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In vitro antioxidant,antilipoxygenase and antimicrobial activities of extracts from seven climbing plants belonging to the Bignoniaceae

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Journal of Integrative Medicine 2018年第4期16卷 255-262页

作者： Carola Analla Torres Cristina Marisel Perez Zamora Maria Beatriz nunez Ana Maria Gonzalez Laboratory of Microbiology and Pharmaceutical Technology Department of Basic and Applied SciencesNational University of Chaco AustralPresidencia Roque Saenz Pena 3700ChacoArgentina National Council for Scientific and Technical Research(CONICET) Godoy Cruz 2290Buenos Aires C1425FQBArgentina Institute of Botany of the Northeast(IBONE-CONICET) Sargento Juan Bautista Cabral 2131CorrientesArgentina

Objectives： This study aimed to evaluate the in vitro antioxidant capacity, to determine the anti-inflammatory effect due to lipoxygenase inhibition and to test the antimicrobial activity of ethanolic extracts from leaves of seven climbing species belonging to the Bignoniaceae family. These species are Adenocalyrnrna rnarginatum （Cham.） DC., Amphilophium vauthieri DC., Cuspidaria convoluta （VEIL） A. H. Gentry, Dolichandra dentata （K. Schum.） L. G. Lohmann, Fridericia caudigera （S. Moore） L. G. Lohmann, Fridericia chica （Bonpl.） L. G. Lohmann and Tanaecium selloi （Spreng.） L. G. Lohmann. Methods： The antioxidant activity was evaluated using three methods, 2,2＇-azino-bis（3-ethylbenzothiazo line-6-sulfonic acid）（ABTS）, 2,2-diphenyl-l-picrylhydrazyl （DPPH）, and ferric reducing antioxidant power. Lipoxygenase-inhibiting activity was assayed spectrophotometrically; the result was expressed as percent inhibition. The antimicrobial activity was assessed using the agar disk diffusion method. Minimal inhibitory concentration （MIC） and minimal bactericidal]fungicidal concentration were also determined for each extract against 12 pathogenic bacterial strains of Staphylococcus aureus and seven fungal strains of the Candida genus. The identification of the major compounds present in the most promising extract was established by high-performance liquid chromatography-tandem mass spectrometry. Results： C convoluta, F. caudigera, and F. chica exhibited the best antioxidant activity by scavenging DPPH and ABTS~ radicals and reducing Fe3＋ ion. These extracts showed a notable inhibition of lipnxygenase. F. caudigera was found to have the lower MIC value against S. aureus strains and six Candida species. The extracts of F. caudigera and C. convoluta were active even against methicillin-resistant S. aureus. C convoluta had higher total phenol content, better antioxidant activity and superior anti- inflammatory and antimicrobial activity. The main phenolic compounds found in this extract

关键词： Cuspidaria Fridericia Antioxidants Lipoxygenase Antimicrobials Herbal drugs Free radical scavengers

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Proposed Strategies to Prevent High Solid Waste Generation,In the Urban Area of Panama

Proposed Strategies to Prevent High Solid Waste Generation,I...

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作者： Idalesky Alejandra nunez Peralta 上海交通大学

学位级别：硕士

The high waste generation in contrast to the limited capacity and infrastructure for its handling,the cultural patterns that exist,is a serious problem in Latin America,and Panama is not exempt from *** collects only the 65% of their total *** the total waste that they generate represents 1.22 *** person per *** does not have an integral system of waste management and treatment,not with the capacity,infrastructure,administration and economic flow for the amount of garbage *** activity in Panama and Latin America is basically done *** by the street workers who are exposed to diseases and pollution every *** contribution represents approximately 98% of the total activity of *** it is estimated that is only 2% of total solid waste ***,it is estimated that 70% of the solid waste of Panama,it is considered *** objectives of this research aims to cover a diagnosis of these factors influencing on the high generation of solid waste in Panama,explore the level of environmental and recycling culture of the citizens,analyze the development of the recycling industry,to evaluate strategies from model countries on waste management to analyze which of these strategies the Panamanian society would be more willing to *** methodology of this study included review of documents from previous studies,interview with the CO Founder of a Panamanian Foundation which helps to collect materials for recycling（Fundacion Costa Recicla）,and a survey for the evaluation of strategies,additional reports from the Government of Panama,at the same time official organizations of Latin America,The World Bank and *** results it was obtained,that in effect it is true the formulated by Forbes,about the five challenges in Latin America,that it is necessary: green politicians,education,fighting poverty,reuse of products and less *** have a good perception of the current and future eco

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Robust Disturbance Rejection Based Control with Extended-state Resonant Observer for Sway Reduction in Uncertain Tower-cranes

