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npj Computational Materials 2022年第1期8卷 2027-2036页

作者： Kuan-Yu Lin santhanamoorthi nachimuthu Han-Wen Huang Jyh-Chiang Jiang Department of Chemical Engineering National Taiwan University of Science and TechnologyTaipeiTaiwanChina

Here,we demonstrate that the lattice oxygen release on the high-capacity cathode,Li_(1.2)Ni_(0.6)Mn_(0.2)O_(2)(LNMO)surface can be successfully suppressed through S-anion-substitution using density functional theory(DFT)calculations and ab initio molecular dynamics(AIMD)*** oxygen evolution mechanisms on pristine and sulfur(S)-substituted LNMO(003)surfaces in the presence of an electrolyte mixture are ***-oxidation of O^(2−)anions during delithiation in the pristine surface results in oxygen evolution and subsequent structural ***,in the S-substituted LNMO,S^(2−)anions primarily participate in charge compensation and further inhibit oxygen evolution and O vacancy formation at high degrees of ***,the S-substitution effectively prevents the formation of Ni^(3+)ions and Jahn-Teller distortion,retaining the layered structure during *** findings provide insight into improving the structural stability of the LNMO(003)surface,paving the way for developing Li-rich LNMO cathode materials for next-generation LIBs.

关键词： substitution sulfur insight

Factors influencing adoption of soil and water conservation practices in the northwest Ethiopian highlands

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International Soil and Water Conservation Research 2020年第1期8卷 80-89页

作者： Agere Belachew Wuletaw Mekuria Kavitha nachimuthu Department of Rural Development and Agricultural Extension University of GondarP.O.Box 196GondarEthiopia RD National Arts and Science(Co-education)College ErodeTamilnaduIndia

Soil erosion has long been a problem in the Ethiopian highlands in general and Dembecha district in particular. The objective of this study was to identify factors influencing adoption of soil and water conservation practices. Both quantitative and qualitative data were collected from primary and sec-ondary sources. The primary data were collected from respondent samples and key informants through interview and personal observation. The secondary data were collected from sources such as books, journals, statistical reports and official documents. A multistage sampling technique was applied to select sample households. Sample sizes of 150 households were selected using simple random sampling. Both descriptive statistics and a multivariate probit econometric model were employed to analyze the data. The model results revealed that the likelihood of decisions to adopt soil bund, stone bund, check dam and strip cropping were 74, 56, 29 and 56%respectively. The joint probability of adopting the selected soil and water conservation practices was 14.2%. The model results also confirmed that age, sex, education level, household size, livestock holding, land size, access to credit, access to extension service and training were significant factors that affected the adoption of soil and water conservation practices in the study area. Based on our findings, the study suggests that the government and stakeholders should focus on strengthening the provision of formal and non-formal training and facilitate an effective extension service.

关键词： Adoption Multivariate probit model Soil degradation Strip cropping

Robust Hybrid Artificial Fish Swarm Simulated Annealing Optimization Algorithm for Secured Free Scale Networks against Malicious Attacks

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Computers, Materials & Continua 2021年第1期66卷 903-917页

作者： Ganeshan Keerthana Panneerselvam Anandan Nandhagopal nachimuthu Anna University Chennai600025India Department of ECE C.Abdul Hakeem College of Engineering and TechnologyVelloreIndia Department of ECE Excel Engineering CollegeSalemIndia

Due to the recent proliferation of cyber-attacks,highly robust wireless sensor networks(WSN)become a critical issue as they survive node ***-free WSN is essential because they endure random attacks *** they are susceptible to malicious attacks,which mainly targets particular significant ***,the robustness of the network becomes important for ensuring the network *** paper presents a Robust Hybrid Artificial Fish Swarm Simulated Annealing Optimization(RHAFS-SA)*** is introduced for improving the robust nature of free scale networks over malicious attacks(MA)with no change in degree *** proposed RHAFS-SA is an enhanced version of the Improved Artificial Fish Swarm algorithm(IAFSA)by the simulated annealing(SA)*** proposed RHAFS-SA algorithm eliminates the IAFSA from unforeseen vibration and speeds up the convergence *** experimentation,free scale networks are produced by the Barabási–Albert(BA)model,and real-world networks are employed for testing the outcome on both synthetic-free scale and real-world *** experimental results exhibited that the RHAFS-SA model is superior to other models interms of diverse aspects.

