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International Journal of Mining Science and Technology 2023年第5期33卷 555-571页

作者： Alberto Fernández JoséA.Sanchidrián Pablo Segarra Santiago Gómez Enming Li Rafael Navarro Universidad Politécnica de Madrid–ETSI Minas y Energía Spain Universidad de Salamanca–gIR Charrock Spain

A procedure to recognize individual discontinuities in rock mass from measurement while drilling(MWD)technology is developed,using the binary pattern of structural rock characteristics obtained from in-hole images for calibration.Data from two underground operations with different drilling technology and different rock mass characteristics are considered,which generalizes the application of the methodology to different sites and ensures the full operational integration of MWD data analysis.Two approaches are followed for site-specific structural model building:a discontinuity index(DI)built from variations in MWD parameters,and a machine learning(ML)classifier as function of the drilling parameters and their variability.The prediction ability of the models is quantitatively assessed as the rate of recognition of discontinuities observed in borehole logs.Differences between the parameters involved in the models for each site,and differences in their weights,highlight the site-dependence of the resulting models.The ML approach offers better performance than the classical DI,with recognition rates in the range 89%to 96%.However,the simpler DI still yields fairly accurate results,with recognition rates 70%to 90%.These results validate the adaptive MWD-based methodology as an engineering solution to predict rock structural condition in underground mining operations.

关键词： Drill monitoring technology Rock mass characterization Underground mining Similarity metrics of binary vectors Structural rock factor Machine learning

A novel simple procedure to consider seismic soil structure interaction effects in 2D models

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Earthquake Engineering and Engineering Vibration 2014年第3期13卷 535-543页

作者： Juan Diego Jaramillo Juan David gómez Doriam Restrepo santiago Rivera Universidad EAFIT Medellín Colombia INTEgRAL S.A Medellín Colombia

A method is proposed to estimate the seismic soil-structure-interaction （SSI） effects for use in engineering practice. It is applicable to 2D structures subjected to vertically incident shear waves supported by homogenous half-spaces. The method is attractive since it keeps the simplicity of the spectral approach, overcomes some of the difficulties and inaccuracies of existing classical techniques and yet it considers a physically consistent excitation. This level of simplicity is achieved through a response spectra modification factor that can be applied to the free-field 5%-damped response spectra to yield design spectral ordinates that take into account the scattered motions introduced by the interaction effects. The modification factor is representative of the Transfer Function （TF） between the structural relative displacements and the free- field motion, which is described in terms of its maximum amplitude and associated frequency. Expressions to compute the modification factor by practicing engineers are proposed based upon a parametric study using 576 cases representative of actual structures. The method is tested in 10 cases spanning a wide range of common fundamental vibration periods.

关键词： seismic soil structure interaction simplified procedures modified response spectra

Impact of aspiration catheter size on first-pass effect in the combined use of contact aspiration and stent retriever technique

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Stroke & Vascular Neurology 2021年第4期6卷 553-560页

作者： Carlos Pérez-garcía Christian Maegerlein santiago Rosati Charlotte Rüther Carlos gómez-Escalonilla Claus Zimmer Juan Arrazola Maria Teresa Berndt Manuel Moreu Interventional Neuroradiology Hospital Clinico Universitario San CarlosMadridSpain Department of Diagnostic and Interventional Neuroradiology Klinikum rechts der Isar der Technischen Universitat MunchenMunchenBayernGermany Neurology Hospital Clinico Universitario San CarlosMadridSpain Radiology Hospital Clinico Universitario San CarlosMadridSpain