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International Journal of Automation and computing 2019年第6期16卷 812-827页

作者： Horacio Coral-Enriquez santiago Pulido-Guerrero John Cortés-Romero Programa de Ingeniería Mecatrónica Facultad de IngenieríaUniversidad de San Buenaventura sede BogotáCra.8H No 172-20 Edif.DBBogotáOf204Colombia Departamento de Ingeniería Eléctrica y Electrónica Facultad de IngenieríaUniversidad Nacional de Colombia sede BogotáCra.30 No 45-03 Edif.453BogotáOf222Colombia

In this paper, the problem of load transportation and robust mitigation of payload oscillations in uncertain tower-cranes is addressed. This problem is tackled through a control scheme based on the philosophy of active-disturbance-rejection. Here, a general disturbance model built with two dominant components: polynomial and harmonic, is stated. Then, a disturbance observer is formulated through state-vector augmentation of the tower-crane model. Thus, better performance of estimations for system states and disturbances is achieved. The control law is then formulated to actively reject the disturbances but also to accommodate the closed-loop system dynamics even under system uncertainty. The proposed control schema is validated via experimentation using a small-scale tower-crane,and compared with other relevant active disturbance rejection control(ADRC)-based techniques. The experimental results show that the proposed control scheme is robust under parametric uncertainty of the system, and provides improved attenuation of payload oscillations even under system uncertainty.

关键词： Active disturbance rejection control(ADRC) extended state observer(ESO) tower-crane control resonant observer disturbance observer linear matrix inequality

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Structure, Thermal Behavior and Characterization of a New Hybrid Iron Fluoride FeF4（2,2′-bipyridine）（H2O）2

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Chemical Research in Chinese Universities 2015年第1期31卷 16-20页

作者： Mouna SMIDA Hager LITAIEM Mohamed DAMMAK santiago GARCIA-GRANDA Laboratoire de Chimie Inorganique Faculte des Sciences de Sfax Universite de Sfax 3000Sfax Tunisie Departement de Chimie Physique Analytique Faculte de Chimie Universite d'Oviedo-CINN 33006 Oviedo Spain

New crystal of FeF4（2,2′-bipyridine）（H2O）2 was prepared by hydrothermal synthesis. Crystalline structure determination is performed from single crystal X-ray diffraction data. The unit cell is monoclinic space group P21/n, with cell parameters a=0.9046（5） nm, b=0.7502（5） nm, c=1.9539（5） nm,β=93.307（5）°, V=1.3238（12） nm^3 and Z=4. The structure of FeF4（2,2＇-bipyridine）（H2O）2 is built up from FeF4N2 octahedra coordinated by two nitrogen atoms of the 2,2＇-bipyridine molecules, and four fluorine atoms as well as uncoordinated H2O molecules. Thermal analysis of the title compound showed that the decomposition introduced four steps. IR spectra confirmed the presence of 2,2＇-bipyridine molecules. The optical absorption was measured at the corresponding 2max using UV-Vis diffuse reflectance spectrum.

关键词： Hydrothermal synthesis Hybrid Iron fluoride

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Premature losses of leaf area in response to drought and insect herbivory through a leaf lifespan gradient

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Journal of Forestry Research 2022年第1期33卷 39-50页

作者： Sonia Mediavilla Montserrat Martínez-Ortega santiago Andrés Javier Bobo Alfonso Escudero Departamento de Ecología Facultad de BiologíaUniversidad de Salamanca37071 SalamancaSpain Departamento de Botánica y Fisiología Vegetal Facultad de BiologíaUniversidad de Salamanca37071 SalamancaSpain

Implications of the differences in leaf life span are still subject to debate in the field of *** leaf traits associated with these differences may be decisive for determining the distribution of tree species,this topic is particularly relevant in the context of climate *** study analyzes the effects of the differences in leaf life span on premature losses of leaf area owing to insect herbivory and to abiotic *** of leaf area may be an important determinant of total leaf carbon *** Mediterranean tree species,distributed on four sites with different climates were *** species exhibited strong differences in leaf life span and in leaf traits,especially leaf mass per unit *** leaf area losses were estimated in response to insect herbivory and summer drought over two *** results revealed that,despite having older leaf cohorts with more damage,species with longer leaf duration had lower area lost to herbivores and less damage due to accelerated senescence during the summer *** respect to the predicted increase in water stress,deciduous species are at a disadvantage due to their high premature loss of leaf area and thus loss of photosynthetic capacity.