关键词： Free scale networks robustness malicious attacks fish swarm algorithm

On-farm gains and losses of soil organic carbon in terrestrial hydrological pathways:A review of empirical research

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International Soil and Water Conservation Research 2016年第4期4卷 245-259页

作者： Gunasekhar nachimuthu Nilantha Hulugalle Department of Primary Industries Australian Cotton Research InstituteNarrabriNSW 2390Australia Fenner School of Environment&Society College of MedicineBiology&EnvironmentAustralian National UniversityCanberra ACT 2601 Australia

Theoretical estimates of soil carbon sequestration in Australian farming systems often do not coincide with measured values of soil carbon,possibly due to post sequestration carbon *** loss through soil erosion is one of several pathways of sequestered carbon loss from agricultural *** details on different loss pathways,especially carbon loss through terrestrial hydrological pathways on a farm scale,are *** this article,we review the Australian and global literature on terrestrial on farm carbon gains and losses in hydrological *** scale,landscape scale and modelling studies are not the focus of this review and are only briefly *** fractions associated with soil erosion and runoff include particulate organic and inorganic carbon,dissolved organic carbon(DOC),dissolved inorganic carbon(DIC),dissolved CO_(2)-C and dissolved *** climatic zones with approximately 500 mm of annual rainfall may receive from 6.4 to 29.5 kg ha^(−1) of DOC in rainfall(with concentration of 1.28-5.9 mg L^(−1) of DOC in rainwater).Carbon addition(net)to a field through irrigation water can range from 4.6 to 30.8 kg ha^(−1).The carbon losses through runoff and erosion may vary from below detection limits to 1072 kg ha^(−1) yr^(−1) and these values are significant proportions of SOC sequestration rates reported in *** carbon enrichment ratios in eroded sediments range from 0.39 to *** organic carbon concentrations in deep drainage below farming lands range from negligible to 90 mg L^(−1).Management practices that may influence soil carbon losses in erosion and runoff include changing land use,tillage,ground cover,farm layout and slope,furrow length and vegetative buffer strips in the tail end of the *** literature surveyed indicated that a large knowledge gap existed in Australia with respect to empirical data on soil carbon lost through erosion and runoff because most studies focussed on nutrients oth

关键词： Runoff Erosion Deep drainage Carbon losses Irrigation

Effect of phase transition on room temperature ferromagnetism in cerium doped ZnS nanorods

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Transactions of Nonferrous Metals Society of China 2019年第4期29卷 811-820页

作者： nachimuthu SUGANTHI Kuppusamy PUSHPANATHAN Nanomaterials Research Laboratory Department of Physics Government Arts College

The effects of Ce doping on the structure,optical,oxidation,thermal and magnetic properties of ZnS:Ce nanorods synthesized by a chemical co-precipitation method were *** crystalline phase transformation from cubic to hexagonal structure was observed upon doping ZnS with *** measurements showed the existence of room temperature ferromagnetism in Ce-doped ZnS nanorods.X-ray photoelectron spectroscopic(XPS)measurements provided evidence for Zn-S bonds and oxidation state of Ce in the near-surface *** spectrum provided evidence for the presence of defects as well as hexagonal structure of 5 wt.%Ce doped ZnS *** substitution induced shape evolution was studied by using *** spectra further validated the incorporation of Ce^3+*** present study reveals that Ce doped ZnS nanorods may find applications in spintronic devices.

关键词： Ce dopant ZnS nanorods phase transition ferromagnetism sulphur vacancy thermal stability

Electrospinning of curcumin loaded chitosan/poly （lactic acid） nanofilm and evaluation of its medicinal characteristics

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Frontiers of Materials Science 2013年第4期7卷 350-361页

作者： Bhaarathi DHURAI nachimuthu SARASWATHY Ramasamy MAHESWARAN Ponnusamy SETHUPATHI Palanisamy VANITHA Sukumar VIGNESHWARAN~, and Venugopal RAMESHBABU Department of Textile Technology Kumaraguru College of Technology Coimbatore 641049 Tamilnadu India Department of Biotechnology Kumaraguru College of Technology Coimbatore 641049 Tamilnadu India

