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Multi-Step Clustering of Smart Meters Time Series:Application to Demand Flexibility Characterization of SME Customers

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 869-907页

作者： santiago Bañales Raquel Dormido Natividad Duro Department of Computer Sciences and Automatic Control Universidad Nacional de Educación a Distancia(UNED)Madrid28040Spain Iberdrola Innovation Middle East Doha210177Qatar

Customer segmentation according to load-shape profiles using smart meter data is an increasingly important application to vital the planning and operation of energy systems and to enable citizens’participation in the energy *** study proposes an innovative multi-step clustering procedure to segment customers based on load-shape patterns at the daily and intra-daily time *** meter data is split between daily and hourly normalized time series to assess monthly,weekly,daily,and hourly seasonality patterns *** dimensionality reduction implicit in the splitting allows a direct approach to clustering raw daily energy time series *** intraday clustering procedure sequentially identifies representative hourly day-unit profiles for each customer and the entire *** the first time,a step function approach is applied to reduce time series *** attributes embedded in surveys are employed to build external clustering validation metrics using Cramer’s V correlation factors and to identify statistically significant determinants of load-shape in energy *** addition,a time series features engineering approach is used to extract 16 relevant demand flexibility indicators that characterize customers and corresponding clusters along four different axes:available Energy(E),Temporal patterns(T),Consistency(C),and Variability(V).The methodology is implemented on a real-world electricity consumption dataset of 325 Small and Medium-sized Enterprise(SME)customers,identifying 4 daily and 6 hourly easy-to-interpret,well-defined *** application of the methodology includes selecting key parameters via grid search and a thorough comparison of clustering distances and methods to ensure the robustness of the *** research can test the scalability of the methodology to larger datasets from various customer segments(households and large commercial)and locations with different weather and socioeconomic conditio

关键词： Electric load clustering load profiling smart meters machine learning data mining demand flexibility demand response

Identification of plant genes putatively involved in the perception of fungal ergosterol-squalene^∞

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Journal of Integrative Plant Biology 2020年第7期62卷 927-947页

作者： Laura Lindo Rosa E.Cardoza Alicia Lorenzana Pedro A.Casquero santiago gutiérrez Area of Microbiology University of LeónCampus of PonferradaPonferradaSpain University Group of Research in Engineering and Sustainable Agriculture University of LeónLeónSpain

Trichoderma biocontrol strains establish a complex network of interactions with plants,in which diverse fungal molecules are involved in the recognition of these fungi as nonpathogenic *** molecules act as microbial-associated molecular patterns that trigger plant *** studies have reported the im-portance of ergosterol produced by Trichoderma *** the ability of these fungi to induce plant growth and *** addition,squalene,a sterol biosynthetic inter-mediate,seems to play an important role in these ***,we analyzed the effect of different concentrations of ergosterol and squalene on tomato(Solanum lycopersicum)growth and on the transcription level of defense-and growth-related *** used an RNA-seq strategy to identify several tomato genesencoding predicted pattern recognition receptor proteins or WRKY transcription factors,both of which are puta-tively involved in the perception and response to ergo-sterol and ***,an analysis of Arabidopsis thaliana mutants lacking the genes homologous to these tomato candidates led to the identification of a WRKY40 transcription factor that negatively regulates salicylic acid-related genes and positively regulates ethylene-and jasmonate-related genes in the presence of ergosterol and squalene.

关键词： plant perception pattern

Exploring the thermophysical properties of natural deep eutectic solvents for gas capture applications:a comprehensive review

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Green Chemical Engineering 2024年第3期5卷 307-338页

作者： Ahmad Al-Bodour Noor Alomari Alberto guti errez santiago Aparicio Mert Atilhan Department of Chemical and Paper Engineering Western Michigan UniversityKalamazooMI49008-5462USA Department of Chemistry University of Burgos Faculty of SciencesBurgos09001Spain

With the intensifying challenge of global warming driven largely by anthropogenic activities,effective greenhouse gas capture techniques are *** paper focuses on the role of deep eutectic solvents(DES)as promising agents for such capture at the *** review the key DES-based methods for greenhouse gas capture,drawing conclusions from a thorough analysis of the existing *** particular,we examine the effect of DES structure on gas solubilities and explore the mechanism of gas solubility in DES through molecular *** present a synthesis of state-of-the-art results in this area,assessing the potential of DES as an alternative to current industrial gas capture ***,we propose future research directions for the design of novel DES tailored to more specific applications.