Background and purpose The first-pass effect(FPE),defined as a first-pass Expanded Treatment in Cerebral Ischaemia(eTICI)2c/3 reperfusion,has emerged as a key metric of efficacy in mechanical thrombectomy(MT)for acute ischaemic stroke.The proximal balloon occlusion together with direct thrombus aspiration during stent retriever thrombectomy(PROTECT)-PLUS technique consists in the use of a balloon guide catheter and a combined MT approach involving contact aspiration and a stent retriever.The aim of this study is to assess the effectiveness and safety of the PROTECT-PLUS technique using distal aspiration catheters(DACs)with different inner diameters by comparing the large-bore DAC Catalyst 7 versus the use of medium-bore DACs.Methods Retrospective analysis of a prospectively maintained database of patients treated with PROTECT-PLUS using Catalyst 7,Catalyst 6 or Catalyst 5 with an occlusion of either the terminal carotid artery or the M1 or M2 segments of the middle cerebral artery from 2018 to 2020 in two comprehensive stroke centres.Baseline characteristics and procedural,safety and clinical outcomes were compared between groups.Multivariable logistic regression analysis was performed in order to find independent predictors of FPE.Results We identified 238 consecutive patients treated with PROTECT-PLUS as front-line approach using Catalyst 7(n=86),Catalyst 6(n=78)and Catalyst 5(n=76).The rate of FPE was higher with Catalyst 7(54%)than Catalyst 6(33%,p=0.009)and Catalyst 5(32%,p=0.005),in addition to higher final eTICI 2c/3 reperfusion rates,shorter procedural times,lower need of rescue therapy and fewer procedure-related complications.After multivariable analysis the sole independent factor associated to FPE was the use of Catalyst 7(OR 2.34;95%CI 1.19 to 4.58;p=0.014).Conclusion Further development of combined MT by incorporating larger-bore aspiration catheters is associated with higher reperfusion rates,shorter procedure times,and lower need of rescue therapy while reducing the complication rates.

关键词： shorter effect maintained

Alcoholic liver disease:Utility of animal models

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World Journal of gastroenterology 2018年第45期24卷 5063-5075页

作者： Arantza Lamas-Paz Fengjie Hao Leonard J Nelson Maria Teresa Vázquez santiago Canals Manuel gómez del Moral Eduardo Martínez-Naves Yulia A Nevzorova Francisco Javier Cubero Department of Immunology Ophthalmology and ORLComplutense University School of MedicineMadrid 28040Spain 12 de Octubre Health Research Institute(imas12) Madrid 28041Spain Institute for Bioengineering(IBioE) School of EngineeringFaraday BuildingThe University of EdinburghEdinburgh EH9 3 JLScotlandUnited Kingdom Department of Human Anatomy and Embryology Complutense University School of MedicineMadrid 28040Spain Instituto de Neurociencias Consejo Superior de Investigaciones CientíficasUniversidad Miguel HernándezSan Juan de Alicante 03550Spain Department of Cell Biology Complutense University School of MedicineMadrid 28040Spain Department of genetics Physiology and MicrobiologyFaculty of BiologyUniversidad ComplutenseMadrid 28040Spain Department of Internal Medicine Ⅲ University Hospital RWTH AachenAachen 52062Germany

Alcoholic liver disease(ALD) is a major cause of acute and chronic liver injury. Extensive evidence has been accumulated on the pathological process of ALD during the past decades. However, effective treatment options for ALD are very limited due to the lack of suitable in vivo models that recapitulate the full spectrum of ALD. Experimental animal models of ALD, particularly rodents, have been used extensively to mimic human ALD. An ideal animal model should recapitulate all aspects of the ALD process, including significant steatosis, hepatic neutrophil infiltration, and liver injury. A better strategy against ALD depends on clear diagnostic biomarkers, accurate predictor(s) of its progression and new therapeutic approaches to modulate stop or even reverse the disease. Numerous models employing rodent animals have been established in the last decades to investigate the effects of acute and chronic alcohol exposure on the initiation and progression of ALD. Although significant progress has been made in gaining better knowledge on the mechanisms and pathology of ALD, many features of ALD are unknown, and require further investigation, ideally with improved animal models that more effectively mimic human ALD. Although differences in the degree and stages of alcoholic liver injury inevitably exist between animal models and human ALD, the acquisition and translational relevance will be greatly enhanced with the development of new and improved animal models of ALD.

关键词： Steatohepatitis Cirrhosis Hepatocellular carcinoma Alcoholic liver disease Reactive oxygen species

Narcea—an unknown,ancient cultivated rose variety from northern Spain

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Horticulture Research 2020年第1期7卷 2217-2228页