The curcumin loaded chitosanlpoly （lactic acid）（PLA） nanoflbers were produced using electrospinning. Box-Behnken experimental design was used for the optimization of variables （-1, 0, ＋ 1 coded level） like chitosan/PLA strength （% w/v）, curcumin strength （% w/v） and applied voltage （kV） to obtain uniform fiber diameter. The morphology of nanofibers was shown by SEM. Molecular interactions and the presence of each chemical compound of curcumin loaded chitosanlPLA fibers were characterized by FTIR and EDX analysis. Antioxidant, drug release and in vitro cytotoxicity tests were performed to evaluate the suitability of nanofibers that would be used for wound healing. In vivo wound healing studies on excision and incision wounds created on rat model showed significant reduction of wound area when compared to untreated. The better healing efficiency can be attributed to the presence of curcumin and chitosan.

关键词： Box-Behnken chitosan curcumin electrospinning poly (lactic acid) (PLA)

Highlighting novel genes associated with the classical Rett syndrome patient from India

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Genes & Diseases 2022年第6期9卷 1394-1396页

作者： Gomathi Mohan Ranjan Jyoti Sarma Mahalaxmi Iyer nachimuthu Senthil Kumar Balachandar Vellingiri UGC-RGNF Senior Research Fellow Human Molecular Cytogenetics and Stem Cell LaboratoryDepartment of Human Genetics and Molecular BiologyBharathiar UniversityCoimbatore 641046Tamil NaduIndia Department of Biotechnology Mizoram University(A Central University)Aizawl 796004MizoramIndia Livestock Farming&Bioresource Technology Tamil NaduIndia Human Molecular Cytogenetics and Stem Cell Laboratory Department of Human Genetics and Molecular BiologyBharathiar UniversityCoimbatore 641046Tamil NaduIndia

Rett syndrome(RTT)is a rare X-linked brain disorder predominantly in females,caused by mutations in Methyl-CpGBinding Protein2(MECP2)gene with the characteristic features of progressive developmental delay,severe intellectual disability,microcephaly,retarded growth,loss of communication abilities,loss of purposeful hand movements,abnormal walking or gait abnormalities,repetitive hand movements,abnormal breathing,irritability and abnormal behaviours.1 Over the last five years,more than eighty genes related to RTT were found using next generation sequencing.2 Here we presented a comprehensive clinical report of a 38-year-old RTT woman having de novo heterozygous Laminin Subunit Gamma 3 gene(LAMC3)mutation G>A(Chr9:133944387;p.C947Y)links with RTT neurological dysfunctions,brain malformations,reduced brain volume and hypoplasia of corpus *** new finding supports the possibility of targeting LAMC3 gene for rescuing the neuropathology of *** deleterious mutations found in genes such as,CACNA1B(rs4422842),CUBN(rs2271460),GPATCH3(rs779537923),TUBB1(rs463312),KCNJ5(rs768906222),VWA5A(rs551469534),DNAAF1(rs751148678),and PARP1(rs3219145)were unreported in RTT patients.

关键词： RTT lighting delay

Ethnobotanical survey of medicinal plants used in the management of cancer and diabetes

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Journal of Traditional Chinese Medicine 2020年第6期40卷 1007-1017页

作者： Garima Singh Ajit Kumar Passari Marcy D Momin Sakthivel Ravi Bhim Pratap Singh nachimuthu Senthil Kumar Department of Biotechnology Mizoram UniversityAizawl 796004India Department of Botany Pachhunga University CollegeAizawl 796001India Departamento de Biologia Molecular y Biotecnologia Instituto de Investigaciones BiomedicasUniversidad Nacional Autonoma de Mexico(UNAM)Ciudad de Mexico-04510Mexico Department of Agriculture&Environmental Sciences(AES) National Institute of Food Technology Entrepreneurship&Management(NIFTEM)SonepatHaryanaIndia