关键词： Global warming Climate change Deep eutectic solvents Gas capture Gas separation

Systematic exploration of signal-based indicators for failure diagnosis in the context of cyber-physical systems

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Frontiers of Information Technology & Electronic Engineering 2019年第2期20卷 152-175页

作者： santiago ruiz-ARENAS Zoltán RUSáK Imre HORVáTH Ricardo MEJí-gutiErrez Faculty of Industrial Design Engineering Delft University of Technology Grupo de Investigación en Ingeniería de Diseno Universidad EAFIT

Malfunction or breakdown of certain mission critical systems(MCSs) may cause losses of life, damage the environments, and/or lead to high costs. Therefore, recognition of emerging failures and preventive maintenance are essential for reliable operation of MCSs. There is a practical approach for identifying and forecasting failures based on the indicators obtained from real life processes. We aim to develop means for performing active failure diagnosis and forecasting based on monitoring statistical changes of generic signal features in the specific operation modes of the system. In this paper, we present a new approach for identifying emerging failures based on their manifestations in system signals. Our approach benefits from the dynamic management of the system operation modes and from simultaneous processing and characterization of multiple heterogeneous signal sources. It improves the reliability of failure diagnosis and forecasting by investigating system performance in various operation modes, includes reasoning about failures and forming of failures using a failure indicator matrix which is composed of statistical deviation of signal characteristics between normal and failed operations, and implements a failure indicator concept that can be used as a plug and play failure diagnosis and failure forecasting feature of cyber-physical systems. We demonstrate that our method can automate failure diagnosis in the MCSs and lend the MCSs to the development of decision support systems for preventive maintenance.

关键词： Failure indicators Failure classification Failure detection and diagnosis Complex systems

Resource economics and coordination among above- and below-ground functional traits of three dominant shrubs from the Chilean coastal desert

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Journal of Plant Ecology 2015年第1期8卷 70-78页

作者： Joaquín Morales Francisco A.Squeo Yann Tracol Cristina Armas Julio R.gutiérrez Facultad de Ciencias Universidad de La SerenaCasilla 554La SerenaChile Institute of Ecology and Biodiversity(IEB) Casilla 653SantiagoChile Center of Advanced Studies in Arid Zones Casilla 554La SerenaChile

Aims Plant functional traits determine how plants respond to environmen-tal factors and influence ecosystem *** them,root traits and analyses of relations between above and below-ground traits in natural communities are *** we characterized a set of above-and below-ground traits of three dominant shrub species in a semiarid shrub-steppe that had contrasting leaf pheno-logical habits(deciduous,semideciduous and evergreen).We ana-lysed if there was coordination among above-and below-ground resource economics patterns:*** of biomass allocation,construction costs and *** Findings Above-and below-ground traits and their resource economics relations pointed to species-specific functional strategies to cope with drought and poor soils and to a species ranking of fast to slow whole-plant strategies in terms of resource uptake,biomass con-struction costs and *** deciduous shrub,Proustia cunei-folia,had relatively deep and even distribution of roots,and high proportion of short-lived tissues of low C construction costs:it had high fine to coarse root and high leaf-to-stem biomass ratios,high specific leaf area(SLA),and stems of low wood *** strat-egy allows Proustia to maximize and coordinate above-and below-ground resources uptake as long as the most limiting factor(water)is available,but at the cost of having relative high plant biomass *** evergreen Porlieria chilensis,instead,displayed a more conservative and slow strategy in terms of resource *** had~80%of the roots in the 40 cm topsoil profile,low pro-portion of fine compared with coarse roots and low leaf-to-stem ratios,low SLA and stems of high wood density,*** invested in C costly tissues that,overall,persist longer but probably at the cost of having lower plant resource uptake *** in the semide-ciduous Adesmia bedwellii were in between these two functional *** results revealed high functional diversity and above-

关键词： drought functional diversity mass fractions root distribution specific leaf area

c-Abl kinase at the crossroads of healthy synaptic remodeling and synaptic dysfunction in neurodegenerative diseases

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Neural Regeneration Research 2023年第2期18卷 237-243页

作者： Daniela A.gutiérrez América Chandía-Cristi María JoséYáñez Silvana Zanlungo Alejandra R.Alvarez Cell Signaling Laboratory Department of Cellular and Molecular BiologyCenter for Aging and Regeneration(CARE)Millennium Institute on Immunology and ImmunotherapyBiological Sciences FacultyPontificia Universidad Católica de ChileSantiagoChile School of Medical Technology Health Sciences FacultyUniversidad San SebastianSede Los LeonesSantiagoChile Department of Gastroenterology Faculty of MedicinePontificia Universidad Católica de ChileSantiagoChile