作者： María-Carmen Martínez José-Luis santiago Susana Boso Pilar gago InmaculadaÁlvarez-Acero María-Estela De Vega Miguel Martínez-Bartolomé RafaelÁlvarez-Nogal Pilar Molíst Matteo Caser Valentina Scariot Daniel gómez-garcía Misión Biológica de galicia(CSIC) Carballeira 8Salcedo 36143 PontevedraSpain Instituto de Ciencia y Tecnología de Alimentos y Nutrición(CSIC)(Spain) C/JoséAntonio Novais 1028040 MadridSpain Departamento de Biología Molecular-Área de Biología Celular Universidad de LeónCampus de Vegazana s/n24071 LeónSpain grupo Neurolamb Biología funcional y Ciencias de la SaludUniversidad de Vigo(Spain)36310 As Lagoas-MarcosendeSpain Department of Agricultural Forest and Food SciencesUniversity of TorinoLargo Paolo Braccini 210095 GrugliascoTurinItaly Instituto Pirenaico de Ecología(CSIC) Dpto.Conservación de Ecosistemas NaturalesAvda.Montaña S/NZaragoza50016 ZaragozaSpain

The present work reports the discovery and the complete characterisation of an ancient cultivated rose variety found growing in a private garden in the southwest of the Principality of Asturias(northern Spain).The variety is here given the name Narcea.The majority of roses currently cultivated belong to the so-called group of‘Modern Roses’,all of which were obtained after 1867 via artificial crosses and improvement programmes.All are destined for ornamental use.Until the 19th century,the great majority of the many ancient cultivated roses in Europe were used in perfumery and cosmetics,or had medicinal uses.Rosa damascena and Rosa centifollia are still grown and used by the French and Bulgarian perfume industries.The Asturian Massif of the Cantabrian Mountain Range provides a natural habitat for some 75%of the wild members of the genus Rosa,but until now there was no evidence that this area was home to ancient cultivated roses.A complete botanical description is here provided for a discovered ancient rose.It is also characterised according to a series of sequence tagged microsatellite sites,and its agronomic features are reported.In addition,a histological description(optical and scanning electronic microscope studies)of the petals is offered,along with an analysis of the volatile compounds present in these organs as determined by solid phase microextraction and gas chromatography-mass spectroscopy.The results reveal the uniqueness of this ancient type of rose and suggest it may be of interest to the perfume industry.

关键词： ancient southwest majority

Nightlife in the city: drivers of the occurrence and vocal activity of a tropical owl

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Avian Research 2020年第2期11卷 92-105页

作者： Oscar Humberto Marín‑gómez Michelle garcía‑Arroyo Camilo ESánchez‑Sarria JRoberto Sosa‑López Diego santiago‑Alarcon Ian Macgregor‑Fors Red de Ambiente y Sustentabilidad Instituto de Ecología A.C.Carretera antigua a Coatepec 351El Haya91073 XalapaVeracruzMexico Departamento de Ciencias Naturales y Matemáticas Pontificia Universidad Javeriana Cali760044 CaliColombia Centro Interdisciplinario de Investigación para el Desarrollo Integral Regional Unidad Oaxaca(CIIDIR) Instituto Politécnico NacionalOaxacaMexico Dirección de Cátedras Consejo Nacional de Ciencia y Tecnología(CONACYT)Mexico CityMexico Red de Biología y Conservación de Vertebrados Instituto de Ecología A.C91073 XalapaVeracruzMexico

Background:Cities differ from non-urban environments by the intensity,scale,and extent of anthropogenic pres-sures,which can drive the occurrence,physiology,and behavior of the organisms thriving in these settings.Traits as green cover often predict the occurrence patterns of bird species in urban areas.Yet,anthropogenic noise and artificial light at night(ALAN)could also limit the presence and disrupt the behavior of birds.However,there is still a dearth of knowledge about the influence of urbanization through noise and light pollution on nocturnal bird species ecology.In this study,we assessed the role of green cover,noise,and light pollution on the occurrence and vocal activity of the Mottled Owl(Ciccaba virgata)in the city of Xalapa(Mexico).Methods:We obtained soundscape recordings in 61 independent sites scattered across the city of Xalapa using autonomous recording units.We performed a semi-automated acoustic analysis of the recordings,corroborating all Mottled Owl vocalizations.We calculated two measures of anthropogenic noise at each study site:daily noise(during 24 h)and masking noise(mean noise amplitude at night per site that could mask the owl’s vocalizations).We further performed generalized linear models to relate green cover,ALAN,daily noise,and masking noise in relation to the owl’s occurrence(i.e.,detected,undetected).We also ran linear models to assess relationships among the beginning and ending of vocal activity with ALAN,and with the anthropogenic and masking noise levels at the moment of which vocalizations were emitted.Finally,we explored variations of the vocal activity of the Mottled Owl measured as vocalization rate across time.Results:The presence of Mottled Owls increased with the size of green cover and decreased with increases in both artificial light at night and noise levels.At the temporal scale,green cover was positively related with the ending of the owl’s vocal activity,while daily noise and ALAN levels were not related to the timing and vocal output(i.e.,number of vocalization