OBJECTIVE:To conduct an ethnobotanical survey and document the traditional anticancer and antidiabetic plants used by the local tribes of Mizoram,Northeast ***:A systematic survey was conducted in rural and urban areas of Mizoram by interviewing traditional practitioners,and cancer and diabetes patients.A detailed literature search was carried out using MEDLINE and SCOPUS and available literatures were selected and included in the *** use value(UV)of the selected plants was calculated based on the number of citations per species given by ***:Data was obtained for 201 traditional medicinal plants from Mizoram,Northeast *** plants were from 72 different families and belonged to 140 *** these,103 plants were reported for the first time as possessing either anticancer or antidiabetic potential,and 105 plants were identified that were used for the treatment of both *** plants(Phlogacanthus thysiformis,Solanum gilo and Lobelia angulata)with antidiabetic potential,and six plants(Dillenia scabrella,Circium sinesis,Eupatorium nodiflorum,Pratia begonifolia,Vernonia teres and Plantago erosa)with both as anticancer and antidiabetic potential were documented for the first ***:In this study,we documented several explored and unexplored medicinal plants that may be useful for the management of cancer and *** study suggests that there is a broad scope fordeveloping potent anticancer and antidiabetic agent from the flora of Mizoram,Northeast India.

关键词： Plants medicinal Antineoplastic agents Hypoglycemic agents Ethanobotanical survey Traditional knowledge

Novel technique(Ramalingam technique)of port site retrograde intra renal surgery through exteriorized ureter during laparoscopy

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Asian Journal of Urology 2023年第3期10卷 372-375页

作者： Manickam Ramalingam Kallappan Senthil Sivasankaran nachimuthu Urology Department Hindusthan HospitalCoimbatoreIndia

Occurrence of significant sized renal calculi along with ureteric pathology is not *** presented two patients:one with significant sized renal calculi along with lower ureteric stricture,and second case with significant sized renal calculi with primary obstructive mega ureter needing surgery for both the renal calculi and ureteric *** both patients laparoscopy was done,and the ureter was mobilised and divided just above the level of the pathology and exteriorised through the nearest sited port,and retrograde intra-renal surgery(RIRS)was done using flexible ureteroscope and *** laparoscopy was resumed,and ureteric reimplantation directly into the bladder or with a Boari flap was *** entire procedure was completed in a single *** novel technique of exteriorizing the ureter through the laparoscopic port site for flexible ureteroscopy in a case of lower ureteric pathology with renal stone is an advantageous option to manage both pathologies in a single *** has a better stone clearance than shock wave lithotripsy and less morbidity than percutaneous nephrolithotomy(PCNL).

关键词： ureter surgery bladder

Pharmacological and Immunological Aspects of Phage Therapy

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Infectious Microbes & Diseases 2019年第2期1卷 34-42页

作者： Prasanth Manohar Ashok.J.Tamhankar Sebastian Leptihn nachimuthu Ramesh Antibiotic Resistance and Phage Therapy Laboratory Department of Biomedical SciencesSchool of Biosciences and TechnologyVellore Institute of Technology(VIT)Vellore 632014Tamil NaduIndia Global Health Health Systems and Policy:Medicines-focusing AntibioticsDepartment of Public Health SciencesKarolinska InstitutetStockholmSweden Indian Initiative for Management of Antibiotic resistance Department of Environmental MedicineRuxmaniben Deepchand Gardi Medical CollegeUjjainIndia Zhejiang University School of Medicine Zhejiang University-Edinburgh University(ZJU-UoE)InstituteInternational CampusZhejiang UniversityHainingZhejiang 314400China Department of Infectious Diseases Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhouChina.

Bacteriophages,or viruses of microbes,when used as a medical strategy,might be able to solve the current crisis mankind faces with the increasing number of pathogens being antibiotic-resistant,where chemical drugs seized to show any therapeutic *** socalled phage therapy may be one of the most promising alternatives to treat infections caused by antibiotic-resistant bacteria,which are killed after infection by a *** phages that destroy the host by lysis are chosen for therapy,many pharmacological and immunological aspects of phages as medicines have not been established so *** immune system plays an important role in a process called phage acceptance where both,innate and adaptive immune responses of the host are ***,not only medical aspects but also social ones such as lacking public awareness or acceptance,and lack of structured regulatory guidelines are challenges that have to be addressed in the near future to establish phage therapy as a reliable and safe alternative for the treatment of *** review focuses on the unique pharmacological and immunological aspects of phages used in therapy.

关键词： phage therapy phage immune response phage stability bacteriophages phage