Our ability to learn and remember depends on the active formation,remodeling,and elimination of ***,the development and growth of synapses as well as their weakening and elimination are essential for neuronal *** structural reorganization of synaptic complexes,changes in actin cytos keleton and organelle dynamics,as well as modulation of gene expression,determine synaptic *** has been proposed that dys regulation of these key synaptic homeostatic processes underlies the synaptic dysfunction observed in many neurodegenerative *** is known about downstream signaling of activated N-methyl-D-aspartate andα-amino-3-hydroxy-5-methyl-4-isoazolepro pionate receptors;howeve r,other signaling pathways can also contribute to synaptic plasticity and long-lasting changes in learning and *** non-receptor tyrosine kinase c-Abl(ABL1)is a key signal transducer of intra and extracellular signals,and it shuttles between the cyto plasm and the *** review focuses on c-Abl and its synaptic and neuronal ***,we discuss the evidence showing that the activation of c-Abl can be detrimental to neurons,promoting the development of neurodegenerative ***,c-Abl activity seems to be in a pivotal balance between healthy synaptic plasticity,regulating dendritic spines remodeling and gene expression after cognitive training,and synaptic dysfunction and loss in neurodegenerative ***,c-Abl genetic ablation not only improves learning and memory and modulates the brain genetic program of trained mice,but its absence provides dendritic spines resiliency against *** re,the present review has been designed to elu cidate the common links between c-Abl regulation of structural changes that involve the actin cytos keleton and organelles dynamics,and the transc riptional program activated during synaptic *** summarizing the recent discove ries on c-Abl functions,we aim to provide an overview of how

关键词： actin cytoskeleton activity-dependent plasticity Alzheimer's disease c-Abl dendritic spines learning synapse synaptic plasticity transcription tyrosine kinase

Psychotherapy in anorexia nervosa: What does the absence of evidence mean?

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World Journal of Translational Medicine 2014年第3期3卷 150-157页

作者： Emilio gutiérrez Olaia Carrera Unidad Venres Clínicos Facultad de Psicología Campus Vida15782 Santiago de Compostela Spain Departamento de Psicología Clínica y Psicobiología Facultad de Psicología Universidad de SantiagoCampus Vida 15782 Santiago de Compostela Spain

Psychological treatment in anorexia nervosa(AN) is disheartening. Psychotherapy is the "treatment of choice" for adults though this recommendation is grounded on the absence of good quality clinical studies. This paper seeks to address the question of why improvements in the psychological treatment of AN have been thwarted, and why one of the best treatments available for adult patients is specialist supportive clinical management that has entered the stage through the backdoor of nonspecific supportive treatments originally serving as a placebo treatment assigned in randomized clinical trials to control for non-specific aspects of true psychosocial treatments. The possibility that most of the psychopathological features that characterise the AN symptoms profile could be best understood as the direct consequences of emaciation would enhance the utility of research with animal models for generating new hypothesis to improve AN treatment.

关键词： Psychotherapy Anorexia nervosa Specialist supportive clinical management Non-specific Placebo Efficacy

The sexually dimorphic expression of glutamate transporters and their implication in pain after spinal cord injury

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Neural Regeneration Research 2025年第11期20卷 3317-3329页

作者： Jennifer M.Colón-Mercado Aranza I.Torrado-Tapias Iris K.Salgado Jose M.santiago Samuel E.Ocasio Rivera Dina P.Bracho-Rincon Luis H.Pagan Rivera Jorge D.Miranda Department of Physiology University of Puerto RicoMedical Sciences CampusSan JuanPRUSA National Institutes of Health National Human Genome Research InstituteBethesdaMDUSA Universidad Central del Caribe School of MedicineBayamónPRUSA University of Puerto Rico Carolina CampusCarolinaPRUSA Institute of Neurobiology San JuanPRUSA

