac and 120 F2 families for Cry2Ab2 were established using mass mating and light trap *** screened 13,568 and 15,360 neonates using a discriminatory dose of Cry1Ac and Cry2Ab2,*** results showed that 93.4%and 35.0%of the F2 families could survive on the discriminatory dose of Cry1Ac and Cry2Ab2,*** estimated resistance allele frequency for Cry1Ac in *** ranged from 0.4150 to 0.4975 and for Cry2Ab2 ranged from 0.1097 and *** data indicate that the frequency of alleles conferring resistance to Cry1 and Cry2 proteins in *** in Texas are *** addition,our data suggest the resistance to Cry1Ac and Cry2Ab2 in the screened families of *** varies from recessive to *** information in this study provides precise estimates of Cry resistance allele frequencies in *** and increases our understanding of the risks to the sustainability of Bt crops.

关键词： allele frequency Bacillus thuringiensis CrylAc Cry2Ab2 Helicoverpa zea resistance

Abundance of White-fronted Parrots and diet of an urban parrot assemblage(Aves:Psittaciformes)in a green Neotropical city

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Avian Research 2022年第1期13卷 36-42页

作者： CristelAlvarez-Castillo Ian MacGregor-Fors Stefan LArriaga-Weiss Claudio Mota-Vargas Diego santiago-Alarcon Biología y Conservación de Vertebrados Instituto de EcologíaA.C.-CONACYTXalapaMexico Biological and Environmental Sciences University of HelsinkiLahtiFinland División Académica de Ciencias Biológicas Universidad Juárez Autónoma de TabascoVillahermosaMexico Biología Evolutiva Instituto de EcologíaA.C.-CONACYTXalapaMexico Department of Integrative Biology University of South FloridaTampaUSA

Urban ecosystems are evolutionarily recent novel environments acting as biodiversity *** birds are considered successful urban adapters mainly due to their generalist feeding and opportunistic behavior,allowing them to occupy environments from cold temperate to dry xeric ***,it is important to understand how these species interact in the urban *** studied the interannual(2013–2016)abundance of the White-fronted Parrot(Amazona albifrons)in the Neotropical cities of Xalapa and Coatepec,in Central Veracruz,Mé***,we studied the feeding ecology during 13 months of 6 parrot species detected in the city of *** abundance of the White-fronted Parrot was significantly higher in Xalapa than in Coatepec,and it was homogeneous across ***-native plants represented 30–41%of Psittacidae diets in Xalapa,where seeds were the most commonly consumed *** recorded the highest Psittacidae species richness and highest diet overlap among species by the end of the dry season(April–May).The White-fronted Parrot had the highest plant richness in its diet,followed by the Monk Parakeet(Myiopsitta monachus)and the Green Parakeet(Psittacara holochlorus);yet,the White-fronted Parrot had a specialized diet dominated by two plant species(Grevillea robusta and Ficus aurea).The diet overlap among the three above-mentioned parrot species was not significantly different to a null model,where the White-fronted Parrot and the Monk Parakeet overlapped during the months of February,April,June,and *** White-fronted Parrot is an urban adapter that has successfully expanded its geographic range via natural means and by human *** invasive Monk Parakeet is currently restricted to one park in Xalapa,and it has remained in that stage for many years(i.e.,pre-expansion phase).Exotic plant species in Xalapa represent∼55%of the woody vegetation,some of which have longer flowering and fruiting periods that may have aided the s

关键词： Biological invasions Feeding ecology Population biology Psittacidae Urban ecology