关键词： Accelerated senescence Insect herbivory Leaf life span Leaf structural reinforcement Summer drought

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Rethinking de novo immune hepatitis,an old concept for liver allograft rejection:relevance of glutathione S-transferase T1 mismatch

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World Journal of Gastroenterology 2018年第29期24卷 3239-3249页

作者： Isabel Aguilera Elena Aguado-Dominguez Jose Manuel Sousa Antonio nunez-Roldan Department of Immunology Instituto de Biomedicina de Sevilla(IBIS)Hospital Universitario Virgen del RocíoSevilla 41013Spain Digestive and Liver Diseases Service Hospital Universitario Virgen del RocíoSevilla 41013Spain

Antibody-mediated rejection(AMR) in liver transplantation has long been underestimated. The concept of the liver as an organ susceptible to AMR has emerged in recent years, not only in the context of the major histocompatibility complex with the presence of HLA donor-specific antibodies, but also with antigens regarded as "minor", whose role in AMR has been demonstrated. Among them, antibodies against glutathione S-transferase T1 have been found in 100% of patients with de novo autoimmune hepatitis(dn AIH) when studied. In its latest update, the Banff Working Group for liver allograft pathology proposed replacing the term dn AIH with plasma cell(PC)-rich rejection. Antibodies to glutathione S-transferase T1(GSTT1) in null recipients of GSTT1 positive donors have been included as a contributory but nonessential feature of the diagnosis of PC-rich rejection. Also in this update, non-organ-specific anti-nuclear or smooth muscle autoantibodies are no longer included as diagnostic criteria. Although initially found in a proportion of patients with PC-rich rejection, the presence of autoantibodies is misleading since they are not diseasespecific and appear in many different contexts as bystanders. The cellular types and proportions of the inflammatory infiltrates in diagnostic biopsies have been studied in detail very recently. PC-rich rejection biopsies present a characteristic cellular profile with a predominance of T lymphocytes and a high proportion of PCs, close to 30%, of which 16.48% are Ig G4+. New data on the relevance of GSTT1-specific T lymphocytes to PC-rich rejection will be discussed in this review.

关键词： glutathione S-transferase T1 mismatch liver allograft rejection plasma cell-rich rejection de novo autoimmune hepatitis donor-specific antibodies newCAST cell quantification IgG4+plasma cell T lymphocytes

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Sailboat navigation control system based on spiking neural networks

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Control Theory and Technology 2023年第4期21卷 489-504页

作者： Nelson santiago Giraldo Sebastián Isaza Ricardo Andrés Velásquez Department of Electronics and Telecommunications Engineering University of Antioquia67 stMedellin050010AntioquiaColombia

In this paper,we presented the development of a navigation control system for a sailboat based on spiking neural networks(SNN).Our inspiration for this choice of network lies in their potential to achieve fast and low-energy computing on specialized *** train our system,we use the modulated spike time-dependent plasticity reinforcement learning rule and a simulation environment based on the BindsNET library and USVSim *** objective was to develop a spiking neural network-based control systems that can learn policies allowing sailboats to navigate between two points by following a straight line or performing tacking and gybing strategies,depending on the sailing scenario *** presented the mathematical definition of the problem,the operation scheme of the simulation environment,the spiking neural network controllers,and the control strategy *** a result,we obtained 425 SNN-based controllers that completed the proposed navigation task,indicating that the simulation environment and the implemented control strategy work ***,we compare the behavior of our best controller with other algorithms and present some possible strategies to improve its performance.

关键词： Sailboat Control Spiking neuron Reinforcement learning BindsNet USVSim

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Evolution of radical hysterectomy for cervical cancer along the last two decades: single institution experience

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Chinese Journal of Cancer Research 2016年第2期28卷 215-220页

作者： Claudia Arispe Ana Isabel Pomares Javier De santiago Ignacio Zapardiel Gynecologic Oncology Department La Paz University Hospital

Background： The radical hysterectomy （RH） surgical technique has improved along the years. It is used for the treatment of cervical cancer, endometrial cancer when affecting the cervix, and upper vaginal carcinomas. Our aim was to describe the historical evolution of the technique after the introduction of laparoseopy at our institution. Methods： We performed a retrospective review of medical records of patients who underwent RH, grouped in three periods according to the year of surgery： 1990-1999, 2000-2009 and 2010-2013. Patients＇ characteristics, pathologic details, intraoperative and postoperative complications were analyzed and comoared throughout the time periods. Results： A total of 102 cases of RH were performed at our center during the study period. Among all data collected, the presence of necrosis, age, number of lymph nodes, surgery route, operating time, hospital stay, blood loss and transfusion requirement were statistically significant different among groups. Conversion to laparotomy rate was 19% for the second period compared to the absence of cases in the last one. No significant differences （P=0.124） were observed in the adjuvant treatment received among the three different groups. At the time of the last contact the patients free of disease were 12 （85.7%）, 53 （91.3%） and 26 （86.6%） respectively （P=0.406）. Regarding the disease-free interval, we found significant better outcomes in the group of laparotomy compared to laparoscopy （P=0.015）.Conclusions： Laparoscopic RH is an acceptable surgery with advantages like magnified vision of the operation＇s field, lower surgical complications, shorter hospital stay and earlier resumption to daily activities.