In addition to the loss of motor function,~60% of patients develop pain after spinal cord *** cellular-molecular mechanisms are not well understood,but the data suggests that plasticity within the rostral,epicenter,and caudal penumbra of the injury site initiates a cellularmolecular interplay that acts as a rewiring mechanism leading to central neuropathic *** can lead to the formation of new connections triggering abnormal sensory *** excitatory glutamate transporters are responsible for the reuptake of extracellular glutamate which makes them a critical target to prevent neuronal hyperexcitability and *** previous studies showed a sexually dimorphic therapeutic window for spinal cord injury after treatment with the selective estrogen receptor modulator *** this study,we investigated the anti-allodynic effects of tamoxifen in male and female rats with spinal cord *** hypothesized that tamoxifen exerts anti-allodynic effects by increasing the expression of glutamate transporters,leading to reduced hyperexcitability of the secondary neuron or by decreasing aberrant *** and female rats received a moderate contusion to the thoracic spinal cord followed by subcutaneous slow-release treatment of tamoxifen or matrix pellets as a control(placebo).We used von Frey monofilaments and the“up-down method”to evaluate mechanical *** treatment decreased allodynia only in female rats with spinal cord injury revealing a sexdependent *** expression profile of glutamatergic transporters(excitatory amino acid transporter 1/glutamate aspartate transporter and excitatory amino acid transporter 2/glutamate transporter-1)revealed a sexual dimorphism in the rostral,epicenter,and caudal areas of the spinal cord with a pattern of expression primarily on *** rodents showed a significantly higher level of excitatory amino acid transporter-1 expression while male rodents showed increased

关键词： allodynia central neuropathic pain EAAT-1/GLAST EAAT-2/GLT-1 glutamate transporters selective estrogen receptor modulator sexual dimorphism spinal cord injury trauma

Opposed elevational variation in prevalence and intensity of endoparasites and their vectors in a lizard

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Current Zoology 2018年第2期64卷 197-204页

作者： Lola ALVAREZ-ruiz Rodrigo MEGIA-PALMA Senda REGUERA santiago Rulz Francisco J. ZAMORA-CAMACHO Jordi FIGUEROLA Gregorio MORENO-RUEDA Centro de Investigaciones sobre Desertificacion-CSIC Ctra. Naquera Kin. 4.5 Moncada Valencia E-46113 Spain Departarnento de Ecologia Evolutiva Museo Nacional de Ciencias Naturales-CSIC c/Jose Gutierrez Abascal Madrid E-28006 Spain Unit of Ethology and Animal Welfare Faculty of Veterinary University CEU Cardenal Herrera Alfara del Patriarca (Valencia) E-46113 Spain Servicio de Control de Mosquitos DiputaciGn Provincial de Huelva Centro de InvestigaciGn Biornedica en Red Epidemiologia y Salud Publica (CIBERESP) Huelva Spain CIBER de Epidemiologia y Salud Peblica (CIBERESP) Spain Departamento de Biogeografia y Carnbio Global Museo Nacional de Ciencias Naturales-CSIC C/Jose Gutierrez Abascal 2 Madrid E-28006 Spain Departarnento de Ecologia de Hurnedales Estacion Biologica de Dofiana-CSIC c/Americo Vespucio s/n Sevilla E-41092 Spain Departamento de Zoologia Facultad de Ciencias Universidad de Granada Granada E-18071 Spain

Studying the causes of parasite geographic distribution is relevant to understand ecological and evolutionary processes that affect host populations as well as for species conservation. Temperature is one of the most important environmental variables affecting parasite distribution, as raising temperatures positively affect development, reproduction, and rate of transmission of both endo- and ectoparasites. In this context, it is generally accepted that, in mountains, parasite abundance decreases with elevation. However, empirical evidence on this topic is limited. In the present study, we analyzed the elevational variation of hemoparasites and ectoparasites of a lizard, Psammodromus algirus, along a 2,200-m elevational gradient in Sierra Nevada （SE Spain）. As pre- dicted, ectoparasite （mites, ticks, mosquitoes, and sandflies） abundance decreased with elevation. However, hemoparasite prevalence and intensity in the lizard augmented with altitude, showing a pattern contrary to their vectors （mites）. We suggest that tolerance to hemoparasites may increase with elevation as a consequence of lizards at high altitudes taking advantage of increased body condition and food availability, and reduced oxidative stress. Moreover, lizards could have been selected for higher resistance against hemoparasites at lowlands （where higher rates of replication are expected）, thus reducing hemoparasite prevalence and load. Our findings imply that, in a scen- ario of climate warming, populations of lizards at high elevation may face increased abundance of ectoparasites, accompanied with strong negative effects.

关键词： elevation immune system parasite distribution Psammodromus algirus reptile