关键词： Anthropogenic noise Acoustic monitoring Nighttime ecology Urban ecology Urbanization Vocal activity

Pitfalls of barcodes in the study of worldwide SARSCoV-2 variation and phylodynamics

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Zoological Research 2021年第1期42卷 87-93页

作者： Jacobo Pardo-Seco Alberto gómez-Carballa Xabier Bello Federico Martinón-Torres Antonio Salas Unidade de Xenética Instituto de Ciencias Forenses(INCIFOR)Facultade de MedicinaUniversidade de Santiago de Compostelaand GenPoB Research GroupInstituto de Investigación Sanitaria(IDIS)Hospital Clínico Universitario de Santiago(SERGAS)Galicia 15706Spain genetics Vaccines and Pediatric Infectious Diseases Research Group(GENVIP)Instituto de Investigación Sanitaria de Santiago(IDIS)and Universidad de Santiago de Compostela(USC)Galicia 15706Spain Translational Pediatrics and Infectious Diseases Department of PediatricsHospital Clínico Universitario de Santiago de Compostela(SERGAS)Galicia 15706Spain

DEAR EDITOR,Analysis of SARS-CoV-2 genome variation using a minimal number of selected informative sites conforming a genetic barcode presents several drawbacks.We show that purely mathematical procedures for site selection should be supervised by known phylogeny(i)to ensure that solid tree branches are represented instead of mutational hotspots with poor phylogeographic proprieties,and(ii)to avoid phylogenetic redundancy.We propose a procedure that prevents information redundancy in site selection by considering the cumulative informativeness of previously selected sites(as a proxy for phylogenetic-based criteria).This procedure demonstrates that,for short barcodes(e.g.,11 sites),there are thousands of informative site combinations that improve previous proposals.We also show that barcodes based on worldwide databases inevitably prioritize variants located at the basal nodes of the phylogeny,such that most representative genomes in these ancestral nodes are no longer in circulation.Consequently,coronavirus phylodynamics cannot be properly captured by universal genomic barcodes because most SARS-CoV-2 variation is generated in geographically restricted areas by the continuous introduction of domestic variants.

关键词： dynamics properly purely

Characteristics and in-hospital mortality of elderly patients with heart failure in Spanish hospitals

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Journal of geriatric Cardiology 2023年第4期20卷 247-255页

作者： Alberto Esteban-Fernández Manuel Anguita-Sánchez Juan Luis Bonilla-Palomas María Anguita-gámez María garcía JoséLuis Bernal Náyade Del Prado Cristina Fernández-Pérez Julián Pérez-Villacastin Juan Joségómez-Doblas Francisco Javier Elola Cardiology Department Hospital Universitario Severo OchoaMadridSpain Cardiology Department Hospital Universitario Reina SofíaCórdobaSpain Cardiology Department Hospital San Juan de la CruzÚbedaSpain Cardiology Department Hospital Clínico San CarlosMadridSpain Fundación Instituto para la Mejora de la Asistencia Sanitaria MadridSpain Management Control Department Hospital Universitario 12 de OctubreMadridSpain Department of Preventive Medicine Área Sanitaria de Santiago de Compostela y BarbanzaInstituto de Investigación de SantiagoSantiago de CompostelaSpain Cardiology Department Hospital Universitario Virgen de la VictoriaMálagaSpain