关键词： Gynaecological cancer radical hysterectomy (RH) laparoscopy cervical cancer

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The Iberian Roma Population Variant Server(IRPVS)

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Journal of Genetics and Genomics 2024年第7期51卷 769-773页

作者： Fabiola Mavillard Javier Perez-Florido Francisco M.Ortuño Amador Valladares Miren L.Álvarez-Villegas Gema Roldán Rosario Carmona Manuel Soriano santiago Susarte Pilar Fuentes Daniel López-López Ana María Nuñez-Negrillo Alejandra Carvajal Yolanda Morgado Daniel Arteaga Rosa Ufano Pablo Mir Juan F.Gamella Joaquín Dopazo Carmen Paradas Macarena Cabrera-Serrano Instituto de Biomedicina de Sevilla(IBiS) Hospital Universitario Virgen del Rocío/CSIC/Universidad de SevillaSevillaSpain Centro Investigación Biomédica en Red Enfermedades Neurodegenerativas(CIBERNED) Instituto de Salud CarlosⅢSevillaSpain Plataforma Andaluza de Medicina Computacional Fundación Progreso y Salud(FPS)Hospital Virgen del RocíoSevillaSpain Grupo de medicina computacional de sistemas Instituto de Biomedicina de Sevilla(IBiS)Hospital Virgen del RocíoSevillaSpain Nodo de Genómica Funcional (INB-ELIXIR-es)Fundación Progreso y Salud(FPS)Hospital Virgen del RocíoSevilla 41013Spain Bioinformática en Enfermedades raras(BiER) Centro de Investigación Biomédica en Red de Enfermedades Raras(CIBERER)Instituto de salud CarlosⅢSevillaSpain Departamento de Ingeniería de Computadores Automática y RobóticaUniversidad de GranadaGranadaSpain Servicio de Urgencias de Atención Primaria Distrito SevillaSevillaSpain Centro de Servicios Sociales Negociado de Servicios EspecializadosAyuntamiento de SevillaSevillaSpain Departamento de Enfermería Facultad de Ciencias de la SaludUniversidad de GranadaGranadaSpain Departamento de Neurología Hospital Virgen de las NievesGranadaSpain Departamento de Neurología Hospital Virgen de ValmeSevillaSpain Centro de Salud Utrera Sur SevillaSpain Centro de Salud Polígono Sur SevillaSpain Unidad de Trastornos del Movimiento Servicio de Neurología y Neurofisiología ClínicaHospital Universitario Virgen del RocíoSevillaSpain Departamento de Medicina Facultad de MedicinaUniversidad de SevillaSevilleSpain Departamento de Antropología Social Universidad de GranadaSpain Unidad Enfermedades Neuromusculares Servicio de Neurología y Neurofisiología ClínicaHospital Universitario Virgen del RocíoSevillaSpain

In recent years,the number of known disease genes has exponentially grown due to the widespread adoption of cost-effective massive parallel *** identify new disease variants,especially in monogenic disorders,a frequen... 详细信息

关键词： Server filtering massive

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Thrombolysis in elderly patients

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Journal of Geriatric Cardiology 2007年第4期4卷 250-253页

作者： santiago Herrero Jose Antonio Lapuerta-Irigoyen Pacemaker and Coronary Unit Intensive Care ServiceCabuees HospitalGijon Spain Pacemaker and Coronary Unit Intensive Care ServiceCabuees HospitalGijonSpain

The elderly population consists of those over age 75 years and appears to represent the fastest-growing segment of the population. Intravenous thrombolytic therapy (TT) is the most common strategy for the treatment of acute myocardial infarction (AMI) in many parts of the world. However, TT carries a higher risk of intra-cranial hemorrhage (ICH) in the elderly patients. Primary percutaneous transluminal coronary angioplasty and stenting (PCI) represents an important alternative in these elderly individuals with contraindications to TT. In developing countries, or in areas without availability of primary PCI, TT remains the only therapeutic modality. Dedicated randomized trials are needed to provide a comprehensive understanding of AMI management in the elderly group.(J Geriatr Cardiol 2007;4:250-253.)

关键词： acute myocardial infarction thrombolysis elderly

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