BACKgROUND The prevalence of heart failure(HF)increases with age,and it is one of the leading causes of hospitalization and death in older patients.However,there are little data on in-hospital mortality in patients with HF≥75 years in Spain.METHODS A retrospective analysis of the Spanish Minimum Basic Data Set was performed,including all HF episodes discharged from public hospitals in Spain between 2016 and 2019.Coding was performed using the International Classification of Diseases,10th Revision.Patients≥75 years with HF as the principal diagnosis were selected.We calculated:(1)the crude in-hospital mortality rate and its distribution according to age and sex;(2)the risk-standardized in-hospital mortality ratio;and(3)the association between in-hospital mortality and the availability of an intensive cardiac care unit(ICCU)in the hospital.RESULTS We included 354,792 HF episodes of patients over 75 years.The mean age was 85.2±5.5 years,and 59.2%of patients were women.The most frequent comorbidities were renal failure(46.1%),diabetes mellitus(35.5%),valvular disease(33.9%),cardiorespiratory failure(29.8%),and hypertension(26.9%).In-hospital mortality was 12.7%,and increased with age[odds ratio(OR)=1.07,95%CI:1.07–1.07,Pgenic shock(OR=19.5,95%CI:16.8–22.7,Pgher in males and elderly patients.The main predictors of mortality were cardiogenic shock,stroke,and advanced cancer.There was a trend toward lower mortality in centers with an ICCU.

关键词： patients mortality diagnosis

Biogeographical informativeness of Y-STR haplotypes

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Science Bulletin 2019年第19期64卷 1381-1384页

作者： Jacobo Pardo-Seco Alberto gómez-Carballa Xabier Bello Federico Martinón-Torres Antonio Salas Unidade de Xenética Instituto de Ciencias Forenses(INCIFOR)Facultade de MedicinaUniversidade de Santiago de Compostelaand GenPoB Research GroupInstitutode Investigaciones Sanitarias(IDIS)Hospital Clínico Universitario de Santiago(SERGAS)GaliciaSpain grupo de Investigación en genética VacunasInfecciones y Pediatría(GENVIP)Universidade de Santiago de Compostelaand Hospital Clínico Universitario de Santiago(SERGAS)GaliciaSpain

Research on biogeographical ancestry(BgA)is becoming of growing interest in forensic genetics and in the biomedical literature(1)Thus,for instance,the need to predict ethnicity of an unknown suspect based on DNA profiles found at the crime scene is of maximum interest in criminalistics[2],and several autosomal SNP panels have been designed and tested for BgA investigations[3,4].Most of these panels aim at discriminating three main continental groups(sub-Saharan Africans,Europeans,and Asians)by way of testing a number of ancestry informative markers(AIMs)that run from a few dozens to a few hundred[5](see more background in Supplementary data online).

关键词： BgA STR Biogeographical informativeness of Y-STR haplotypes

Understanding Chemical Reactivity in Extended Systems：Exploring Models of Chemical Softness in Carbon Nanotubes

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物理化学学报 2018年第6期34卷 631-638页

作者： CáRDENAS Carlos MUNOZ Macarena CONTRERAS Julia AYERS Paul W. gómez Tatiana FUENTEALBA Patricio Departamento de Flsica Facultad de Ciencias Universidad de Chile Casilla 653 Santiago Chile Centro para el Desarrollo de la Nanociencias y Nanotecnologia CEDENNA Avenida Ecuador 3493 Santiago Chile Nucleo de Matematicas Fisica y Estad

Chemical reactivity towards electron transfer is captured by the Fukui function.However,this is not well defined when the system or its ions have degenerate or pseudo-degenerate ground states.In such a case,the first-order chemical response is not independent of the perturbation and the correct response has to be computed using the mathematical formalism of perturbation theory for degenerate states.Spatialpseudo-degeneracy is ubiquitous in nanostructures with high symmetry and totally extended systems.given the size of these systems,using degenerate-state perturbation theory is impractical because it requires the calculation of many excited states.Here we present an alternative to compute the chemical response of extended systems using models of local softness in terms of the local density of states.The local softness is approximately equal to the density of states at the Fermi level.However,such approximation leaves out the contribution of inner states.In order to include and weight the contribution of the states around the Fermi level,a model inspired by the long-range behavior of the local softness is presented.Single wall capped carbon nanotubes(SWCCNT) illustrate the limitation of the frontier orbital theory in extended systems.Thus,we have used a C360 SWCCNT to test the proposed model and how it compares with available models based on the local density of states.Interestingly,a simple Hü ckel approximation captures the main features of chemical response of these systems.Our results suggest that density-of-states models of the softness along simple tight binding Hamiltonians could be used to explore the chemical reactivity of more complex system,such a surfaces and nanoparticles.

关键词： Local softness Fukui function Reactivity Carbon nanotubes Density of states